GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
CONCLUSION: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.IMPACT: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.PMID:38658664 | DOI:10.1038/s41390-024-031...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Fangfang Zhang Mingyu Cui Lijuan Zhang Bangzhen Ma Feng Guo Gang Wang Source Type: research
Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?
In conclusion, this review supports the need for randomized clinical trials to test the hypothesis that additional choline or PC provided parenterally or enterally can reduce the incidence of NEC in preterm infants. IMPACT STATEMENT: Low choline status in preterm infants who are managed by conventional nutrition is plausibly linked to the risk of developing necrotizing enterocolitis.PMID:38658665 | DOI:10.1038/s41390-024-03212-5 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Douglas C Drenckpohl Danielle N Christifano Susan E Carlson Source Type: research
Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age
CONCLUSION: In preterm-born children, iFGF-23 and secretoneurin both offer prospects as valuable cardiovascular biomarkers, potentially allowing for risk stratification and timely implementation of preventive measures.IMPACT: Former very preterm infants have increased plasma concentrations of the novel cardiovascular biomarkers intact fibroblast growth factor-23 (iFGF-23) and secretoneurin at kindergarten age. Increases in iFGF-23 concentrations are associated with decreased distensibility of the descending aorta even at this early age. Monitoring of cardiovascular risk factors is essential in individuals with a history of...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Wolfgang Mitterer Irena Odri Komazec Eva Huber Benedikt Schaefer Anna Posod Ursula Kiechl-Kohlendorfer Source Type: research
Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3 β
CONCLUSION: VIRMA can inhibit cell migration and proliferation by upregulating the expression of GSK3β, contributing to the onset of HSCR.IMPACT: The expressions of VIRMA were significantly reduced in HSCR, while GSK3β expression was increased in HSCR, and can be used as a molecular marker. VIRMA overexpression promoted the proliferation and migration of SH-SY5Y and HEK-293T cells. VIRMA can inhibit the degradation of GSK3β mRNA and increase the expression of GSK3β.PMID:38658662 | DOI:10.1038/s41390-024-03136-0 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Yang Yang Mengzhen Zhang Nan Li Chen Wang Huirong Yang Xinwei Hou Jiaming Yang Kaisi Fan Liucheng Yang Kai Wu Source Type: research
ECI biocommentary: Shiraz Badurdeen
Pediatr Res. 2024 Apr 24. doi: 10.1038/s41390-024-03218-z. Online ahead of print.NO ABSTRACTPMID:38658661 | DOI:10.1038/s41390-024-03218-z (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Shiraz Badurdeen Source Type: research
SpO2/FiO2 and PaO2/FiO2 for Predicting Intensive Care Admission in Wheezy Children: An Observational Study
CONCLUSION: SpO2/FiO2 cut-off of < 300 had a good sensitivity in determining need for PICU admission. SF ratio has only a moderate correlation with PF ratio.PMID:38655893 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 24, 2024 Category: Pediatrics Authors: Rakhi Beniwal Prerna Batra Vikram Bhaskar Deepika Harit Source Type: research
Spectrum of Genital and Extragenital Anomalies in Malformation Syndromes Associated With 46, XY Disorders of Sex Development: A Single Center Experience
CONCLUSION: Integration between clinical, laboratory and genetic data is the cornerstone in the management of XY DSD patients for appropriate decision making of surgical intervention and sex assignment, in addition to screening for other associated features of each mutation.PMID:38655886 (Source: Indian Pediatrics)
Source: Indian Pediatrics - April 24, 2024 Category: Pediatrics Authors: Shaymaa Raafat Yasmine Abdelmeguid Mostafa Kotb Ahmed Oshiba Source Type: research
Comparing Accuracy of Night Radiology Interpretations for Pediatric Trauma: Radiology Residents Versus Attending Teleradiologists
Discussion: When interpreting PTP CT imaging, RRs had similar discrepancy rates but faster TTI than ATs. Radiology residents had a higher discrepancy rate for PTP CTs than RR interpretation of adult patients, indicating both RRs and ATs need more focused training in the interpretation of PTP studies.PMID:38655777 | DOI:10.1177/00031348241248794 (Source: The American Surgeon)
Source: The American Surgeon - April 24, 2024 Category: Surgery Authors: Alice M Martino Eric O Yeates Areg Grigorian Justine Chinn Hayley Young Jessica Colin Escobar Justin Glavis-Bloom Arash Anavim Vahid Yaghmai Ninh T Nguyen Matthew Dolich Sebastian D Schubl Laura F Goodman Yigit S Guner Jeffry Nahmias Source Type: research
Comparison of baseline cataract rates in AB and TL wildtype zebrafish strains
In this study, we compared the baseline cataract rate between two commonly used wildtype laboratory strains, AB and TL, and also an outbred transgenic line with mCherry reporter. We assessed a total of 805 lens images of fish at 4 days post-fertilisation for cataracts and scored each cataract observed as mild, moderate or severe. We found that the AB strain had a cataract rate of 16.2%, TL had 8.9%, and mCherry had 0.7% and these rates were significantly different. We found that TL strain had a lower rate of mild cataracts than AB fish, however, the rate of moderate and severe phenotypes in the AB and the TL strain was sim...
