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Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Source Type: research

Measuring the Absolute Concentration of Microparticles in Suspension Using High-Frequency B-Mode Ultrasound Imaging
Concentration measurement of particles in suspension is an important procedure performed in biological and clinical laboratories. Existing methods based on instruments such as hemocytometers, Coulter counters and flow cytometers are often laborious, destructive and incapable of in vivo measurements. On the other hand, an ultrasound-based method can be non-destructive and non-invasive and have the potential for in vivo measurement. In this work, a method is presented that estimates absolute particle concentration from high-frequency B-mode ultrasound images of a sample. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Authors: John H. Lee, Duane S. Boning, Brian W. Anthony Tags: Original Contribution Source Type: research

Clinicopathological and Ultrasonic Features of Triple-Negative Breast Cancers: A Comparison with Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers
The purpose of this study was to analyze the clinicopathological and ultrasound characteristics of triple-negative breast cancers (TNBCs) and compare these findings with those for hormone receptor-positive (HR-positive)/human epidermal growth factor receptor-2-negative (HER-2-negative) tumors. Seventy-five TNBCs and 135 HR-positive/HER-2-negative breast cancers were reviewed. Data from conventional ultrasound, Doppler vascularity and elastography were included in the analysis. TNBCs had a higher histologic grade and Ki-67 level. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 23, 2018 Category: Radiology Authors: Dongmo Wang, Kai Zhu, Jiawei Tian, Ziyao Li, Guoqing Du, Qiang Guo, Tong Wu, Juan Li Tags: Clinical Note Source Type: research

Quantitative Evaluation of Hepatic Microvascular Perfusion after Ischemia –Reperfusion Injury in Rabbits by Contrast-Enhanced Ultrasound Perfusion Imaging
The aim of this study was to evaluate microvascular perfusion after liver ischemia –reperfusion injury (IRI) in rabbits using the “flash-replenishment” method of contrast-enhanced ultrasound (CEUS) perfusion imaging. Twenty-eight rabbits underwent either 30, 60 or 90 min of ischemia and 120 min of reperfusion. CEUS perfusion imaging was performed using the “flash-reple nishment” model, and hepatic microvascular perfusion parameters, including peak intensity (PI), area under the curve (AUC), and hepatic artery-to-vein transit time (HA-HVTT), were calculated. (Source: Ultrasound in...
Source: Ultrasound in Medicine and Biology - February 22, 2018 Category: Radiology Authors: Fang Xie, Xiang Fei, Ming-Bo Zhang, Yan Zhang, Hong-Wei Wang, Jie Tang, Wen-Bo Tang, Yu-Kun Luo Tags: Original Contribution Source Type: research

Full-Field-of-View Time-Harmonic Elastography of the Native Kidney
The purpose of this study was to analyze full-field-of-view maps of renal shear wave speed (SWS) measured by time-harmonic elastography (THE) in healthy volunteers in terms of reproducibility, regional variation and physiologic effects. The kidneys of 37 healthy volunteers were investigated by multifrequency THE. The complete renal parenchyma, as well as cortex and medulla, was analyzed. A subgroup was investigated to test reproducibility (n  = 3). Significant differences between SWS in cortex, medulla and full parenchyma were observed (2.10 ± 0.17, 1.35 ± 0.11 and 1....
Source: Ultrasound in Medicine and Biology - February 22, 2018 Category: Radiology Authors: Stephan Rodrigo Marticorena Garcia, Markus Grossmann, Sophia Theresa Lang, Manh Nguyen Trong, Michael Schultz, Jing Guo, Bernd Hamm, J ürgen Braun, Ingolf Sack, Heiko Tzschätzsch Tags: Original Contribution Source Type: research

Orthogonal B-Mode Evaluation of Common Carotid Artery Plaques Reveals the Absence of Outward Remodeling
To properly assess morphologic and dynamic parameters of arteries and plaques, we propose the concept of orthogonal distance measurements, that is, measurements made perpendicular to the local lumen axis rather than along the ultrasound beam (vertical direction for a linear array). The aim of this study was to compare orthogonal and vertical artery and lumen diameters at the site of a plaque in the common carotid artery (CCA). Moreover, we investigated the interrelationship of orthogonal diameters and plaque size and the association of artery parameters with plaque echogenicity. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 21, 2018 Category: Radiology Authors: J. Steinbuch, F.H.B.M. Schreuder, K.D. Reesink, A.P.G. Hoeks, W.H. Mess Tags: Original Contribution Source Type: research

