Value-based comparison of ambulatory children with respiratory diseases in an emergency department and a walk-in clinic: a retrospective cohort study in Quebec, Canada
Conclusions
The incidence of return visits and cost of care were significantly higher in the ED, while antibiotic use for URTI was more frequent in the walk-in clinic. These data may help determine which setting offers the highest value to ambulatory children with acute respiratory conditions. (Source: BMJ Open)
Source: BMJ Open - April 25, 2024 Category: General Medicine Authors: Marx, T., Moore, L., Talbot, D., Guertin, J. R., Lachapelle, P., Blais, S., Singbo, N., Simonyan, D., Lavallee, J., Zada, N., Shahrigharahkoshan, S., Huard, B., Olivier, P., Mallet, M., Letourneau, M., Lafreniere, M., Archambault, P., Berthelot, S., For t Tags: Open access, Emergency medicine Source Type: research
Enterovirus-Related Parainfectious Acute Disseminated Encephalomyelitis Presenting with Dorsal Midbrain Syndrome: A Pediatric Case Report
An 8-year-old male patient presented to the pediatric clinic with complaints of cough, cold, lethargy, fever, restricted eye movements, and altered sensorium for one day. A detailed clinical examination revealed bilateral ophthalmoparesis, with left occulomotor nerve involvement leading to limitations of vertical gaze. The patient was referred to the ophthalmology clinic for assessment. Upon evaluation, it was observed that the child exhibited upward gaze palsy and convergence-retraction nystagmus as can be seen in Figure 1. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 25, 2024 Category: Neurology Authors: H Shafeeq Ahmed, Chinmayee J. Thrishulamurthy Tags: Correspondence Source Type: research
Sensory symptoms across the lifespan in people with cerebral palsy
To estimate prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 25, 2024 Category: Neurology Authors: Ariel M. Lyons-Warren, Danielle Guez-Barber, Sruthi P. Thomas, Evelyne K. Tantry, Aditya Mahat, Bhooma Aravamuthan, Cerebral Palsy Research Network Tags: Research Paper Source Type: research
Investigating associations between non-adherence to guideline-recommended treatment of pediatric seizures and adverse outcomes: a Canadian feasibility study
We found evidence of substantial non-adherence to guideline-recommended treatment of pediatric seizures. Medical records do not contain sufficient information to comprehensively investigate this issue. A multi-centre prospective study is the most feasible option to examine the association between non-adherence to guideline-recommended treatment and patient outcomes. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 25, 2024 Category: Neurology Authors: Meaghan Moreau, Helen Coo, Niveditha Pattathil, Vinay Kukreti, Steven C. Brooks, Anupam Sehgal Tags: Research Paper Source Type: research
Pneumatocoele after cochlear implantation with lateral petrosectomy: A minor complication?
. (Source: Cochlear Implants International)
Source: Cochlear Implants International - April 25, 2024 Category: Audiology Authors: Canzi PietroCarlotto ElenaMinervini DomenicoSimoncelli AnnaDe Iasio AndreaOttoboni IlariaChiapparini LuisaBenazzo Marco1 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy2 Department of Otorhinolaryngol Source Type: research
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
In this study, we used six datasets totaling 1679 samples including RNA gene expression and DNA methylation data from primary MB as well as control samples from healthy cerebellum. We identified methylation-driven genes (MDGs) in MB, genes whose expression is correlated with their methylation. We employed LASSO regression, incorporating the MDGs as a parameter to develop the prognostic model. Through this approach, we deri ved a two-gene signature (GS-2) of candidate prognostic biomarkers for MB (CEMIP andNCBP3). Using a risk score model, we confirmed the GS-2 impact on overall survival (OS) with Kaplan-Meier analysis. We ...
