Choosing T-cell sources determines CAR-T cell activity in neuroblastoma

ConclusionCB and 45RA-derived T cells may be used as allogeneic sources of T cells to produce CAR-T cells. Moreover, ex vivo culture with IL-7+IL-15+IL-21 could favor CAR-T products with a longer persistence in the host. Our strategy may complement the current use of Dinutuximab in treating NB through its combination with a targeted CAR-T cell approach.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research