Simple Experimental Models for Elucidating the Mechanism Underlying Vertical Artifacts in Lung Ultrasound: Tools for Revisiting B-Lines
Using simple experimental models, we evaluated the generation, configuration and echo intensity of vertical artifacts by varying the point or plane of contact and height of objects that correspond to sources of vertical artifacts in the subpleural space. We used an ultrasound gel spot to imitate the source and a block of bacon as a chest wall phantom. As the size of the point of contact between the gel spot on the polypropylene sheet and the phantom decreased by peeling the sheet, a vertical artifact measuring ≤1 cm was generated and/or extended deeper, finally reaching 10 cm in depth. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 20, 2021 Category: Radiology Authors: Toru Kameda, Naohisa Kamiyama, Nobuyuki Taniguchi Tags: Original Contribution Source Type: research

Ultrasound Assessment of Plaque Characteristics to Predict Re-occlusion after Surgical Treatment of Internal Carotid Artery Occlusion
The purpose of this study was to explore the relationship between plaque characteristics and re-occlusion after surgical treatment of internal carotid artery occlusion (ICAO). From January 2015 to January 2021, 177 patients with ICAO underwent surgery. Eighty-five cases were included in the study, and in 13 of them, re-occlusion occurred within 6 mo after surgery treatment (13/85, 15.85%). The calcification at the base of the plaque was longer in the re-occlusion group than in the non-occlusion group (10.70 ± 4.22 mm vs. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 18, 2021 Category: Radiology Authors: Huanyan Liu, Yang Hua, Fubo Zhou, Jie Yang, Lingyun Jia, Liqun Jiao, Yan Ma Tags: Original Contribution Source Type: research

Sources of Variability in Shear Wave Speed and Dispersion Quantification with Ultrasound Elastography: A Phantom Study
There is a growing interest in quantifying shear-wave dispersion (SWD) with ultrasound shear-wave elastography (SWE). Recent studies suggest that SWD complements shear-wave speed (SWS) in diffuse liver disease diagnosis. To accurately interpret these metrics in clinical practice, we analyzed the impact of operator-dependent acquisition parameters on SWD and SWS measurements. Considered parameters were the acquisition depth, lateral position and size of the region of interest (ROI), as well as the size of the SWE acquisition box. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 18, 2021 Category: Radiology Authors: Naiara Korta Martiartu, Sherin Nambiar, Iara Nascimento Kirchner, Catherine Paverd, Davide Cester, Thomas Frauenfelder, Lisa Ruby, Marga B. Rominger Tags: Original Contribution Source Type: research

Strain Imaging in the Evaluation of Thyroid Nodules: The Associated Factors Leading to Misdiagnosis
This study analyzed which imaging characteristics may contribute to misdiagnosis of benign and malignant thyroid nodules (TNs) through strain imaging (SI). We analyzed SI parameters and conventional ultrasound (CUS) characteristics of 264 nodules with histopathology results and we applied binary logistic regression analysis to select independent variables for incorrect SI results. The elastography imaging (EI) score and the virtual touch tissue imaging (VTI) score of malignant TNs were remarkably higher than that in benign TNs. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 16, 2021 Category: Radiology Authors: Ye Han, Jia-Qi Wu, Xiu-Juan Hou, Jia-Wei Sun, Zhen-Ya Piao, Fei Teng, Xiao-Lei Wang Tags: Original Contribution Source Type: research

Automatic Extraction of Hiatal Dimensions in 3-D Transperineal Pelvic Ultrasound Recordings
The aims of this work were to create a robust automatic software tool for measurement of the levator hiatal area on transperineal ultrasound (TPUS) volumes and to measure the potential reduction in variability and time taken for analysis in a clinical setting. The proposed tool automatically detects the C-plane (i.e., the plane of minimal hiatal dimensions) from a 3-D TPUS volume and subsequently uses the extracted plane to automatically segment the levator hiatus, using a convolutional neural network. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 15, 2021 Category: Radiology Authors: Helena Williams, Laura Cattani, Dominique Van Schoubroeck, Mohammad Yaqub, Carole Sudre, Tom Vercauteren, Jan D'Hooge, Jan Deprest Tags: Original Contribution Source Type: research

