Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children.
Abstract The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) and the Autism Diagnostic Interview, Revised (ADI-R) have high accuracy as diagnostic instruments in research settings, while evidence of accuracy in clinical settings is less robust. This meta-analysis focused on efficacy of these measures in research versus clinical settings. Articles (n = 22) were analyzed using a hierarchical summary receiver operating characteristics (HSROC) model. ADOS-2 performance was stronger than the ADI-R. ADOS-2 sensitivity and specificity ranged from .89-.92 and .81-.85, respectively. ADOS-2 accuracy in resea...
Source: Journal of Autism and Developmental Disorders - January 21, 2021 Category: Psychiatry Authors: Lebersfeld JB, Swanson M, Clesi CD, O'Kelley SE Tags: J Autism Dev Disord Source Type: research

Lower Risk of Burn Injury in Children and Adolescents with Autism Spectrum Disorder: A Nationwide Population-Based Study.
Abstract Little research has examined burn injury in the pediatric population with autism spectrum disorder (ASD). We used data from Taiwan's National Health Insurance Research Database to identify 15,844 participants aged
Source: Journal of Autism and Developmental Disorders - January 20, 2021 Category: Psychiatry Authors: Chan HL, Hsieh YH, Lin CF, Liang HY, Lee SS, Weng JC, Lee MJ, Chen YL, Chen VC, Gossop M Tags: J Autism Dev Disord Source Type: research

Adults with Autism: Changes in Understanding Since DSM-111.
Abstract Over the past four decades there have been significant advances in our understanding of autism, yet services for autistic adults continue to lag far behind those for children, and prospects for employment and independent living remain poor. Adult outcomes also vary widely and while cognitive and language abilities are important prognostic indicators, the influence of social, emotional, familial and many other factors remains uncertain. For this special issue marking the 40th anniversary of DSM-III, the present paper describes the changing perspectives of autism in adulthood that have occurred over this pe...
Source: Journal of Autism and Developmental Disorders - January 20, 2021 Category: Psychiatry Authors: Howlin P Tags: J Autism Dev Disord Source Type: research

Does Language Matter? Identity-First Versus Person-First Language Use in Autism Research: A Response to Vivanti.
Abstract In response to Vivanti's 'Ask The Editor…' paper [Journal of Autism and Developmental Disorders, 50(2), 691-693], we argue that the use of language in autism research has material consequences for autistic people including stigmatisation, dehumanisation, and violence. Further, that the debate in the use of person-first language versus identity-first language should centre first and foremost on the needs, autonomy, and rights of autistic people, so in to preserve their rights to self-determination. Lastly, we provide directions for future research. PMID: 33474662 [PubMed - as supplied by publis...
Source: Journal of Autism and Developmental Disorders - January 20, 2021 Category: Psychiatry Authors: Botha M, Hanlon J, Williams GL Tags: J Autism Dev Disord Source Type: research

Brief Report: Predicting Sex Differences and Diagnosis from Early Parent Concerns.
This study examined how patterns of parent concerns predicted sex differences and eventual child diagnosis (ASD or developmental delay [DD]). We performed a secondary analysis with n = 273 children ages 36-72 months. Results suggested males with ASD had a higher likelihood of repetitive behavior and speech and language concerns compared to females with ASD. Females with DD were significantly more likely to have problem-solving concerns; whereas, males with DD were significantly less likely to have social communication concerns compared to females with ASD. PMID: 33458810 [PubMed - as supplied by pub...
Source: Journal of Autism and Developmental Disorders - January 18, 2021 Category: Psychiatry Authors: Wallisch A, Behrens S, Salley B, Jamison R, Boyd B Tags: J Autism Dev Disord Source Type: research

High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study.
;ber A, Topal Z, Acikbas U, Giray A, Kütük Ö Abstract The diagnosis of autism spectrum disorder (ASD) in a child affects family processes, increases parenting stress and marital conflicts, and may lead to parental psychopathology. It may also affect the prognosis for their children. The aim of this study is to determine depression and burnout levels as well as their predictors among parents of children with ASD compared with those of healthy children. We also sought to evaluate rate of complementary and alternative medicine (CAM) interventions among parents and explore the associations of this pheno...
Source: Journal of Autism and Developmental Disorders - January 18, 2021 Category: Psychiatry Authors: Kütük MÖ, Tufan AE, Kılıçaslan F, Güler G, Çelik F, Altıntaş E, Gökçen C, Karadağ M, Yektaş Ç, Mutluer T, Kandemir H, Büber A, Topal Z, Acikbas U, Giray A, Kütük Ö Tags: J Autism Dev Disord Source Type: research