Source: Experimental Eye Research - April 24, 2024 Category: Opthalmology Authors: Bibek Khatiwada Johanna L Jones Duran Zhao Robert J Gasperini Bennet J McComish Kathryn P Burdon Source Type: research
Nirsevimab: Expansion of Respiratory Syncytial Virus Prevention Options in Neonates, Infants, and At-Risk Young Children
CONCLUSIONS: Nirsevimab demonstrated clinical efficacy in reducing RSV-associated MA-LRTI and RSV-associated hospitalizations in infants and was well tolerated.PMID:38654469 | DOI:10.1177/10600280241243357 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 24, 2024 Category: Drugs & Pharmacology Authors: J Hunter Fly Lea S Eiland Jeremy S Stultz Source Type: research
Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia
Haematologica. 2024 Apr 24. doi: 10.3324/haematol.2023.284102. Online ahead of print.ABSTRACTNot available.PMID:38654666 | DOI:10.3324/haematol.2023.284102 (Source: Haematologica)
Source: Haematologica - April 24, 2024 Category: Hematology Authors: Marta B Fernandes A Margarida Gomes Mariana L Oliveira Joana Caldas Paulo L úcio Rathana Kim Aur élie Caye-Eude Filomena Pereira Aida B De Sousa Alessia De Stefano Matilde Y Follo Maria V Soares Jo ão F Lacerda Joana Desterro H élène Cavé Emmanuelle Source Type: research
Pediatric anesthesia in Australia and New Zealand and health inequity among First Nations and M āori children
Paediatr Anaesth. 2024 Apr 24. doi: 10.1111/pan.14898. Online ahead of print.ABSTRACTAustralia and New Zealand are two countries in the Southern Pacific region. They share many pediatric anesthesia similarities in terms of medical organizational systems, education, training, and research, however there are important differences between the two nations in relation to geography, the First Nations populations and the history of colonization. While the standards for pediatric anesthesia and the specialty training requirements are set by the Australian and New Zealand College of Anesthetists and the Society for Pediatric Anesth...
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Edith Waugh Jane Thomas Brian J Anderson Paul Lee-Archer Source Type: research
Advances in pediatric anesthesia services over the past 10 years in French-speaking sub-Saharan Africa
CONCLUSION: Progress have been made over the last 10 years in French-speaking SSA to improve infrastructures, human resources, education, medications, and equipment for pediatric anesthesia in French-speaking SSA. However, major efforts must be continued. Standards adapted to the local context should be formulated.PMID:38655778 | DOI:10.1111/pan.14904 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: K élan Bertille Ki Fatou Fleur Sanou Marie Ndoye Diop Ismael Guibla Mamadou Traore Joseph Donamou Moustapha Mangane Yvette Kabre Hadjara Daddy Buhendwa Jean Paul Cikwanine Hamza Sama Joseph Akodjenou Adjougoulta Koboy Do-A-Nduo Bonte Junete Metogo Mbengo Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
