Cow's milk oral immunotherapy has differentially better long-term adherence than peanut or sesame
IgE-mediated food allergy is a global health problem.1,2 In recent years, several scientific societies have endorsed the use of off-the-shelf foods in clinical oral immunotherapy (OIT) practice.3 –5 Moreover, manufactured well-standardized peanut allergens have also been used.6 Our study aimed to evaluate and compare adherence to and safety of OIT in patients with different food allergens at the maintenance dose (MD) phase in a single center. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Meital Almog, Nadira Musallam, Roni Wagner, Larisa Epov, Lisa Kaly, Vika Dor, Aharon Kessel Tags: Letters Source Type: research
A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice
The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Ellen L. Risemberg, Johanna M. Smeekens, Marta C. Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo Manuel de Villena, A. Wesley Burks, William Valdar, Michael D. Kulis, Martin T. Source Type: research
Molecules, Vol. 29, Pages 1947: Characterization of Key Aroma Compounds and Main Contributing Amino Acids in Hot-Pressed Oil Prepared from Various Peanut Varieties
In this study, sensory evaluations, headspace solid-phase micro-extraction gas chromatography mass spectrometry (HS-SPME-GC-MS), odor activity value (OAV) calculations, and correlation analysis were employed to investigate the flavors and main contributing amino acids of hot-pressed oils derived from different peanut varieties. The results confirmed that the levels of alcohols, aldehydes, and heterocyclic compounds in peanut oil varied among nine different peanut varieties under identical processing conditions. The OAVs of 25 key aroma compounds, such as methylthiol, 3-ethyl-2,5-dimethylpyrazine, and 2,3-glutarone, exceede...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Jie Sun Chunhua Zhang Yu Song Baijun Chu Mingqing Wang Zhiran Zhang Xiangyu Wang Tags: Article Source Type: research
Azole resistance mechanisms and population structure of the human pathogen < em > Aspergillus fumigatus < /em > on retail plant products
Appl Environ Microbiol. 2024 Apr 23:e0205623. doi: 10.1128/aem.02056-23. Online ahead of print.ABSTRACTAspergillus fumigatus is a ubiquitous saprotroph and human-pathogenic fungus that is life-threatening to the immunocompromised. Triazole-resistant A. fumigatus was found in patients without prior treatment with azoles, leading researchers to conclude that resistance had developed in agricultural environments where azoles are used against plant pathogens. Previous studies have documented azole-resistant A. fumigatus across agricultural environments, but few have looked at retail plant products. Our objectives were to deter...
Source: Applied and Environmental Microbiology - April 23, 2024 Category: Microbiology Authors: Caroline Wang Natalie Miller Douglas Vines Paul M Severns Michelle Momany Marin T Brewer Source Type: research
Stilbenes: a journey from folklore to pharmaceutical innovation
Arch Microbiol. 2024 Apr 22;206(5):229. doi: 10.1007/s00203-024-03939-z.ABSTRACTIn modern times, medicine is predominantly based on evidence-based practices, whereas in ancient times, indigenous people relied on plant-based medicines with factual evidence documented in ancient books or folklore that demonstrated their effectiveness against specific infections. Plants and microbes account for 70% of drugs approved by the USFDA (U.S. Food and Drug Administration). Stilbenes, polyphenolic compounds synthesized by plants under stress conditions, have garnered significant attention for their therapeutic potential, bridging anci...
Source: Archives of Microbiology - April 22, 2024 Category: Microbiology Authors: Gursharan Kaur Rajinder Kaur Gurleen Kaur Sodhi Nancy George Santosh Kumar Rath Harleen Kaur Walia Vagish Dwibedi Sanjai Saxena Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00073-0. doi: 10.1016/S2213-2600(24)00073-0. Online ahead of print.ABSTRACTBACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.METHODS: This prospective, multicen...
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Sascha Meyer Johannes Bay Axel R Franz Harald Erhardt Lars Klein Jutta Petzinger Christoph Binder Susanne Kirschenhofer Anja Stein Britta H üning Axel Heep Eva Cloppenburg Julia Muyimbwa Torsten Ott Julia Sandk ötter Norbert Teig Susanne Wiegand Michael Source Type: research
Effect of starch and peanut oil on physicochemical and gel properties of myofibrillar protein: Amylose content and addition form
Int J Biol Macromol. 2024 Apr 18:131699. doi: 10.1016/j.ijbiomac.2024.131699. Online ahead of print.ABSTRACTStarch and peanut oil (PO) were widely used to improve the gel properties of surimi, however, the impact mechanism of addition forms on the denaturation and aggregation behavior of myofibrillar protein (MP) is not clear. Therefore, the effect of starch, PO, starch/PO mixture, and starch-based emulsion on the physicochemical and gel properties of MP was investigated. The results showed that amylose could accelerate the aggregation of MP, while amylopectin was conducive to the improvement of gel properties. The additio...
