Interleukin 3 Inhibits Glutamate-Cytotoxicity in Neuroblastoma Cell Line
In this study, we uncover the protective role of IL-3 as an inhibitor of glutamate-induced cell death, analyzing the cytokine's signaling pathways during its protective effect. Specifically, we examined the relevance of JAK/STAT, Ras/MAPK, and PI3 K signaling pathways in the molecular mechanism triggered by IL-3. Our results show that the inhibition of JAK, ERK, and PI3 K signaling pathways, using pharmacological inhibitors, effectively blocked IL-3's protective role against glutamate-induced cell death. Additionally, our findings suggest that Bcl-2 and Bax proteins may be involved in the molecular mechanism triggered by I...
Source: Neurochemical Research - March 21, 2024 Category: Neuroscience Authors: Ver ónica Matus Marcos Castro-Guarda Joaqu ín Cárcamo-Fierro Francisco J Morera Angara Zambrano Source Type: research
GSE261593 Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
Contributors : V Lobo ; I Nowak ; C Fernandez ; A C Muler ; J O Westholm ; H C Huang ; I Fabrik ; H T Huynh ; Evgeniia Shcherbinina ; M Kanik ; A H ärtlova ; D Benhalevy ; D Angeletti ; A A SarshadSeries Type : OtherOrganism :In mammals, RNA interference (RNAi) was historically studied as a cytoplasmic event, however, in the last decade growing number of reports convincingly show nuclear localization of the AGO proteins. Nevertheless, the mechanism and the extent of nuclear RNAi remains to be fully elucidated. We found that reduced Lamin A levels significantly induced nuclear influx of AGO2 in SHSY5Y neuroblasto...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Other Source Type: research
GSE261422 Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
Contributors : V Lobo ; I Nowak ; C Fernandez ; A I Muler ; J O Westholm ; H C Huang ; I Fabrik ; H T Huynh ; Evgeniia Shcherbinina ; M Kanik ; A H ärtlova ; D Benhalevy ; D Angeletti ; A A SarshadSeries Type : OtherOrganism :In mammals, RNA interference (RNAi) was historically studied as a cytoplasmic event, however, in the last decade growing number of reports convincingly show nuclear localization of the AGO proteins. Nevertheless, the mechanism and the extent of nuclear RNAi remains to be fully elucidated. We found that reduced Lamin A levels significantly induced nuclear influx of AGO2 in SHSY5Y neuroblasto...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Other Source Type: research
GSE228194 ALK upregulates POSTN and WNT signaling to drive neuroblastoma
Contributors : Miller Huang ; Alvin Farrel ; John M Maris ; William A WeissSeries Type : Expression profiling by high throughput sequencingOrganism :The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Integrative analysis with machine learning identifies diagnostic and prognostic signatures in neuroblastoma based on differentially DNA methylated enhancers between INSS stage 4 and 4S neuroblastoma
ConclusionBased on multi-omics data and ML algorithms, we successfully developed the ISRS to enable accurate diagnosis and prognostic stratification in NB, which shed light on molecular mechanisms of spontaneous regression and clinical utilization of ISRS. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 21, 2024 Category: Cancer & Oncology Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
CONCLUSIONS: NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.PMID:38507554 | DOI:10.1213/ANE.0000000000006964 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Li Xu Yu Wang Yang Jiao Yulin Huang Rui Xu Xiaoping Gu Wei Zhang Zhengliang Ma Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation
CONCLUSIONS: NP65 modulates the level of GABAAR-α2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP.PMID:38507554 | DOI:10.1213/ANE.0000000000006964 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 20, 2024 Category: Anesthesiology Authors: Li Xu Yu Wang Yang Jiao Yulin Huang Rui Xu Xiaoping Gu Wei Zhang Zhengliang Ma Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
