Corrigendum to 'Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology' Reproductive Biology, Volume 23, Issue 3 (2023), 100787
Reprod Biol. 2024 Apr 13:100885. doi: 10.1016/j.repbio.2024.100885. Online ahead of print.NO ABSTRACTPMID:38614814 | DOI:10.1016/j.repbio.2024.100885 (Source: Reproductive Biology)
Source: Reproductive Biology - April 13, 2024 Category: Reproduction Medicine Authors: Krutika Patil Aalaap Naigaonkar Indira Hinduja Srabani Mukherjee Source Type: research
Corrigendum to 'Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology' Reproductive Biology, Volume 23, Issue 3 (2023), 100787
Reprod Biol. 2024 Apr 13:100885. doi: 10.1016/j.repbio.2024.100885. Online ahead of print.NO ABSTRACTPMID:38614814 | DOI:10.1016/j.repbio.2024.100885 (Source: Reproductive Biology)
Source: Reproductive Biology - April 13, 2024 Category: Reproduction Medicine Authors: Krutika Patil Aalaap Naigaonkar Indira Hinduja Srabani Mukherjee Source Type: research
Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study
CONCLUSIONS: Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.PMID:38609160 | DOI:10.1210/clinem/dgae256 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Iris T Lee John Rees Shakira King Anne Kim Tess Cherlin Stefanie Hinkle Sunni L Mumford Anuja Dokras Source Type: research
LncRNA XIST Protects Against Polycystic Ovary Syndrome via the Regulation of miR-212-3p/RASA1 Axis
Biochem Genet. 2024 Apr 12. doi: 10.1007/s10528-024-10777-7. Online ahead of print.ABSTRACTThe polycystic ovary syndrome (PCOS), a common endocrine disorder, is mainly related to infertility. Moreover, it is characterized by promoted androgen, suppressed ovulation and insulin resistance. Long non-coding RNA X inactive specific transcript (lncRNA XIST), known as an oncogene or a cancer inhabited factor, is involved in several disease. However, the diagnostic mechanisms of lncRNA XIST in PCOS have not been clarified. Our study aimed to explain whether lncRNA XIST regulates KGN cells proliferation and apoptosis via microRNA (...
Source: Biochemical Genetics - April 12, 2024 Category: Genetics & Stem Cells Authors: Xiaomeng Xu Cheng Yin Bing Dong Yuewen Li Shi Liu Jun Chen Source Type: research
Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study
CONCLUSIONS: Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.PMID:38609160 | DOI:10.1210/clinem/dgae256 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Iris T Lee John Rees Shakira King Anne Kim Tess Cherlin Stefanie Hinkle Sunni L Mumford Anuja Dokras Source Type: research
Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints
Talanta. 2024 Apr 8;274:125969. doi: 10.1016/j.talanta.2024.125969. Online ahead of print.ABSTRACTInfertility presents a widespread challenge for many families worldwide, often arising from various gynecological diseases (GDs) that hinder successful pregnancies. Current diagnostic methods for GDs have disadvantages such as low efficiency, high cost, misdiagnose, invasive injury and etc. This paper introduces a rapid, non-invasive, efficient, and straightforward analytical method that utilizes desorption, separation, and ionization mass spectrometry (DSI-MS) platform in conjunction with machine learning (ML) to detect urine...
Source: Talanta - April 12, 2024 Category: Chemistry Authors: Yijiao Qu Ming Chen Yiran Wang Liangliang Qu Ruiyue Wang Huihui Liu Liping Wang Zongxiu Nie Source Type: research
Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study
CONCLUSIONS: Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.PMID:38609160 | DOI:10.1210/clinem/dgae256 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2024 Category: Endocrinology Authors: Iris T Lee John Rees Shakira King Anne Kim Tess Cherlin Stefanie Hinkle Sunni L Mumford Anuja Dokras Source Type: research
Role of Anti-M üllerian Hormone in the Central Regulation of Fertility
Semin Reprod Med DOI: 10.1055/s-0044-1786050In recent years, the expanding roles of anti-Müllerian hormone (AMH) in various aspects of reproductive health have attracted significant attention. Initially recognized for its classical role in male sexual differentiation, AMH is produced postnatally by the Sertoli cells in the male testes and by the granulosa cells in the female ovaries. Traditionally, it was believed to primarily influence gonadal development and function. However, research over the last decade has unveiled novel actions of AMH beyond the gonads, specifically all along the hypothalamic–pituitary–gonadal ...
