Clinical Features and Risk Factors of Hepatic Sinusoidal Obstruction Syndrome in Children after Hematopoietic Stem Cell Transplantation: A Single-center Experience

Hepatic sinusoidal obstruction syndrome (SOS) is an illness with serious life effects that develops after hematopoietic stem cell transplantation (HSCT). We investigated the risk factors and clinical features of hepatic SOS in children following HSCT in 210 children who underwent allogeneic or autologous HSCT between 2009 and 2021 were analyzed in the context of SOS. The syndrome developed in 22 (10.4%) patients:frequently in neuroblastoma [24% (5/21)], hemophagocytic lymphohistiocytosis [57% (4/7)], and thalassemia major [22% (7/31)].
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Source Type: research