A pilot study of multi-modal pain management for same-day discharge after minimally invasive repair of pectus excavatum (Nuss procedure) in children
Conclusion Findings demonstrate the feasibility of multimodal pain management for same-day discharge after the Nuss procedure. Future multisite studies are needed to investigate the superiority of this approach to established methods.Level of EvidenceIII. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 26, 2023 Category: Surgery Source Type: research

Cardiac anomalies in children with congenital duodenal obstruction: a systematic review with meta-analysis
ConclusionThis review shows cardiac anomalies are found in one-third of the patients with DO regardless of the presence of trisomy 21. Therefore, we recommend that patients with DO should receive preoperative cardiac screening.Level of evidenceII. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 26, 2023 Category: Surgery Source Type: research

Idiopathic Pneumonitis Syndrome After Total Body Irradiation in Pediatric Patients Undergoing Myeloablative Hematopoietic Stem Cell Transplantation: A PENTEC Comprehensive Review
Pulmonary complications, especially idiopathic pneumonitis syndrome (IPS), are potentially life altering or fatal sequelae of hematopoietic cell transplantation (HCT). Total body irradiation (TBI) as part of the conditioning regimen has been implicated in IPS. A comprehensive PENTEC (Pediatric Normal Tissues in the Clinic) review was performed to increase our understanding of the role of TBI in the development of acute, noninfectious IPS. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 26, 2023 Category: Radiology Authors: Eric D. Ehler, Lucie M. Turcotte, Sonia Skamene, K. Scott Baker, Shiva K. Das, Louis S. Constine, Jianling Yuan, Kathryn E. Dusenbery Tags: CLINICAL INVESTIGATION Source Type: research

Friends Not Foes
This article discusses the considerations an orthopedist should make when deciding on the timing and the appropriateness of consultation —both preoperatively and perioperatively. Consultation before surgical intervention will especially be useful if the subspecialist will be collaborating in the management of the condition postoperatively (whether inpatient or outpatient). Clear and early consultation in both written and verbal for mat will facilitate quality and expedite the patient’s care. (Source: Orthopedic Clinics of North America)
Source: Orthopedic Clinics of North America - March 26, 2023 Category: Orthopaedics Authors: Nathaniel G. Rogers, Maria Carrillo-Marquez, Annette Carlisle, Catherine D. Sanders, Lauren Burge Source Type: research

Cancers, Vol. 15, Pages 1983: Venetoclax for Acute Myeloid Leukemia in Pediatric Patients: A Texas Medical Center Experience
rdo Guillermo Montalban Bravo Sofia Garces Andrea Marcogliese Hana Paek Zoann Dreyer Julienne Brackett Michele Redell Joanna Yi Guillermo Garcia-Manero Marina Konopleva Alexandra Stevens Branko Cuglievan The BCL-2 inhibitor venetoclax improves survival for adult patients with acute myeloid leukemia (AML) in combination with lower-intensity therapies, but its benefit in pediatric patients with AML remains unclear. We retrospectively reviewed two Texas Medical Center institutions’ experience with venetoclax in 43 pediatric patients with AML; median age 17 years (range, 0.6&nd...
Source: Cancers - March 26, 2023 Category: Cancer & Oncology Authors: Adriana Trabal Amber Gibson Jiasen He David McCall Michael Roth Cesar Nu ñez Miriam Garcia Meredith Buzbee Laurie Toepfer Aram Bidikian Naval Daver Tapan Kadia Nicholas J. Short Ghayas C. Issa Farhad Ravandi Courtney D. DiNardo Guillermo Montalban Bravo Tags: Article Source Type: research