Source: Seminars in Reproductive Medicine - April 12, 2024 Category: Reproduction Medicine Authors: Cotellessa, Ludovica Giacobini, Paolo Tags: Review Article Source Type: research
Alexithymia and Quality of Life in Saudi Women with Polycystic Ovary Syndrome: A Community-Based Study
CONCLUSIONS The presence of alexithymia is associated with poor HRQoL in women with PCOS, which is more pronounced among those who received a diagnosis ≥4 years ago. Alexithymia must be considered when assessing the HRQoL of patients with PCOS, considering the relatively high prevalence of alexithymia in these patients.PMID:38600677 | DOI:10.12659/MSM.943594 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 11, 2024 Category: Research Authors: Leen E Alturki Gomanh M Alofisan Layan K Alsaif Saja A Alharbi Nora M Alturki Shekhah S Aldahash Razan J Almutairi Zeinab A Abd-Elhaleem Source Type: research
A cross talk study on sitagliptin mediated reclamation on TGF β signalling, DPP 4, miR-29a and miR-24 expression in PCOS rats fed with high fat-high fructose diet
In conclusion, current results reflect the potential impact of STG against dyslipidaemia, inflammation and fibrosis in PCOS rats via regulating dyslipidaemia and fibrosis via DPP 4 mediated miR-29a expression.PMID:38604038 | DOI:10.1016/j.tice.2024.102375 (Source: Tissue and Cell)
Source: Tissue and Cell - April 11, 2024 Category: Cytology Authors: Dipti Nanda Anuradha Carani Venkatraman Kalpana Kalaivanan Source Type: research
Alexithymia and Quality of Life in Saudi Women with Polycystic Ovary Syndrome: A Community-Based Study
CONCLUSIONS The presence of alexithymia is associated with poor HRQoL in women with PCOS, which is more pronounced among those who received a diagnosis ≥4 years ago. Alexithymia must be considered when assessing the HRQoL of patients with PCOS, considering the relatively high prevalence of alexithymia in these patients.PMID:38600677 | DOI:10.12659/MSM.943594 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 11, 2024 Category: Research Authors: Leen E Alturki Gomanh M Alofisan Layan K Alsaif Saja A Alharbi Nora M Alturki Shekhah S Aldahash Razan J Almutairi Zeinab A Abd-Elhaleem Source Type: research
A cross talk study on sitagliptin mediated reclamation on TGF β signalling, DPP 4, miR-29a and miR-24 expression in PCOS rats fed with high fat-high fructose diet
In conclusion, current results reflect the potential impact of STG against dyslipidaemia, inflammation and fibrosis in PCOS rats via regulating dyslipidaemia and fibrosis via DPP 4 mediated miR-29a expression.PMID:38604038 | DOI:10.1016/j.tice.2024.102375 (Source: Tissue and Cell)
Source: Tissue and Cell - April 11, 2024 Category: Cytology Authors: Dipti Nanda Anuradha Carani Venkatraman Kalpana Kalaivanan Source Type: research
Biophysical insight into the binding mechanism of epigallocatechin-3-gallate and cholecalciferol to albumin and its preventive effect against AGEs formation: An in vitro and in silico approach
This article focusses on the interaction and antiglycating potential of (-)-Epigallocatechin-3-gallate (EGCG) and vitamin D in combination using various techniques. The formation of the HSA-EGCG and HSA-vitamin D complex was confirmed by UV and fluorescence spectroscopy. Thermodynamic analysis verified the spontaneity of reaction, and presence of hydrogen bonds and van der Waals interactions. FRET confirms high possibility of energy transfer. Cumulative antiglycation resulted in almost 60 % prevention in AGEs formation, decreased alterations at lysine and arginine, and reduced protein carbonylation. Secondary and tertiary ...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Sana Siddiqui Rizwan Ahmad Yusra Ahmad Abul Faiz Faizy Shagufta Moin Source Type: research
Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome
Clin Exp Reprod Med. 2024 Apr 11. doi: 10.5653/cerm.2023.06485. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among reproductive-age women. As a leading cause of anovulatory infertility, it complicates fertility treatments, including in vitro fertilization. The widely accepted 2003 Rotterdam diagnostic criteria for PCOS include sub-phenotypes based on variations in androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. In this systematic review, we examined the impacts of inositol and vitamin D on fertility in PCOS. Adhering to the Preferred ...
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Gitika Katyal Gursharan Kaur Hafsa Ashraf Adiprasad Bodapati Ayesha Hanif Donatus Kaine Okafor Safeera Khan Source Type: research
Biophysical insight into the binding mechanism of epigallocatechin-3-gallate and cholecalciferol to albumin and its preventive effect against AGEs formation: An in vitro and in silico approach
This article focusses on the interaction and antiglycating potential of (-)-Epigallocatechin-3-gallate (EGCG) and vitamin D in combination using various techniques. The formation of the HSA-EGCG and HSA-vitamin D complex was confirmed by UV and fluorescence spectroscopy. Thermodynamic analysis verified the spontaneity of reaction, and presence of hydrogen bonds and van der Waals interactions. FRET confirms high possibility of energy transfer. Cumulative antiglycation resulted in almost 60 % prevention in AGEs formation, decreased alterations at lysine and arginine, and reduced protein carbonylation. Secondary and tertiary ...
Source: International Journal of Biological Macromolecules - April 10, 2024 Category: Biochemistry Authors: Sana Siddiqui Rizwan Ahmad Yusra Ahmad Abul Faiz Faizy Shagufta Moin Source Type: research