Shear Wave Speed Estimation Using Reverberant Shear Wave Fields: Implementation and Feasibility Studies
Elastography is a modality that estimates tissue stiffness and, thus, provides useful information for clinical diagnosis. Attention has focused on the measurement of shear wave propagation; however, many methods assume shear wave propagation is unidirectional and aligned with the lateral imaging direction. Any deviations from the assumed propagation result in biased estimates of shear wave speed. To address these challenges, directional filters have been applied to isolate shear waves with different propagation directions. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 21, 2018 Category: Radiology Authors: Juvenal Ormachea, Benjamin Castaneda, Kevin J. Parker Tags: Original Contribution Source Type: research

Comparison of Two Different Ultrasound Devices Using Strain Elastography Technology in the Diagnosis of Breast Lesions Related to the Histologic Results
This study was conducted to provide evidence that elastograms of two different devices and different manufacturers using the same technical approach provide the same diagnoses. A total of 110 breast lesions were prospectively analysed by two experts in ultrasound, using the strain elastography function from two different manufacturers (Hitachi HI-RTE, Hitachi Medical Systems, Wiesbaden, Germany; and Siemens eSie Touch, Siemens Medical Systems, Erlangen, Germany). Results were compared with the histopathologic results. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 21, 2018 Category: Radiology Authors: Andr é Farrokh, Fritz Schaefer, Friedrich Degenhardt, Nicolai Maass Tags: Original Contribution Source Type: research

Enlarged Size and Impaired Elastic Properties of the Ascending Aorta are Associated with Endothelial Dysfunction and Elevated Plasma Matrix Metalloproteinase-2 Level in Patients with Bicuspid Aortic Valve
The aim of this study was to test whether enlarged size and impaired elastic properties of the ascending aorta are associated with impaired endothelial function and increases in plasma matrix metalloproteinase (MMP)-2 concentrations in patients with bicuspid aortic valve (BAV) without significant valvular dysfunction. The size and the elasticity of the ascending aorta and the flow-mediated vasodilation (FMD) in the brachial artery in response to hyperemia were evaluated with 2-D echocardiography and high-frequency linear ultrasound in 42 patients with BAV without significant valvular dysfunction and 30 age- and sex-matched...
Source: Ultrasound in Medicine and Biology - February 20, 2018 Category: Radiology Authors: Yi-Bin Wang, Yang Li, You-Bin Deng, Ya-Ni Liu, Jun Zhang, Jie Sun, Ying Zhu, Li Li, Qiao-Ying Tang, Wei Zhou Tags: Original Contribution Source Type: research

Revised Value of Contrast-Enhanced Ultrasound for Solid Hypo-Echoic Thyroid Nodules Graded with the Thyroid Imaging Reporting and Data System
The use of ultrasound in differentiation of benign and malignant solid hypo-echoic thyroid nodules is a dilemma in clinical practice. The aim of this study was to investigate the revised value of contrast-enhanced ultrasound (CEUS) for differentiating solid hypo-echoic thyroid nodules using the Thyroid Imaging Reporting and Data System (TI-RADS).The study included 135 patients with 135 nodules confirmed by fine-needle aspiration and/or surgery. Every nodule underwent both conventional US and CEUS. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 19, 2018 Category: Radiology Authors: YanFang Wang, Fang Nie, Ting Liu, Dan Yang, Qi Li, Jing Li, AiLing Song Tags: Original Contribution Source Type: research

Pulmonary Capillary Hemorrhage Induced by Different Imaging Modes of Diagnostic Ultrasound
In this study, a GE Vivid 7 Dimension ultrasound machine with 10  L linear array probe was used at 6.6 MHz to explore the relative PCH efficacy of B-mode imaging, M-mode (fixed beam), color angio mode Doppler imaging and pulsed Doppler mode (fixed beam). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 7, 2018 Category: Radiology Authors: Douglas L. Miller, Zhihong Dong, Chunyan Dou, Krishnan Raghavendran Tags: Original Contribution Source Type: research

Local Texture Anisotropy as an Estimate of Muscle Quality in Ultrasound Imaging
This study introduces local pattern texture anisotropy as a novel parameter to differentiate healthy and disordered muscle and to gauge the severity of muscle impairments based on B-mode ultrasound images. Preliminary human results are also presented. A local pattern texture anisotropy index (TAI) was computed in one region of interest in the short head of the biceps brachii. The effects of gain settings and box sizes required for TAI computation were investigated. Between-day reliability was studied in patients with sporadic inclusion body myositis (n  = 26). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 7, 2018 Category: Radiology Authors: Guillaume J.R. Dubois, Damien Bachasson, Lilian Lacourpaille, Olivier Benveniste, Jean-Yves Hogrel Tags: Technical Note Source Type: research

