[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
Viruses, Vol. 16, Pages 444: The Prevalence of Tick-Borne Encephalitis Virus in Wild Rodents Captured in Tick-Borne Encephalitis Foci in Highly Endemic Lithuania
This study shows that wild rodents are suitable sentinel animals to confirm TBEV foci. In addition, the study results demonstrate that sample cultivation in cell culture is a highly efficient method for increasing TBEV viral load to detectable quantities. (Source: Viruses)
Source: Viruses - March 13, 2024 Category: Virology Authors: Evelina Simkute Arnoldas Pautienius Juozas Grigas Marina Sidorenko Jana Radzijevskaja Algimantas Paulauskas Arunas Stankevicius Tags: Article Source Type: research
GSE248283 Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor
Contributors : Waise Quarni ; Jie Fang ; Hongjian Jin ; Jun YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress and therapies is poorly understood. Here, we demonstrate that Jumonji Domain Containing 6, Arginine Demethylase and Lysine Hydroxylase, or JMJD6...
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology
This study analyzed the related pathways and targets of Tan-IIA in the treatment of human neuroblastoma, as well as the potential anticancer and anti-tumor targets and related signaling pathways of Tan-IIA, which provides a reference for us to find and explore effective drugs for the treatment of human neuroblastoma. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Source Type: research
Chemo-immunotherapy with dinutuximab beta in patients with relapsed/progressive high-risk neuroblastoma: does chemotherapy backbone matter?
This study presents the chemo-immunotherapy experience in patients with relapsed/progressive high-risk neuroblastoma treated within the off-label use program of the Neuroblastoma Committee of the French Society of Pediatric Oncology (SFCE). (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 11, 2024 Category: Cancer & Oncology Authors: Patricia Raiser, Gudrun Schleiermacher, Marion Gambart, Benoit Dumont, Anne-Sophie Defachelles, Estelle Thebaud, Julie Tandonnet, Claudia Pasqualini, St éphanie Proust, Natacha Entz-Werle, Isabelle Aerts, Lee A. Ndounga-Diakou, Arnaud Petit, Chloe Puiseu Tags: Original Research Source Type: research
Multifunctional Liposomes Targeting Amyloid ‐β Oligomers for Early Diagnosis and Therapy of Alzheimer's Disease
Early detection and treatment of Alzheimer's disease (AD) are achieved through a novel liposome-based platform. In relevantCaenorhabditis elegans AD models, biocompatible cyclicd,l- α-peptide (CP-2) conjugated liposomes (CP-2-LPs) enhance cognition and extend lifespan by reducing toxic Aβ levels. Administration of fluorescently labeled CP-2-LPs to young AD mice enables precise diagnosis, underscoring their value for early detection and targeted therapy. AbstractEarly detection and treatment are crucial for Alzheimer's disease (AD) management. Current diagnostic and therapeutic methods focus on late-stage amyloid fibrils ...
Source: Small - March 10, 2024 Category: Nanotechnology Authors: Sudipta Senapati,
Kuldeep Tripathi,
Khadeja Awad,
Shai Rahimipour Tags: Research Article Source Type: research
TDCPP and TiO < sub > 2 < /sub > NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition
In this study, we investigated this combined toxicity and the potential mechanisms of toxicity of TDCPP and titanium dioxide nanoparticles (TiO2 NPs) aggregates on human neuroblastoma SH-SY5Y cells. TDCPP and TiO2 NPs aggregates were exposed in various concentration combinations, revealing that TDCPP (25 μg/mL) reduced cell viability, while synergistic exposure to TiO2 NPs aggregates exacerbated cytotoxicity. This combined exposure also disrupted mitochondrial function, leading to dysregulation in the expression of mitochondrial fission proteins (DRP1 and FIS1) and fusion proteins (OPA1 and MFN1). Consequently, excessive ...
Source: Environmental Pollution - March 10, 2024 Category: Environmental Health Authors: Ling Wang Binquan Wang Xiaoyan Zhang Ziyi Yang Xing Zhang Hongyang Gong Yuanyuan Song Ke Zhang Mingkuan Sun Source Type: research
TDCPP and TiO < sub > 2 < /sub > NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition
In this study, we investigated this combined toxicity and the potential mechanisms of toxicity of TDCPP and titanium dioxide nanoparticles (TiO2 NPs) aggregates on human neuroblastoma SH-SY5Y cells. TDCPP and TiO2 NPs aggregates were exposed in various concentration combinations, revealing that TDCPP (25 μg/mL) reduced cell viability, while synergistic exposure to TiO2 NPs aggregates exacerbated cytotoxicity. This combined exposure also disrupted mitochondrial function, leading to dysregulation in the expression of mitochondrial fission proteins (DRP1 and FIS1) and fusion proteins (OPA1 and MFN1). Consequently, excessive ...
