Bioelectronic Research Tackles Hemorrhagic Shock
Jared Huston, MD, a trauma surgeon at Northwell Health on New York's Long Island, spoke straight to the point about the current state of treatment for hemorrhagic shock. While traumatic wounds to extremities can be treated with a tourniquet, such wounds suffered internally are often fatal unless the patient can be transported quickly to an operating room. "There are no efficacious approaches to treating noncompressible hemorrhage," Huston said. "That's really the problem. If you're injured intra-abdominally or in the chest, and you're not brought somewhere where a trauma surgeon can operate on you and stop t...
Source: MDDI - February 19, 2020 Category: Medical Devices Authors: Greg Goth Tags: Electronics Source Type: news

Janssen Announces Submission to U.S. FDA for New DARZALEX ® (Daratumumab)-Based Combination Regimen for Patients with Relapsed/Refractory Multiple Myeloma
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “W...
Source: Johnson and Johnson - February 10, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

FDA Approves First Drug To Treat Peanut Allergies In Children
(CNN) — The US Food and Drug Administration approved the first drug to treat peanut allergies in children on Friday, following an advisory committee vote of approval in September. The drug, Palforzia, can be used for children between 4 and 17 years old. It’s designed to minimize the incidence and severity of a child’s allergic reaction to peanuts, as even a small amount of exposure can be harmful to children with the allergy. Children are left attempting to avoid exposure to peanuts to avoid reactions. Though that will continue to be necessary with Palforzia, the risk of a reaction will be lessened, says ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 3, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Peanut Allergy Source Type: news

FDA OKs Palforzia, First Drug for Peanut Allergy in Children FDA OKs Palforzia, First Drug for Peanut Allergy in Children
Palforzia will carry a boxed warning on the risk of anaphylaxis, and initial doses can be given only by certified professionals in certified settings.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - February 1, 2020 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Alert Source Type: news

FDA approves first drug for treatment of peanut allergy for children
Today the U.S. Food and Drug Administration approved Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp] to mitigate allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanuts. Treatment with Palforzia may be initiated in individuals ages 4 through 17 years with a confirmed diagnosis of peanut allergy and may be continued in individuals 4 years of age and older. (Source: World Pharma News)
Source: World Pharma News - January 31, 2020 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Beta-Blockers, ACE Inhibitors Don ’ t Raise Anaphylaxis Risk From Cardiac Catheterization Beta-Blockers, ACE Inhibitors Don ’ t Raise Anaphylaxis Risk From Cardiac Catheterization
The risk of anaphylactic reactions from contrast media used during cardiac catheterization is not increased in patients on beta-blockers or angiotensin-converting enzyme (ACE) inhibitors, according to results from a retrospective case-control study.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - December 20, 2019 Category: Radiology Tags: Cardiology News Source Type: news

Errors Common in Epinephrine Use for Pediatric Anaphylaxis Errors Common in Epinephrine Use for Pediatric Anaphylaxis
At least one medication error occurred in two-thirds of epinephrine administrations for simulated pediatric anaphylaxis, even in academic pediatric hospitals, a new international study has found.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 17, 2019 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Delayed admission and management of pediatric acute kidney injury and multiple organ dysfunction syndrome in children with multiple wasp stings: a case series - Ambarsari CG, Sindih RM, Saraswati M, Trihono PP.
Multiple wasp stings may cause fatal complications, such as anaphylactic reactions, intravascular hemolysis, rhabdomyolysis, acute kidney injury (AKI), increased levels of liver enzymes, clotting abnormalities, or even death. AKI-related mortality due to m... (Source: SafetyLit)
Source: SafetyLit - December 16, 2019 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

College student died of allergic reaction to MILK after drinking something with the ingredient
Logan Lewis, 20, a second-year student at Hocking College in Ohio, died after his family says he went into anaphylactic shock when he drank something he didn't know had milk in it. (Source: the Mail online | Health)
Source: the Mail online | Health - December 11, 2019 Category: Consumer Health News Source Type: news

