GSE228194 ALK upregulates POSTN and WNT signaling to drive neuroblastoma

Contributors : Miller Huang ; Alvin Farrel ; John M Maris ; William A WeissSeries Type : Expression profiling by high throughput sequencingOrganism :The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research