Who are the potential patients for Omalizumab for Food Allergy?
Food allergies affect an estimated 8% of the United States population and have risen significantly in the last 20 years.1 IgE-mediated reactions to food can range from simple urticaria to life-threatening anaphylaxis. The only treatment was avoidance of the allergen and treatment of allergic reactions with epinephrine until 2020, when an oral immunotherapy (OIT) product (Palforzia) was approved for the treatment of peanut allergy.2 There was no FDA approved treatment for other foods or multiple foods until the recent approval of omalizumab for any food allergy for patients 1 years of age or older with the appropriate total...
Source: Annals of Allergy, Asthma and Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Hugh A. Sampson, J. Andrew Bird, David Fleischer, Wayne G. Shreffler, Jonathan Spergel Tags: Perspective Source Type: research

Real-world safety experience with Peanut (Arachis hypogaea) Allergen Powder-dnfp in 2,500 peanut-allergic children
Peanut allergy is one of the most common food allergies, affecting 1 –2% of the United States population.1 Symptoms typically manifest in childhood, often appearing at 12–24 months of age, and can include lifelong hypersensitivity.2 Although reactions from accidental peanut exposure are rarely fatal, severe reactions, including anaphylaxis, can occur with exposur e to variable amounts, including trace amounts for some.2 Epinephrine is the first-line treatment for anaphylaxis, and individuals with peanut allergy must always carry injectable epinephrine. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Michele Jara, Ekaterina Walker, Stephen Tilles, Aikaterini Anagnostou Tags: Letters Source Type: research

Real-world safety experience with Peanut (Arachis hypogaea) Allergen Powder-dnfp in 2500 children with peanut allergy
Peanut allergy is one of the most common food allergies, affecting 1% to 2% of the US population.1 Symptoms typically manifest in childhood, often appearing at 12 to 24 months of age, and can include lifelong hypersensitivity.2 Although reactions from accidental peanut exposure are rarely fatal, severe reactions, including anaphylaxis, can occur with exposure to variable amounts, including trace amounts for some.2 Epinephrine is the first-line treatment for anaphylaxis, and individuals with peanut allergy must always carry injectable epinephrine. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Michele Jara, Ekaterina Walker, Stephen Tilles, Aikaterini Anagnostou Tags: Letters Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Highly efficient dual-mode detection of AFB1 based on the inner filter effect: Donor-acceptor selection and application
Anal Chim Acta. 2024 Apr 15;1298:342384. doi: 10.1016/j.aca.2024.342384. Epub 2024 Feb 22.ABSTRACTBACKGROUND: The utilization of inner filter effect (IFE) brings more opportunities for construction of fluorescence immunoassays but remains a great challenge, especially how to select best donor in the face of extensive fluorescent nanomaterials. Aflatoxin B1 possesses high toxicity among mycotoxins and is frequently found in agricultural products that may significantly threaten to human health. Therefore, with the help of signal transduction mechanism of IFE to develop a convenient and sensitive approach for AFB1 detection i...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jincheng Xiong Boyan Sun Shuai Zhang Sihan Wang Linqian Qin Haiyang Jiang Source Type: research

Primary, secondary and tertiary prevention of food allergy: current practices and future directions
Allergol Immunopathol (Madr). 2024 Mar 1;52(2):32-44. doi: 10.15586/aei.v52i2.1023. eCollection 2024.ABSTRACTThe incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that...
Source: Allergologia et Immunopathologia - March 9, 2024 Category: Allergy & Immunology Authors: Caoimhe Cronin Noah Salzberg Yuxin Woon Juan Trujillo Wurttele Source Type: research

Primary, secondary and tertiary prevention of food allergy: current practices and future directions
Allergol Immunopathol (Madr). 2024 Mar 1;52(2):32-44. doi: 10.15586/aei.v52i2.1023. eCollection 2024.ABSTRACTThe incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that...
Source: Allergologia et Immunopathologia - March 9, 2024 Category: Allergy & Immunology Authors: Caoimhe Cronin Noah Salzberg Yuxin Woon Juan Trujillo Wurttele Source Type: research

Primary, secondary and tertiary prevention of food allergy: current practices and future directions
Allergol Immunopathol (Madr). 2024 Mar 1;52(2):32-44. doi: 10.15586/aei.v52i2.1023. eCollection 2024.ABSTRACTThe incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that...
Source: Allergologia et Immunopathologia - March 9, 2024 Category: Allergy & Immunology Authors: Caoimhe Cronin Noah Salzberg Yuxin Woon Juan Trujillo Wurttele Source Type: research

Primary, secondary and tertiary prevention of food allergy: current practices and future directions
Allergol Immunopathol (Madr). 2024 Mar 1;52(2):32-44. doi: 10.15586/aei.v52i2.1023. eCollection 2024.ABSTRACTThe incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that...
Source: Allergologia et Immunopathologia - March 9, 2024 Category: Allergy & Immunology Authors: Caoimhe Cronin Noah Salzberg Yuxin Woon Juan Trujillo Wurttele Source Type: research

Primary, secondary and tertiary prevention of food allergy: current practices and future directions
Allergol Immunopathol (Madr). 2024 Mar 1;52(2):32-44. doi: 10.15586/aei.v52i2.1023. eCollection 2024.ABSTRACTThe incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that...
Source: Allergologia et Immunopathologia - March 9, 2024 Category: Allergy & Immunology Authors: Caoimhe Cronin Noah Salzberg Yuxin Woon Juan Trujillo Wurttele Source Type: research