Sex-Based Differences in Autism Symptoms in a Large, Clinically-Referred Sample of Preschool-Aged Children with ASD.
This study provides additional evidence of sex-based differences in ASD symptoms present from an early age. PMID: 33459916 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 18, 2021 Category: Psychiatry Authors: Stephenson KG, Norris M, Butter EM Tags: J Autism Dev Disord Source Type: research

The Impact of Stigma, Autism Label and Wording on the Perceived Desirability of the Online Dating Profiles of Men on the Autism Spectrum.
This study presented dating profiles with and without an explicit label of autism and positive or negative wording to 306 'females seeking a male partner'. Participants assessed the men's dating profiles in terms of perceived attractiveness, trustworthiness and desire-to-date. They also completed a questionnaire on their level of stigmatisation of, and familiarity with, autism. An explicit autism label and positive wording positively impacted perceived attractiveness. With positively worded profiles, those with highly stigmatising views reported decreased desire-to-date when an explicit label of autism was present; those w...
Source: Journal of Autism and Developmental Disorders - January 18, 2021 Category: Psychiatry Authors: Brosnan M, Gavin J Tags: J Autism Dev Disord Source Type: research

Promoting Positive Health Outcomes in an Urban Community-Based Physical Activity Intervention for Preschool Aged Children on the Autism Spectrum.
Abstract While there is wide consensus regarding the importance of early intervention, health is rarely considered within priorities. Twenty-five children on the autism spectrum (Mage = 4.67, SD = 0.82) participated in a 12-week physical activity intervention. Primary objective was to examine impact of a physical activity intervention on physical activity, fitness and motor competence. Secondary objective was to examine associations between motor behavior and ASD symptoms. Ball skills (p  -  .49, p 
Source: Journal of Autism and Developmental Disorders - January 18, 2021 Category: Psychiatry Authors: Ketcheson L, Staples K, Pitchford EA, Loetzner F Tags: J Autism Dev Disord Source Type: research

Detecting Feeding Problems in Young Children with Autism Spectrum Disorder.
Abstract Feeding problems are prevalent in children with ASD. We investigated whether the Montreal Children's Hospital Feeding Scale (MCH-FS, Ramsay et al. in Pediatrics and Child Health 16:147-151, 2011) can be used for young children with ASD. Participants (1-6 years) were selected from a clinical ASD sample (n = 80) and a general population sample (n = 1389). Internal consistency was good in both samples. In general, parents of children with ASD reported more feeding problems than those from the population sample. The response patterns on the individual items was highly similar....
Source: Journal of Autism and Developmental Disorders - January 16, 2021 Category: Psychiatry Authors: van Dijk MWG, Buruma ME, Blijd-Hoogewys EMA Tags: J Autism Dev Disord Source Type: research

Evidence-Based Practices for Children, Youth, and Young Adults with Autism: Third Generation Review.
vage MN Abstract This systematic review describes a set of practices that have evidence of positive effects with autistic children and youth. This is the third iteration of a review of the intervention literature (Odom et al. in J Autism Dev Disorders 40(4):425-436, 2010a; Prevent School Fail 54(4):275-282, 2010b; Wong et al. in https://autismpdc.fpg.unc.edu/sites/autismpdc.fpg.unc.edu/files/imce/documents/2014-EBP-Report.pdf ; J Autism Dev Disorders 45(7):1951-1966, 2015), extending coverage to articles published between 1990 and 2017. A search initially yielded 31,779 articles, and the subsequent screening and e...
Source: Journal of Autism and Developmental Disorders - January 15, 2021 Category: Psychiatry Authors: Hume K, Steinbrenner JR, Odom SL, Morin KL, Nowell SW, Tomaszewski B, Szendrey S, McIntyre NS, Yücesoy-Özkan S, Savage MN Tags: J Autism Dev Disord Source Type: research

Content Validity Evidence for the Verbal Behavior Milestones Assessment and Placement Program.
Abstract The purpose of this study is to provide content validity evidence for the Verbal Behavior Milestones Assessment and Placement Program (VB-MAPP). A national panel of 13 experts provided an evaluation of the domain relevance, age appropriateness, method of measurement appropriateness, and domain representation across the three levels of the Milestones Assessment, Early Echoic Skills Assessment (EESA), and Barriers Assessment. Overall, the content validity evidence for the VB-MAPP Milestones, EESA, and Barriers Assessment was moderate to strong across the evaluated areas although there were areas with limite...
Source: Journal of Autism and Developmental Disorders - January 14, 2021 Category: Psychiatry Authors: Padilla KL, Akers JS Tags: J Autism Dev Disord Source Type: research