Reliability of a New Semi-automatic Image Analysis Method for Evaluating the Doppler Signal and Intratendinous Vascular Resistance in Patellar Tendinopathy
The aim of this study was to determine the intra- and inter-rater reliability of a new semi-automatic image analysis method for quantification of the shape of the Doppler signal and the intratendinous vascular resistance in patellar tendinopathy. Thirty athletes (27.4 y, standard deviation  = 8.57 y) with patellar intratendinous vascularity were included in a cross-sectional study (42 tendons analyzed). The intratendinous blood flow was assessed with power Doppler and ImageJ (Version 1.50b, National Institutes of Health, Bethesda, MD, USA) quantification software over a manually sel ected region of interest. (Sou...
Source: Ultrasound in Medicine and Biology - September 15, 2021 Category: Radiology Authors: Francisco J. Molina-Pay á, José Ríos-Díaz, Francisco Carrasco-Martínez, Jacinto J. Martínez-Payá Tags: Original Contribution Source Type: research

Application of Ultrasonography in the Diagnosis of Rhabdomyolysis
Early diagnosis and treatment of rhabdomyolysis are very important, but difficult to achieve for some atypical cases. Our study was aimed at determining the diagnostic value of ultrasonography in rhabdomyolysis caused by different factors. The study enrolled 50 patients with rhabdomyolysis diagnosed in our hospital. Among the 50 cases (mean age  = 38.4 y, 22 women) of rhabdomyolysis, 26 cases (mean age = 35.5 y, 8 women) were induced by exercise. During the patients’ first visit, 5 cases (mean age = 30.6 y, 1 woman) were suspected of having rhabdomyolysis and were diagnosed by clinicians...
Source: Ultrasound in Medicine and Biology - September 15, 2021 Category: Radiology Authors: Qi Xu, Ming Tian, Jianguo Xia, Wenbin Zhu, Leilei Yang Tags: Original Contribution Source Type: research

Feasibility of Bilinear Mechanical Characterization of the Abdominal Aorta in a Hypertensive Mouse Model
This study was aimed at investigating the feasibility of monitoring the non-linear material behavior in an angiotensin II hypertensive mice model. Aortas from 13 hypertensive mice were imaged with pulse wave imaging (PWI) over 4 wk using a 40-MHz linear array. The pulse wave velocity was estimated using two wave features: (i) the maximum axial acceleration of the foot (PWVdia) and (ii) the maximum axial acceleration of the dicrotic notch (PWVend −sys). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 7, 2021 Category: Radiology Authors: Paul P.N. Kemper, Salah Mahmoudi, Iason Zacharias Apostolakis, Elisa E. Konofagou Tags: Original Contribution Source Type: research

Ultrasound Molecular Imaging for the Guidance of Ultrasound-Triggered Release of Liposomal Doxorubicin and Its Treatment Monitoring in an Orthotopic Prostatic Tumor Model in Rat
Liposome encapsulation of drugs is an interesting approach in cancer therapy to specifically release the encapsulated drug at the desired treatment site. In addition to thermo-, pH-, light-, enzyme- or redox-responsive liposomes, which have had promising results in (pre-) clinical studies, ultrasound-triggered sonosensitive liposomes represent an exciting alternative to locally trigger the release from these cargos. Localized drug release requires precise tumor visualization to produce a targeted and ultrasound stimulus. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 6, 2021 Category: Radiology Authors: Alexandre Helbert, Mathew von Wronski, Jean-Louis Mestas, Isabelle Tardy, Thierry Bettinger, Cyril Lafon, Jean-Marc Hyvelin, Fr édéric Padilla Tags: Original Contribution Source Type: research

Added Value of Superb Microvascular Imaging and Virtual Touch Imaging Quantification in Assisting Thyroid Cancer Classification
This prospective study determined the value added by superb microvascular imaging (SMI) and Virtual Touch imaging quantification (VTIQ) to conventional ultrasonography in classifying malignant and benign thyroid nodules. One hundred eighty-three thyroid nodules (TNs) in 120 patients (112 benign and 71 malignant TNs) were evaluated. SMI revealed noticeable variance between benign and malignant TNs (p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 3, 2021 Category: Radiology Authors: Yi-Cheng Zhu, Yuan Zhang, Jun Shan, Shu-Hao Deng, Xiu-Rong Shi, Quan Jiang Tags: Original Contribution Source Type: research

