New LC-MS/MS reference data for estradiol show mini-puberty in both sexes and typical pre-pubertal and pubertal patterns

CONCLUSIONS: Variability of RIs for E2 between studies illustrates importance of laboratory-specific RIs despite using a liquid chromatographic tandem mass spectrometry (LC-MS/MS) reference method. In boys, the striking E2 peak during mini-puberty as well as high pubertal E2 without phenotypic estrogenization in regular male puberty indicate that the role of E2 in children, and especially in boys requires better functional understanding.PMID:38652605 | DOI:10.1093/ejendo/lvae046

Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Alexandra E Kulle Amke Caliebe Tabea Lamprecht Thomas Reinehr Gunter Simic-Schleicher Esther Schulz Michaela Kleber Juliane Rothermel Sabine Heger Olaf Hiort Paul-Martin Holterhus Source Type: research