Source: Environmental Pollution - March 10, 2024 Category: Environmental Health Authors: Ling Wang Binquan Wang Xiaoyan Zhang Ziyi Yang Xing Zhang Hongyang Gong Yuanyuan Song Ke Zhang Mingkuan Sun Source Type: research
Impact of Risk-Based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the childhood cancer survivor study
CONCLUSION: Survivors of high-risk disease treated in the early days of risk stratification carry a markedly elevated burden of late recurrence, SMN, and organ-related multi-morbidity, while survivors of low/intermediate-risk disease have a modest risk of late adverse outcomes.PMID:38460547 | DOI:10.1093/jnci/djae062 (Source: Cancer Control)
Source: Cancer Control - March 9, 2024 Category: Cancer & Oncology Authors: Danielle Novetsky Friedman Pamela J Goodman Wendy M Leisenring Lisa R Diller Susan L Cohn Rebecca M Howell Susan A Smith Emily S Tonorezos Suzanne L Wolden Joseph P Neglia Kirsten K Ness Todd M Gibson Paul C Nathan Lucie M Turcotte Brent R Weil Leslie L R Source Type: research
Identifying Protein Phosphorylation Site-Disease Associations Based on Multi-Similarity Fusion and Negative Sample Selection by Convolutional Neural Network
AbstractAs one of the most important post-translational modifications (PTMs), protein phosphorylation plays a key role in a variety of biological processes. Many studies have shown that protein phosphorylation is associated with various human diseases. Therefore, identifying protein phosphorylation site-disease associations can help to elucidate the pathogenesis of disease and discover new drug targets. Networks of sequence similarity and Gaussian interaction profile kernel similarity were constructed for phosphorylation sites, as well as networks of disease semantic similarity, disease symptom similarity and Gaussian inte...
Source: Interdisciplinary Sciences, Computational Life Sciences - March 8, 2024 Category: Bioinformatics Source Type: research
Phase II Study of Allogeneic Hematopoietic Stem Cell Transplantation for Children with High-Risk Neuroblastoma Using a Reduced-Intensity Conditioning Regimen: Results from the AIEOP trial
Neuroblastoma (NB) represents the most frequent extra-cranial pediatric tumor and the most common solid tumor in children aged less than 5 years1. Patients with high-risk (HR) disease, most of which have metastatic disease at presentation, are particularly challenging2 –5. Current multimodal protocols for HR NB include multiagent chemotherapy, surgical resection of the primary site, autologous hematopoietic stem cell transplantation (auto-HCT), and radiotherapy6. In a large retrospective study by the Children's Oncology Group, HR NB patients exhibited a 5-year e vent-free survival rate of 50.8%7. (Source: Biology of Bloo...
Source: Biology of Blood and Marrow Transplantation - March 7, 2024 Category: Hematology Authors: Arcangelo Prete, Edoardo Lanino, Francesco Saglio, Alessandra Biffi, Elisabetta Calore, Maura Faraci, Roberto Rondelli, Claudio Favre, Marco Zecca, Gabriella Casazza, Fulvio Porta, Roberto Luksch, Simone Cesaro, Marco Rabusin, Rosanna Parasole, Rosa Maria Source Type: research
Clinical Features and Risk Factors of Hepatic Sinusoidal Obstruction Syndrome in Children after Hematopoietic Stem Cell Transplantation: A Single-center Experience
Hepatic sinusoidal obstruction syndrome (SOS) is an illness with serious life effects that develops after hematopoietic stem cell transplantation (HSCT). We investigated the risk factors and clinical features of hepatic SOS in children following HSCT in 210 children who underwent allogeneic or autologous HSCT between 2009 and 2021 were analyzed in the context of SOS. The syndrome developed in 22 (10.4%) patients:frequently in neuroblastoma [24% (5/21)], hemophagocytic lymphohistiocytosis [57% (4/7)], and thalassemia major [22% (7/31)]. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - March 7, 2024 Category: Hematology Authors: İbrahim Kartal, Canan Albayrak, Ayhan Dağdemir, Oğuz Salih Dinçer, Hülya Kangal Şimşek, Ünsal Özgen, Davut Albayrak Source Type: research
Effects of astaxanthin on expression of apoptosis and oxidative stress related genes in H2O2 induced oxidative stress BE(2)-C human neuroblastoma cell line
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - March 5, 2024 Category: Biochemistry Authors: Hormozi, Maryam Beigi Boroujeni, Nasim Beigi Boroujeni, Mandana Source Type: research