Viruses, Vol. 15, Pages 849: Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far
This study reported a 67.5% reduction in perinatal HIV transmission with prophylactic antenatal, intrapartum, and postnatal zidovudine. Numerous studies since then have provided compelling evidence to further optimize interventions, such that annual transmission rates of 0% are now reported by many health departments in the US and elimination has been validated in several countries around the world. Despite this success, the elimination of HIV’s vertical transmission on the global scale remains a work in progress, limited by socioeconomic factors such as the prohibitive cost of antiretrovirals. Here, we revie...
Source: Viruses - March 26, 2023 Category: Virology Authors: Maria Camila Cardenas Sheila Farnan Benjamin L. Hamel Maria Camila Mejia Plazas Elise Sintim-Aboagye Dawn R. Littlefield Supriya Behl Sohan Punia Elizabeth Ann L Enninga Erica Johnson Zelalem Temesgen Regan Theiler Clive M. Gray Rana Chakraborty Tags: Review Source Type: research

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function
AbstractPPP1R21 acts as a co-factor for protein phosphatase 1 (PP1), an important serine/threonine phosphatase known to be essential for cell division, control of glycogen metabolism, protein synthesis, and muscle contractility. Bi-allelic pathogenic variants inPPP1R21 were linked to a neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities (NEDHFBA) with pediatric onset. Functional studies unraveled impaired vesicular transport as being part of PPP1R21-related pathomechanism. To decipher further the pathophysiological processes leading to the clinical manifestation of NEDHFBA, we investigat...
Source: Molecular Neurobiology - March 25, 2023 Category: Neurology Source Type: research

Effects of pictorial warnings on parents' purchases and perceptions of sugar ‐sweetened beverage categories
ConclusionsWarning labels may have heterogeneous effects across SSB categories. Future research should assess the psychological mechanisms underlying these heterogeneous effects. (Source: Pediatric Obesity)
Source: Pediatric Obesity - March 25, 2023 Category: Eating Disorders & Weight Management Authors: Aline D'Angelo Campos, Lindsey Smith Taillie, Gabriela Vatavuk ‐Serrati, Anna H. Grummon, Isabella C. A. Higgins, Marissa G. Hall Tags: ORIGINAL RESEARCH Source Type: research

The application of hemoadsorption for hyperbilirubinemia and its impact on bilirubin removal kinetics in critically ill children
Int J Artif Organs. 2023 Mar 24:3913988231163608. doi: 10.1177/03913988231163608. Online ahead of print.ABSTRACTExtracorporeal blood purification (EBP) is increasingly applied for bilirubin removal in critical care setting. We retrospectively reviewed the clinical features of children aged 1 month to 18 years old who received EBP for hyperbilirubinemia and explored the bilirubin removal kinetics by hemoadsorption (HA) in the pediatric intensive care unit of Hong Kong Children's Hospital from 3/2019 to 7/2022. Among the 14 episodes of EBP from six patients with a median age (interquartile range [IQR]) of 9.3(5.5) years old,...
Source: The International Journal of Artificial Organs - March 25, 2023 Category: Transplant Surgery Authors: Wun Fung Hui Wing Lum Cheung Kam Lun Hon Shu Wing Ku Source Type: research

Droplet digital PCR development for adenovirus load monitoring in children after hematopoietic stem cell transplantation
In conclusion, ddPCR was more sensitive and reproducible in detecting AdV DNA among pediatric HSCT recipients than qPCR. DdPCR represents the potential to provide a more accurate DNAemia detection, determine cutoff values for treatment initiation, and antiviral efficacy assessment.PMID:36965664 | DOI:10.1016/j.jmoldx.2023.03.004 (Source: Molecular Medicine)
Source: Molecular Medicine - March 25, 2023 Category: Molecular Biology Authors: Kazunori Haruta Suguru Takeuchi Makoto Yamaguchi Kazuhiro Horiba Takako Suzuki Yuka Torii Atsushi Narita Hideki Muramatsu Yoshiyuki Takahashi Yoshinori Ito Jun-Ichi Kawada Source Type: research

Exploring the perception of parents on children's screentime: a systematic review and meta-synthesis of qualitative studies
CONCLUSION: The findings highlighted the varied reasons parents promote ST. Parents reported their concerns and confusion about ST and shared some strategies and approaches for better ST. Future research is needed to develop and evaluate educational programs to ensure that parents understand the risks and benefits of ST and in turn, ensure the appropriate adoption of ST for their children.IMPACT: In the digital era, parents' attitudes towards screentime (ST) for their children are mixed. This review presents the dilemma parents face and their struggles with using optimal screen time for their children. This review provides...
Source: Pediatric Research - March 25, 2023 Category: Pediatrics Authors: Shang Chee Chong Wei Zhou Teo Shefaly Shorey Source Type: research

