New LC-MS/MS reference data for estradiol show mini-puberty in both sexes and typical pre-pubertal and pubertal patterns
CONCLUSIONS: Variability of RIs for E2 between studies illustrates importance of laboratory-specific RIs despite using a liquid chromatographic tandem mass spectrometry (LC-MS/MS) reference method. In boys, the striking E2 peak during mini-puberty as well as high pubertal E2 without phenotypic estrogenization in regular male puberty indicate that the role of E2 in children, and especially in boys requires better functional understanding.PMID:38652605 | DOI:10.1093/ejendo/lvae046 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Alexandra E Kulle Amke Caliebe Tabea Lamprecht Thomas Reinehr Gunter Simic-Schleicher Esther Schulz Michaela Kleber Juliane Rothermel Sabine Heger Olaf Hiort Paul-Martin Holterhus Source Type: research
Anesthetic challenges in patients with multicompartmental lymphatic failure after Fontan palliation undergoing transcatheter thoracic duct decompression
Paediatr Anaesth. 2024 Apr 23. doi: 10.1111/pan.14891. Online ahead of print.ABSTRACTLymphatic flow abnormalities are central to the development of protein losing enteropathy, plastic bronchitis, ascites and pleural effusions in patients palliated to the Fontan circulation. These complications can occur in isolation or multicompartmental (two or more). The treatment of multicompartmental lymphatic failure aims at improving thoracic duct drainage. Re-routing the innominate vein to the pulmonary venous atrium decompresses the thoracic duct, as atrial pressure is lower than systemic venous pressure in Fontan circulation. Tran...
Source: Paediatric Anaesthesia - April 23, 2024 Category: Anesthesiology Authors: Kirsten R Groody Susan C Nicolson David R Jobes Source Type: research
Characteristics of radiotherapy for adolescents and young adults
This article reviews the characteristics to be taken into account in adolescent and young adult patients radiotherapy and more particularly in some of the most common diseases.PMID:38652674 | DOI:10.1016/j.canrad.2023.08.002 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 23, 2024 Category: Cancer & Oncology Authors: L Ollivier A Laprie E Jouglar L Claude V Martin X Muracciole L Padovani S Supiot A Escande Source Type: research
Individual patient data meta-analysis on awake pediatric extracorporeal life support: Feasibility and safety of analgesia, sedation and respiratory support weaning, and physiotherapy
CONCLUSION: Awake ECLS strategy with active physiotherapy can be applied in children from neonatal age. Ambulation is also possible in selected cases. Complications related to such management were limited. Further studies on aECLS are needed to evaluate safety and efficacy of early physiotherapy and define patient selection.PMID:38652693 | DOI:10.1177/02676591241240377 (Source: Perfusion)
Source: Perfusion - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Marta Cucchi Silvia Mariani Michal J Kawczynski Emma Shkurka Fabio Ius Giuseppe Comentale Aparna Hoskote Roberto Lorusso Source Type: research
The approach to extracorporeal cardiopulmonary resuscitation (ECPR) in children. A narrative review by the paediatric ECPR working group of EuroELSO
Perfusion. 2024 Apr;39(1_suppl):81S-94S. doi: 10.1177/02676591241236139.ABSTRACTExtracorporeal Cardiopulmonary Resuscitation (ECPR) has potential benefits compared to conventional Cardiopulmonary Resuscitation (CCPR) in children. Although no randomised trials for paediatric ECPR have been conducted, there is extensive literature on survival, neurological outcome and risk factors for survival. Based on current literature and guidelines, we suggest recommendations for deployment of paediatric ECPR emphasising the requirement for protocols, training, and timely intervention to enhance patient outcomes. Factors related to outc...
Source: Perfusion - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: H A Mensink A Desai M Cvetkovic M Davidson A Hoskote M O'Callaghan T Thiruchelvam P P Roeleveld Source Type: research
Rehabilitation for adult patients undergoing extracorporeal membrane oxygenation
CONCLUSION: Current practice focuses on rehabilitative protocols that incorporate exercise routines with progressive intensity, greater emphasis on out-of-bed activities, and a multidisciplinary approach to patient mobilization.PMID:38651577 | DOI:10.1177/02676591231226289 (Source: Perfusion)
Source: Perfusion - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Massimiliano Polastri Allaina Eden Justyna Swol Source Type: research
What the pediatric nurse needs to know about the Impella cardiac assist device
Perfusion. 2024 Apr;39(1_suppl):95S-106S. doi: 10.1177/02676591241237761.ABSTRACTBackground: Cardiogenic shock in children still carries a high mortality risk despite advances in medical therapy. The use of temporary mechanical circulatory supports is an accepted strategy to bridge patients with acute heart failure to recovery, decision, transplantation or destination therapy. These devices are however limited in children and extracorporeal membrane oxygenation (ECMO) remains the most commonly used device. Veno-arterial ECMO may provide adequate oxygen delivery, but it does not significantly unload the left ventricle, and ...