How eating a vegan burger could kill you 
The rise in popularity of meat free burgers could leave vulnerable people at risk of suffering an anaphylactic reaction due to the growth in the use of pea protein, experts have warned. (Source: the Mail online | Health)
Source: the Mail online | Health - December 8, 2019 Category: Consumer Health News Source Type: news

Is Peanut Oral Immunotherapy Too Risky? Is Peanut Oral Immunotherapy Too Risky?
A recent study found that peanut OIT was associated with increased risk for anaphylaxis and serious adverse events, but the analysis leaves out some important considerations, says Dr Brian Vickery.Medscape Allergy & Immunology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2019 Category: Consumer Health News Tags: Allergy & Clinical Immunology Commentary Source Type: news

Meet one of thousands of Britons who suffer with a 'co-factor' allergy
Kate Ball, 30, first suffered anaphylaxis when she was just 15 after eating a fish paella while on holiday in Spain. She later found out that a combination of ingredients caused her allergic reaction. (Source: the Mail online | Health)
Source: the Mail online | Health - November 26, 2019 Category: Consumer Health News Source Type: news

Search for the source of antibodies would help treat allergies
(Sechenov University) Researchers of Sechenov University together with their colleagues from Russia and Austria summarised everything known about cells producing group E antibodies. These molecules are responsible for most of the allergic reactions, including such dangerous diseases as asthma, Quincke's edema and anaphylaxis. Studying them and deepening our understanding of how to manage these reactions would help us fight against allergies and make patients' lives easier. The research was published in Cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 25, 2019 Category: International Medicine & Public Health Source Type: news

Clinicians Hesitant to Offer New Oral Immunotherapies Clinicians Hesitant to Offer New Oral Immunotherapies
Concerns over staffing needs and the risk for anaphylaxis with new oral immunotherapies have physicians questioning the next steps.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 18, 2019 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news

Woman, 46, with severe allergy to penicillin goes into anaphylactic shock after unprotected sex
The 46-year-old, from Baltimore, Maryland, broke out in blotchy red patches, began sweating profusely and became dizzy within an hour after intercourse. She was taken to A&E and hooked up to an IV. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2019 Category: Consumer Health News Source Type: news

FDA Watch List Adds Drugs With Anaphylaxis, Fetal Death Risk FDA Watch List Adds Drugs With Anaphylaxis, Fetal Death Risk
Four dozen drugs were added to the quarterly list after the FDA identified potential signs of serious risk or received new information on a safety issue.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 28, 2019 Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

Risk factors for severe systemic sting reactions in wasp (
This study aims to investigate potential risk factors for severe sting reactions in wasp (Vespula spp.) and honeybee (Apis mellifer... (Source: SafetyLit)
Source: SafetyLit - October 26, 2019 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

AAP: Antihistamine Use for Anaphylaxis May Delay Care Seeking
FRIDAY, Oct. 25, 2019 -- Administering antihistamine medication to a child experiencing anaphylaxis is associated with increased odds of a delay in seeking medical care, according to a study presented at the annual meeting of the American Academy of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 25, 2019 Category: Pharmaceuticals Source Type: news

Health Tip: Living With Nut Allergy
-- From hives and itchiness to anaphylaxis, an allergic reaction to nuts can manifest itself in many ways, says the University of Rochester. If you are living with a nut allergy, the school suggests: When grocery shopping, check every item's... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 25, 2019 Category: General Medicine Source Type: news

Anaphylactic Reactions Tied to PICC Insertion With Magnetic Tip
Anaphylactic, anaphylactoid reactions linked to PICC insertion using Sherlock tip locating system (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 10, 2019 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Allergy, Emergency Medicine, Nursing, Pharmacy, Pulmonology, Journal, Source Type: news

Anaphylactic Reactions Tied to PICC Insertion With Magnetic Tip
THURSDAY, Oct. 10, 2019 -- Potential anaphylactic or anaphylactoid reactions have been associated with insertion of peripherally inserted central catheters (PICCs) using the Sherlock tip locating system (TLS), which features a magnetized stylet... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 10, 2019 Category: Pharmaceuticals Source Type: news

