Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans
Semin Reprod Med 2018; 36: 361-370 DOI: 10.1055/s-0039-1678749Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and progra...
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Gawron, Lori M. Mohanty, April F. Kaiser, Jennifer E. Gundlapalli, Adi V. Tags: Review Article Source Type: research

The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women
Semin Reprod Med 2018; 36: 351-360 DOI: 10.1055/s-0039-1678751As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies to assess potential increased risks for adverse reproductive and infant health outcomes in the military population. Military personnel endure unique physical and mental demands as a part of their occupational duties (e.g., extensive preventive care...
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Khodr, Zeina G. Bukowinski, Anna T. Hall, Clinton Gumbs, Gia R. Wells, Natalie Y. Conlin, Ava Marie S. Tags: Review Article Source Type: research

The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen
Semin Reprod Med 2018; 36: 340-350 DOI: 10.1055/s-0039-1678752 Chlamydia trachomatis is the most common sexually transmitted bacterial infection in the United States. Within the U.S. military, the age- and race-adjusted chlamydia infection rates among female service members are consistently higher than civilian rates, with a 20% annual acquisition rate among young active-duty women. The sequelae of chlamydia disproportionately impact women in terms of severity and cost. Untreated chlamydia progresses to pelvic inflammatory disease in 40% of cases, and is a leading cause of fallopian tube damage and pelvic adhesive disea...
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Nadeau, Christine Fujii, Dennis Lentscher, Jessica Haney, Amanda Burney, Richard O. Tags: Review Article Source Type: research

Preconception Care in the Veterans Health Administration
Semin Reprod Med 2018; 36: 327-339 DOI: 10.1055/s-0039-1678753Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial ...
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Callegari, Lisa S. Edmonds, Stephanie W. Borrero, Sonya Ryan, Ginny L. Cusack, Caitlin M. Zephyrin, Laurie C. Tags: Review Article Source Type: research

Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military
Semin Reprod Med 2018; 36: 323-326 DOI: 10.1055/s-0039-1681084The U.S. military mirrors the U.S. population given the diverse ethnic and cultural backgrounds of the service members. Active-duty military members, veterans, and Department of Defense beneficiaries can be negatively impacted by infertility. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Pilgrim, Justin Healy, Mae Yauger, Belinda J. Torrealday, Saioa Csokmay, John Hill, Micah Tags: Review Article Source Type: research

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017
This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. We excluded studies that were not original research, only included active-duty women, or had few women Veterans in their sample. Manuscripts were reviewed using a standardized abstraction form. We identified 52 manuscripts. Nearly half (48%) of the new manuscripts addressed contraception and preconception care (n = 15) or pregnancy (n = 10). The pregnancy and family planning literature showed tha...
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Katon, Jodie G. Zephyrin, Laurie Meoli, Anne Hulugalle, Avanthi Bosch, Jeane Callegari, Lisa Galvan, Ileana V. Gray, Kristen E. Haeger, Kristin O. Hoffmire, Claire Levis, Silvina Ma, Erica W. Mccabe, Jennifer E. Nillni, Yael I. Pineles, Suzanne L. Reddy, Tags: Review Article Source Type: research

Reproductive Health Needs of the Military and Veterans: Part 1
Semin Reprod Med 2018; 36: 313-314 DOI: 10.1055/s-0039-1683423 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Burney, Richard Christy, Alicia Y. Tags: Preface Source Type: research

Alicia Y. Christy, MD, MHSCR, FACOG and Richard Burney, MD, MSc
Semin Reprod Med 2018; 36: 311-312 DOI: 10.1055/s-0039-1683914 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - April 19, 2019 Category: Reproduction Medicine Authors: Segars, James H. Tags: Introduction Source Type: research

Legal Issues in Gamete and Embryo Cryopreservation: An Overview
This article provides an overview of existing and developing law surrounding IVF embryos and those who handle them. It discusses what law and legal theories of liability may apply to embryology labs, and gamete and embryo banks in the context of embryo loss, abandonment, shipping and implantation. It explores how often intertwined theories of law have been applied to this unique field, including contract, informed consent, health, tort and Constitutional law. Recent so-called “Personhood” initiatives are reviewed for their impact on ART practice. The article also explores how legal principles related to patient...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Crockin, Susan L. Gottschalk, Kathryn C. Tags: Review Article Source Type: research

