Exploring the molecular mechanisms by which per- and polyfluoroalkyl substances induce polycystic ovary syndrome through in silico toxicogenomic data mining
This study utilized toxicogenomics and comparative toxicogenomics databases to analyze data and investigate how PFAS mixtures may contribute to the development of PCOS. The results indicated that 74 genes are associated with both PFAS exposure and PCOS progression. Enrichment analysis suggested that cell cycle regulation and steroid hormone synthesis may be crucial pathways through which PFAS mixtures participate in the development of PCOS, involving important genes such as CCNB1 and SRD5A1. Furthermore, the study identified transcription factors (TFs) and miRNAs that may be involved in the onset and progression of PCOS, c...
Source: Ecotoxicology and Environmental Safety - March 27, 2024 Category: Environmental Health Authors: Xueming Xu Xiaoping Zhang Jiake Chen Xiushuai Du Yi Sun Liqin Zhan Wenxiang Wang Yuchen Li Source Type: research
Exploring the molecular mechanisms by which per- and polyfluoroalkyl substances induce polycystic ovary syndrome through in silico toxicogenomic data mining
This study utilized toxicogenomics and comparative toxicogenomics databases to analyze data and investigate how PFAS mixtures may contribute to the development of PCOS. The results indicated that 74 genes are associated with both PFAS exposure and PCOS progression. Enrichment analysis suggested that cell cycle regulation and steroid hormone synthesis may be crucial pathways through which PFAS mixtures participate in the development of PCOS, involving important genes such as CCNB1 and SRD5A1. Furthermore, the study identified transcription factors (TFs) and miRNAs that may be involved in the onset and progression of PCOS, c...
Source: Ecotoxicology and Environmental Safety - March 27, 2024 Category: Environmental Health Authors: Xueming Xu Xiaoping Zhang Jiake Chen Xiushuai Du Yi Sun Liqin Zhan Wenxiang Wang Yuchen Li Source Type: research
Relationship between serum apelin, visfatin levels, and body composition in Polycystic ovary syndrome patients
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects the female reproductive system. It is characterized by irregular ovulation, high levels of androgens, and multiple cysts on the ovaries. PCOS is a common condition among women of reproductive age [1]. Epidemiological findings indicate that the incidence of PCOS ranges from 3.7 % to 22.5 % [2]. The prevalence of PCOS in Chinese women is 7.8 %, affecting the reproductive health of approximately 24 million women [3]. In addition, PCOS is a systemic metabolic disorder that is often associated with obesity, insulin resistance, metabolic disorders, and...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 27, 2024 Category: OBGYN Authors: Dan Kuai, Qingtao Tang, Xiang wang, Qi Yan, Wenyan Tian, Huiying Zhang Tags: Full length article Source Type: research
The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome
AbstractEndometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases are inversely related to one another, representing a pair of diametrical diseases in terms of opposite alterations in reproductive physiological processes but also contrasting phenotypic traits. However, to fully explain the phenotypic features observed in women with these conditions, we need to establish a potential nexus system between the reproductive system and...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Comparative analysis of conventional in vitro fertilization and intracytoplasmic sperm injection in patients with polycystic ovarian syndrome, tubal factor infertility, and unexplained infertility whose partners exhibit normal semen parameters: a retrospective study of sibling oocytes
CONCLUSION: Our results indicated that the conventional IVF method was associated with higher zygote production and a higher proportion of grade A embryos when all infertile groups were evaluated together. Thus, ICSI is not suggested for patients with these causes of infertility if their partner has normal semen parameters.PMID:38525518 | DOI:10.5653/cerm.2023.06408 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - March 25, 2024 Category: Reproduction Medicine Authors: Sareh Ashourzadeh Somayyeh Safari Robabe Hosseinisadat Raheleh Kafaeinezhad Saeed Shokri Sanaz Alaee Source Type: research