Is Do-It-Yourself Medicine at 30,000 Feet A Good Idea? A New D.C. Lobby Group Wants Congress To Make ‘EpiPens’ Available On All Flights
Some of the millions of Americans with food allergies who are at risk of anaphylactic shock forget to bring epinephrine devices when they travel, or don't have them. It might seem simple to mandate airlines stock them, but there are risks. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 26, 2019 Category: Pharmaceuticals Authors: Dan Reed, Contributor Source Type: news

Peanut Oral Immunotherapy Might Be Needed for Life Peanut Oral Immunotherapy Might Be Needed for Life
Peanut oral immunotherapy (OIT) can desensitize adults and children and prevent anaphylaxis but protection may wane when OIT is discontinued or continued at a reduced dose, according a new study.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 24, 2019 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Bear Grylls health: ‘That was crazy!’ Survival expert’s life-threatening allergic reaction
BEAR GRYLLS, known for his survival skills in the great outdoors, had to be saved by medics after suffering a life-threatening allergic reaction while filming for his new series. The former SAS serviceman went into anaphylactic shock, which can prove fatal. (Source: Daily Express - Health)
Source: Daily Express - Health - September 16, 2019 Category: Consumer Health News Source Type: news

EMTs in Israel In Need of Lifesaving EpiPens Following Worldwide Shortage
Photo provided by United Hatzalah An EMT in Israel administers an EpiPen to a young girl. There is a worldwide shortage of EpiPens, which is affecting individuals who have severe allergies that can cause anaphylactic reactions. The EpiPen is an auto-injection delivery system that administers a dose of adrenaline hormones which increases the heart rate and blood pressure and reverses the swelling of the airways. In cases of severe anaphylactic reactions, it can slow the allergic reaction and reverse its effects long enough to allow first responders to arrive or for a person to get to the hospital to receive f...
Source: JEMS Patient Care - September 5, 2019 Category: Emergency Medicine Tags: International Patient Care Press Releases Source Type: news

Thirteen is the charm in anaphylaxis
(Source: ScienceNOW)
Source: ScienceNOW - August 29, 2019 Category: Science Authors: Scanlon, S. T. Tags: Immunology twis Source Type: news

Identification of a T follicular helper cell subset that drives anaphylactic IgE
We report a rare population of IL-13–producing TFH cells present in mice and humans with IgE to allergens, but not when allergen-specific IgE was absent or only low-affinity. These "TFH13" cells have an unusual cytokine profile (IL-13hiIL-4hiIL-5hiIL-21lo) and coexpress the transcription factors BCL6 and GATA3. TFH13 cells are required for production of high- but not low-affinity IgE and subsequent allergen-induced anaphylaxis. Blocking TFH13 cells may represent an alternative therapeutic target to ameliorate anaphylaxis. (Source: ScienceNOW)
Source: ScienceNOW - August 29, 2019 Category: Science Authors: Gowthaman, U., Chen, J. S., Zhang, B., Flynn, W. F., Lu, Y., Song, W., Joseph, J., Gertie, J. A., Xu, L., Collet, M. A., Grassmann, J. D. S., Simoneau, T., Chiang, D., Berin, M. C., Craft, J. E., Weinstein, J. S., Williams, A., Eisenbarth, S. C. Tags: Immunology, Online Only r-articles Source Type: news

Emergency Department Visits for Anaphylaxis have Increased Since 2008
Study from The Journal of Allergy and Clinical Immunology: In Practice, an official journal of the AAAAI, reveals visits increased 3.2-fold among children from 2008 to 2016 and 1.9-fold among adults.(PRWeb August 26, 2019)Read the full story at https://www.prweb.com/releases/emergency_department_visits_for_anaphylaxis_have_increased_since_2008/prweb16517311.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - August 26, 2019 Category: Pharmaceuticals Source Type: news

Why Parents Are Turning to a Controversial Treatment for Food Allergies
This article was originally published on Undark. Read the original article. (Source: TIME: Health)
Source: TIME: Health - August 15, 2019 Category: Consumer Health News Authors: Esther Landhuis / Undark Tags: Uncategorized allergies health onetime syndication Source Type: news