Altered maturation in brainstem neural conduction in very premature babies with fetal growth restriction
CONCLUSION: FGR babies born very prematurely are associated with accelerated or precocial neural maturation at caudal brainstem regions, but moderately delayed maturation at rostral brainstem regions. The altered brainstem neural maturation is different from previously reported mildly delayed maturation in FGR babies born less prematurely, and may have important implication for neurodevelopmental outcome.IMPACT: This first MLS BAER study in FGR found that brainstem neural maturation in very premature FGR babies differed from age-matched non-FGR babies. Neural maturation in very premature FGR babies is accelerated or precoc...
Source: Pediatric Research - March 25, 2023 Category: Pediatrics Authors: Ze Dong Jiang Cui Wang Li Li Ping Rong Yin Source Type: research

The association of intrapartum deceleration and acceleration areas with MRI findings in neonatal encephalopathy
CONCLUSION: In neonates treated for HIE, acceleration area and acceleration-to-deceleration ratio are associated with the risk of neonatal brain MRI abnormalities. To increase the role of these measurements as a relevant clinical tool, larger, more powered prospective trials are needed, using computerized real-time analysis.IMPACT: The current cardiotocography predictive value for neonatal outcome is limited. This study aimed to assess the association of intrapartum deceleration and acceleration areas with the degree of cerebral injury in early cerebral MRI of neonates with encephalopathy. Lower acceleration area and accel...
Source: Pediatric Research - March 25, 2023 Category: Pediatrics Authors: Neta Geva Yael Geva Shimrit Yaniv Salem Kyla Anna Marks Reut Rotem Ramy Abramsky Reli Hershkovitz Ilan Shelef Evelyn Farkash Novik Adi Yehuda Weintraub Eilon Shany Source Type: research

Risk-prediction models for intravenous immunoglobulin resistance in Kawasaki disease: Risk-of-Bias Assessment using PROBAST
CONCLUSION: IVIG resistance models for Kawasaki disease showed high ROB. An emphasis on improving their quality can provide high-quality evidence for clinical practice.IMPACT STATEMENT: This study systematically evaluated the risk of bias (ROB) of existing prediction models for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease to provide guidance for future model development meeting clinical expectations. This is the first study to systematically evaluate the ROB of IVIG resistance in Kawasaki disease by using PROBAST. ROB may reduce model performance in different populations. Future prediction models should...
Source: Pediatric Research - March 25, 2023 Category: Pediatrics Authors: Shuhui Wang Hongbiao Huang Miao Hou Qiuqin Xu Weiguo Qian Yunjia Tang Xuan Li Guanghui Qian Jin Ma Yiming Zheng Yueping Shen Haitao Lv Source Type: research

Reduction in avoidance mediates effects of brief behavioral therapy for pediatric anxiety and depression
Behav Res Ther. 2023 Mar 8;164:104290. doi: 10.1016/j.brat.2023.104290. Online ahead of print.ABSTRACTBrief behavioral therapy (BBT) is an efficacious transdiagnostic intervention for pediatric anxiety and depression that targets behavioral avoidance as a key mechanism. It is unknown if change in avoidance mediates treatment effects, as theorized. Data on avoidance at baseline and Week 16 were available on 52 youth (ages 8-16 years) from a randomized controlled trial (Weersing, Jeffreys, et al., 2017) comparing BBT and assisted referral to community care (ARC). BBT had significant effects on youth-reported behavioral avoid...
Source: Behaviour Research and Therapy - March 25, 2023 Category: Psychiatry & Psychology Authors: Selena A Baca Pauline Goger Dale Glaser Michelle Rozenman Araceli Gonzalez John F Dickerson Frances L Lynch Giovanna Porta David A Brent V Robin Weersing Source Type: research