Safe Storage of Gametes and Embryos: No Time for Complacency
Semin Reprod Med 2018; 36: 289-298 DOI: 10.1055/s-0039-1678596Recent serious untoward incidents in the field of assisted reproduction have once again highlighted the need for vigilance and in particular improved risk management in relation to the cryopreservation of gametes and embryos. Despite increasing levels of regulation and the requirement to adhere to total quality management practices, catastrophic incidents such as the death of an employee or the loss of a freezer full of patient embryos or sperm continue to occur sufficiently frequently for the industry to be concerned and highlight the need to make practices con...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Tomlinson, Mathew James Tags: Review Article Source Type: research

Reproductive Tissue Storage: Quality Control and Management/Inventory Software
Semin Reprod Med 2018; 36: 280-288 DOI: 10.1055/s-0038-1676851The recent failure of two liquid nitrogen storage tanks at two separate facilities in the United States has highlighted the need to reexamine our approach to how reproductive laboratories handle the storage of tissue. If we wish to truly understand how we can increase the security and safety of stored reproductive tissue, we really need to understand how often these events (tank failure) occur and what are the ultimate causes of these failures. Are there design flaws in the storage tanks or are these really failures in protocols and following protocols? Unfortun...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Pomeroy, Kimball O. Marcon, Mark Tags: Review Article Source Type: research

Life Interrupted: The Nature and Consequences of Cryostasis
Semin Reprod Med 2018; 36: 273-279 DOI: 10.1055/s-0038-1676850Cryopreservation and associated cryostorage has become a well-established technique in both basic and clinical science. When the potentially lethal consequences of freezing itself are ameliorated, existence at cryogenic temperatures seems to be a form of true viable stasis that can persist for long periods of time. Natural cryopreservation and revival after long-term periods in cryostasis is reality in many species. While some evidence exists for imperfections in artificial cryopreservation protocols and storage, these protocols are for the most part successful ...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Malter, Henry Tags: Review Article Source Type: research

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management
Semin Reprod Med 2018; 36: 265-272 DOI: 10.1055/s-0038-1676849Millions of human oocytes and embryos are stored in thousands of locations across the globe. This inventory continues to grow as cryopreservation becomes more successful and more widely applied. The results of studies assessing pregnancy and neonatal outcomes following frozen embryo transfer (FET) have been encouraging, showing lower incidences of small for gestational age neonates and preterm birth compared with fresh transfers. However, many of these studies have also shown that the odds of large for gestational age births and macrosomia are higher after FET. ...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Alikani, Mina Parmegiani, Lodovico Tags: Review Article Source Type: research

Perspectives in Gamete and Embryo Cryopreservation
Semin Reprod Med 2018; 36: 253-264 DOI: 10.1055/s-0038-1677463Cryopreserved gametes and embryos are a major feature of human-assisted reproduction and patient care services, accounting for an increasing number of births worldwide. Since the first success obtained using frozen human spermatozoa, cryopreservation technology has been successfully extended to include oocytes and embryos, in a variety of both medical and nonmedical indications. Over the years, the available procedures have become widely implemented and the increasing evidence of its efficacy has contributed to acceptance of the technology. Nevertheless, a gold ...
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Rienzi, Laura Francesca Iussig, Benedetta Dovere, Lisa Fabozzi, Gemma Cimadomo, Danilo Ubaldi, Filippo Maria Tags: Review Article Source Type: research

Gamete and Embryo Storage
Semin Reprod Med 2018; 36: 251-252 DOI: 10.1055/s-0039-1678597 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Cohen, Jacques Tags: Preface Source Type: research

Jacques Cohen, PhD
Semin Reprod Med 2018; 36: 249-250 DOI: 10.1055/s-0039-1678595 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - April 4, 2019 Category: Reproduction Medicine Authors: Segars, James H. Tags: Introduction Source Type: research

