A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice

The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice.

Source: Journal of Allergy and Clinical Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Ellen L. Risemberg, Johanna M. Smeekens, Marta C. Cruz Cisneros, Brea K. Hampton, Pablo Hock, Colton L. Linnertz, Darla R. Miller, Kelly Orgel, Ginger D. Shaw, Fernando Pardo Manuel de Villena, A. Wesley Burks, William Valdar, Michael D. Kulis, Martin T. Source Type: research