Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway
In conclusion, this study is the first to demonstrate that CRMP signaling is involved in the suppression of neurite outgrowth by low zinc.PMID:38583951 | DOI:10.1248/bpb.b24-00019 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Hisaka Kurita Misa Ueda Miyu Kimura Ayu Okuda Kazuki Ohuchi Isao Hozumi Masatoshi Inden Source Type: research
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway
In conclusion, this study is the first to demonstrate that CRMP signaling is involved in the suppression of neurite outgrowth by low zinc.PMID:38583951 | DOI:10.1248/bpb.b24-00019 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Hisaka Kurita Misa Ueda Miyu Kimura Ayu Okuda Kazuki Ohuchi Isao Hozumi Masatoshi Inden Source Type: research
Mdivi-1: Effective but complex mitochondrial fission inhibitor
In this study, we could better understand the molecular network of Mdivi-1 by analyzing DNA methylation and mRNA transcription in the nucleus and further investigating various changes in mitochondria, providing inspiration for studying nuclear-mitochondrial communications.PMID:38581953 | DOI:10.1016/j.bbrc.2024.149886 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 6, 2024 Category: Biochemistry Authors: Seor I Ahn Sung Kyung Choi Myoung Jun Kim Jinhong Wie Jueng Soo You Source Type: research
Mdivi-1: Effective but complex mitochondrial fission inhibitor
In this study, we could better understand the molecular network of Mdivi-1 by analyzing DNA methylation and mRNA transcription in the nucleus and further investigating various changes in mitochondria, providing inspiration for studying nuclear-mitochondrial communications.PMID:38581953 | DOI:10.1016/j.bbrc.2024.149886 (Source: Cell Research)
Source: Cell Research - April 6, 2024 Category: Cytology Authors: Seor I Ahn Sung Kyung Choi Myoung Jun Kim Jinhong Wie Jueng Soo You Source Type: research
Mdivi-1: Effective but complex mitochondrial fission inhibitor
In this study, we could better understand the molecular network of Mdivi-1 by analyzing DNA methylation and mRNA transcription in the nucleus and further investigating various changes in mitochondria, providing inspiration for studying nuclear-mitochondrial communications.PMID:38581953 | DOI:10.1016/j.bbrc.2024.149886 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 6, 2024 Category: Biochemistry Authors: Seor I Ahn Sung Kyung Choi Myoung Jun Kim Jinhong Wie Jueng Soo You Source Type: research
Genes, Vol. 15, Pages 460: Allele-Specific Regulation of the Candidate Autism Liability Gene RAI1 by the Enhancer Variant rs4925102 (C/G)
In this study, we provide experimental evidence based on reporter gene, chromatin immunoprecipitation (ChIP), and chromatin conformation capture (3C) assays that rs4925102 regulates RAI1 mRNA expression in an allele-specific manner in human cell lines, including the neuroblastoma-derived cell line SH-SY5Y. We also describe a statistically significant association between rs4925102 genotype and autism spectrum disorder (ASD) diagnosis in a case-control study and near-statistically significant association in an Autism Genome Project (AGP) transmission disequilibrium (TDT) study using Caucasian subjects. (Source: Genes)
Source: Genes - April 6, 2024 Category: Genetics & Stem Cells Authors: Xi Yuan Li Chen David Saffen Tags: Article Source Type: research
Percutaneous core needle biopsy of neuroblastoma in the pediatric population: what have we learned in the last decade
ConclusionsCNB is a safe method and should be considered the first choice for obtaining tissue diagnosis when feasible due to its high adequacy in terms of tumor histopathological features. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 6, 2024 Category: Surgery Source Type: research
A nationwide phase II study of delayed local treatment for children with high-risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN-H-11
CONCLUSION: This study indicates that delayed local treatment is feasible and shows promising efficacy, suggesting that this treatment should be considered further in a comparative study of high-risk neuroblastoma.PMID:38577760 | DOI:10.1002/pbc.30976 (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Akihiro Yoneda Hiroyuki Shichino Tomoro Hishiki Kimikazu Matsumoto Miki Ohira Takehiko Kamijo Tatsuo Kuroda Toshinori Soejima Atsuko Nakazawa Tetsuya Takimoto Isao Yokota Satoshi Teramukai Hideto Takahashi Takashi Fukushima Junichi Hara Michio Kaneko Hito Source Type: research
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults
Eur J Med Chem. 2024 Mar 20;270:116353. doi: 10.1016/j.ejmech.2024.116353. Online ahead of print.ABSTRACTDue to the putative role of butyrylcholinesterase (BChE) in regulation of acetylcholine levels and functions in the late stages of the Alzheimer's disease (AD), the potential of selective inhibitors (BChEIs) has been envisaged as an alternative to administration of acetylcholinesterase inhibitors (AChEIs). Starting from our recent findings, herein the synthesis and in vitro evaluation of cholinesterase (ChE) inhibition of a novel series of some twenty 3,4,5,6-tetrahydroazepino[4,3-b]indol-1(2H)-one derivatives, bearing ...