Sesame Allergy More Common Than Once Thought, Study Finds
More than one million children and adults are allergic to sesame in the United States, scientists report. But sesame is not among the allergens that must be listed on food labels. (Source: NYT Health)
Source: NYT Health - August 2, 2019 Category: Consumer Health News Authors: Eric Athas Tags: Labeling and Labels (Product) Food Allergies Epinephrine (Drug) Nuts Food and Drug Administration United States Northwestern University Anaphylactic Shock Source Type: news

Study identifies new cell type that triggers deadly allergic reactions
A particular subset of T cells, dubbed Tfh13, helps to initiate the immune response anaphylaxis — a finding that may improve how allergy trials are analyzed. (Source: Yale Science and Health News)
Source: Yale Science and Health News - August 1, 2019 Category: Universities & Medical Training Source Type: news

Scientists discover immune cell subtype in mice that drives allergic reactions
NIH-funded study suggests targeting cell may help prevent anaphylaxis in humans. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - August 1, 2019 Category: American Health Source Type: news

Kissing Bugs in Arizona Do Not Appear to Transmit Chagas Disease to Humans, but Anaphylaxis Is Common Kissing Bugs in Arizona Do Not Appear to Transmit Chagas Disease to Humans, but Anaphylaxis Is Common
Bites from kissing bugs in Arizona that harbor Trypanosoma cruzi commonly cause allergic reactions but not Chagas disease, researchers report.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 30, 2019 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Medical and pathologic characteristics of fatal anaphylaxis: a Spanish nationwide 17-year series - Mart ínez-Fernandez P, Vallejo-de-Torres G, Sánchez-de-León-Robles MS, Navarro-Escayola E, Moro-Moro M, Alberti-Masgrau N, Tejedor-Alonso MA.
We report on the medicolegal, demographic and histopathological characteristics of a series of sudden deaths which wer... (Source: SafetyLit)
Source: SafetyLit - July 15, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Protamine Reversal of Heparin: A Fishy Practice? Protamine Reversal of Heparin: A Fishy Practice?
This commentary underscores the possibility of potentially life-threatening anaphylactic reactions to protamine infusion for reversal of heparin after catheter ablation of AF.Europace (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 15, 2019 Category: Allergy & Immunology Tags: Emergency Medicine Journal Article Source Type: news

A shocking contributor in anaphylaxis
(Source: ScienceNOW)
Source: ScienceNOW - July 11, 2019 Category: Science Authors: Pujanandez, L. Tags: twis Source Type: news

An Alternative Route to Anesthesia-Induced Anaphylaxis
A study in patients identifies a nontraditional immune pathway that can cause a severe reaction to anesthetic drugs. (Source: The Scientist)
Source: The Scientist - July 10, 2019 Category: Science Tags: News & Opinion Source Type: news

'Sexiest doctor alive' saves a life on a flight to Israel after man, 26, went into shock
Matt Faraco, 26, from Atlanta, Georgia, went into anaphylactic shock on June 30 during a flight from New York City to Tel Aviv and was saved by Dr Mikhail Varshavski - better known as Doctor Mike. (Source: the Mail online | Health)
Source: the Mail online | Health - July 8, 2019 Category: Consumer Health News Source Type: news

Fatal anaphylaxis following a hornet sting in a yellow jacket venom-sensitized patient with undetected monoclonal mast cell activation syndrome and without previous history of a systemic sting reaction - Blank S, Pehlivanli S, Methe H, Schmidt-Weber CB, Biedermann T, Horny HP, Kristensen T, Amar Y, K öberle M, Brockow K, Stömmer PE.
Clinical implications Fatal anaphylaxis may occur in vespid venom-sensitized individuals suffering from mast cell disorders without previous history of a systemic sting reaction. A detailed necropsy including serologic measurements of tryptase and sI... (Source: SafetyLit)
Source: SafetyLit - July 8, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Risk factors and indicators of severe systemic insect sting reactions - Stoevesandt J, Sturm G, Bonadonna P, Oude Elberink JNG, Trautmann A.
Hymenoptera venom allergy ranks among the top three causes of anaphylaxis worldwide, and approximately one quarter of sting-induced reactions are classified as severe. Fatal sting reactions are exceedingly rare, but certain factors may entail a considerabl... (Source: SafetyLit)
Source: SafetyLit - June 19, 2019 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