Impact of Acoustic Radiation Force Excitation Geometry on Shear Wave Dispersion and Attenuation Estimates
Shear wave elasticity imaging (SWEI) characterizes the mechanical properties of human tissues to differentiate healthy from diseased tissue. Commercial scanners tend to reconstruct shear wave speeds for a region of interest using time-of-flight methods reporting a single shear wave speed (or elastic modulus) to the end user under the assumptions that tissue is elastic and shear wave speeds are not dependent on the frequency content of the shear waves. Human tissues, however, are known to be viscoelastic, resulting in dispersion and attenuation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 5, 2018 Category: Radiology Authors: Samantha L. Lipman, Ned C. Rouze, Mark L. Palmeri, Kathryn R. Nightingale Tags: Original Contribution Source Type: research

Microembolic Signals Predict Recurrence of Ischemic Events in Symptomatic Patients with Middle Cerebral Artery Stenosis
Middle cerebral artery (MCA) stenosis is a common cause of ischemic stroke in Asian populations. We sought to determine whether microembolic signals (MESs) can predict the occurrence or recurrence of ischemia in symptomatic and asymptomatic patients with MCA stenosis. The symptomatic group had a significantly higher incidence of MES (30% vs. 16.2%, p   (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 3, 2018 Category: Radiology Authors: Xiaomin Chen, Kangding Liu, Xiujuan Wu, Sibo Wang, Ting Li, Yingqi Xing Tags: Original Contribution Source Type: research

High Intensity Focused Ultrasound (HIFU) Heating Improves Perfusion and Antimicrobial Efficacy in Mouse Staphylococcus Abscess
Chronic wounds typically require long-duration treatment with a combination of antibiotics administered systemically. This incurs adverse side effects and can require aversive surgical treatments and limb amputations. To improve non-invasive antimicrobial therapy, the objective of this study was to investigate antimicrobial chemotherapy combined with high-intensity focused ultrasound (HIFU) heating (HT). A Staphylococcus aureus abscess (80  ± 30 mm3) was generated in the mouse flank region. Once the average temperature (~42 °C–46 °C) in the abscess was reached with HI...
Source: Ultrasound in Medicine and Biology - February 3, 2018 Category: Radiology Authors: Rachel Wardlow, Kaustuv Sahoo, Danielle Dugat, Jerry Malayer, Ashish Ranjan Tags: Technical Note Source Type: research

Sonodynamic Therapy Mediated by Emodin Induces the Oxidation of Microtubules to Facilitate the Sonodynamic Effect
In previous studies, sonodynamic therapy mediated by emodin (emodin-SDT) induced cytoskeletal filament disruption and apoptosis of THP-1-derived macrophages. In this research, we investigated the underlying mechanism. THP-1-derived macrophages were incubated with emodin and exposed to ultrasound irradiation. After emodin-SDT, we measured the production of reactive oxygen species (ROS) and analyzed the level of amino acid oxidation in microtubules, the cleavage of microtubules and the mitochondrial membrane potential (MMP). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 3, 2018 Category: Radiology Authors: Jili Qian, Qianping Gao Tags: Original Contribution Source Type: research

Multidirectional Estimation of Arterial Stiffness Using Vascular Guided Wave Imaging with Geometry Correction
We previously found that vascular guided wave imaging (VGWI) could non-invasively quantify transmural wall stiffness in both the longitudinal (r –z plane, 0°) and circumferential (r–θ plane, 90°) directions of soft hollow cylinders. Arterial stiffness estimation in multiple directions warrants further comprehensive characterization of arterial health, especially in the presence of asymmetric plaques, but is currently lacking. This stu dy therefore investigated the multidirectional estimation of the arterial Young's modulus in a finite-element model, in vitro artery-mimicking phantoms and an excise...
Source: Ultrasound in Medicine and Biology - February 2, 2018 Category: Radiology Authors: Yuexin Guo, Yahua Wang, Enoch Jing-Han Chang, Wei-Ning Lee Tags: Original Contribution Source Type: research

