AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis
Oncogene, Published online: 27 February 2024; doi:10.1038/s41388-024-02980-yAF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis (Source: Oncogene)
Source: Oncogene - February 27, 2024 Category: Cancer & Oncology Authors: Babak Oskouian Joanna Y. Lee Shahab Asgharzadeh Ranjha Khan Meng Zhang Julia R. Weisbrod Youn-Jeong Choi Latika Puri Ana E. Aguilar Piming Zhao Julie D. Saba Source Type: research
BPTF cooperates with MYCN and MYC to link neuroblastoma cell cycle control to epigenetic cellular states
bioRxiv [Preprint]. 2024 Feb 12:2024.02.11.579816. doi: 10.1101/2024.02.11.579816.ABSTRACTThe nucleosome remodeling factor BPTF is required for the deployment of the MYC-driven transcriptional program. Deletion of one Bptf allele delays tumor progression in mouse models of pancreatic cancer and lymphoma. In neuroblastoma, MYCN cooperates with the transcriptional core regulatory circuitry (CRC). High BPTF levels are associated with high-risk features and decreased survival. BPTF depletion results in a dramatic decrease of cell proliferation. Bulk RNA-seq, single-cell sequencing, and tissue microarrays reveal a positive corr...
Source: Cancer Control - February 26, 2024 Category: Cancer & Oncology Authors: Irene Felipe Jaime Mart ínez-de-Villarreal Khushbu Patel Jorge Mart ínez-Torrecuadrada Liron D Grossmann Giovanna Roncador Mariona Cubells Alvin Farrell Nathan Kendsersky Sergio Sabroso-Lasa Luc ía Sancho-Temiño Kyabeth Torres Daniel Martinez Javier M Source Type: research
Treatment Outcome of Olfactory Neuroblastoma: A Multicenter Study by the Korean Sinonasal Tumor and Skull Base Surgery Study Group
CONCLUSION: Clinical staging and pathologic grading are important prognostic factors in ONB. Dural resection in mKadish A and B did not show a significant survival benefit. Induction chemotherapy did not show a survival benefit, even after stage matching.PMID:38404243 | DOI:10.21053/ceo.2023.00089 (Source: Clinical and Experimental Otorhinolaryngology)
Source: Clinical and Experimental Otorhinolaryngology - February 26, 2024 Category: ENT & OMF Authors: Sang Duk Hong Song I Park Ji Heui Kim Sung Jae Heo Sung-Woo Cho Tae-Bin Won Hyun-Jin Cho Dong Hoon Lee Sue Jean Mun Soo Kyoung Park Yong-Wan Kim Dong-Young Kim Source Type: research
