Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship
AbstractAlthough appendicitis has been described for more than 300 years, its optimal management remains a topic of active investigation. Acute appendicitis is the most common cause of peritonitis in children, and rates of perforated appendicitis are much higher in children than in adults. Increased risk for perforated appendicitis in children is related to a delay in diagnosis due to age, size, access to care, and more. Surgical options include immediate appendectomy versus nonoperative management with intravenous antibiotics ± a drainage procedure, with a subsequent interval appendectomy. Microbiota of perforated append...
Source: Pediatric Drugs - April 24, 2024 Category: Pediatrics Source Type: research
Congenital agenesis of the common bile duct
(Source: Pediatric Radiology)
Source: Pediatric Radiology - April 24, 2024 Category: Radiology Source Type: research
Long-gap esophageal atresia: gastric transposition or esophageal lengthening with delayed primary anastomosis? A systematic review
ConclusionsThis systematic review highlights the morbidity associated with both surgical procedures and the variety in reporting outcomes. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 24, 2024 Category: Surgery Source Type: research
Comparison of hypospadias phenotype pixel segmentation to GMS score.
Hypospadias phenotype assessment determines if the anatomy is favorable for reconstruction. Glans-Urethral Meatus-Shaft (GMS) has been adopted in an effort to standardize hypospadias classification. While extremely subjective, GMS has been widely used to classify the severity of the phenotype to predict surgical outcomes. The use of digital image analysis has proven to be feasible and prior efforts by our team have demonstrated that machine learning algorithms can emulate an expert ’s assessment of the phenotype. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - April 24, 2024 Category: Urology & Nephrology Authors: Joshua Caldwell, Meghan Noonavath, Adam Maxwell, Viktoriya Sapkalova, Margarett Shnorhavorian, Nicolas Fernandez Source Type: research
Comment on Beneki E, Dimitriadis K, Antonopoulos A, Aggeli K & Tsioufis K. Kounis syndrome due to remdesivir allergy
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - April 24, 2024 Category: Toxicology Authors: Öner ÖzdemirDivision of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye Source Type: research
Clinical course and predictors of outcome following surgical treatment of benign peripheral nerve sheath tumors, a single center retrospective study
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - April 24, 2024 Category: Neuroscience Authors: Erik ÖhlénVictor Gabriel El-HajjAlexander Fletcher-SandersjööErik EdströmAdrian Elmi-Terandera Department of Pediatrics, Mälar Hospital, Eskilstuna, Swedenb Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Swedenc Capio Spine C Source Type: research
Exploration of the impact of dysbiosis in the gut microbiota on microbial composition in children ’s neurodevelopment
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - April 24, 2024 Category: Neuroscience Authors: Ting GuoZhenzhong ZengLiangfeng LinDepartment of Pediatrics, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China Source Type: research
Diagnosis of Pediatric Appendicovesical Fistula by Contrast-enhanced Ultrasound: A Case Report
We reported a pediatric case of appendicovesical fistula that remained undiagnosed by non-contrast CT, fluoroscopic voiding cystourethrography (VCUG). Although the bladder orifice was identified during cystoscopy, its connection to the fistula site could not be determined. However, the trans-vesical contrast-enhanced ultrasound clearly demonstrated the presence of fistula. (Source: Urology)
Source: Urology - April 24, 2024 Category: Urology & Nephrology Authors: Yang Xiuzhen, Xu Zheming, Yan Xiang, Ye Jingjing, Fu Junfen Source Type: research
Epidemiology of Spinal Muscular Atrophy Based on the Results of a Large-Scale Pilot Project on 202,908 Newborns
This study presents the findings of a newborn screening (NBS) pilot project for spinal muscular atrophy (SMA) 5q in multiple regions across Russia for a period of 2022 year. The aim was to assess the feasibility and reproducibility of NBS for SMA5q in diverse populations and estimate the real prevalence of SMA5q in Russia as well as the distribution of patients with different number of SMN2 copies. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 24, 2024 Category: Neurology Authors: Irina Yu. Efimova, Rena A. Zinchenko, Andrey V. Marakhonov, Natalya V. Balinova, Kristina A. Mikhalchuk, Olga A. Shchagina, Alexander V. Polyakov, Dzhaina A. Mudaeva, Djamila H. Saydaeva, Svetlana A. Matulevich, Polina D. Parshintseca, Elena Yu. Belyashov Tags: Research Paper Source Type: research