Assisted Reproductive Technologies and the Placenta: Clinical, Morphological, and Molecular Outcomes
Semin Reprod Med 2018; 36: 240-248 DOI: 10.1055/s-0038-1676640As the biological bridge between mother and fetus, the placenta is not only important for the health of the mother and fetus during pregnancy but it also impacts the lifelong health of the fetus. Assisted reproductive technologies (ARTs) involve procedures and exposures that are not characteristic of in vivo reproduction. Moreover, ART procedures occur when the gametes and embryos are undergoing extensive epigenetic reprogramming. Thus, the oxidative, thermal, and mechanical stress that ART procedures introduce can impact the biological processes of placental gr...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Riesche, Laren Bartolomei, Marisa S. Tags: Review Article Source Type: research

Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offsprings
Semin Reprod Med 2018; 36: 233-239 DOI: 10.1055/s-0038-1677047Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male fertility and early embryo development. In addition, sperm epigenetics appear to be altered by specific environmental exposures, which could provide a link for investigating the role of these triggers in somatic health of off springs produced. This...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Ibrahim, Yetunde Hotaling, Jim Tags: Review Article Source Type: research

Assisted Reproductive Technology and Epigenetics
Semin Reprod Med 2018; 36: 221-232 DOI: 10.1055/s-0038-1675780Assisted reproductive technology (ART) is responsible for 1.7% of births in the United States annually. Despite a large number of studies promoting the efficacy and safety of these practices, there have been reports of imprinting disorders occurring at higher frequencies in children born through ART. Driven by findings in animal studies, it has been postulated that various ART procedures employed at critical points in embryonic development may predispose the genomic imprinting process to errors. Alterations in DNA methylation patterns at imprinting control cente...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: DeAngelis, Anthony M. Martini, Anne E. Owen, Carter M. Tags: Review Article Source Type: research

Embryo Culture Conditions and the Epigenome
Semin Reprod Med 2018; 36: 211-220 DOI: 10.1055/s-0038-1675777Assisted reproductive technologies (ARTs) lead to an increased risk for pregnancy complications, congenital abnormalities, and specific imprinting disorders. Epigenetic dysfunction is thought to be one common mechanism which may be affecting these outcomes. The timing of multiple ART interventions overlaps with developmental time periods that are particularly vulnerable to epigenetic change. In vitro embryo culture is known to impact blastocyst development, in vitro fertilization (IVF) success rates, as well as neonatal outcomes. Embryo culture, in contrast to o...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Mani, Sneha Mainigi, Monica Tags: Review Article Source Type: research

Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting?
Semin Reprod Med 2018; 36: 204-210 DOI: 10.1055/s-0038-1677526The use of assisted reproductive technologies (ARTs) has increased significantly in recent years. While this is partially due to improved access for infertile patients, another contribution to the growth of ART utilization is represented by individuals without infertility, who electively chose to freeze their gametes and embryos for future use, before ever attempting conception spontaneously. Overall, the safety of ART for parents and children is well described and the risks are modest. However, while long-term health consequences for offspring as postulated by ...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Rinaudo, Paolo Adeleye, Amanda Tags: Review Article Source Type: research

Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Semin Reprod Med 2018; 36: 195-203 DOI: 10.1055/s-0038-1677048The majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies f...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Morin, Scott J. Seli, Emre Tags: Review Article Source Type: research

Child Health: Is It Really Assisted Reproductive Technology that We Need to Be Concerned About?
Semin Reprod Med 2018; 36: 183-194 DOI: 10.1055/s-0038-1675778Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. To study whether the techniques used in infertility treatment cause health differences, however, remains challenging due to identification of a...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Yeung, Edwina H. Kim, Keewan Purdue-Smithe, Alexandra Bell, Griffith Zolton, Jessica Ghassabian, Akhgar Vafai, Yassaman Robinson, Sonia L. Mumford, Sunni L. Tags: Review Article Source Type: research

Developmental Origins of Health and Disease: The History of the Barker Hypothesis and Assisted Reproductive Technology
Semin Reprod Med 2018; 36: 177-182 DOI: 10.1055/s-0038-1675779Since Barker's publication of “The fetal and infant origins of adult disease” in 1990, significant emphasis has been placed on the intrauterine environment and its effect on adult disease. Historical events such as the Dutch Famine and the 1918 Flu Pandemic have provided organic data about the epigenetic changes that can result from famine, infection, and stress. Mechanisms that allow for intrauterine survival may predispose to adult disease states when the fetus enters a world of abundance. As the field of in vitro fertilization (IVF) has developed ...
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Carpinello, Olivia J. DeCherney, Alan H. Hill, Micah J. Tags: Review Article Source Type: research