Junk food may be fuelling rise in food allergies, say experts
Children with food allergies are found to have higher levels of substance in processed foodsA ballooning diet of junk food might be one of the factors fuelling a rise in food allergies, researchers have suggested.Experts say they have seen a rise infood allergies in western countries, including the UK. While true prevalence can be tricky to determine,data published by NHS Digital shows episodes of anaphylactic shock in England due to adverse food reactions rose steadily from 1,362 in 2011-12 to 1,922 in 2016-17.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - June 8, 2019 Category: Science Authors: Nicola Davis Tags: Allergies Society Nutrition Science UK news World news Source Type: news

Guidelines for managing anaphylaxis in children need an update
(McGill University Health Centre) Treatment guidelines for managing anaphylaxis in children should be reassessed, according to a new Canadian study published in the Journal of Allergy and Clinical Immunology: In Practice. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 31, 2019 Category: International Medicine & Public Health Source Type: news

Peanut Oral Immunotherapy May Increase Risk for Anaphylaxis Peanut Oral Immunotherapy May Increase Risk for Anaphylaxis
A new review finds that oral immunotherapy for peanut allergy may result in desensitization but is associated with more anaphylaxis events.Medscape Medical News (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - April 30, 2019 Category: Pediatrics Tags: Allergy & Clinical Immunology News Source Type: news

News reader KATE SILVERTON reveals shock allergic reaction to prawn salad 'nearly killed' her
KATE SILVERTON: Almost 11 years have passed since I nearly died from anaphylaxis. My saviour, a woman called Kate Dale, was allergic to nuts, so carried her life-saving shot of adrenaline at all times. (Source: the Mail online | Health)
Source: the Mail online | Health - April 28, 2019 Category: Consumer Health News Source Type: news

Does Peanut Allergy Immunotherapy Cause More Risk?
People undergoing peanut immunotherapy had a 22% risk of anaphylaxis, compared with 7% for untreated peanut allergy sufferers, researchers found. (Source: WebMD Health)
Source: WebMD Health - April 26, 2019 Category: Consumer Health News Source Type: news

Peanut Oral Immunotherapy May Up Allergic Reaction Risk
FRIDAY, April 26, 2019 -- Current peanut oral immunotherapy approaches are associated with increased risk and frequency of allergic reactions, including anaphylaxis, according to a review published online April 25 in The Lancet. Derek K. Chu, Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 26, 2019 Category: Pharmaceuticals Source Type: news

Peanut Allergy Immunotherapy Increases Anaphylaxis Risk: Study
Although the oral treatment seems to work, an analysis of the results from 12 clinical trials finds kids who got an immunotherapy have a greater rate of serious reactions. (Source: The Scientist)
Source: The Scientist - April 26, 2019 Category: Science Tags: News & Opinion Source Type: news

A Promising Peanut Allergy Treatment May Not Work So Well After All, Research Review Says
In a new review published in the Lancet, researchers came to a disappointing conclusion about recent studies on treating peanut allergies. They found that treating children by exposing them to small amounts of peanuts, which has shown success in several studies, is actually associated with an increased risk of allergic reactions, including anaphylaxis. This approach, called oral Immunotherapy, involves repeated controlled exposure to whatever is causing an allergic reaction — in this case peanut allergens — to retrain the immune system. Allergic reactions occur when the immune system treats benign substances, l...
Source: TIME: Health - April 26, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Research Source Type: news

Experimental treatment for peanut allergy increases anaphylaxis risk, study finds
An experimental treatment for peanut allergy may actually multiply someone's risk for serious allergic reactions -- much like the ones it aims to prevent, according to a new analysis. (Source: CNN.com - Health)
Source: CNN.com - Health - April 26, 2019 Category: Consumer Health News Source Type: news

Immune-Targeted Treatment Might Help Prevent Peanut Allergy Crises
MONDAY, April 8, 2019 -- Allergic reactions to peanuts can be incredibly dangerous, causing the throat to close, the chest to tighten, and throw a person into life-threatening anaphylactic shock. But researchers now believe they've found a way to... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 8, 2019 Category: General Medicine Source Type: news