Delayed diagnosis of serious paediatric conditions in 13 regional emergency departments
Conclusion
Delayed diagnosis was uncommon across 13 regional EDs but was more likely among children with Hispanic ethnicity, CCCs or normal vital signs. Delays were associated with a higher risk of complications. (Source: BMJ Quality and Safety)
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Michelson, K. A., McGarghan, F. L. E., Patterson, E. E., Samuels-Kalow, M. E., Waltzman, M. L., Greco, K. F. Tags: Original research Source Type: research
Cancers, Vol. 16, Pages 1634: Late Changes in Renal Volume and Function after Proton Beam Therapy in Pediatric and Adult Patients: Children Show Significant Renal Atrophy but Deterioration of Renal Function Is Minimal in the Long-Term in Both Groups
ei Nakai
Satoshi Kamizawa
Chie Kawano
Yoshiko Oshiro
Hideyuki Sakurai
To compare late renal effects in pediatric and adult patients with malignancies after PBT involving part of the kidney. A retrospective study was conducted to assess changes in renal volume and function in 24 patients, including 12 children (1–14 years old) and 12 adults (51–80 years old). Kidney volumes were measured from CT or MRI images during follow-up. Dose-volume histograms were calculated using a treatment planning system. In children, the median volume changes for the irradiated and control kidneys were &am...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Yinuo Li Masashi Mizumoto Hazuki Nitta Hiroko Fukushima Ryoko Suzuki Sho Hosaka Yuni Yamaki Motohiro Murakami Keiichiro Baba Masatoshi Nakamura Toshiki Ishida Hirokazu Makishima Takashi Iizumi Takashi Saito Haruko Numajiri Kei Nakai Satoshi Kamizawa Chie Tags: Article Source Type: research
New LC-MS/MS reference data for estradiol show mini-puberty in both sexes and typical pre-pubertal and pubertal patterns
CONCLUSIONS: Variability of RIs for E2 between studies illustrates importance of laboratory-specific RIs despite using a liquid chromatographic tandem mass spectrometry (LC-MS/MS) reference method. In boys, the striking E2 peak during mini-puberty as well as high pubertal E2 without phenotypic estrogenization in regular male puberty indicate that the role of E2 in children, and especially in boys requires better functional understanding.PMID:38652605 | DOI:10.1093/ejendo/lvae046 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Alexandra E Kulle Amke Caliebe Tabea Lamprecht Thomas Reinehr Gunter Simic-Schleicher Esther Schulz Michaela Kleber Juliane Rothermel Sabine Heger Olaf Hiort Paul-Martin Holterhus Source Type: research
Anesthetic challenges in patients with multicompartmental lymphatic failure after Fontan palliation undergoing transcatheter thoracic duct decompression
Paediatr Anaesth. 2024 Apr 23. doi: 10.1111/pan.14891. Online ahead of print.ABSTRACTLymphatic flow abnormalities are central to the development of protein losing enteropathy, plastic bronchitis, ascites and pleural effusions in patients palliated to the Fontan circulation. These complications can occur in isolation or multicompartmental (two or more). The treatment of multicompartmental lymphatic failure aims at improving thoracic duct drainage. Re-routing the innominate vein to the pulmonary venous atrium decompresses the thoracic duct, as atrial pressure is lower than systemic venous pressure in Fontan circulation. Tran...
Source: Paediatric Anaesthesia - April 23, 2024 Category: Anesthesiology Authors: Kirsten R Groody Susan C Nicolson David R Jobes Source Type: research
Characteristics of radiotherapy for adolescents and young adults
This article reviews the characteristics to be taken into account in adolescent and young adult patients radiotherapy and more particularly in some of the most common diseases.PMID:38652674 | DOI:10.1016/j.canrad.2023.08.002 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 23, 2024 Category: Cancer & Oncology Authors: L Ollivier A Laprie E Jouglar L Claude V Martin X Muracciole L Padovani S Supiot A Escande Source Type: research
Individual patient data meta-analysis on awake pediatric extracorporeal life support: Feasibility and safety of analgesia, sedation and respiratory support weaning, and physiotherapy
CONCLUSION: Awake ECLS strategy with active physiotherapy can be applied in children from neonatal age. Ambulation is also possible in selected cases. Complications related to such management were limited. Further studies on aECLS are needed to evaluate safety and efficacy of early physiotherapy and define patient selection.PMID:38652693 | DOI:10.1177/02676591241240377 (Source: Perfusion)
Source: Perfusion - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marta Cucchi Silvia Mariani Michal J Kawczynski Emma Shkurka Fabio Ius Giuseppe Comentale Aparna Hoskote Roberto Lorusso Source Type: research
