Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Atherosclerosis - March 13, 2024 Category: Cardiology Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis
Fitoterapia. 2024 Mar 11:105908. doi: 10.1016/j.fitote.2024.105908. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene bearing a...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Xian-Zhe Fan Jia-Qi Song Xin-Yi Shi Jin-Fang Zhou Rui-Juan Yuan Ting Liu Xiang-Qian Kong Ya-Si Huang Li-Jun Zhang Hai-Bing Liao Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Atherosclerosis - March 13, 2024 Category: Cardiology Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis
Fitoterapia. 2024 Mar 11:105908. doi: 10.1016/j.fitote.2024.105908. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene bearing a...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Xian-Zhe Fan Jia-Qi Song Xin-Yi Shi Jin-Fang Zhou Rui-Juan Yuan Ting Liu Xiang-Qian Kong Ya-Si Huang Li-Jun Zhang Hai-Bing Liao Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis
Fitoterapia. 2024 Mar 11;175:105908. doi: 10.1016/j.fitote.2024.105908. Online ahead of print.ABSTRACTThree undescribed sesquiterpenes, designed as pichinenoid A-C (1-3), along with nine known ones (4-12) were isolated from the stems and leaves of Picrasma chinensis. The new isolates including their absolute configurations were elucidated based on extensive spectroscopic methods, single crystal X-ray diffraction, and electronic circular dichroism (ECD) experiments, as well as comparison with literature data. Structurally, compounds 1 and 2 are descending sesquiterpenes, while pichinenoid C (3) is a rare sesquiterpene beari...
Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Xian-Zhe Fan Jia-Qi Song Xin-Yi Shi Jin-Fang Zhou Rui-Juan Yuan Ting Liu Xiang-Qian Kong Ya-Si Huang Li-Jun Zhang Hai-Bing Liao Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