Angiosomes of the Ulnar Nerve at the Elbow: A Cadaver Trial Using Contrast-Enhanced Ultrasound
Three major arteries supplying the ulnar nerve in the cubital tunnel are commonly known. However, their vascular territories (angiosomes) have not been described yet. Contrast-enhanced ultrasound was used to identify the angiosomes of posterior ulnar recurrent artery, inferior ulnar collateral artery and superior ulnar collateral artery in 20 fresh, non-frozen human body donors. The arteries were cannulated, and physiologic blood flow was simulated. Contrast agent was applied in each vessel in a randomized sequence, and the length of the contrast-enhancing ulnar nerve segment was measured by a radiologist blinded to the se...
Source: Ultrasound in Medicine and Biology - August 31, 2021 Category: Radiology Authors: Tobias Rossmann, Lukas F. Reissig, Wolfgang K. Pfisterer, Wolfgang Grisold, Wolfgang J. Weninger, Stefan Meng Tags: Original Contribution Source Type: research

Lung Ultrasound Severity Index: Development and Usefulness in Patients with Suspected SARS-Cov-2 Pneumonia. A Prospective Study
COVID-19 spreads across the world with a strong impact on populations and health systems. Lung Ultrasound is increasingly employed in clinical practice but a standard approach and data about the accuracy of Lung Ultrasound are still needed. Our study's objective is to evaluate Lung Ultrasound diagnostic and prognostic characteristics in patients with suspected COVID-19. We conducted a monocentric, prospective, observational study. Patients with respiratory distress and suspected COVID-19 consecutively admitted in the Emergency Medicine Unit were enrolled. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2021 Category: Radiology Authors: Michele Domenico Spampinato, Andrea Sposato, Maria Teresa Migliano, Giovanni Gordini, Vincenzo Bua, Soccorsa Sofia Tags: Original Contribution Source Type: research

Value of Low-Mechanical-Index Contrast-Enhanced Transabdominal Ultrasound for Diagnosis of Pancreatic Cancer: A Meta-analysis
The incidence and mortality rates of pancreatic cancer (PC) are increasing. It is important to discriminate PC from the other pancreatic lesions; however, differential diagnosis based on conventional transabdominal ultrasound (US) remains challenging even though US is often the first examination performed. Transabdominal contrast-enhanced ultrasound (CEUS) has high diagnostic accuracy for PC. This meta-analysis aimed to examine the utility of low-mechanical-index CEUS with enhancement for PC diagnosis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 28, 2021 Category: Radiology Authors: Yasunobu Yamashita, Toshio Shimokawa, Reiko Ashida, Christoph F. Dietrich, Mirko D'Onofrio, Yoshiki Hirooka, Masatoshi Kudo, Hideaki Mori, Atsushi Sofuni, Masayuki Kitano Tags: Review Article Source Type: research

Utility of B-Mode, Color Doppler and Elastography in the Diagnosis of Breast Cancer: Results of the CD-CONFIRM Multicenter Study of 1351 Breast Solid Masses
The usefulness of color Doppler ultrasound (CD) in distinguishing between benign and malignant breast lesions remains controversial. Our prior study, the Japan Association of Breast and Thyroid Sonology (JABTS) BC-04 study (malignant: 839, benign: 569), found CD was useful in breast cancer diagnosis, and we developed CD diagnostic criteria. The first aim of the current study (the CD-CONFIRM study) was to evaluate the usefulness of the CD diagnostic criteria. The second aim was to evaluate the relationship between CD and elastography. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 27, 2021 Category: Radiology Authors: Takanori Watanabe, Takuhiro Yamaguchi, Toshitaka Okuno, Sachiyo Konno, Rie Takaki, Megumi Sato, Masahiko Tsuruoka, Hideaki Shirai, Yukari Ogawa, Kanako Ban, Yasuhisa Fujimoto, Koichi Hirokaga, Ryoji Watanabe, Takako Morita Tags: Original Contribution Source Type: research

Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study
This study aimed to investigate left atrium (LA) strain components in the assessment of cardiac function and its clinical correlates in pre-eclampsia (PE). With the use of speckle tracking echocardiography, phasic LA strain and (LASr)/(E/e'), the surrogate of LA compliance, were compared between healthy pregnant women (n  = 70) and those with PE (n = 146) and among different diastolic dysfunction (DD) grades in PE. Receiver operating characteristic curves and logistic regression analysis were used to identify the role of strain components in distinguishing DD grades and predicting cardiac complications....
Source: Ultrasound in Medicine and Biology - August 27, 2021 Category: Radiology Authors: Rui Li, Fei Sun, Shunfu Piao, Xiangqin He, Rong Li, Lin Xu, Guanghui Song, Juan Cong Tags: Original Contribution Source Type: research

Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors
In this study, we investigated the feasibility of treating primary OS tumors with histotripsy using a 500-kHz transducer on excised canine OS samples harvested after surgery at the Veterinary Teaching Hospital at Virginia Tech. Samples were embedded in gelatin tissue phantoms and treated with the 500-kHz histotripsy system using one- or two-cycle pulses at a pulse repetition frequency of 250 Hz and a dosage of 4000 pulses/point. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 27, 2021 Category: Radiology Authors: Lauren Arnold, Alissa Hendricks-Wenger, Sheryl Coutermarsh-Ott, Jessica Gannon, Alayna N. Hay, Nikolaos Dervisis, Shawna Klahn, Irving C. Allen, Joanne Tuohy, Eli Vlaisavljevich Tags: Original Contribution Source Type: research

Acoustic Droplet Vaporization of Perfluorocarbon Droplets in 3D-Printable Gelatin Methacrylate Scaffolds
Scientists face a significant challenge in creating effective biomimetic constructs in tissue engineering with sustained and controlled delivery of growth factors. Recently, the addition of phase-shift droplets inside the scaffolds is being explored for temporal and spatial control of biologic delivery through vaporization using external ultrasound stimulation. Here, we explore acoustic droplet vaporization (ADV) in gelatin methacrylate (GelMA), a popular hydrogel used for tissue engineering applications because of its biocompatibility, tunable mechanical properties and rapid reproducibility. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 26, 2021 Category: Radiology Authors: Jenna Osborn, Megan S. Anderson, Morgan Beddingfield, Lijie Grace Zhang, Kausik Sarkar Tags: Original Contribution Source Type: research

Evaluation of Robustness of Local Phase Velocity Imaging in Homogenous Tissue-Mimicking Phantoms
Shear wave elastography (SWE) is a method of evaluating mechanical properties of soft tissues. Most current implementations of SWE report the group velocity for shear wave velocity, which assumes an elastic, isotropic, homogenous and incompressible tissue. Local phase velocity imaging (LPVI) is a novel method of phase velocity reconstruction that allows for accurate evaluation of shear wave velocity at specified frequencies. This method's robustness was evaluated in 11 elastic and 8 viscoelastic phantoms using linear and curvilinear arrays. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 26, 2021 Category: Radiology Authors: Benjamin G. Wood, Piotr Kijanka, Hsiao-Chuan Liu, Matthew W. Urban Tags: Original Contribution Source Type: research

Masthead
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Source: Ultrasound in Medicine and Biology - August 25, 2021 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 25, 2021 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 25, 2021 Category: Radiology Source Type: research

Calendar
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Source: Ultrasound in Medicine and Biology - August 25, 2021 Category: Radiology Source Type: research

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study
In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1 °C, no vessel damage as assessed by histology and no downstream clot particles>500 µm. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 23, 2021 Category: Radiology Authors: Leela Goel, Huaiyu Wu, Bohua Zhang, Jinwook Kim, Paul A. Dayton, Zhen Xu, Xiaoning Jiang Tags: Original Contribution Source Type: research

Effect of Extracorporeal Shock Wave Therapy on Muscle Mass and Function in Patients Undergoing Maintenance Hemodialysis: A Randomized Controlled Pilot Study
This study was aimed at evaluating the effect of radial extracorporeal shock wave therapy (rESWT) on muscle mass and function in patients on MHD. This single blind controlled study was conducted on patients on MHD from September 2018 to December 2019. Eighteen patients were enrolled in the rESWT and control groups. rESWT was performed once a week for 12 wk in both quadriceps femoris muscles of the ESWT group. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 23, 2021 Category: Radiology Authors: Yoon Soo Cho, So Young Joo, Eun Kyung Lee, Youn Kyung Kee, Cheong Hoon Seo, Do Hyoung Kim Tags: Clinical Note Source Type: research

Statistical Analysis of Ultrasonic Scattered Echoes Enables the Non-invasive Measurement of Temperature Elevations inside Tumor Tissue during Oncological Hyperthermia
We report the results of our clinical trial study in which the temperature increases inside the tumor tissues of patients with right renal cell carcinoma and pseudomyxoma peritonei induced by radiofrequency current irradiation for 40 min could be detected by statistical analysis of ultrasonic scattered echoes. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 23, 2021 Category: Radiology Authors: Michio Takeuchi, Toshihiko Sakai, Gabor Andocs, Tsuyoshi Takanaka, Masashi Taka, Kuniko Yamashita, Masahiro Kawahara, Tomoko Nojiri, Asaka Tanaka, Azusa Norishima, Yoshitaka Omoto, Masaaki Omura, Ryo Nagaoka, Keizo Takao, Hideyuki Hasegawa Tags: Technical Note Source Type: research