Assisted Reproductive Technologies and the Developmental Origins of Human Health and Disease
Semin Reprod Med 2018; 36: 175-176 DOI: 10.1055/s-0039-1683393 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Hill, Micah J. Tags: Preface Source Type: research

Assisted Reproductive Technologies and the Developmental Origins of Health and Disease
Semin Reprod Med 2018; 36: 173-174 DOI: 10.1055/s-0038-1676641 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - March 13, 2019 Category: Reproduction Medicine Authors: Segars, James H. Tags: Introduction Source Type: research

The Neuroanatomy of Reproduction: Seeing Is Believing
The objective of this pictorial tour is to elucidate anatomical and clinical relationships while showcasing the neuroanatomy of reproduction. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - January 3, 2019 Category: Reproduction Medicine Authors: Vlasak, Alexander L. Schaub, Amelia Barry, Margaret E. Robin Rhoton-Vlasak, Alice S. Tags: Review Article Source Type: research

Opioids and Alternatives in Female Chronic Pelvic Pain
This article reviews nonpharmacologic therapies including pelvic floor physical therapy, dietary modifications, psychotherapy, and acupuncture. These interventions are low risk and should be incorporated into treatment for chronic pelvic pain, as they show promise for successful symptom relief in many overlapping chronic pain conditions. Common nonopioid medications for pelvic are also reviewed, including analgesics, hormone modulating agents, antidepressants, and anticonvulsants. Guidelines for cautious and responsible opioid use are also summarized. While data specific to chronic pelvic pain management remain limited, ev...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Valentine, Lindsey N. Deimling, Timothy A. Tags: Review Article Source Type: research

Interventional Pain Management and Female Pelvic Pain: Considerations for Diagnosis and Treatment
Semin Reprod Med 2018; 36: 159-163 DOI: 10.1055/s-0038-1676104Chronic pelvic pain (CPP) is a recurring and/or constant pain of at least six months duration that has resulted in either functional or psychological disability that can require interventional treatments. Chronic pelvic pain can be visceral, somatic, neuropathic, or a combination. Patients with CPP often suffer from concurrent bowel or bladder dysfunction, sexual dysfunction, depression, and anxiety. The complexity of chronic pelvic pain can be challenging to treat, which can lead to frustration for both patients and their physicians. Treatment should involve a ...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Smith, Sadie E. Eckert, Jill M. Tags: Review Article Source Type: research

Female Sexual Dysfunction in Women with Pelvic Pain
This article provides a discussion of various conditions, offering diagnostic and therapeutic measures to consider in women with pelvic pain experiencing sexual dysfunction. Treatment and management options are also reviewed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Tam, Teresa Levine, Elliot M. Tags: Review Article Source Type: research

Endometriosis and Female Pelvic Pain
Semin Reprod Med 2018; 36: 143-151 DOI: 10.1055/s-0038-1676103Endometriosis is a nonmalignant gynecologic disorder that can have a significant impact on a woman's quality of life with pelvic pain and possible lasting effects on one's fertility. Symptoms, when present, can be severe and affect many organ systems including the gastrointestinal and urinary systems. Other etiologies of pelvic pain must be ruled out and/or need to be addressed concurrently for optimal patient care. There are numerous medical and surgical treatment options available that have been shown to be beneficial for endometriosis-related pelvic pain. Rec...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Kim, Jin Hee Han, Esther Tags: Review Article Source Type: research

Fibromyalgia and Irritable Bowel Syndrome in Female Pelvic Pain
Semin Reprod Med 2018; 36: 136-142 DOI: 10.1055/s-0038-1676090Fibromyalgia and irritable bowel syndrome are common disorders which often coexist in women with chronic pelvic pain. Like pelvic pain, these disorders describe symptoms without pathologic findings. Women with chronic pelvic pain have a higher prevalence of fibromyalgia (4–31%) and irritable bowel syndrome (8–41%) than the general population. Aberrant pain processing and psychosocial stressors are implicated in the co-occurrence of these pain syndromes (chronic overlapping pain conditions), but active epidemiologic, psychosocial, and neurobiologic re...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Johnson, Christina M. Makai, Gretchen E. H. Tags: Review Article Source Type: research