Quantitative Ultrasound Imaging to Assess the Biceps Brachii Muscle in Chronic Post-Stroke Spasticity: Preliminary Observation
We prospectively investigated the feasibility of using quantitative ultrasound imaging (QUI) to assess the biceps brachii muscle (BBM) in individuals with chronic post-stroke spasticity. To quantify muscle echogenicity and stiffness, we measured QUI parameters (gray-scale pixel value and shear wave velocity [SWV, m/s]) of the BBM in three groups: 16 healthy BBMs; 12 post-stroke, non-spastic BBMs; and 12 post-stroke, spastic BBMs. The QUI results were compared with the Modified Ashworth Scale and Tardieu Scale. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 2, 2018 Category: Radiology Authors: Jing Gao, Wen He, Li-Juan Du, Johnson Chen, David Park, Michael Wells, Brian Fowlkes, Michael O'Dell Tags: Original Contribution Source Type: research

Could Ultrasound Elastography Reflect Liver Function?
The purpose of this study was to investigate whether ultrasound elastography reflects liver function reserve relative to liver fibrosis histology. Sixty-five New Zealand rabbits were divided into an experimental group (n  = 45) and a control group (n = 20). In the experimental group, liver fibrosis (F1–F4) was induced by subcutaneous injection of carbon tetrachloride. Point shear wave elastography and the indocyanine green (ICG) elimination test were performed for the two groups at 4-wk intervals for 56  wk. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 2, 2018 Category: Radiology Authors: Tingting Qiu, Hong Wang, Jinzhen Song, Gang Guo, Yujun Shi, Yan Luo, Jibin Liu Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 27, 2018 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 27, 2018 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 27, 2018 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 27, 2018 Category: Radiology Source Type: research

Quantitative Evaluation of Combretastatin A4 Phosphate Early Efficacy in a Tumor Model with Dynamic Contrast-Enhanced Ultrasound
Combretastatin A4 phosphate (CA4P) is a vascular disrupting agent that rapidly shuts down blood supply to tumors. Early monitoring of tumor perfusion plays a crucial role in determining the optimal strategy to managing treatment and guiding future therapy. The aim of this study was to investigate the potential value of dynamic contrast-enhanced ultrasound (CEUS) in quantitative evaluation of tumor perfusion at an early stage in CA4P therapy. Central and peripheral perfusion of tumors was detected by CEUS pre-treatment (0  h) and 2, 12 and 48 h after CA4P injection. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 23, 2018 Category: Radiology Authors: Pingyu Zhang, Yihan Chen, JinFeng Liu, Yali Yang, Qing Lv, Jing Wang, Li Zhang, Mingxing Xie Tags: Original Contribution Source Type: research

3-D Quantitative Dynamic Contrast Ultrasound for Prostate Cancer Localization
To investigate quantitative 3-D dynamic contrast-enhanced ultrasound (DCE-US) and, in particular 3-D contrast-ultrasound dispersion imaging (CUDI), for prostate cancer detection and localization, 43 patients referred for 10 –12-core systematic biopsy underwent 3-D DCE-US. For each 3-D DCE-US recording, parametric maps of CUDI-based and perfusion-based parameters were computed. The parametric maps were divided in regions, each corresponding to a biopsy core. The obtained parameters were validated per biopsy location a nd after combining two or more adjacent regions. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 23, 2018 Category: Radiology Authors: Stefan G. Schalk, Jing Huang, Jia Li, Libertario Demi, Hessel Wijkstra, Pintong Huang, Massimo Mischi Tags: Original Contribution Source Type: research

Diaphragmatic Ultrasound Correlates with Inspiratory Muscle Strength and Pulmonary Function in Healthy Subjects
Diaphragm ultrasound (DUS) has been used to identify diaphragm dysfunction. However, its correlations with respiratory strength and lung function are unclear, even in healthy patients. A total of 64 healthy patients (30 males) had lung function and inspiratory strength (maximal inspiratory pressure and sniff nasal inspiratory pressure) measured. Gastric and oesophageal pressures were measured in a subgroup (n  = 40). DUS was characterized by mobility (quiet breathing [QB] and deep breathing [DB]) and thickness (at functional residual capacity [ThFRC] and total lung capacity [ThTLC]). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 18, 2018 Category: Radiology Authors: Let ícia Zumpano Cardenas, Pauliane Vieira Santana, Pedro Caruso, Carlos Roberto Ribeiro de Carvalho, André Luís Pereira de Albuquerque Tags: Original Contribution Source Type: research