Contrast-Enhanced Ultrasound: A Viable Diagnostic Tool in Predicting Treatment Failure after Non-union Revision Surgery for Upper- and Lower-Limb Non-unions
Non-unions remain a major complication in the treatment of long-bone fractures and affect quality of life considerably. Both early detection and treatment of non-unions are essential to secure subsequent fracture union. Sufficient vascularization plays a key role in the healing process. The aim of this prospective study was to quantify the microperfusion within non-unions by means of contrast-enhanced ultrasound (CEUS) as early as 12 wk after non-union surgery and to examine the prognostic capability of CEUS in predicting treatment failure. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2021 Category: Radiology Authors: Julian Doll, Stefan Waizenegger, Gerhard Schmidmaier, Marc-Andr é Weber, Christian Fischer Tags: Original Contribution Source Type: research

Clinical Application of Transabdominal Ultrasound Combined with PICCO in Septic Shock Fluid Resuscitation and Its Predictive Value for Survival Outcome
To investigate the clinical value of transabdominal ultrasound combined with pulse index continuous cardiac output (PICCO) in fluid resuscitation of septic shock patients, and to analyze the predictive value of survival outcomes, 68 patients with septic shock were randomly divided into the ultrasound + PICCO group and PICCO group. Compared with before treatment, blood lactic acid (BLA) was cleared, and central venous pressure (CVP) and oxygenation index were significantly increased in all patients. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2021 Category: Radiology Authors: Yongyuan Yao, Meng Su, Yanyan Guan, Xingxiao Gao, Wei Liu, Yunbo Sun Tags: Original Contribution Source Type: research

Ultrasound Protocols to Assess Skeletal and Diaphragmatic Muscle in People Who Are Critically Ill: A Systematic Review
This study aims to review published studies that use protocols and ultrasound measurements to evaluate skeletal and diaphragmatic muscles in patients who are critically ill. We searched for references on databases through September 2020 and included in our systematic review studies that used muscular ultrasound to assess skeletal or diaphragm muscles in patients who are critically ill. Seventy-six studies were included, 32 (1720 patients) using skeletal-muscle ultrasound and 44 (2946 patients) using diaphragmatic-muscle ultrasound, with a total of 4666 patients. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 18, 2021 Category: Radiology Authors: Ta ís Silva Nascimento, Rodrigo Santos de Queiroz, Ana Carolina Conceição Ramos, Bruno Prata Martinez, Cássio Magalhães Da Silva e Silva, Mansueto Gomes-Neto Tags: Review Article Source Type: research

Contrast-Enhanced Ultrasound Patterns for the Non-invasive Diagnosis of Hepatocellular Carcinoma: A Prospective Multicenter Study in Histologically Proven Liver Lesions in a Real-Life Setting Demonstrating the Benefit of Extended Late Phase Observation
The hallmark for the non-invasive diagnosis of hepatocellular carcinoma (HCC) with contrast-enhanced ultrasound (CEUS) in cirrhosis is arterial phase hyperenhancement (APHE), followed by late-onset (>60 s), mild washout. Large retrospective studies report this pattern of washout to occur in the vast majority of HCCs. However, a prospective multicenter validation of these findings is still missing. Thus, we initiated a prospective multicenter validation study assessing CEUS enhancement patterns in focal liver lesions of patients at risk for HCC. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 18, 2021 Category: Radiology Authors: Barbara Schellhaas, Thomas Bernatik, Klaus Dirks, Daniel Jesper, Martin Mauch, Andrej Potthoff, Patrick Zimmermann, Deike Strobel Tags: Original Contribution Source Type: research

Using Ultrasound Color Doppler Twinkling to Identify Biopsy Markers in the Breast and Axilla
In breast radiology, ultrasound detection of biopsy markers or clips for localization purposes is often challenging, especially in the axilla. The purpose of this research was to test the hypothesis that the surface roughness of biopsy clips would elicit a twinkling signature on color Doppler, making them more readily identifiable by ultrasound. Ultrasound color Doppler imaging of 12 biopsy markers was performed and consensus scoring of the degree of twinkling (0 [no twinkling] to 4 [exuberant twinkling]) was obtained for each of the markers. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 16, 2021 Category: Radiology Authors: Christine U. Lee, Gina K. Hesley, Susheil Uthamaraj, Nicholas B. Larson, James F. Greenleaf, Matthew W. Urban Tags: Original Contribution Source Type: research