Source: Perfusion - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Giorgia Borrelli Ilaria Nittolo Chiara Bochicchio Laura Trainelli Valerio Confalone Tiziana Satta Federica Cancani Richard Kirk Antonio Amodeo Matteo Di Nardo Source Type: research
Pediatric Diffuse Leptomeningeal Glioneuronal Tumors: Diagnosis, Follow-up and Treatment Options
CONCLUSION: Further work with larger cohorts is required to determine a common algorithm for DLGNT treatment and follow-up. This analysis may keep this entity in mind in patients with pediatric communicating hydrocephalus and may present insight into diagnosis, follow-up, and treatment options.PMID:38650559 | DOI:10.5137/1019-5149.JTN.43742-23.2 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Ali Ozen Bahattin Tanrikulu Ayca Ersen Danyeli Memet Ozek Source Type: research
Percutaneous Ventriculoatrial Shunting as a Salvage Method in the Pediatric Hydrocephalus Patients with Peritoneal Problems
CONCLUSION: Percutaneous ventriculoatrial shunting under the guidance of intraoperative fluoroscopy and ultrasound is a safe, effective, and easy alternative in patients with peritoneal complications and a history of multiple operations.PMID:38650557 | DOI:10.5137/1019-5149.JTN.43472-23.2 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Kadir Oktay Sinan Sozutok Umur Anil Pehlivan Dogu Cihan Yildirim Mevlana Akbaba Kerem Mazhar Ozsoy Nuri Eralp Cetinalp Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Delta-S-Cys-Albumin as a Marker of Pediatric Biospecimen Integrity
We report application of a previously developed assay in adults-the ΔS-Cys-Albumin assay, which facilitates estimation of plasma and serum exposure to thawed conditions-to a population of pediatric EDTA plasma samples from patients aged 3-18 years to determine the assay's applicability, estimate its reference range for pediatric samples, and assess the impact of pre-centrifugation delay at 0°C. In addition, the effect of plasma thawed-state exposure to a range of times at 23°C, 4°C, and -20°C on ΔS-Cys-Albumin was evaluated. Using 98 precollected and processed pediatric EDTA plasma specimens, no difference was found ...
Source: Biopreservation and Biobanking - April 23, 2024 Category: Biomedical Science Authors: Schuyler Kremer Valentina Shakhnovich Amanda K Riffel Lisa Harvey Chad R Borges Source Type: research
Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health
This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children's Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hy...
Source: Journal of Autism and Developmental Disorders - April 23, 2024 Category: Psychiatry Authors: Amrita Minhas Kerri Whitlock Cory Rosenfelt Julie Shatto Brittany Finlay Jennifer Zwicker Sarah Lippe Sebastien Jacquemont Randi Hagerman Kara Murias Francois V Bolduc Source Type: research
Adalimumab Dose Reduction and Withdrawal in Stable Non-Infectious Pediatric Uveitis: An Open-Label, Prospective, Pilot Study
CONCLUSIONS: In PNIU children who reached remission for 6 months, ADA dose reduction and withdrawal were associated with a high risk of inflammation recurrence. Timely adjustment of ADA to the last effective dosage frequency can regain control of the inflammation. Detection of ADA serum levels in patients with recurrence may help find the appropriate interval of ADA use.PMID:38652891 | DOI:10.1080/09273948.2024.2343084 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 23, 2024 Category: Allergy & Immunology Authors: P D Yuan Y W Hu X Q Chen G Y Chen Y Pan H Y Lao D Liang Source Type: research
The Use of the RETeval Portable Electroretinography Device for Low-Cost Screening: A Mini-Review
Klin Monbl Augenheilkd. 2024 Apr;241(4):533-537. doi: 10.1055/a-2237-3814. Epub 2024 Apr 23.ABSTRACTElectroretinography (ERG) provides crucial insights into retinal function and the integrity of the visual pathways. However, ERG assessments classically require a complicated technical background with costly equipment. In addition, the placement of corneal or conjunctival electrodes is not always tolerated by the patients, which restricts the measurement for pediatric evaluations. In this short review, we give an overview of the use of the RETeval portable ERG device (LKC Technologies, Inc., Gaithersburg, MD, USA), a modern ...
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: Amr Saad Ferhat Turgut Chiara Sommer Matthias Becker Delia DeBuc Mirella Barboni Gabor Mark Somfai Source Type: research
Positive Airway Pressure and Metabolic Markers in Children With Obstructive Sleep Apnea
CONCLUSIONS: Although evidence on effects of PAP on metabolic markers in children with OSA is encouraging, available literature is limited. Longitudinal studies are still required to further assess the long-term influence of PAP on metabolic and inflammatory markers, particularly in children with obesity.PMID:38653555 | DOI:10.4187/respcare.11679 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Christopher A Gerdung Daniel B Ofosu Sara Rodriguez-Lopez Stefan Palkowski Diana Keto-Lambert Meng Lin Maria L Castro-Codesal Source Type: research