Arterial Phantoms with Regional Variations in Wall Stiffness and Thickness
Regional wall stiffening and thickening are two common pathological features of arteries. To account for these two features, we developed a new arterial phantom design framework to facilitate the development of vessel models that contain a lesion segment whose wall stiffness and thickness differ from those of other segments. This new framework is based on multi-part injection molding principles that sequentially casted the lesion segment and the flank segments of the vessel model using molding parts devised with computer-aided design tools. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 18, 2018 Category: Radiology Authors: Adrian J.Y. Chee, Billy Y.S. Yiu, Chung Kit Ho, Alfred C.H. Yu Tags: Original Contribution Source Type: research

Characteristic Echocardiographic Manifestations of Beh çet's Disease
The objective of this study was to determine the characteristic echocardiographic manifestations of Beh çet's disease. Ninety-seven Behçet's patients admitted to our hospital from January 2002 to December 2016 were retrospectively analyzed. There were 63 patients (64.9%) with cardiac involvement; these included 47 men (74.6%) and 16 women (25.4%). Of these 63 patients, most (74.6%) exhibited valvula r lesions, especially aortic regurgitation. The primary characteristic manifestations of valves were cusp prolapse with aneurysmal changes, vegetation-like lesions and echo-free spaces within the annulus. (Source:...
Source: Ultrasound in Medicine and Biology - January 18, 2018 Category: Radiology Authors: Lihong Pu, Rongjuan Li, Jinjie Xie, Ya Yang, Guowen Liu, Yueli Wang, Yijia Li Tags: Original Contribution Source Type: research

Ultrasound-Mediated Microbubble Destruction Suppresses Melanoma Tumor Growth
In this study, we investigated a novel treatment approach, the use of low-intensity ultrasound (2.3 W/cm2 at 1  MHz)-mediated Optison microbubble (MB) destruction (UMMD) to treat melanoma in a flank tumor model. The effect of UMMD was first evaluated in the melanoma cell line B16 F10 (B16) in vitro and then in mice inoculated with B16 cells. MB+B16 cells were exposed to US in vitro, resulting in significan t cell death proportional to duty cycle (R2 = 0.74): approximately 30%, 50%, 80% and 80% cell death at 10%, 30%, 50% and 100% DC respectively. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 18, 2018 Category: Radiology Authors: Kee W. Jang, Dongrim Seol, Lei Ding, Tae-Hong Lim, Joseph A. Frank, James A. Martin Tags: Original Contribution Source Type: research

Point Shear Wave Elastography of the Spleen: Its Role in Patients with Portal Hypertension
The goals of the study described here were to evaluate the feasibility and reproducibility of measuring spleen stiffness (SS) using point shear wave elastography in a series of cirrhotic patients and to investigate whether SS, liver stiffness (LS) and other non-invasive parameters are correlated with the presence of esophagogastric varices (EVs). Fifty-four cirrhotic patients with low-grade EVs or without EVs at esophago-gastro-duodenoscopy were enrolled. They underwent abdominal ultrasound and Doppler ultrasound of hepatic vessels simultaneously with p-SWE of the liver and spleen. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 16, 2018 Category: Radiology Authors: Natalie Lucchina, Chiara Recaldini, Monica Macchi, Valeria Molinelli, Mario Montanari, Sergio Segato, Raffaele Novario, Carlo Fugazzola Tags: Original Contribution Source Type: research

Quantitative Evaluation of Enzyme-Induced Porcine Articular Cartilage Degeneration Based on Observation of Entire Cartilage Layer Using Ultrasound
Enzyme-induced articular cartilage degeneration resembling osteoarthritis was evaluated using a newly defined acoustic parameter, the “averaged magnitude ratio” (AMR), which has been suggested as an indicator of articular cartilage degeneration. In vitro experiments were conducted on porcine cartilage samples digested with trypsin for 2 h (n = 10) and 4 h (n = 13) and healthy control samples (n = 13). AMR was d etermined with 15- and 25-MHz ultrasound, and the integrated reflection coefficient (IRC) and apparent integrated backscattering coefficient (AIB) ...
Source: Ultrasound in Medicine and Biology - January 15, 2018 Category: Radiology Authors: Jingchen Zhang, Liying Xiao, Lingying Tong, Chao Wan, Zhixiu Hao Tags: Original Contribution Source Type: research