Quantitative Evaluation of Renal Cortex Perfusion Using Contrast-Enhanced Ultrasound Imaging Parameters in Ischemia –Reperfusion Injury in Rabbits
The aim of this study was to evaluate blood perfusion of the renal cortex during ischemia –reperfusion (I/R) injury using quantitative contrast-enhanced ultrasound (CEUS) parameters. In this experiment, 24 rabbits were randomly divided into four groups (N = 6): sham-operated group, 24-h post-operation for I/R injury group (24-h I/R), 3-d post-operation for I/R injury group (3-d I/R) and 5 d post-operation for I/R injury group (5 d I/R). All quantitative CEUS parameters were monitored and included the gradient from the start frame to the peak frame (Grad), area under the curve (Area), time-to-peak (TTP), dif...
Source: Ultrasound in Medicine and Biology - August 13, 2021 Category: Radiology Authors: Zhijian Luo, Yulu Liu, Ziyi Tang, Jialing Liu, Xuemei Xu, Mingxing Li, Yan Dai Tags: Original Contribution Source Type: research

Operator Evaluation of Ultrasound Fusion Imaging Usefulness in the Percutaneous Ablation of Hepatic Malignancies: A Prospective Study
The purpose of the work described here was to evaluate the use of ultrasound fusion imaging (US-FI) in percutaneous ablation of hepatic malignancies with respect to its global usefulness, improvement of conspicuity, confidence increment, needle route changes, and time savings. Thirty-four hepatic tumors (28 hepatocellular carcinomas, 6 metastases) were prospectively ablated in 16 consecutive patients (64 ± 11 y, 75% males), first simulating B-mode-only planning and then synchronizing computed tomography/magnetic resonance images with US and proceeding to needle insertion and tumor ablation under US-FI guidance. (Sou...
Source: Ultrasound in Medicine and Biology - August 12, 2021 Category: Radiology Authors: Alessandro Bele ù, Alessandro Drudi, Alvise Giaretta, Riccardo De Robertis, Ilaria Fedrigo, Enrico Martone, Conci Simone, Chiara Bovo, Mirko D'Onofrio Tags: Original Contribution Source Type: research

Quality Assurance of Segmental Strain Values Provided by Commercial 2-D Speckle Tracking Echocardiography Using in Silico Models: A Report from the EACVI-ASE Strain Standardization Task Force
The aim of this study was to determine the accuracy and reproducibility of vendor-specific regional strain values by echocardiography using in silico data. Synthetic 2-D ultrasound gray-scale images of the left ventricle (LV) were generated with knowledge of the longitudinal segmental strain values from the underlying electromechanical LV model. Four of five models mimicked transmural infarctions with systolic segmental stretching in different vascular areas. Cine loops in the three apical views were synthetically generated at four noise levels. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 12, 2021 Category: Radiology Authors: Assami R øsner, Martino Alessandrini, Didrik Kjønås, Oana Mirea, Sandro Queirós, Jan D`hooge Tags: Original Contribution Source Type: research

Focal Bone-Marrow Defects in the Jawbone Determined by Ultrasonography —Validation of New Trans-Alveolar Ultrasound Technique for Measuring Jawbone Density in 210 Participants
The objective was to determine whether TAU-n readings accurately indicate the clinical parameters to detect BMDJ/FDOJ. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 12, 2021 Category: Radiology Authors: Johann Lechner, Bernd Zimmermann, Marlene Schmidt Tags: Original Contribution Source Type: research

Multi-View 3-D Fusion Echocardiography: Enhancing Clinical Feasibility with a Novel Processing Technique
A novel system for fusing 3-D echocardiography data sets from complementary acoustic windows was evaluated in 12 healthy volunteers and 12 patients with heart failure. We hypothesized that 3-D fusion would enable 3-D echocardiography in patients with limited acoustic windows. At least nine 3-D data sets were recorded, while three infrared cameras tracked the position and orientation of the transducer and chest respiratory movements. Corresponding 2-D planes of the fused 3-D data sets and of single-view 3-D data sets were assessed for image quality and compared with measurements of left ventricular function obtained with co...
Source: Ultrasound in Medicine and Biology - August 10, 2021 Category: Radiology Authors: Tyler Lamb, Victoria Sarban, Miriam Shanks, Eila Mirhadi, Abhilash Hareendranathan, Michelle Noga, Kumaradevan Punithakumar, Pierre Boulanger, Harald Becher Tags: Original Contribution Source Type: research