Interstitial Cystitis/Bladder Pain Syndrome
Semin Reprod Med 2018; 36: 123-135 DOI: 10.1055/s-0038-1676089Interstitial cystitis/bladder pain syndrome is an uncommon but potentially devastating pelvic pain disorder affecting both women and men. This condition is often confusable and comorbid with other pelvic pain disorders. Although our understanding of the underlying pathophysiology is growing, the exact longitudinal course by which peripheral and central aberrations involving the bladder mucosa, peripheral inflammation, and central dysregulation of bladder sensitivity create painful bladder symptoms remains an area in need of further study. Only a limited number o...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Marcu, Ioana Campian, E. Cristian Tu, Frank F. Tags: Review Article Source Type: research

Pelvic Pain in Adolescents
Semin Reprod Med 2018; 36: 116-122 DOI: 10.1055/s-0038-1676088Dysmenorrhea and noncyclic pelvic pain (chronic pelvic pain) are common in adolescents. The evaluation of teens with dysmenorrhea or chronic pelvic pain is aimed to diagnose possible gynecologic conditions (endometriosis, pelvic inflammatory disease, ovarian cysts, and obstruction of the reproductive tract) and nongynecologic conditions (irritable bowel syndrome, interstitial cystitis, and myofascial pain). The management of chronic pelvic pain in adolescents is often more complex than in adult women because both the adolescent and her parents are counseled and ...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Smorgick, Noam As-Sanie, Sawsan Tags: Review Article Source Type: research

Musculoskeletal Considerations in Female Patients with Chronic Pelvic Pain
This article provides an overview of the pathophysiology of persistent pelvic pain, as it relates to musculoskeletal disorders. The symptomatology, anatomy, evaluation, and treatment of these disorders are summarized specifically for healthcare providers (including gynecologists) who do not have pelvic musculoskeletal expertise. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Lamvu, Georgine Carrillo, Jorge Witzeman, Kathryn Alappattu, Meryl Tags: Review Article Source Type: research

Evaluation of Female Pelvic Pain
Semin Reprod Med 2018; 36: 099-106 DOI: 10.1055/s-0038-1676084Chronic pelvic pain is a condition defined by pelvic pain for more than six months which is severe enough to cause functional disability or require treatment. When pain becomes a chronic condition, it is more challenging to evaluate and treat. Chronic pelvic pain patients often have multiple factors contributing to their pain. Here, we review the approach to the evaluation of chronic female pelvic pain. It is important to establish a trusting patient–physician relationship. When evaluating a female patient with chronic pelvic pain, an in-depth history and ...
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Chandler, Jessica Wagner, Elena Riley, Kristin Tags: Review Article Source Type: research

Female Pelvic Pain
Semin Reprod Med 2018; 36: 097-098 DOI: 10.1055/s-0038-1676086 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Harkins, Gerald J. Tags: Preface Source Type: research

Gerald J. Harkins, MD, MPT, FACOG
Semin Reprod Med 2018; 36: 095-096 DOI: 10.1055/s-0038-1676367 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - December 19, 2018 Category: Reproduction Medicine Authors: Legro, Richard S. Tags: Introduction Source Type: research

Integrated Model of Care for Polycystic Ovary Syndrome
Semin Reprod Med 2018; 36: 086-094 DOI: 10.1055/s-0038-1667310Polycystic ovary syndrome (PCOS) affects approximately one in seven women worldwide from early adulthood with heterogeneity in their healthcare needs through the life cycle. PCOS is challenging to diagnose and manage, with one-third of women reporting at least a 2-year delay in diagnosis. Current clinical services do not satisfactorily educate and support women with their diverse reproductive, metabolic, and psychological care needs with fragmentation of services across health providers. Women are dissatisfied with the care they received, while the first contact...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Tay, Chau T. Moran, Lisa J. Wijeyaratne, Chandrika N. Redman, Leanne M. Norman, Robert J. Teede, Helena J. Joham, Anju E. Tags: Review Article Source Type: research

