Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
Tiam1 regulates proliferation, invasion, and differentiation in neuroblastoma through the Tiam1/Rac1 signaling pathway
Neoplasma. 2024 Feb;71(1):37-47. doi: 10.4149/neo_2024_221217N1184. Epub 2024 Jan 23.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in children. The purpose of the present study is to detect the prognostic role and potential therapeutic efficacy of the T lymphoma invasion and metastasis 1 (Tiam1) in neuroblastoma. The overexpression of Tiam1 protein is frequently observed in neuroblastoma. Tiam1 expression is closely associated with adverse prognosis of neuroblastoma and risk group classification. Knockdown of TIAM1 by lentivirus expressing short hairpin RNA against TIAM1 (sh-TIAM1) inhibited the prolife...
Source: Neoplasma - March 20, 2024 Category: Cancer & Oncology Authors: Xue Li Bin Liu Xiaoming Wang Yong Zhuang Taihong Gao Nianzheng Sun Source Type: research
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
Eur J Pharmacol. 2024 Mar 17:176505. doi: 10.1016/j.ejphar.2024.176505. Online ahead of print.ABSTRACTAlpha-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson's disease (PD). Here, we explored the efficacy of N,N,N',N'-tetraethyl-10H-phenothiazine-3,7-diamine dihydrochloride (LETC), a protein aggregation inhibitor, on α-Syn aggregation. In both cellular models and transgenic mice, α-Syn aggregation was achieved by the overexpression of full-length human α-Syn fused with a signal sequence peptide. α-Syn accumulated in transfected DH60.21 neur...
Source: European Journal of Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Karima Schwab Silke Frahm Mandy Magbagbeolu David Horsley Elizabeth A Goatman Valeria Melis Franz Theuring Ahtsham Ishaq John M D Storey Charles R Harrington Claude M Wischik Gernot Riedel Source Type: research
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
Eur J Pharmacol. 2024 Mar 17:176505. doi: 10.1016/j.ejphar.2024.176505. Online ahead of print.ABSTRACTAlpha-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson's disease (PD). Here, we explored the efficacy of N,N,N',N'-tetraethyl-10H-phenothiazine-3,7-diamine dihydrochloride (LETC), a protein aggregation inhibitor, on α-Syn aggregation. In both cellular models and transgenic mice, α-Syn aggregation was achieved by the overexpression of full-length human α-Syn fused with a signal sequence peptide. α-Syn accumulated in transfected DH60.21 neur...
Source: European Journal of Pharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Karima Schwab Silke Frahm Mandy Magbagbeolu David Horsley Elizabeth A Goatman Valeria Melis Franz Theuring Ahtsham Ishaq John M D Storey Charles R Harrington Claude M Wischik Gernot Riedel Source Type: research
Neuroendocrine and undifferentiated sinonasal and skull base tumors: An up-to-date narrative review
In conclusion, neuroendocrine and undifferentiated tumors arising from the nose, paranasal sinuses and the skull base represent a unique group of malignancies. A thorough understanding of their clinical features, molecular changes, diagnostic approaches, treatment modalities, and prognostic factors is critical for providing optimal patient care. Still, continued research efforts and multidisciplinary collaboration are warranted, in order to improve outcomes for patients diagnosed with these rare and aggressive tumors. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - March 19, 2024 Category: ENT & OMF Source Type: research
The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy
ConclusionsThe local control rate of ONB treated with postoperative radiation therapy was 100%. This may be attributed to cross-departmental cooperation between head and neck surgeons, pathologists, and radiation oncologists, which resulted in accurate matching of CT images for treatment planning with the location of the tumor and positive margins. Longer follow-up periods are required to evaluate the effectiveness of our strategy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 18, 2024 Category: Cancer & Oncology Authors: Yuki Tsutsumi,
Kazuhiro Omura,
Yoshikazu Kijima,
Masao Kobayashi,
Nei Fukasawa,
Teppei Takeda,
Teru Ebihara,
Satoshi Aoki,
Nobuyoshi Otori,
Hiromi Kojima,
Manabu Aoki Tags: RESEARCH ARTICLE Source Type: research
Predicting event-free survival after induction of remission in high-risk pediatric neuroblastoma: combining 123I-MIBG SPECT-CT radiomics and clinical factors
Conclusion123I-MIBG SPECT-CT-based radiomics can accurately predict the event-free survival of high-risk neuroblastoma after induction of remission The constructed nomogram may enable an individualized assessment of high-risk neuroblastoma prognosis and assist clinicians in optimizing patient treatment and follow-up plans, thereby potentially improving patient survival.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - March 16, 2024 Category: Radiology Source Type: research
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
Elife. 2024 Mar 15;12:RP90993. doi: 10.7554/eLife.90993.ABSTRACTDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress and therapies is poorly understood. Here, we demonstrate that jumonji domain containing 6, arginine demethylase, and lysine hydroxylase, JMJD6, acts as a hub connecting splicing and metabolism in MYC-driven human neuroblastoma. JMJD6 c...