Dynamic Filtering of Adherent and Non-adherent Microbubble Signals Using Singular Value Thresholding and Normalized Singular Spectrum Area Techniques
In this study, the image filtering techniques of singular value thresholding (SVT) and normalized singular spectrum area (NSSA) were combined to isolate and identify vascular endothelial growth factor receptor 2-targeted microbubbles in a mouse hindlimb tumor model (n  = 24). By use of a Verasonics Vantage 256 imaging system with an L12-5 transducer, a custom-programmed pulse inversion sequence employing synthetic aperture virtual source element imaging was used to collect contrast images of mouse tumors perfused with microbubbles. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2021 Category: Radiology Authors: Elizabeth B. Herbst, Alexander L. Klibanov, John A. Hossack, F. William Mauldin Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Source Type: research

Evaluation of Pre-malignant Lesions of the Uterine Cervix by Shear Wave Elastography: A New Diagnostic Tool
The objective of the study was to evaluate the difference in the stiffness between a healthy cervix (no pre-invasive lesions [NPILs]) and a cervix with a pre-invasive lesion (PIL). In the PIL group, we determined whether there was a difference in stiffness between the cervix with persistent low-grade lesions (>2 y, LSIL-persistent) and that with high-grade lesions (HSILs). Evaluation was performed using 2-D shear-wave elastography (SWE) in the midsagittal-plane of the uterine cervix (UC) at 0.5 cm (cervical canal, anterior and posterior cervical lips). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Authors: Jos é Antonio Sainz, Laura Castro, José María Romo, Ainhoa Holgado, Ana Fernández-Palacín, José Antonio García-Mejido Tags: Clinical Note Source Type: research

Improved Ultrasound Attenuation Measurement Method for the Non-invasive Evaluation of Hepatic Steatosis Using FibroScan
This study assessed the performance of a new CAP method by ex vivo and in vivo assessments. The major difference with the new method is that it uses ultrasound data continuously acquired during the imaging phase of the FibroScan examination. Seven reference tissue-mimicking phantoms were used to test the performance. In vivo performance was assessed in two cohorts (in total 195 patients) of patients using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as a reference. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2021 Category: Radiology Authors: St éphane Audière, Aymeric Labourdette, Véronique Miette, Céline Fournier, Redouane Ternifi, Salem Boussida, Philippe Pouletaut, Fabrice Charleux, Sabine F. Bensamoun, Stephen A. Harrison, Laurent Sandrin Tags: Original Contribution Source Type: research

Strain Estimation of the Murine Right Ventricle Using High-Frequency Speckle-Tracking Ultrasound
Right ventricular (RV) strain measurements from ultrasound via speckle-tracking techniques are being used more frequently as a non-invasive diagnostic tool for a variety of cardiopulmonary pathologies. However, despite the clinical utility of ultrasound RV strain measurements, quantification of RV strain in rodents remains difficult owing to unique image artifacts and non-standardized methodologies. We demonstrate here a simple approach for measuring RV strain in both mice and rats using high-frequency ultrasound and automated speckle tracking. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2021 Category: Radiology Authors: Conner C. Earl, Frederick W. Damen, Melissa Yin, Kristiina L. Aasa, Sarah K. Burris, Craig J. Goergen Tags: Technical Note Source Type: research

In Memoriam: Morimichi Fukuda (1929 –2021)
Dr. Morimichi Fukuda passed away on April 1, 2021. We express our deepest condolences to his family and friends and express our sincere gratitude to him for his contributions. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2021 Category: Radiology Authors: Hiroshi Natori Tags: Obituary Source Type: research

Pleural Effusions Identified by Point-of-Care Ultrasound Predict Poor Outcomes in Decompensated Cirrhosis
This article prospectively evaluates whether detection of PEs on thoracic ultrasound (TUS) at the bedside independently predicts mortality and length of stay (LOS) in hospitalized patients with a decompensated CLD. A total of 116 consecutive inpatients with decompensated cirrhosis underwent antero-posterior chest radiographs (CXR) and TUS to detect PEs. Their median age was 54 y (interquartile range, 47 –62), 90 (70.6%) were male, and 61 (52.6%) fell into the Child-Pugh class C categorization. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2021 Category: Radiology Authors: Erick Joel Rend ón-Ramírez, Marusia González-Villarreal, Linda Elsa Muñoz-Espinoza, Perla Rocío Colunga–Pedraza, Juan Francisco Moreno, Matias Salinas-Chapa, Roberto Mercado-Longoria, Karla Belén Treviño-García, Erika Cazares-Rendón, José M. P Tags: Clinical Note Source Type: research