An Association Study of Gamma-Aminobutyric Acid Type A Receptor Variants and Susceptibility to Autism Spectrum Disorders.
Abstract In this pilot study, we aim to identify the role of few genetic variants of GABA-receptor type A subunits GABRB3 (rs4906902, rs7171660), GABRG3 (rs208129, rs140679), GABRA5 (rs 140681) in the aetiology of autism spectrum disorders in a population of West Bengal. 192 ASD probands, their parents and 184 ethnically-matched healthy controls were recruited for the study. The rs4906902G and the rs140679T conferred significant risk towards ASD. rs7171660 and rs140679 had transmission bias in the family. Neither alleles of rs 208129 and rs 140681 showed significant over-representation in either groups. All these ...
Source: Journal of Autism and Developmental Disorders - January 13, 2021 Category: Psychiatry Authors: Adak P, Sinha S, Banerjee N Tags: J Autism Dev Disord Source Type: research

Sibling Adjustment and Sibling Relationships Associated with Clusters of Needs in Children with Autism: A Novel Methodological Approach.
Abstract We tested a novel methodological approach to examine associations between characteristics of autistic children and outcomes for siblings. Cluster analysis was used to define five groups of children with autism (n = 168) based on autism symptoms, adaptive behavior, pro-social behavior, and behavior problems. Primary and secondary parent carers, and siblings themselves, reported on sibling relationship quality and psychological adjustment. Siblings of autistic children with a mild symptom profile, high levels of adaptive skills, but high internalizing and externalizing problems had the highest...
Source: Journal of Autism and Developmental Disorders - January 13, 2021 Category: Psychiatry Authors: Rixon L, Hastings RP, Kovshoff H, Bailey T Tags: J Autism Dev Disord Source Type: research

Educational and Diagnostic Classification of Autism Spectrum Disorder and Associated Characteristics.
Abstract Research continues to highlight discrepancies between clinical diagnoses of Autism Spectrum Disorder (ASD) and determination of special education eligibility for services within school settings. However, limited research has been conducted on the impact of those discrepancies for the identification of appropriate services within schools. The aim of the current study is to examine students' characteristics (e.g., language, social emotional) associated with educational eligibility and clinical diagnoses. More specifically, the study examines characteristics differentially associated with ASD diagnoses to in...
Source: Journal of Autism and Developmental Disorders - January 13, 2021 Category: Psychiatry Authors: Stichter J, Stormont M, Buranova N, Herzog M, O'Donnell R Tags: J Autism Dev Disord Source Type: research

Improving Early Identification and Access to Diagnosis of Autism Spectrum Disorder in Toddlers in a Culturally Diverse Community with the Rapid Interactive screening Test for Autism in Toddlers.
The objective of this study was to test a screening model that employs the Rapid Interactive Screening Test for Autism in Toddlers (RITA-T), in an underserved community to improve ASD detection. We collaborated with a large Early Intervention (EI) program and trained 4 providers reliably on the RITA-T. Toddlers received the Modified Checklist for Autism in Toddlers (MCHAT-R/F), the RITA-T, developmental and autism testing, and a best-estimate clinical diagnosis. Eighty-One toddlers were enrolled: 57 with ASD and 24 with Developmental Delay (DD) non-ASD. Wait-time for diagnosis was on average 6 weeks. The RITA-T correl...
Source: Journal of Autism and Developmental Disorders - January 9, 2021 Category: Psychiatry Authors: Choueiri R, Lindenbaum A, Ravi M, Robsky W, Flahive J, Garrison W Tags: J Autism Dev Disord Source Type: research

Correction to: Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials).
Falissard B PMID: 33423216 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 9, 2021 Category: Psychiatry Authors: Crutel V, Lambert E, Penelaud PF, Albarrán Severo C, Fuentes J, Rosier A, Hervás A, Marret S, Oliveira G, Parellada M, Kyaga S, Gouttefangeas S, Bertrand M, Ravel D, Falissard B Tags: J Autism Dev Disord Source Type: research

Using Prevent Teach Reinforce for Young Children to Manage Challenging Behaviors in Public Specialized Early Intervention Services for Autism.
Abstract This proof-of-concept study assessed the feasibility of implementing Prevent-Teach-Reinforce-for-Young-Children (PTR-YC) program to address challenging behaviors in children with autism within the context of public, specialized early intensive behavioral intervention (EIBI) services offered in community settings. Following a 2-day training and with brief weekly supervision meetings, children's EIBI educators acted as facilitators in 35 families' home environments. Small and moderate effect sizes were observed for children's behavioral outcomes and parenting stress. Recruitment and retention rates, impleme...
Source: Journal of Autism and Developmental Disorders - January 9, 2021 Category: Psychiatry Authors: Rivard M, Mello C, Mestari Z, Terroux A, Morin D, Forget J, Lefebvre C, Argumedes M Tags: J Autism Dev Disord Source Type: research