Source: European Journal of Medicinal Chemistry - April 5, 2024 Category: Chemistry Authors: Francesco Samarelli Rosa Purgatorio Gianfranco Lopopolo Caterina Deruvo Marco Catto Michael Andresini Antonio Carrieri Orazio Nicolotti Annalisa De Palma Daniela Valeria Miniero Modesto de Candia Cosimo D Altomare Source Type: research
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults
Eur J Med Chem. 2024 Mar 20;270:116353. doi: 10.1016/j.ejmech.2024.116353. Online ahead of print.ABSTRACTDue to the putative role of butyrylcholinesterase (BChE) in regulation of acetylcholine levels and functions in the late stages of the Alzheimer's disease (AD), the potential of selective inhibitors (BChEIs) has been envisaged as an alternative to administration of acetylcholinesterase inhibitors (AChEIs). Starting from our recent findings, herein the synthesis and in vitro evaluation of cholinesterase (ChE) inhibition of a novel series of some twenty 3,4,5,6-tetrahydroazepino[4,3-b]indol-1(2H)-one derivatives, bearing ...
Source: European Journal of Medicinal Chemistry - April 5, 2024 Category: Chemistry Authors: Francesco Samarelli Rosa Purgatorio Gianfranco Lopopolo Caterina Deruvo Marco Catto Michael Andresini Antonio Carrieri Orazio Nicolotti Annalisa De Palma Daniela Valeria Miniero Modesto de Candia Cosimo D Altomare Source Type: research
Recurrence morbidity of olfactory neuroblastoma
ConclusionsRecurrent cases of ONB have significantly different stages and preoperative imaging factors. Patients with local or neck recurrence, however, have better DSS than those with intracranial or distant recurrence, independent of initial tumor stage or Hyams grade. Identifying specific factors that confer an increased risk of recurrence and DSS is important for patient counseling in addition to surveillance planning. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 4, 2024 Category: Allergy & Immunology Authors: Katie Melder,
Jess C. Mace,
Garret Choby,
Joao Paulo Almeida,
Pierre ‐Olivier Champagne,
Erik Chan,
Jeremy Ciporen,
Mark B. Chaskes,
Juan Fernandez‐Miranda,
Nicholas K. Fung,
Paul Gardner,
Peter Hwang,
Keven Seung Yong Ji,
Aristotelis Kal Tags: ORIGINAL ARTICLE Source Type: research
A Preliminary Study on the Application of Contrast-Enhanced Ultrasonography in Children With Peripheral Neuroblastic Tumors
The purpose of this study was to retrospectively analyze the characteristics of contrast-enhanced ultrasound (CEUS) images and quantitative parameters of time-intensity curves (TICs) in children's peripheral neuroblastic tumors (pNTs). By comparing the imaging features and quantitative parameters of the TICs of neuroblastoma (NB) and ganglioneuroblastoma (GNB) patients, we attempted to identify the distinguishing points between NB and GNB. A total of 35 patients confirmed to have pNTs by pathologic examination were included in this study. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - April 4, 2024 Category: Radiology Authors: Ting Wang, Dan Han, Huan Xiao, Hao Yang, Jing-Yu Chen, Yi Tang Tags: Review Source Type: research
Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells
In this study, we demonstrated that MCT1 and 2 are major contributors to L-lactate transport in differentiated human neuroblastoma SH-SY5Y cells from the viewpoint of kinetic analysis. These results lead to a better understanding of ANLS in humans, and further exploration of the factors that can promote MCT1 and 2 functions is required.PMID:38569835 | DOI:10.1248/bpb.b23-00860 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Sakuma Yuto Mukai Atsushi Yamaguchi Yudai Suganuma Keisuke Okamoto Ayako Furugen Katsuya Narumi Shuhei Ishikawa Yoshitaka Saito Masaki Kobayashi Source Type: research
