Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3 β

CONCLUSION: VIRMA can inhibit cell migration and proliferation by upregulating the expression of GSK3β, contributing to the onset of HSCR.IMPACT: The expressions of VIRMA were significantly reduced in HSCR, while GSK3β expression was increased in HSCR, and can be used as a molecular marker. VIRMA overexpression promoted the proliferation and migration of SH-SY5Y and HEK-293T cells. VIRMA can inhibit the degradation of GSK3β mRNA and increase the expression of GSK3β.PMID:38658662 | DOI:10.1038/s41390-024-03136-0

Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Yang Yang Mengzhen Zhang Nan Li Chen Wang Huirong Yang Xinwei Hou Jiaming Yang Kaisi Fan Liucheng Yang Kai Wu Source Type: research