Autism Spectrum Disorder Alertness in Dutch Youth and Family Center Physicians: Effects of a Live Online Educational Program.
Abstract We investigated the effect of a live online educational program in 93 Dutch Youth and Family Center (YFC) physicians who were screening for Autism Spectrum Disorder (ASD) in the general child population. The educational program raised the physicians' level of specific ASD knowledge and it remained higher at six months follow-up (p 
Source: Journal of Autism and Developmental Disorders - January 9, 2021 Category: Psychiatry Authors: van 't Hof M, van Nieuwenhuyzen ADY, van Berckelaer-Onnes I, Deen M, Hoek HW, Ester WA Tags: J Autism Dev Disord Source Type: research

Group Virtual Mindfulness-Based Intervention for Parents of Autistic Adolescents and Adults.
Abstract Mindfulness-based approaches have been shown to be effective in improving the mental health of parents of youth and adults with autism and other developmental disabilities, but prior work suggests that geography and caregiving demands can make in-person attendance challenging. The purpose of this study was to evaluate the feasibility, acceptability and preliminary outcomes of a mindfulness-based group intervention delivered to parents virtually. It was feasible to deliver this manualized intervention. Twenty-one of 39 parents completed the intervention and completers reported high satisfaction ratings. Pa...
Source: Journal of Autism and Developmental Disorders - January 9, 2021 Category: Psychiatry Authors: Lunsky Y, Albaum C, Baskin A, Hastings RP, Hutton S, Steel L, Wang W, Weiss J Tags: J Autism Dev Disord Source Type: research

Toward Novel Tools for Autism Identification: Fusing Computational and Clinical Expertise.
Abstract Barriers to identifying autism spectrum disorder (ASD) in young children in a timely manner have led to calls for novel screening and assessment strategies. Combining computational methods with clinical expertise presents an opportunity for identifying patterns within large clinical datasets that can inform new assessment paradigms. The present study describes an analytic approach used to identify key features predictive of ASD in young children, drawn from large amounts of data from comprehensive diagnostic evaluations. A team of expert clinicians used these predictive features to design a set of assessm...
Source: Journal of Autism and Developmental Disorders - January 8, 2021 Category: Psychiatry Authors: Corona LL, Wagner L, Wade J, Weitlauf AS, Hine J, Nicholson A, Stone C, Vehorn A, Warren Z Tags: J Autism Dev Disord Source Type: research

A Longitudinal Study of Parent Gestures, Infant Responsiveness, and Vocabulary Development in Infants at Risk for Autism Spectrum Disorder.
Abstract We investigated gestures that parents used with 12-, 18-, and 24-month-old infants at high or low risk for autism spectrum disorder (ASD; high-risk diagnosed with ASD: n = 21; high-risk classified as no ASD: n = 34; low-risk classified as no ASD: n = 34). We also examined infant responses to parent gestures and assessed the extent to which parent gesture relates to vocabulary development. Parents of three groups gestured in similar frequencies and proportions. Infants, in turn, responded similarly to parent gestures regardless of the infan...
Source: Journal of Autism and Developmental Disorders - January 8, 2021 Category: Psychiatry Authors: Choi B, Shah P, Rowe ML, Nelson CA, Tager-Flusberg H Tags: J Autism Dev Disord Source Type: research

Dimensions of Autistic Traits Rated by Parents of Children and Adolescents with Suspected Autism Spectrum Disorders.
uml;pfner M Abstract To examine the factor structure of autism spectrum disorder (ASD) and the psychometric properties of the German Symptom Checklist for Autism Spectrum Disorders (SCL-ASD). Data were collected from 312 clinical referrals with suspected ASD (2-18 years). Confirmatory factor analyses and analyses of reliability, convergent and divergent validity were performed. A bifactor model with one general ASD factor and two specific factors (interaction-communication; restricted, repetitive behaviors) provided an adequate data fit. Internal consistencies of the SCL-ASD subscales and the total scale were...
Source: Journal of Autism and Developmental Disorders - January 8, 2021 Category: Psychiatry Authors: Del Giudice T, Dose C, Görtz-Dorten A, Steiner J, Bruning N, Bell H, Roland P, Walter D, Junghänel M, Döpfner M Tags: J Autism Dev Disord Source Type: research

