Joint transcriptomic and cytometric study of peanut allergic children reveals molecular and cellular cross-talk in reaction thresholds
Reaction thresholds in peanut allergy are highly variable. Elucidating causal relationships between molecular and cellular processes associated with variable thresholds could point to therapeutic pathways for raising thresholds. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 23, 2024 Category: Allergy & Immunology Authors: Lingdi Zhang, Yoojin Chun, Zoe Arditi, Galina Grishina, Tracy Lo, Kayla Wisotzkey, Charuta Agashe, Alexander Grishin, Julie Wang, Hugh A. Sampson, Scott Sicherer, Cecilia Berin, Supinda Bunyavanich Source Type: research
Serologic Measurements for Peanut Allergy: Predicting Clinical Severity is Complex
Allergist-immunologists use serologic peanut allergy testing to maximize test sensitivity and specificity while minimizing cost and inconvenience. Recent advances towards this goal include a better understanding of specific IgE (sIgE) and component testing, epitope-sIgE assay, and basophil activation testing. Predicting reaction severity with serologic testing is challenged by a range of co-factors that influence reaction severity, such as the amount and form of any allergen consumed as well as comorbid disease. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2024 Category: Allergy & Immunology Authors: Alexandra E Conway, David B.K. Golden, Helen A. Brough, Alexandra F Santos, Marcus S Shaker Tags: Review Source Type: research
Serologic measurements for peanut allergy
Allergist-immunologists use serologic peanut allergy testing to maximize test sensitivity and specificity while minimizing cost and inconvenience. Recent advances toward this goal include a better understanding of specific IgE (sIgE) and component testing, epitope-sIgE assays, and basophil activation testing. Predicting reaction severity with serologic testing is challenged by a range of co-factors that influence reaction severity, such as the amount and form of any allergen consumed and comorbid disease. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2024 Category: Allergy & Immunology Authors: Alexandra E. Conway, David B.K. Golden, Helen A. Brough, Alexandra F. Santos, Marcus S. Shaker Tags: Review Source Type: research
Joint transcriptomic and cytometric study of children with peanut allergy reveals molecular and cellular cross talk in reaction thresholds
Reaction thresholds in peanut allergy are highly variable. Elucidating causal relationships between molecular and cellular processes associated with variable thresholds could point to therapeutic pathways for raising thresholds. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 23, 2024 Category: Allergy & Immunology Authors: Lingdi Zhang, Yoojin Chun, Zoe Arditi, Galina Grishina, Tracy Lo, Kayla Wisotzkey, Charuta Agashe, Alexander Grishin, Julie Wang, Hugh A. Sampson, Scott Sicherer, M. Cecilia Berin, Supinda Bunyavanich Tags: Brief report Source Type: research
Eliciting and stop dose during oral food challenges for peanut and common tree nuts in different age groups
ConclusionsTwo third of children under 6 years of age successfully consumed all the provided doses during OFCs with a negative outcome. The eliciting dose for objective symptoms was not associated with age, and in a substantial number of OFCs with positive outcome, symptoms occurred after eating the final dose. These findings suggest that in case of an uneventful OFC, the outcome should be drawn only after a cumulative dose of 4.4 g has been consumed to avoid the risk of a potential false negative outcome. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2024 Category: Allergy & Immunology Authors: Wouter W. de Weger,
Diede Jansen,
Lidy van Lente,
Gerbrich N. van der Meulen,
Arvid W. A. Kamps Tags: ORIGINAL ARTICLE Source Type: research
