Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells

In this study, we demonstrated that MCT1 and 2 are major contributors to L-lactate transport in differentiated human neuroblastoma SH-SY5Y cells from the viewpoint of kinetic analysis. These results lead to a better understanding of ANLS in humans, and further exploration of the factors that can promote MCT1 and 2 functions is required.PMID:38569835 | DOI:10.1248/bpb.b23-00860

Source: Biological and Pharmaceutical Bulletin - April 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Sakuma Yuto Mukai Atsushi Yamaguchi Yudai Suganuma Keisuke Okamoto Ayako Furugen Katsuya Narumi Shuhei Ishikawa Yoshitaka Saito Masaki Kobayashi Source Type: research