GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway

CONCLUSION: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.IMPACT: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.PMID:38658664 | DOI:10.1038/s41390-024-03158-8

Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Fangfang Zhang Mingyu Cui Lijuan Zhang Bangzhen Ma Feng Guo Gang Wang Source Type: research