Safety of Image-Guided Treatment of the Liver with Ultrasound and Microbubbles in an in Vivo Porcine Model
Ultrasound and microbubbles are useful for both diagnostic imaging and targeted drug delivery, making them ideal conduits for theranostic interventions. Recent reports have indicated the preclinical success of microbubble cavitation for enhancement of chemotherapy in abdominal tumors; however, there have been limited studies and variable efficacy in clinical implementation of this technique. This is likely because in contrast to the high pressures and long cycle lengths seen in successful preclinical work, current clinical implementation of microbubble cavitation for drug delivery generally involves low acoustic pressures ...
Source: Ultrasound in Medicine and Biology - August 4, 2021 Category: Radiology Authors: Sara B. Keller, Yak-Nam Wang, Stephanie Totten, Raymond S. Yeung, Michalakis A. Averkiou Tags: Original Contribution Source Type: research

Chemotherapy Augmentation Using Low-Intensity Ultrasound Combined with Microbubbles with Different Mechanical Indexes in a Pancreatic Cancer Model
The aim of the study was to explore the optimal mechanical indexes (MIs) for low-intensity ultrasound (LIUS) combined with microbubbles to enhance tumor blood perfusion and improve drug concentration in pancreatic cancer-bearing nude mice. Fifty-four nude mice bearing bilateral pancreatic tumors on the hind legs were randomly divided into three groups (the MI was set at 0.3, 0.7 and 1.1 in groups A, B and C, respectively). Five nude mice in each group were intravenously injected with the fluorescent dye DiR iodide (DiIC18(7),1,1 ′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide); for each mous...
Source: Ultrasound in Medicine and Biology - August 4, 2021 Category: Radiology Authors: Shuang Feng, Wei Qiao, Jiawei Tang, Yanlan Yu, Shunji Gao, Zheng Liu, Xiansheng Zhu Tags: Original Contribution Source Type: research

Models for Predicting Sentinel and Non-sentinel Lymph Nodes Based on Pre-operative Ultrasonic Breast Imaging to Optimize Axillary Strategies
Axillary strategy decisions have become more complex and controversial in considering minimally traumatic therapy instead of sentinel lymph node biopsy, axillary lymph node dissection or regional nodal irradiation for people with breast cancer. The purpose of this study was to noninvasively predict sentinel lymph node (SLN) and non-sentinel lymph node (NSLN) status based on pre-operative sonographic and clinicopathologic features to determine optimal decisions regarding axillary therapy. In total, 701 patients with breast cancer from two independent centers were retrospectively analyzed. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 3, 2021 Category: Radiology Authors: Dongmei Liu, Xia Li, Yujia Lan, Lei Zhang, Tong Wu, Hao Cui, Ziyao Li, Ping Sun, Peng Tian, Jiawei Tian Tags: Original Contribution Source Type: research

Efficacy of Ultrasound-Guided Peripheral Intravenous Cannulation versus Standard of Care: A Systematic Review and Meta-analysis
Peripheral intravenous cannulation (PIV) is a common and necessary procedure in the emergency department (ED). Patients with PIV access encounter significant treatment delay. Ultrasound guidance for PIV (USGPIV) cannulation is a modality to reduce delay of care in such patients, but its efficacy, when compared with cannulation by the standard of care (SOC), the landmark and palpation method, has not been well established. We performed a random effects meta-analysis of available literature that compared USGPIV with SOC cannulation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 3, 2021 Category: Radiology Authors: Quincy K. Tran, Matthew Fairchild, Isha Yardi, Danielle Mirda, Katherine Markin, Ali Pourmand Tags: Review Source Type: research

Skills Classification in Cardiac Ultrasound with Temporal Convolution and Domain Knowledge Using a Low-Cost Probe Tracker
As point-of-care ultrasound (POCUS) becomes more integrated into clinical practice, it is essential to address all aspects of ultrasound operator proficiency. Ultrasound proficiency requires the ability to acquire, interpret and integrate bedside ultrasound images. The difference in image acquisition psychomotor skills between novice (trainee) and expert (instructor) ultrasonographer has not been described. We created an inexpensive system, called Probe Watch, to record probe motion and assess image acquisition in cardiac POCUS using an inertial measurement device and software for data recording based on open-source compon...
Source: Ultrasound in Medicine and Biology - August 2, 2021 Category: Radiology Authors: Matthew S. Holden, Alberto Portillo, Gerard Salame Tags: Original Contribution Source Type: research