Alterations in Rapid Social Evaluations in Individuals with High Autism Traits.
Abstract Typically developing adults with low and high Autism Spectrum Quotient (AQ) scores made rapid social evaluations of neutral faces when these were primed by briefly presented emotional faces. High AQ participants rated neutral faces as more threatening than low AQ participants, regardless of the prime condition. Both groups rated target neutral faces as more threatening with fearful compared with neutral primes, while neither group demonstrated an effect of happy primes on the ratings of neutral target faces. These results demonstrate subtle anomalies in rapid visual processing of emotional faces acro...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Becker C, Caterer E, Chouinard PA, Laycock R Tags: J Autism Dev Disord Source Type: research

DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders.
Abstract Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Siu MT, Goodman SJ, Yellan I, Butcher DT, Jangjoo M, Grafodatskaya D, Rajendram R, Lou Y, Zhang R, Zhao C, Nicolson R, Georgiades S, Szatmari P, Scherer SW, Roberts W, Anagnostou E, Weksberg R Tags: J Autism Dev Disord Source Type: research

The Effects of Contact and Labeling on Attitudes Towards Individuals with Autism.
Abstract Typically developing young adults perceive their peers with autism more negatively than those without autism, but less so when they have experience with individuals with autism. Study 1 examined whether typically developing university students' (n = 70) judgments of their peers would differ as a function of interpersonal contact and being labeled as autistic. Perceptions of peers with autism were consistent with stereotypes about autism and were associated with contact. In Study 2, typically developing university students (n = 130) imagined interacting with a student with manip...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Dickter CL, Burk JA Tags: J Autism Dev Disord Source Type: research

Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development.
Abstract Gastrointestinal symptoms (GIS) are commonly reported in children with autism spectrum disorder (ASD). This multi-site study evaluated the prevalence of GIS in preschool-aged children with ASD/(n = 672), with other developmental delays (DD)/(n = 938), and children in the general population (POP)/(n = 851). After adjusting for covariates, children in the ASD group were over 3 times more likely to have parent-reported GIS than the POP group, and almost 2 times more likely than the DD group. Children with GIS from all groups had more behavioral and sleep problems. Wi...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Reynolds AM, Soke GN, Sabourin KR, Croen LA, Daniels JL, Fallin MD, Kral TVE, Lee LC, Newschaffer CJ, Pinto-Martin JA, Schieve LA, Sims A, Wiggins L, Levy SE Tags: J Autism Dev Disord Source Type: research

Entitlement, Hope, and Life Satisfaction Among Mothers of Children with Developmental Disabilities.
Abstract The interplay between sense of entitlement and hope might have a unique contribution to mothers of children with developmental disabilities (DD) life satisfaction. Seventy-three mothers of children with DD and 47 mothers of children without DD participated in the study. Mothers of children with DD (vs. without DD) experienced low levels of life satisfaction and high levels of entitlement. The relationship between being a mother of children with DD and life satisfaction was mediated by the interaction between sense of entitlement and hope. Higher entitlement was negatively related to life satisfaction when...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: George-Levi S, Laslo-Roth R Tags: J Autism Dev Disord Source Type: research

CGH Findings in Children with Complex and Essential Autistic Spectrum Disorder.
This study identifies loci of interest for ASD and highlights the importance of a careful phenotypic characterization, as complex ASD is related to higher rate of pathogenic CNVs. PMID: 33394245 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Annunziata S, Bulgheroni S, D'Arrigo S, Esposito S, Taddei M, Saletti V, Alfei E, Sciacca FL, Rizzo A, Pantaleoni C, Riva D Tags: J Autism Dev Disord Source Type: research

A Study of the Families Included in Receiving Better Special Education Services (FIRME) Project for Latinx Families of Children with Autism and Developmental Disabilities.
Abstract Family-professional partnership is an essential component of the special education process for children with intellectual and/or developmental disabilities (IDD), including autism spectrum disorder (ASD). Latinx families face systemic barriers when participating in educational decision-making for their children with IDD. Few studies have examined the effectiveness of advocacy trainings among Latinx families of children with IDD, including ASD. The purpose of this pilot study was to examine the effectiveness and feasibility of the Familias Incluidas en Recibiendo Mejor Educación Especial (...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Rios K, Burke MM, Aleman-Tovar J Tags: J Autism Dev Disord Source Type: research

Electroconvulsive Therapy for Catatonia with mTOR Mutation.
PMID: 33394247 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Mormando CB, Garman JC, Mikoluk C, Francis A Tags: J Autism Dev Disord Source Type: research