Source: International Journal of Biological Macromolecules - April 20, 2024 Category: Biochemistry Authors: Hongbo Mi Nan Su Shangyun Liang Jianrong Li Jingxin Chen Xuepeng Li Source Type: research
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
This study refined the decision aid ’s content to better reflect patients’ and caregivers’ lived experience.Recent FindingsCurrent standard of care for peanut allergy is avoidance, although peanut oral immunotherapy has been approved by the Food and Drug Administration for use in patients 4 –17 years old.SummaryAn advisory board of allergy therapy experts (n = 3) and patient advocates (n = 3) informed modifications to the decision aid. The revised tool underwent cognitive debriefing interviews (CDIs) among adolescents (12–17 years old) with peanut allergy and caregivers of patients 4–17 years old with p...
Source: Current Allergy and Asthma Reports - April 19, 2024 Category: Allergy & Immunology Source Type: research
The OUtMATCH study: treating multiple allergies
It is recognised that of those children who do have allergies (about 8% of the population), 30–80% have responses to multiple foods. A double blind, placebo-controlled, randomised clinical trial, the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food Allergic Participants (OUtMATCH) study is a three phase study comparing omalizumab to placebo in children with multiple food allergies and is in its first phase. The study then goes on to phase two, a longer-term (52 weeks) treatment with omalizumab with oral immunotherapy and then the third stage will assess the introduction of...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research
Effect of homemade peanut oil consumption during pregnancy on low birth weight and preterm birth outcomes: a cohort study in Southwestern China
CONCLUSIONS: Homemade peanut oil consumption was a potential risk factor for both LBW and PB, of which health authorities who are responsible for food safety of the country should pay more attention to providing recommendation for oil consumption during pregnancy.PMID:38629142 | DOI:10.1080/16549716.2024.2336312 (Source: Global Health Action)
Source: Global Health Action - April 17, 2024 Category: International Medicine & Public Health Authors: Yanxu Zhong Huan Lu Yuyan Jiang Minyan Rong Xiangming Zhang Tippawan Liabsuetrakul Source Type: research
Purification and Characterization of Desferrioxamine B of Pseudomonas fluorescens and Its Application to Improve Oil Content, Nutrient Uptake, and Plant Growth in Peanuts
Microb Ecol. 2024 Apr 17;87(1):60. doi: 10.1007/s00248-024-02377-0.ABSTRACTMicroorganisms produce siderophores, which are low-molecular-weight iron chelators when iron availability is limited. The present analyzed the role of LNPF1 as multifarious PGPR for improving growth parameters and nutrient content in peanut and soil nutrients. Such multifarious PGPR strains can be used as effective bioinoculants for peanut farming. In this work, rhizosphere bacteria from Zea mays and Arachis hypogaea plants in the Salem area of Tamil Nadu, India, were isolated and tested for biochemical attributes and characteristics that stimulate ...
Source: Microbial Ecology - April 17, 2024 Category: Microbiology Authors: S Nithyapriya Lalitha Sundaram Sakthi Uma Devi Eswaran Kahkashan Perveen Najla A Alshaikh R Z Sayyed Andrea Mastinu Source Type: research
Ecological and health risk assessments of heavy metals and their accumulation in a peanut-soil system
This study evaluated the potential ecological and health risks of heavy metals (Cu, Cr, Cd, Pb, Zn, Ni, and As) and their accumulation in a peanut-soil system based on 34 soil and peanut kernel paired samples across China. Soil As and Cd posed the greatest pollution risk with 47.1% and 17.6% of soil samples exceeding the risk screen levels, respectively, with 26.5% and 20.6% of the soil sites at relatively strong potential ecological risk level, respectively, and with the geo-accumulation levels at several soil sites in the uncontaminated to moderately contaminated categories. About 35.29% and 2.94% of soil sites were mode...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Xiaoqing Zhang Huanhuan Liu Xin Li Zhaowei Zhang Zhihua Chen Dajun Ren Shuqin Zhang Source Type: research
Ecological and health risk assessments of heavy metals and their accumulation in a peanut-soil system
This study evaluated the potential ecological and health risks of heavy metals (Cu, Cr, Cd, Pb, Zn, Ni, and As) and their accumulation in a peanut-soil system based on 34 soil and peanut kernel paired samples across China. Soil As and Cd posed the greatest pollution risk with 47.1% and 17.6% of soil samples exceeding the risk screen levels, respectively, with 26.5% and 20.6% of the soil sites at relatively strong potential ecological risk level, respectively, and with the geo-accumulation levels at several soil sites in the uncontaminated to moderately contaminated categories. About 35.29% and 2.94% of soil sites were mode...
Source: Environmental Research - April 17, 2024 Category: Environmental Health Authors: Xiaoqing Zhang Huanhuan Liu Xin Li Zhaowei Zhang Zhihua Chen Dajun Ren Shuqin Zhang Source Type: research