Microvenous Reflux in the Skin of Limbs with Superficial Venous Incompetence
This study investigated whether microvenous reflux can be detected in limbs with chronic venous disease using superb microvascular imaging (SMI) and colour Doppler imaging. Participants with venous disease (limbs, n  = 26) and without venous disease (limbs, n = 10) were studied. The skin in the medial gaiter region was imaged using both SMI and colour Doppler to identify reflux in the small vessels in response to distal augmentation. The diameters and depths of responsive vessels were measured. In limbs with venous disease, reflux in response to provocation was visualised with SMI in a greater n...
Source: Ultrasound in Medicine and Biology - January 11, 2018 Category: Radiology Authors: Darshna Govind, Kate N. Thomas, Brigid G. Hill, Andre M. van Rij Tags: Original Contribution Source Type: research

Clinical Utility of Fetal Short-Lag Spatial Coherence Imaging
In this study, we evaluate the clinical utility of fetal short-lag spatial coherence (SLSC) imaging. Previous work has documented significant improvements in image quality with fetal SLSC imaging as quantified by measurements of contrast and contrast-to-noise ratio (CNR). The objective of this study was to examine whether this improved technical efficacy is indicative of the clinical utility of SLSC imaging. Eighteen healthy volunteers in their first and second trimesters of pregnancy were scanned using a modified Siemens SC2000 clinical scanner. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 11, 2018 Category: Radiology Authors: Will Long, Dongwoon Hyun, Kingshuk Roy Choudhury, David Bradway, Patricia McNally, Brita Boyd, Sarah Ellestad, Gregg E. Trahey Tags: Original Contribution Source Type: research

Assessment of Diastolic Function Using Ultrasound Elastography
In this study, we investigate the potential of SWEI for providing diastolic functional assessment. In 11 isolated rabbit hearts, pressure-volume (PV) measurements were recorded simultaneously with SWEI recordings from the left ventricle free wall before and after induction of global ischemia. PV-based end diastolic stiffness increased by 100% after ischemia (p   (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 10, 2018 Category: Radiology Authors: Maryam Vejdani-Jahromi, Jenna Freedman, Young-Joong Kim, Gregg E. Trahey, Patrick D. Wolf Tags: Original Contribution Source Type: research

Differentiation of Inflammatory From Fibrotic Ileal Strictures among Patients with Crohn's Disease Based on Visual Analysis: Feasibility Study Combining Conventional B-Mode Ultrasound, Contrast-Enhanced Ultrasound and Strain Elastography
The aim of this pilot study was to assess prospectively the feasibility of conventional B-mode ultrasound (US) and contrast-enhanced ultrasound (CEUS) combined with real-time strain elastography (SE) in the differentiation of inflammatory from fibrotic ileal strictures among patients with Crohn's disease (CD) based on visual analysis. Twenty non-consecutive patients (15 male and 5 female; mean age  ± standard deviation, 40.2 ± 10.22 y) with CD and stricture of the terminal ileal loop were scanned by conventional B-mode US and CEUS and, subsequently, by real-time SE. (Source: Ultras...
Source: Ultrasound in Medicine and Biology - January 10, 2018 Category: Radiology Authors: Emilio Quaia, Antonio Giulio Gennari, Maria Assunta Cova, Edwin J.R. van Beek Tags: Original Contribution Source Type: research

Assessing Risk Category of Breast Cancer by Ultrasound Imaging Characteristics
The purpose of our study was to assess the potential clinical value of ultrasound imaging in predicting risk category in patients with breast cancer. Three hundred thirty-six patients were enrolled and divided into a high-risk group (99, 29.5%) and mid- to low-risk group (237, 70.5%) according to the St. Gallen risk criteria. All data were retrospectively collected to analyze correlations between ultrasound features and risk category. The results revealed that the ultrasound features of irregular shape (p  = 0.002), vertical growth orientation (p = 0.002), angular contour (p = 0.02...
Source: Ultrasound in Medicine and Biology - January 10, 2018 Category: Radiology Authors: Qiang Guo, Lei Zhang, Zhixin Di, Chunping Ning, Zhiwu Dong, Ziyao Li, Dongmo Wang, Chong Liu, Ming Zhao, Jiawei Tian Tags: Original Contribution Source Type: research

