A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice
The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Ellen L. Risemberg, Johanna M. Smeekens, Marta C. Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo Manuel de Villena, A. Wesley Burks, William Valdar, Michael D. Kulis, Martin T. Source Type: research
Molecules, Vol. 29, Pages 1947: Characterization of Key Aroma Compounds and Main Contributing Amino Acids in Hot-Pressed Oil Prepared from Various Peanut Varieties
In this study, sensory evaluations, headspace solid-phase micro-extraction gas chromatography mass spectrometry (HS-SPME-GC-MS), odor activity value (OAV) calculations, and correlation analysis were employed to investigate the flavors and main contributing amino acids of hot-pressed oils derived from different peanut varieties. The results confirmed that the levels of alcohols, aldehydes, and heterocyclic compounds in peanut oil varied among nine different peanut varieties under identical processing conditions. The OAVs of 25 key aroma compounds, such as methylthiol, 3-ethyl-2,5-dimethylpyrazine, and 2,3-glutarone, exceede...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Jie Sun Chunhua Zhang Yu Song Baijun Chu Mingqing Wang Zhiran Zhang Xiangyu Wang Tags: Article Source Type: research
Azole resistance mechanisms and population structure of the human pathogen < em > Aspergillus fumigatus < /em > on retail plant products
Appl Environ Microbiol. 2024 Apr 23:e0205623. doi: 10.1128/aem.02056-23. Online ahead of print.ABSTRACTAspergillus fumigatus is a ubiquitous saprotroph and human-pathogenic fungus that is life-threatening to the immunocompromised. Triazole-resistant A. fumigatus was found in patients without prior treatment with azoles, leading researchers to conclude that resistance had developed in agricultural environments where azoles are used against plant pathogens. Previous studies have documented azole-resistant A. fumigatus across agricultural environments, but few have looked at retail plant products. Our objectives were to deter...
Source: Applied and Environmental Microbiology - April 23, 2024 Category: Microbiology Authors: Caroline Wang Natalie Miller Douglas Vines Paul M Severns Michelle Momany Marin T Brewer Source Type: research
Stilbenes: a journey from folklore to pharmaceutical innovation
Arch Microbiol. 2024 Apr 22;206(5):229. doi: 10.1007/s00203-024-03939-z.ABSTRACTIn modern times, medicine is predominantly based on evidence-based practices, whereas in ancient times, indigenous people relied on plant-based medicines with factual evidence documented in ancient books or folklore that demonstrated their effectiveness against specific infections. Plants and microbes account for 70% of drugs approved by the USFDA (U.S. Food and Drug Administration). Stilbenes, polyphenolic compounds synthesized by plants under stress conditions, have garnered significant attention for their therapeutic potential, bridging anci...
Source: Archives of Microbiology - April 22, 2024 Category: Microbiology Authors: Gursharan Kaur Rajinder Kaur Gurleen Kaur Sodhi Nancy George Santosh Kumar Rath Harleen Kaur Walia Vagish Dwibedi Sanjai Saxena Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Does Use of a Peanut Ball Improve Labor Outcomes in Patients With an Epidural?
Am Fam Physician. 2024 Apr;109(4):367-368.NO ABSTRACTPMID:38648837 (Source: American Family Physician)
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Brian Ostler Soumya Choudhury Amanda Kim Jon O Neher Sarah Safranek Source Type: research
Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00073-0. doi: 10.1016/S2213-2600(24)00073-0. Online ahead of print.ABSTRACTBACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.METHODS: This prospective, multicen...
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Sascha Meyer Johannes Bay Axel R Franz Harald Erhardt Lars Klein Jutta Petzinger Christoph Binder Susanne Kirschenhofer Anja Stein Britta H üning Axel Heep Eva Cloppenburg Julia Muyimbwa Torsten Ott Julia Sandk ötter Norbert Teig Susanne Wiegand Michael Source Type: research
