Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Exp Eye Res. 2024 Apr 10:109887. doi: 10.1016/j.exer.2024.109887. Online ahead of print.ABSTRACTThe pathophysiology of Primary Open Angle Glaucoma (POAG) remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. High resolution mass spectrometry-based TMT6plex quantitative proteomics analysis is performed on AH samples collected from POAG patients, and compared against a control group of patients with cataracts. Data are available via ProteomeXchange with identifier PXD033153. 1589 proteins...
Source: Experimental Eye Research - April 12, 2024 Category: Opthalmology Authors: Darren Mun Yoong Choy Bryan Chin Hou Ang Sunil S Adav Zheng Yu Bo Caius Jun Shyan Goh Jin Wei Arjunan Kumaran Chua Chun Hau Nicola Yian Gan Sze Siu Kwan Leonard Wai Leon Yip Source Type: research
Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Exp Eye Res. 2024 Apr 10:109887. doi: 10.1016/j.exer.2024.109887. Online ahead of print.ABSTRACTThe pathophysiology of Primary Open Angle Glaucoma (POAG) remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. High resolution mass spectrometry-based TMT6plex quantitative proteomics analysis is performed on AH samples collected from POAG patients, and compared against a control group of patients with cataracts. Data are available via ProteomeXchange with identifier PXD033153. 1589 proteins...
Source: Experimental Eye Research - April 12, 2024 Category: Opthalmology Authors: Darren Mun Yoong Choy Bryan Chin Hou Ang Sunil S Adav Zheng Yu Bo Caius Jun Shyan Goh Jin Wei Arjunan Kumaran Chua Chun Hau Nicola Yian Gan Sze Siu Kwan Leonard Wai Leon Yip Source Type: research
Bilateral adrenal neuroblastoma: peculiar pattern of a rare pediatric presentation
ConclusionBSN treatment is similar to unilateral disease. A more conservative surgical approach with adrenal tissue preservation on less extensive side should be considered. Biological variables and extent of disease are amongst the most important prognostic determinants. Future studies are warranted to further address the biologic profiling of BSN and highlight prognostic significance of size difference between both adrenal sides. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
GSE263118 Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation [RNA-seq siMETTL3]
Contributors : Monica M Pomaville ; Mohansrinivas Chennakesavalu ; Pingluan Wang ; Zhiwei Jiang ; Hui-Lung Sun ; Peizhe Ren ; Ryan Borchert ; Varsha Gupta ; Chang Ye ; Ruiqi Ge ; Zhongyu Zhu ; Mallory Brodnik ; Yuhao Zhong ; Kelley Moore ; Helen Salwen ; Rani E George ; Malgorzata Krajewska ; Alexandre Chlenski ; Mark A Applebaum ; Chuan He ; Susan L CohnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransfera...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE262731 Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation [RNA-Seq STM]
Contributors : Monica M Pomaville ; Mohansrinivas Chennakesavalu ; Pingluan Wang ; Zhiwei Jiang ; Hui-Lung Sun ; Peizhe Ren ; Ryan Borchert ; Varsha Gupta ; Chang Ye ; Ruiqi Ge ; Zhongyu Zhu ; Mallory Brodnik ; Yuhao Zhong ; Kelley Moore ; Helen Salwen ; Rani E George ; Malgorzata Krajewska ; Alexandre Chlenski ; Mark A Applebaum ; Chuan He ; Susan L CohnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransfera...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE240595 Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation
Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE240582 Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation [meRIP-Seq]