Bubble-Induced Color Doppler Feedback Correlates with Histotripsy-Induced Destruction of Structural Components in Liver Tissue
In this study, BCD is used to monitor tissue fractionation during histotripsy tissue therapy, and the BCD signal is correlated with the destruction of structural and non-structural components identified histologically to further understand how BCD monitors the extent of treatment. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 9, 2018 Category: Radiology Authors: Jonathan J. Macoskey, Xi Zhang, Timothy L. Hall, Jiaqi Shi, Shahaboddin Alahyari Beig, Eric Johnsen, Fred T. Lee, Charles A. Cain, Zhen Xu Tags: Original Contribution Source Type: research

Motorizing and Optimizing Ultrasound Strain Elastography for Detection of Intrauterine Growth Restriction Pregnancies
Intrauterine growth restriction is a prevalent disease in pregnancy in which placental insufficiency leads to 5 to 10 times higher mortality and lifelong morbidities. The current detection rate is poor, and recently, ultrasound strain elastography (USEL) was proposed as a new diagnostic technique. Currently, placental USEL uses maternal subcutaneous fat as the reference layer, but this is not ideal as fat tissue stiffness can vary widely between subjects. Current USEL also uses manual palpation, and under different compression depths and rates, viscoelastic tissues such as placenta can yield different stiffness results. (S...
Source: Ultrasound in Medicine and Biology - January 9, 2018 Category: Radiology Authors: Shier Nee Saw, Jess Yi Ru Low, Citra Nurfarah Zaini Mattar, Arijit Biswas, Lujie Chen, Choon Hwai Yap Tags: Original Contribution Source Type: research

Preliminary Clinical Experience with a Combined Automated Breast Ultrasound and Digital Breast Tomosynthesis System
We analyzed the performance of a mammographically configured, automated breast ultrasound (McABUS) scanner combined with a digital breast tomosynthesis (DBT) system. The GE Invenia ultrasound system was modified for integration with GE DBT systems. Ultrasound and DBT imaging were performed in the same mammographic compression. Our small preliminary study included 13 cases, six of whom had contained invasive cancers. From analysis of these cases, current limitations and corresponding potential improvements of the system were determined. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 5, 2018 Category: Radiology Authors: Eric D. Larson, Won-Mean Lee, Marilyn A. Roubidoux, Mitchell M. Goodsitt, Chris Lashbrook, Cynthia E. Davis, Oliver D. Kripfgans, Paul L. Carson Tags: Technical Note Source Type: research

Low-Intensity Ultrasound Reduces High Glucose-Induced Nitric Oxide Generation in Retinal Pigment Epithelial Cells
In this study, we examined whether low-intensity ultrasound (LIUS) stimulation can reduce HG-induced NO generation. We determined that LIUS stimulation decreased the HG-induced NO generation possibly via inhibition of reactive oxygen species (ROS) and subsequently diminished the associated pro-inflammatory pathway involving the induced expression of inducible nitric oxide synthase, cyclooxygenase-2 and vascular endothelial growth factor. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 4, 2018 Category: Radiology Authors: Mrigendra Bir Karmacharya, Binika Hada, So Ra Park, Byung Hyune Choi Tags: Original Contribution Source Type: research

New Definition Criteria of Myocardial Dysfunction in Patients with Liver Cirrhosis: A Speckle Tracking and Tissue Doppler Imaging Study
There are no clear recommendations regarding cirrhotic cardiomyopathy (CC) evaluation in patients with pre-transplant liver cirrhosis. The roles of new methods, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) in the diagnosis and prognosis of cirrhotic cardiomyopathy remain controversial. We investigated the utility of TDI/STE parameters in cirrhotic cardiomyopathy diagnosis and also in predicting mortality in patients with liver cirrhosis. Left/right ventricular function was studied using conventional TDI (velocities) and STE (strain/strain rate). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 3, 2018 Category: Radiology Authors: Roxana Cristina Rimba ş, Sorina Mihăilă Baldea, Ruxandra Drăgoi Galrinho Antunes Guerra, Simona Ionela Visoiu, Mihai Rimbaş, Corina Silvia Pop, Dragoş Vinereanu Tags: Original Contribution Source Type: research

Combination of Sonoelastography and TIRADS for the Diagnostic Assessment of Thyroid Nodules
To evaluate the diagnostic performance of elastography alone and combined with Thyroid Imaging Reporting And Data System (TIRADS) for the assessment of non-autonomous thyroid nodules. We included 244 thyroid nodules and analyzed the visual elasticity scores, strain value (SV) and TIRADS classification. Histologic examination revealed 38 malignant (16%) and 206 benign nodules. The SV was lower in malignant nodules than in benign with an optimal cutoff ≤0.225. The visual elasticity scores showed a better diagnostic performance than the SV measurement. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 2, 2018 Category: Radiology Authors: Simone Schenke, Michael Zimny Tags: Original Contribution Source Type: research