Informing Translation: The Accuracy of Information on Websites for Lifestyle Management of Polycystic Ovary Syndrome
Semin Reprod Med 2018; 36: 080-085 DOI: 10.1055/s-0038-1667309Lifestyle (diet, physical activity [PA], and/or behavioral) interventions are recommended for all women with polycystic ovary syndrome (PCOS) in international guidelines. The internet is a widely used health information resource. However, the accuracy of lifestyle information on PCOS websites is unknown and is reviewed here to inform translation of the international guideline on PCOS. An internet search was conducted with three search engines across different web browsers and countries. Accuracy was assessed through a checklist of 29 questions based on internati...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Htet, Thaw Cassar, S. Boyle, Jacqueline A. Kuczynska-Burggraf, Millicent Gibson-Helm, Melanie Chiu, Wei-Ling Stepto, N. K. Moran, Lisa J. Tags: Review Article Source Type: research

A Governance Model Addressing the Challenges of Contemporary Research
Semin Reprod Med 2018; 36: 073-079 DOI: 10.1055/s-0038-1667157In this paper, we describe the robust governance structures and processes underpinning the development of the first International Evidence-Based Guideline for the Assessment and Management Polycystic Ovary Syndrome (2018). The guideline was an outcome of the Centre of Research Excellence for Polycystic Ovary Syndrome, and an example of a transformative, strategic research initiative to impact delivery model. The governance structure supported and delivered critical ethical and regulatory outcomes, including: broad and diverse representation across health profess...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Downes, Linda Garad, Rhonda Teede, Helena J. Norman, Robert J. Tags: Review Article Source Type: research

Personalized Mobile Tool AskPCOS Delivering Evidence-Based Quality Information about Polycystic Ovary Syndrome
Semin Reprod Med 2018; 36: 066-072 DOI: 10.1055/s-0038-1667156Despite polycystic ovary syndrome (PCOS) being the most common endocrine condition affecting reproductive-aged women, studies have shown the information needs of PCOS consumers are not currently met. The expressed need by women with PCOS for accessible, evidence-based personalized PCOS information informed the design and development of the PCOS mobile tool—AskPCOS. The App provides a range of unique features such as: evidence-based PCOS health information, self-diagnostic function, a question prompt list to optimize health practitioner engagement, and a co...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Xie, Jue Burstein, Frada Garad, Rhonda Teede, Helena J. Boyle, Jacqueline A. Tags: Review Article Source Type: research

Ask PCOS: Identifying Need to Inform Evidence-Based App Development for Polycystic Ovary Syndrome
Conclusion Women with PCOS would use a PCOS-specific app of good quality that responds to their needs and facilitates self-care; however, currently available apps are unlikely to meet their information needs. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Boyle, Jacqueline A. Xu, Rebecca Gilbert, Emily Kuczynska-Burggraf, Millicent Tan, Bryan Teede, Helena Vincent, Amanda Gibson-Helm, Melanie Tags: Review Article Source Type: research

What Can You Find about Polycystic Ovary Syndrome (PCOS) Online? Assessing Online Information on PCOS: Quality, Content, and User-Friendliness
Conclusion The majority of PCOS Web sites were commercially derived, targeted women, and were not accredited. There is a significant lack of quality, easy-to-read, evidence-based information online for women with PCOS. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Reproductive Medicine)
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Chiu, Wei-Ling Kuczynska-Burggraf, Millicent Gibson-Helm, Melanie Teede, Helena J. Vincent, Amanda Boyle, Jacqueline A. Tags: Review Article Source Type: research

Evaluation of a Center of Research Excellence in Polycystic Ovary Syndrome as a Large-Scale Collaborative Research Translation Initiative, Including Evaluating Translation of Guideline Impact
Semin Reprod Med 2018; 36: 042-049 DOI: 10.1055/s-0038-1667308Research translation and evaluation are often underconsidered in research design and implementation thus limiting research benefit to the end user. In this article, we first describe a best practice approach to evaluation, for a center of research excellence in polycystic ovary syndrome. Within this, we outline a comprehensive research translation program with inbuilt evaluation of the first International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (2018). We seek to provide a real-world example of comprehensive approa...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Garad, Rhonda Kozica-Olenski, Samantha Teede, Helena J. Tags: Review Article Source Type: research