Contributors : Monica M Pomaville ; Mohansrinivas Chennakesavalu ; Pingluan Wang ; Zhiwei Jiang ; Hui-Lung Sun ; Peizhe Ren ; Ryan Borchert ; Varsha Gupta ; Chang Ye ; Ruiqi Ge ; Zhongyu Zhu ; Mallory Brodnik ; Yuhao Zhong ; Kelley Moore ; Helen Salwen ; Rani E George ; Malgorzata Krajewska ; Alexandre Chlenski ; Mark A Applebaum ; Chuan He ; Susan L CohnSeries Type : OtherOrganism : Homo sapiensThe N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE240581 Small-molecule Inhibition of METTL3 Suppresses Tumor Growth and Promotes Neuroblastoma Differentiation [RNA-Seq Decay]
Contributors : Monica M Pomaville ; Mohansrinivas Chennakesavalu ; Pingluan Wang ; Zhiwei Jiang ; Hui-Lung Sun ; Peizhe Ren ; Ryan Borchert ; Varsha Gupta ; Chang Ye ; Ruiqi Ge ; Zhongyu Zhu ; Mallory Brodnik ; Yuhao Zhong ; Kelley Moore ; Helen Salwen ; Rani E George ; Malgorzata Krajewska ; Alexandre Chlenski ; Mark A Applebaum ; Chuan He ; Susan L CohnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransfera...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers
CONCLUSIONS: These results pave the way for clinical investigation of GD2IL18CART in pediatric and adult patients with neuroblastoma and other GD2-positive cancers (EU CT 2022-501725-21-00).PMID:38593230 | DOI:10.1158/1078-0432.CCR-23-3157 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Lena Fischer-Riepe Sareetha Kailayangiri Katharina Zimmermann Rita Pfeifer Michael Aigner Bianca Altvater Sascha Kretschmann Simon V ölkl Jordan Hartley Celine Dreger Katja Petry Andreas Bosio Angelika von D öllen Wolfgang Hartmann Holger Lode Dennis G Source Type: research
Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers
CONCLUSIONS: These results pave the way for clinical investigation of GD2IL18CART in pediatric and adult patients with neuroblastoma and other GD2-positive cancers (EU CT 2022-501725-21-00).PMID:38593230 | DOI:10.1158/1078-0432.CCR-23-3157 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 9, 2024 Category: Cancer & Oncology Authors: Lena Fischer-Riepe Sareetha Kailayangiri Katharina Zimmermann Rita Pfeifer Michael Aigner Bianca Altvater Sascha Kretschmann Simon V ölkl Jordan Hartley Celine Dreger Katja Petry Andreas Bosio Angelika von D öllen Wolfgang Hartmann Holger Lode Dennis G Source Type: research
Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Indoxyl sulphate-TNF α axis mediates uremic encephalopathy in rodent acute kidney injury
In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal injection of cisplatin 8 and 20 mg/kg, respectively. We showed that cisplatin treatment significantly inhibited the expressions of OAT3, synaptophysin and microtubule-associated protein 2 (MAP2), impaired locomotor and exploration activities, and increased accumulation of uremic toxins in the brain of AKI rats and mice. In vitro studies showed that uremic toxins neither alter OAT3 expression in human cerebral microvascular endothelial cells, nor synaptophysin and MAP2 expressions in human...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Ling Jiang Xue-Ying Sun Si-Qian Wang Yan-Lin Liu Ling-Jue Lu Wen-Han Wu Hao Zhi Zhong-Yan Wang Xiao-Dong Liu Li Liu Source Type: research
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway
In conclusion, this study is the first to demonstrate that CRMP signaling is involved in the suppression of neurite outgrowth by low zinc.PMID:38583951 | DOI:10.1248/bpb.b24-00019 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Hisaka Kurita Misa Ueda Miyu Kimura Ayu Okuda Kazuki Ohuchi Isao Hozumi Masatoshi Inden Source Type: research
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway
In conclusion, this study is the first to demonstrate that CRMP signaling is involved in the suppression of neurite outgrowth by low zinc.PMID:38583951 | DOI:10.1248/bpb.b24-00019 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Hisaka Kurita Misa Ueda Miyu Kimura Ayu Okuda Kazuki Ohuchi Isao Hozumi Masatoshi Inden Source Type: research