A Combined Study on the Use of the Child Behavior Checklist 1 ½-5 for Identifying Autism Spectrum Disorders at 18 Months.
A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months. J Autism Dev Disord. 2021 Jan 04;: Authors: Chericoni N, Balboni G, Costanzo V, Mancini A, Prosperi M, Lasala R, Tancredi R, Scattoni ML, NIDA Network, Muratori F, Apicella F Abstract The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Chericoni N, Balboni G, Costanzo V, Mancini A, Prosperi M, Lasala R, Tancredi R, Scattoni ML, NIDA Network, Muratori F, Apicella F Tags: J Autism Dev Disord Source Type: research

Rigorous Translation and Cultural Adaptation of an Autism Screening Tool: First Years Inventory as a Case Study.
This study implemented a rigorous translation and cultural adaptation process by translating the First Years Inventory v3.1 (Baranek et al. First year inventory (FYI) 3.1. University of North Carolina at Chapel Hill Chapel Hill, NC, 2003) for a US-based Spanish-speaking population. A description of this process is provided with results from data collected during each phase. The unique challenges that were identified and addressed are detailed for future translation teams. PMID: 33394249 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: DuBay M, Watson LR, Baranek GT, Lee H, Rojevic C, Brinson W, Smith D, Sideris J Tags: J Autism Dev Disord Source Type: research

Sex Differences in Co-occurring Conditions Among Autistic Children and Youth in Florida: A Retrospective Cohort Study (2012-2019).
Abstract Autistic children have a high prevalence of co-occurring mental health, developmental/behavioral, and medical conditions, but research on sex/gender differences has been mixed. We used Florida healthcare claims data to characterize sex differences (female/male) in co-occurring conditions among autistic children ages 1-21 (N = 83,500). After adjusting for age, race, ethnicity, urbanicity, and insurance, autistic girls had significantly higher odds of anxiety disorders, mood disorders, intellectual disability, developmental disorders, epilepsy, metabolic disorders, gastrointestinal disorders, ...
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Angell AM, Deavenport-Saman A, Yin L, Zou B, Bai C, Varma D, Solomon O Tags: J Autism Dev Disord Source Type: research

Correction to: Serum  Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear Cells in Autism Spectrum Disorder (ASD).
Correction to: Serum Ischemia-Modified Albumin Levels, Myeloperoxidase Activity and Peripheral Blood Mononuclear Cells in Autism Spectrum Disorder (ASD). J Autism Dev Disord. 2021 Jan 04;: Authors: Ceylan MF, Tural Hesapcioglu S, Yavas CP, Senat A, Erel O PMID: 33394251 [PubMed - as supplied by publisher] (Source: Journal of Autism and Developmental Disorders)
Source: Journal of Autism and Developmental Disorders - January 4, 2021 Category: Psychiatry Authors: Ceylan MF, Tural Hesapcioglu S, Yavas CP, Senat A, Erel O Tags: J Autism Dev Disord Source Type: research

Factors Associated with a Delayed Autism Spectrum Disorder Diagnosis in Children Previously Assessed on Suspicion of Autism.
This study aimed to investigate factors associated with a delayed autism spectrum (ASD) diagnosis when compared to children with either no or early ASD diagnosis. Among 893 children assessed for ASD before age 8, 39% had no ASD at baseline, of which 21% received a later ASD diagnosis. Autism symptoms, diagnostic history of other developmental disorders, cognitive ability, and socioeconomic factors were associated with delayed ASD. Autism Diagnostic Observation Schedule (ADOS) scores in delayed ASD fell between early and no ASD. Other developmental disorders, time and clinical trends like ADOS use and low parental education...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Avlund SH, Thomsen PH, Schendel D, Jørgensen M, Carlsen AH, Clausen L Tags: J Autism Dev Disord Source Type: research

First-Hand Accounts of Interoceptive Difficulties in Autistic Adults.
In this study, we analyzed texts of adults who self-identify as autistic describing their interoceptive challenges. Many individuals described limited awareness of hunger, satiation, or thirst, which contributed to eating disordered behavior in some instances. Others described limited awareness or difficulty understanding affective arousal, pain or illness, and difficulty differentiating benign body signals from signals that represent medical concerns. Findings from this study call for increased research attention on this topic, and a need for valid and objective measures for assessing interoception in ASD. PMID: 3338...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Trevisan DA, Parker T, McPartland JC Tags: J Autism Dev Disord Source Type: research

Comparison of Serum VEGF, IGF-1, and HIF-1 α Levels in Children with Autism Spectrum Disorder and Healthy Controls.
Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls. J Autism Dev Disord. 2021 Jan 03;: Authors: Şimşek F, Işık Ü, Aktepe E, Kılıç F, Şirin FB, Bozkurt M Abstract The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1α levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1α were measured using commercial enzyme-linked immuno...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Şimşek F, Işık Ü, Aktepe E, Kılıç F, Şirin FB, Bozkurt M Tags: J Autism Dev Disord Source Type: research