The Needs of Women and Healthcare Providers regarding Polycystic Ovary Syndrome Information, Resources, and Education: A Systematic Search and Narrative Review
This article aims to identify and summarize the information, resource, and education needs of women with polycystic ovary syndrome (PCOS) and their healthcare providers. A systematic search of peer-reviewed, primary research literature was conducted. A total of 4,230 articles were identified, duplicates were removed, as well as the title and abstract of 2,819 studies and the full texts of 123 studies were screened against predetermined inclusion criteria. Findings from 35 included studies are described narratively. Main outcome measures include women's perceived needs for, and experiences of, PCOS care and information; hea...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Gibson-Helm, Melanie Tassone, Eliza C. Teede, Helena J. Dokras, Anuja Garad, Rhonda Tags: Review Article Source Type: research

Large-Scale Evidence-Based Guideline Development Engaging the International PCOS Community
Semin Reprod Med 2018; 36: 028-034 DOI: 10.1055/s-0038-1667312The evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) integrates the best available evidence with international, multidisciplinary clinical expertise and consumer preferences to provide health professionals, consumers, and policy makers with high-quality, comprehensive guidance about diagnosing and managing PCOS. Here, we outline the rigorous and systematic process, defined a priori and documented to be reproducible, to minimize bias and maintain transparency, in alignment with the Appraisal of Guidelines for Research...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Misso, Marie L. Tassone, Eliza C. Costello, Michael F. Dokras, Anuja Laven, Joop Moran, Lisa J. Teede, Helena J. Tags: Review Article Source Type: research

Knowledge and Practices Regarding Polycystic Ovary Syndrome among Physicians in Europe, North America, and Internationally: An Online Questionnaire-Based Study
Semin Reprod Med 2018; 36: 019-027 DOI: 10.1055/s-0038-1667155 Background To inform knowledge translation by identifying evidence–practice gaps in polycystic ovary syndrome (PCOS) care and variations between disciplines and across world regions via an online, anonymous, devised questionnaire distributed via professional societies and completed by 1,495 physicians (2015–2016). Methods Multivariable logistic regression analyses generated adjusted odds ratios (OR) and 95% confidence intervals (CI) for associations between outcome measures and world region, specialty, annual patients with PCOS, age,...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Gibson-Helm, Melanie Dokras, Anuja Karro, Helle Piltonen, Terhi Teede, Helena J. Tags: Review Article Source Type: research

Application of Monash Centre for Health Research and Implementation Framework to the Development of Polycycstic Ovary Syndrome Guideline: A Case Study on Implementation
Semin Reprod Med 2018; 36: 013-018 DOI: 10.1055/s-0038-1667311Implementation of healthcare guidelines, a set of recommendations aiming to optimize patient care, can be a complex process which is at risk of poor translation into practice. Failure to adopt new evidence-based healthcare findings can contribute to a large variation in care, potentially affecting outcomes for service users. Designed to avoid this issue, the Monash Centre for Health Research and Implementation (MCHRI) knowledge translation framework was created to support the development and future implementation of clinical practice guidelines. The framework is...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Robinson, Tracy Skouteris, Helen Melder, Angela Bailey, Cate Morris, Heather Garad, Rhonda Teede, Helena J. Tags: Review Article Source Type: research

A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines
Semin Reprod Med 2018; 36: 005-012 DOI: 10.1055/s-0038-1668085Polycystic ovary syndrome (PCOS) is a common hormonal condition with reproductive, metabolic, and psychological sequelae. The Rotterdam Criteria are now internationally accepted, with different phenotypes recognized with varying clinical presentations and risk profiles. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications and management strategies. PCOS remains underdiagnosed and women experience significant delays to diagnosis. Effective dissemination of evidence-based management is therefore ...
Source: Seminars in Reproductive Medicine - September 6, 2018 Category: Reproduction Medicine Authors: Neven, Adriana Catharina Helena Laven, Joop Teede, Helena J. Boyle, Jacqueline A. Tags: Review Article Source Type: research