Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification
British Journal of Cancer, Published online: 29 March 2024; doi:10.1038/s41416-024-02666-yIdentification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification (Source: British Journal of Cancer)
Source: British Journal of Cancer - March 29, 2024 Category: Cancer & Oncology Authors: Xiaoxiao Hu Yilu Zhou Charlotte Hill Kai Chen Cheng Cheng Xiaowei Liu Peiwen Duan Yaoyao Gu Yeming Wu Rob M. Ewing Zhongrong Li Zhixiang Wu Yihua Wang Source Type: research
MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
by Zhihui Liu, Xiyuan Zhang, Man Xu, Jason J. Hong, Amanda Ciardiello, Haiyan Lei, Jack F. Shern, Carol J. Thiele
MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood. Our study finds that MYCN binds promoters to up-regulate canonical MYC targets but binds to both enhancers and promoters to repress differentiation genes. MYCN binding also increases H3K4me3 and H3K27ac on canonical MYC target promoters and decreases H3K27ac ...
Source: PLoS Biology: Archived Table of Contents - March 28, 2024 Category: Biology Authors: Zhihui Liu Source Type: research
Disposable paper electrodes for detection of changes in dopamine concentrations in rat brain homogenates
Talanta. 2024 Mar 26;274:125940. doi: 10.1016/j.talanta.2024.125940. Online ahead of print.ABSTRACTDopamine, the main catecholamine neurotransmitter plays an important role in renal, cardiovascular, central nervous systems, and pathophysiological processes. The abnormal dopamine levels can result in neurological disorders such as Parkinson's, Alzheimer's, schizophrenia, acute anxiety, neuroblastoma and also contribute to cognitive dysfunctions. Given the widespread importance of dopamine concentration levels, it is imperative to develop sensors that are able to monitor dopamine. Herein, we have developed pre-anodized dispo...
Source: Talanta - March 27, 2024 Category: Chemistry Authors: J Sonia B N Kumara Kevin Joakim Pinto A Hashim E S Sindhu Priya B Kalpana Renjtih Thomas K Sudhakara Prasad Source Type: research
Disposable paper electrodes for detection of changes in dopamine concentrations in rat brain homogenates
Talanta. 2024 Mar 26;274:125940. doi: 10.1016/j.talanta.2024.125940. Online ahead of print.ABSTRACTDopamine, the main catecholamine neurotransmitter plays an important role in renal, cardiovascular, central nervous systems, and pathophysiological processes. The abnormal dopamine levels can result in neurological disorders such as Parkinson's, Alzheimer's, schizophrenia, acute anxiety, neuroblastoma and also contribute to cognitive dysfunctions. Given the widespread importance of dopamine concentration levels, it is imperative to develop sensors that are able to monitor dopamine. Herein, we have developed pre-anodized dispo...
Source: Talanta - March 27, 2024 Category: Chemistry Authors: J Sonia B N Kumara Kevin Joakim Pinto A Hashim E S Sindhu Priya B Kalpana Renjtih Thomas K Sudhakara Prasad Source Type: research
Choosing T-cell sources determines CAR-T cell activity in neuroblastoma
ConclusionCB and 45RA-derived T cells may be used as allogeneic sources of T cells to produce CAR-T cells. Moreover, ex vivo culture with IL-7+IL-15+IL-21 could favor CAR-T products with a longer persistence in the host. Our strategy may complement the current use of Dinutuximab in treating NB through its combination with a targeted CAR-T cell approach. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research
Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation
AbstractHistorically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a patient's quality of life without definitive added benefit in survival. The prevalence of occult intracranial disease is low, especially for Hyams grade I and II tumors. A unilateral approach sparing the contralateral cribriform plate and olfactory system can be considered for select cases of early stage, low-grade tumors when the disease does not cross midline to...
Source: International Forum of Allergy and Rhinology - March 26, 2024 Category: Allergy & Immunology Authors: Harish Dharmarajan,
Garret Choby,
Ralph Abi Hachem,
Edward C. Kuan,
Corinna G. Levine,
Olabisi Sanusi,
Theodore Schuman,
Dennis Tang,
Michael Yim,
Mathew Geltzeiler Tags: VIEWPOINT Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
Local control and toxicity outcomes following consolidative radiation therapy in patients with high-risk neuroblastoma: a 20-year experience at a single center
CONCLUSIONS: In patients with high-risk neuroblastoma, consolidative radiotherapy to the primary tumor site resulted in excellent local control and a tolerable safety profile.PMID:38523384 | DOI:10.24953/turkjped.2023.575 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Jeong Yun Jang Jin-Hong Park Yeon Joo Kim Ho Joon Im Kyung-Nam Koh Hyery Kim Sung Han Kang Ha Un Kim Seung Do Ahn Source Type: research