A Driver Training Program Intervention for Student Drivers with Autism Spectrum Disorder: A Multi-site Randomised Controlled Trial.
Abstract The purpose of this multi-site randomised controlled trial was to evaluate the effectiveness of a Driving Training Program, an intervention designed for student drivers with autism spectrum disorder (ASD). Participants were 72 student drivers with ASD (ages 16-31) who were randomly assigned to an intervention or control group. Student drivers received ten driving lessons with a professional driving instructor via a standardised driving route. The Driving Performance Checklist was used as the outcome measure to evaluate the driving performance of student drivers during on-road pre- and post-observational d...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Vindin P, Cordier R, Wilson NJ, Lee H Tags: J Autism Dev Disord Source Type: research

Autism in Australia: Community Knowledge and Autistic People's Experiences.
Abstract This paper presents two studies that explored community attitudes to autism in Australia; and autistic people and their families' perspectives of community attitudes. In Study One 2424 (primarily non-autistic) people completed a survey on autism-related knowledge and attitudes; identifying a number of misperceptions and knowledge gaps in the general community. In Study Two 1353 people (primarily parents and carers of autistic people) completed a survey on autism-related experiences; identifying that the community's awareness of autism does not appear to extend to understanding how to support autistic peop...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Jones SC, Akram M, Gordon CS, Murphy N, Sharkie F Tags: J Autism Dev Disord Source Type: research

Randomized Controlled Trial of a Video Gaming-Based Social Skills Program for Children on the Autism Spectrum.
Abstract Families often face financial and geographical barriers to services for children with autism. The current study explored the effectiveness of a parent-supported adaptation of the computer game-based social skills program Secret Agent Society (SAS). Seventy child-parent dyads were randomized to SAS (n = 35) or a caregiver-supported cognitive skills training game (CIA-control comparison; n = 35), both completed over 10 weeks. Child participants were on the autism spectrum and aged seven to 12 years (60 boys, 10 girls). SAS participants improved more than CIA participant...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Beaumont R, Walker H, Weiss J, Sofronoff K Tags: J Autism Dev Disord Source Type: research

Interventions to Improve the Mental Health of Mothers of Children with a Disability: Systematic Review, Meta-analysis and Description of Interventions.
Abstract To investigate the effectiveness of interventions that aim to improve the mental health of mothers of children with disabilities. Seven databases were searched. Interventions incorporated primarily cognitive-behavioural, psychoeducation, mindfulness or support-group approaches. The Template-for-Intervention-Description-and-Replication guided descriptions. Meta-analyses using a random effect model of randomized controlled trials assessed intervention effects on parenting stress and mental health. Of the 1591 retrieved papers, 31 met criteria to be appraised and 17 were included in the meta-analysis. Cognit...
Source: Journal of Autism and Developmental Disorders - January 3, 2021 Category: Psychiatry Authors: Bourke-Taylor HM, Lee DA, Tirlea L, Joyce K, Morgan P, Haines TP Tags: J Autism Dev Disord Source Type: research

A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder.
This study examined RRBs among 827 preschool-age children, ages 35 to 71 months, through an exploratory factor analysis of RRB items from the Autism Diagnostic Interview-Revised (ADI-R) collected through the Study to Explore Early Development. The factor structures of RRBs among children with confirmed ASD versus those with non-autism developmental concerns were qualitatively compared. Correlations between RRB factors and participant characteristics were examined in the ASD group. Three conceptually well-defined factors characterized as repetitive sensorimotor behaviors (RSMB), insistence on sameness (IS), and a novel...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Hiruma L, Pretzel RE, Tapia AL, Bodfish JW, Bradley C, Wiggins L, Hsu M, Lee LC, Levy SE, Daniels J Tags: J Autism Dev Disord Source Type: research

Brief Report: Impact of COVID-19 on Individuals with ASD and Their Caregivers: A Perspective from the SPARK Cohort.
Abstract The impact of the 2019 coronavirus pandemic (COVID-19) in the United States is unprecedented, with unknown implications for the autism community. We surveyed 3502 parents/caregivers of individuals with an autism spectrum disorder (ASD) enrolled in Simons Powering Autism Research for Knowledge (SPARK) and found that most individuals with ASD experienced significant, ongoing disruptions to therapies. While some services were adapted to telehealth format, most participants were not receiving such services at follow-up, and those who were reported minimal benefit. Children under age five had the most severely...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: White LC, Law JK, Daniels AM, Toroney J, Vernoia B, Xiao S, SPARK Consortium, Feliciano P, Chung WK Tags: J Autism Dev Disord Source Type: research