Source: Genomics Proteomics ... - March 15, 2024 Category: Genetics & Stem Cells Authors: Carolyn M Jablonowski Waise Quarni Shivendra Singh Haiyan Tan Dhanushka Hewa Bostanthirige Hongjian Jin Jie Fang Ti-Cheng Chang David Finkelstein Ji-Hoon Cho Dongli Hu Vishwajeeth Pagala Sadie Miki Sakurada Shondra M Pruett-Miller Ruoning Wang Andrew Murp Source Type: research
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
Elife. 2024 Mar 15;12:RP90993. doi: 10.7554/eLife.90993.ABSTRACTDysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress and therapies is poorly understood. Here, we demonstrate that jumonji domain containing 6, arginine demethylase, and lysine hydroxylase, JMJD6, acts as a hub connecting splicing and metabolism in MYC-driven human neuroblastoma. JMJD6 c...
Source: Genomics Proteomics ... - March 15, 2024 Category: Genetics & Stem Cells Authors: Carolyn M Jablonowski Waise Quarni Shivendra Singh Haiyan Tan Dhanushka Hewa Bostanthirige Hongjian Jin Jie Fang Ti-Cheng Chang David Finkelstein Ji-Hoon Cho Dongli Hu Vishwajeeth Pagala Sadie Miki Sakurada Shondra M Pruett-Miller Ruoning Wang Andrew Murp Source Type: research
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Eur J Med Chem. 2024 Feb 28;269:116266. doi: 10.1016/j.ejmech.2024.116266. Online ahead of print.ABSTRACTIn neurodegenerative diseases, using a single molecule that can exert multiple effects to modify the disease may have superior activity over the classical "one molecule-one target" approach. Herein, we describe the discovery of 6-hydroxybenzothiazol-2-carboxamides as highly potent and selective MAO-B inhibitors. Variation of the amide substituent led to several potent compounds having diverse side chains with cyclohexylamide 40 displaying the highest potency towards MAO-B (IC50 = 11 nM). To discover new compounds with e...
Source: European Journal of Medicinal Chemistry - March 15, 2024 Category: Chemistry Authors: Omar M Al-Saad Moustafa Gabr Sarah S Darwish Mariagrazia Rullo Leonardo Pisani Daniela Valeria Miniero Grazia Maria Liuzzi Andreas M Kany Anna K H Hirsch Ashraf H Abadi Matthias Engel Marco Catto Mohammad Abdel-Halim Source Type: research
A Randomised Phase II Trial to Evaluate the Feasibility of Radiotherapy Dose Escalation, Facilitated by Intensity Modulated Arc Radiotherapy Techniques, in High-Risk Neuroblastoma
AND PURPOSE: For high-risk neuroblastoma, planning target volume coverage is often compromised to respect adjacent kidney tolerance. This trial investigated whether intensity modulated arc radiotherapy techniques (IMAT) could facilitate dose escalation better than conventional techniques. (Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Jennifer E. Gains, Amit Patel, Yen-Ch ’ing Chang, Henry C. Mandeville, Gregory Smyth, Christopher Stacey, James Talbot, Keith Wheatley, Mark N. Gaze Tags: Original Article Source Type: research
PD-1-induced encephalopathy: a report of 2 cases on neurological toxicities with immune checkpoint inhibitors
CONCLUSIONS: These case reports show the difficulty in distinguishing PD-1-induced encephalopathy from other neurological disorders, especially paraneoplastic neurological syndromes. If not treated properly, patients' lives may be endangered. Thus, early identification and early treatment are very important.PMID:38482411 | PMC:PMC10928638 | DOI:10.21037/tcr-23-2043 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Xingrui Chen Minting Ye Ruyu Ai Changguo Shan Minyao Lai Weiping Hong Yanying Yang Hui Wang Juan Li Junjie Zhen Jiangfen Zhou Qingjun Hu Shaoqun Li Antonio Rossi Toyoaki Hida Rafael Rosell Shuisheng Zhong Linbo Cai Source Type: research
PIM Kinase inhibition sensitizes neuroblastoma to doxorubicin
Chemoresistance contributes to relapse in high-risk neuroblastoma. Cancer cells acquire resistance through multiple mechanisms, including drug efflux pumps. In neuroblastoma, multidrug resistance-associated protein-1 (MRP1/ABCC1) efflux pump expression correlates with worse outcomes. These pumps are regulated by PIM kinases, a family of serine-threonine kinases, overexpressed in neuroblastoma. We hypothesized PIM kinase inhibition would sensitize neuroblastoma cells by modulating MRP1. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 14, 2024 Category: Surgery Authors: Janet R. Julson, Colin H. Quinn, Nazia Nazam, Laura V. Bownes, Jerry E. Stewart, Elizabeth A. Beierle Tags: Original Article Source Type: research