Automated Visualization and Quantification of Spiral Artery Blood Flow Entering the First-Trimester Placenta, Using 3-D Power Doppler Ultrasound
The goal of our research was to quantify the placental vascularity in 3-D at 11 –13 + 6 wk of pregnancy at precise distances from the utero-placental interface (UPI) using 3-D power Doppler ultrasound. With this automated image analysis technique, differences in vascularity between normal and pathologic pregnancies may be observed. The algorithm was validated using a co mputer-generated image phantom and applied retrospectively in 143 patients. The following features from the PD data were recorded: The number of spiral artery jets into the inter-villous space, total geometric and PD area. (Source...
Source: Ultrasound in Medicine and Biology - January 2, 2018 Category: Radiology Authors: Gordon N. Stevenson, J. Alison Noble, Alec W. Welsh, Lawrence Impey, Sally L. Collins Tags: Original Contribution Source Type: research

Comparison between Several Ultrasound Hand Joint Scores and Conventional Radiography in Diagnosing Hand Osteoarthritis
This is the first study to investigate the usefulness of a standardized ultrasound (US) examination protocol in diagnosing hand osteoarthritis (OA). We conducted a cross-sectional study including 62 patients, ultimately diagnosed with hand OA based on imaging evidence of osteoarthritic changes with the particular distribution required for fulfilment of American College of Radiology diagnosis criteria. We compared a 32-joint US score (wrists, metacarpophalangeal [MCP], proximal interphalangeal [PIP] or distal interphalangeal [DIP] and carpometacarpal [CMC]-1 joints), with smaller, predefined joint scores, assessing 22 joint...
Source: Ultrasound in Medicine and Biology - December 27, 2017 Category: Radiology Authors: Priyanka Sivakumaran, Sidra Hussain, Coziana Ciurtin Tags: Original Contribution Source Type: research

The Dependence of Glomerular Capillary Hemorrhage Induced by Contrast Enhanced Diagnostic Ultrasound on Microbubble Diameter
A recently proposed two-criterion model for cavitational bioeffects in tissue with microbubbles (MBs) was tested. The glomerular capillary hemorrhage bioeffect was observed in rat kidney for contrast agent MB suspensions with mean diameters of 1.6, 3.1 and 5.5  µm. A diagnostic ultrasound machine was used at 3.6 MHz and 5.5 MHz for intermittent scans at power settings 2 dB apart. Petechial hemorrhage counts scored on the surface of the kidneys, and glomeruli were scored in histology. Thresholds for the petechial hemorrhage measurements were the s ame for the large and medium MB suspensions...
Source: Ultrasound in Medicine and Biology - December 26, 2017 Category: Radiology Authors: Douglas L. Miller, Xiaofang Lu, Chunyan Dou, Mario L. Fabiilli, Charles C. Church Tags: Original Contribution Source Type: research

Quantitative Analysis of Helical Flow with Accuracy Using Ultrasound Speckle Image Velocimetry: In Vitro and in Vivo Feasibility Studies
In this study, we used the ultrasound speckle image velocimetry (SIV) technique, which utilizes the speckle patterns of red blood cells (RBCs) created by ultrasound waves to measure 3-D valvular flows quantitatively. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - December 26, 2017 Category: Radiology Authors: Sang Joon Lee, Jun Hong Park, Jeong Ju Kim, Eunseop Yeom Tags: Original Contribution Source Type: research

Inter-Scan Reproducibility of Carotid Plaque Volume Measurements by 3-D Ultrasound
We tested a novel 3-D matrix transducer with respect to inter-scan reproducibility of carotid maximum plaque thickness (MPT) and volume measurements. To improve reproducibility while focusing on the largest plaque/most diseased part of the carotid artery, we introduced a new partial plaque volume (PPV) measure centered on MPT. Total plaque volume (TPV), PPV from a 10-mm segment and MPT were measured using dedicated semi-automated software on 38 plaques from 26 patients. Inter-scan reproducibility was assessed using the t-test, Bland –Altman plots and Pearson's correlation coefficient. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - December 25, 2017 Category: Radiology Authors: Benjamin V. Sandholt, Antoine Collet-Billon, Robert Entrekin, Henrik H. Sillesen Tags: Original Contribution Source Type: research