The Efficacy of Pivotal Response Treatment in Teaching Question-Asking Initiations to Young Turkish Children with Autism Spectrum Disorder.
Abstract In the present study, a concurrent multiple baseline design across participants was used to evaluate the efficacy of pivotal response treatment (PRT) on the acquisition, maintenance, and generalization of the question-asking initiations by four children with autism spectrum disorder (ASD). The researchers also examined whether the implementation of PRT resulted in collateral changes in language development and other areas of development. The results of this study indicate that PRT is highly effective in teaching question-asking initiations. Participating children with ASD were able to generalize in natura...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Bozkus-Genc G, Yucesoy-Ozkan S Tags: J Autism Dev Disord Source Type: research

Self-Conscious Emotion Processing in Autistic Adolescents: Over-Reliance on Learned Social Rules During Tasks with Heightened Perspective-Taking Demands May Serve as Compensatory Strategy for Less Reflexive Mentalizing.
Abstract Autistic adolescents experience a secondary wave of social cognitive challenges which impact interpersonal success. We investigated self-conscious emotion (SCE) processing in autistic and neurotypical adolescents. Participants watched videos of peers acting embarrassed and proud and rated inferred and empathic SCEs. We compared intensity ratings across groups and conducted correlations with social cognitive abilities and autistic features. Autistic adolescents recognized SCEs and felt empathic SCEs; however, they made atypical emotion attributions when perspective-taking demands were high, which more stro...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Jankowski KF, Pfeifer JH Tags: J Autism Dev Disord Source Type: research

Enhancing Social Initiations Using Naturalistic Behavioral Intervention: Outcomes from a Randomized Controlled Trial for Children with Autism.
This study examined the effects of a naturalistic behavioral social skills intervention in improving social initiations to peers through a randomized controlled trial. Analyses of multimethod, multi-informant measures indicated that children in the active group (SIMI) demonstrated greater improvement in the types of initiations which were systematically prompted and reinforced during treatment (i.e., behavior regulation). Generalization to joint attention and social interaction initiation types, as well as collateral gains in broader social functioning on clinician- and parent-rated standardized measures were also observed...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Gengoux GW, Schwartzman JM, Millan ME, Schuck RK, Ruiz AA, Weng Y, Long J, Hardan AY Tags: J Autism Dev Disord Source Type: research

Testing the Latent Structure of the Autism Spectrum Quotient in a Sub-clinical Sample of University Students Using Factor Mixture Modelling.
Abstract In the present study, factor mixture models (FMMs) were used to examine the latent structure underlying the Autism-Spectrum Quotient (AQ) among a sample of 633 undergraduate students. FMM represents a combination of latent-class, person-centered approaches and common-factor, variable-centered approaches to modeling population heterogeneity. Findings suggest the presence of either two or six latent classes with distinct profiles across the set of 50 AQ items. In addition, within each class, individuals can be further differentiated according to their scores on five latent factors. These results suggest the...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Leth-Steensen C, Gallitto E, Mintah K, Parlow SE Tags: J Autism Dev Disord Source Type: research

Shared Features or Co-occurrence? Evaluating Symptoms of Developmental Coordination Disorder in Children and Adolescents with Autism Spectrum Disorder.
Abstract Motor differences are common in Autism Spectrum Disorder (ASD), but rarely evaluated against diagnostic criteria for Developmental Coordination Disorder (DCD). We aimed to determine whether motor problems in ASD represent the possible co-occurrence of DCD. We retrospectively reviewed standardized assessments and parent-reports to evaluate motor ability in 43 individuals with ASD against diagnostic criteria for DCD, and compared to 18 individuals with DCD. Over 97% of cases in the ASD group scored below the 16th percentile in motor ability, with most below the 5th percentile. Over 90% of cases in the ASD g...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Miller HL, Sherrod GM, Mauk JE, Fears NE, Hynan LS, Tamplain PM Tags: J Autism Dev Disord Source Type: research

Increasing Verbal Behavior in a Young Adolescent Girl with Catatonia and Autism Spectrum Disorder.
This study analyzed the effects of a prompt-fading behavioral treatment package on the verbal behavior of an adolescent girl with autism and catatonia. Data were collected on three verbal responses previously observed in the participant's repertoire, including "Hi," "That sounds great," and "Excuse me." Instructors provided full manual guidance, in conjunction with a verbal model, when needed, to assist the participant in emitting the verbal responses. A functional relation was demonstrated between the prompt-fading package and the three verbal responses, and independent verbal responding emer...
Source: Journal of Autism and Developmental Disorders - January 2, 2021 Category: Psychiatry Authors: Vener SM, Gillis AM, Poulson CL Tags: J Autism Dev Disord Source Type: research