Source: Journal of Molecular Neuroscience - April 25, 2024 Category: Neuroscience Source Type: research
Supporting occupational therapy outcomes for children and young people with cerebral palsy: key considerations for impactful outcomes
This article seeks to support understanding of how occupational therapy practice fits into the ICF framework and to demonstrate the need to address all ICF domains. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - April 25, 2024 Category: Pediatrics Authors: Christopher Colborne Tags: Symposium: special educational needs and disability Source Type: research
Cancers, Vol. 16, Pages 1667: Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach
Jean-Francois Peyron
Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) relapses are still associated with a dismal outcome, justifying the search for new therapeutic targets and relapse biomarkers. Using single-cell RNA sequencing (scRNAseq) data from three paired samples of pediatric T-ALL at diagnosis and relapse, we first conducted a high-dimensional weighted gene co-expression network analysis (hdWGCNA). This analysis highlighted several gene co-expression networks (GCNs) and identified relapse-associated hub genes, which are considered potential driver genes. Shared relapse-expressed genes were found to be re...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Anthony Kypraios Juba Bennour V éronique Imbert L éa David Julien Calvo Fran çoise Pflumio Rapha ël Bonnet Marie Couralet Virginie Magnone Kevin Lebrigand Pascal Barbry Pierre S. Rohrlich Jean-Francois Peyron Tags: Article Source Type: research
Effectiveness of atopic dermatitis patient education programs – a systematic review and meta-analysis
In this study, we conducted a systematic review of the literature to determine the effectiveness of online programming in AD education compared to in-person interventions. A comprehensive search was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions 2019. Studies were retrieved based on articles published up to 04 April 2023. Adherence to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement guided the reportage process for this systematic review and meta-analysis. The primary outcome of our meta-analysis was the effect of various educational modali...
Source: Archives of Dermatological Research - April 25, 2024 Category: Dermatology Source Type: research
The need for surgery in pediatric patients with inflammatory bowel disease treated with biologicals
ConclusionDespite initiation of biological treatment, the risk of intestinal surgery remains high in pediatric IBD patients and often the need for surgery emerges after the transition to adult IBD clinics. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Advances in Immune Tolerance Induction in Enzyme Replacement Therapy
AbstractInborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a metabolic/biochemical pathway or other disturbances in the metabolic pathway including transport protein or activator protein deficiencies, cofactor deficiencies, organelle biogenesis, maturation or trafficking problems. These disorders are collectively significant due to their substantial impact on both the well-being and survival of affected individuals. In the quest for effective treatments, enzyme replacement therapy (ERT) has emerged as a viable strategy for patients with many o...
Source: Pediatric Drugs - April 25, 2024 Category: Pediatrics Source Type: research
Efficacy of non-instrumental Endodontic treatment in primary teeth: a systematic review of clinical randomized trials
ConclusionNo difference between the NIET technique and the conventional endodontic therapy in primary molars requiring pulpectomy could be confirmed. Results of the present review need to be interpreted with caution since the quality of evidence according to the GRADE was considered as moderate to very low. Therefore, additional clinical trials on the NIET technique are recommended. (Source: Systematic Reviews)
Source: Systematic Reviews - April 25, 2024 Category: International Medicine & Public Health Source Type: research
A systematic review on the biochemical threshold of mitochondrial genetic variants [REVIEW]
Mitochondrial DNA (mtDNA) variants cause a range of diseases from severe pediatric syndromes to aging-related conditions. The percentage of mtDNA copies carrying a pathogenic variant, variant allele frequency (VAF), must reach a threshold before a biochemical defect occurs, termed the biochemical threshold. Whether the often-cited biochemical threshold of >60% VAF is similar across mtDNA variants and cell types is unclear. In our systematic review, we sought to identify the biochemical threshold of mtDNA variants in relation to VAF by human tissue/cell type. We used controlled vocabulary terms to identify articles measu...
Source: Genome Research - April 25, 2024 Category: Genetics & Stem Cells Authors: Smith, K. K., Moreira, J. D., Wilson, C. R., Padera, J. O., Lamason, A. N., Xue, L., Gopal, D. M., Flynn, D. B., Fetterman, J. L. Tags: REVIEW Source Type: research
Biocompatibility and acid resistance of preformed crowns in children: an in vitro study
ConclusionAs PPCs can be exposed to highly acidic environments for many years, thus the release of metallic ions from V-PMCs should form the further investigation in future studies. (Source: European Archives of Paediatric Dentistry)
Source: European Archives of Paediatric Dentistry - April 25, 2024 Category: Dentistry Source Type: research
The ‘Manchester method’ of minimal access fixation of the zygomatic arch in zygomatic complex fractures: A case series
We present a case series of seven patients. In all patients the arch component was successfully reduced and fixed with our minimal access technique. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - April 25, 2024 Category: ENT & OMF Authors: Sunil Dixit Khandavilli, Zachary Cole-Healy, Andrew Douglas Source Type: research
