Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells
In this study, we demonstrated that MCT1 and 2 are major contributors to L-lactate transport in differentiated human neuroblastoma SH-SY5Y cells from the viewpoint of kinetic analysis. These results lead to a better understanding of ANLS in humans, and further exploration of the factors that can promote MCT1 and 2 functions is required.PMID:38569835 | DOI:10.1248/bpb.b23-00860 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Sakuma Yuto Mukai Atsushi Yamaguchi Yudai Suganuma Keisuke Okamoto Ayako Furugen Katsuya Narumi Shuhei Ishikawa Yoshitaka Saito Masaki Kobayashi Source Type: research
Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells
In this study, we demonstrated that MCT1 and 2 are major contributors to L-lactate transport in differentiated human neuroblastoma SH-SY5Y cells from the viewpoint of kinetic analysis. These results lead to a better understanding of ANLS in humans, and further exploration of the factors that can promote MCT1 and 2 functions is required.PMID:38569835 | DOI:10.1248/bpb.b23-00860 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Sakuma Yuto Mukai Atsushi Yamaguchi Yudai Suganuma Keisuke Okamoto Ayako Furugen Katsuya Narumi Shuhei Ishikawa Yoshitaka Saito Masaki Kobayashi Source Type: research
Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells
In this study, we demonstrated that MCT1 and 2 are major contributors to L-lactate transport in differentiated human neuroblastoma SH-SY5Y cells from the viewpoint of kinetic analysis. These results lead to a better understanding of ANLS in humans, and further exploration of the factors that can promote MCT1 and 2 functions is required.PMID:38569835 | DOI:10.1248/bpb.b23-00860 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Sakuma Yuto Mukai Atsushi Yamaguchi Yudai Suganuma Keisuke Okamoto Ayako Furugen Katsuya Narumi Shuhei Ishikawa Yoshitaka Saito Masaki Kobayashi Source Type: research
Synthesis of Novel Plant-Derived Encapsulated Radiolabeled Compounds for the Diagnosis of Parkinson ’s Disease and the Evaluation of Biological Effects with In Vitro/In Vivo Methods
This study contributes to the advancement of drug delivery agents in the field of brain research. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - April 3, 2024 Category: Neurology Source Type: research
Molecules, Vol. 29, Pages 1592: Oleoylethanolamide and Palmitoylethanolamide Enhance IFN & beta;-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
In this study, we investigated the effect of OEA and PEA on human neuroblastoma SH-SY5Y cells treated with IFNβ. We focused on evaluating cell viability, cell proliferation, and cell signaling. Co-exposure to either OEA or PEA along with IFNβ leads to increased apoptotic cell death marked by the cleavage of caspase 3 and poly-(ADP ribose) polymerase (PARP) alongside a decrease in survivin and IKBα levels. Moreover, we found that OEA and PEA did not affect IFNβ signaling through the JAK-STAT pathway and the STAT1-inducible protein kinase R (PKR). OEA and PEA also increase...
Source: Molecules - April 2, 2024 Category: Chemistry Authors: Chiara Camoglio Jihane Balla Paola Fadda Simona Dedoni Tags: Article Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
Endoscopic transorbital approach in children: surgical technique and early results
CONCLUSIONS: In select cases, the ETOA can be considered a minimally invasive alternative for conventional skull base approaches in the armamentarium of pediatric skull base surgery. Further investigation and the accumulation of experience are warranted in the future to enhance the efficacy and applicability of the ETOA in pediatric patients.PMID:38560935 | DOI:10.3171/2024.1.FOCUS23858 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2024 Category: Neurosurgery Authors: Chiman Jeon Kyuha Chong Hyung Jin Shin Doo-Sik Kong Source Type: research
