Evaluation of Placental Micro-vascularization by Superb Micro-vascular Imaging Doppler in Cases of Intra-uterine Growth Restriction: A First Step
In this study, we present the application of SMI Doppler to assess placental micro-vascularization in cases of placental insufficiency. We observed fewer secondary and tertiary villi in cases of intra-uterine growth restriction, as well as a lower pulsatile index of secondary villi. The observations made in our study stress the diagnostic potential of SMI Doppler in placental insufficiency. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 27, 2021 Category: Radiology Authors: Roc ío García-Jiménez, Eva Arroyo, Carlota Borrero, José Antonio Garcia-Mejido, Francisco Sosa, Ana Fernández-Palacín, José Antonio Sainz Tags: Original Contribution Source Type: research

The Asian Federation of Societies for Ultrasound in Medicine and Biology (AFSUMB) Guidelines for Contrast-Enhanced Endoscopic Ultrasound
The Asian Federation of Societies for Ultrasound in Medicine and Biology aimed to provide information on techniques and indications for contrast-enhanced harmonic endoscopic ultrasound (CH-EUS), and to create statements including the level of recommendation. These statements are based on current scientific evidence reviewed by a Consensus Panel of 15 internationally renowned experts. The reliability of clinical questions was measured by agreement rates after voting. Six statements were made on techniques, including suitable contrast agents for CH-EUS, differences between contrast agents, setting of mechanical index, dual i...
Source: Ultrasound in Medicine and Biology - February 27, 2021 Category: Radiology Authors: Masayuki Kitano, Yasunobu Yamashita, Ken Kamata, Tiing Leong Ang, Hiroo Imazu, Eizaburo Ohno, Yoshiki Hirooka, Pietro Fusaroli, Dong-Wan Seo, Bertrand Napol éon, Anthony Yuen Bun Teoh, Tae Hyeon Kim, Christoph F. Dietrich, Hsiu-Po Wang, Masatoshi Kudo, W Tags: Review Article Source Type: research

Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy
Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor cells and the vasculature. However, hypoxic regions in the tumor have been shown to not only decrease treatment response but also increase the likelihood of recurrence and metastasis. Ultrasound-sensitive micro-bubbles are emerging as a useful diagnostic and therapeutic tool within RT. Contrast-enhanced ultrasound (CEUS) has shown great promise in early prediction of tumor response to RT. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 27, 2021 Category: Radiology Authors: Quezia Lacerda, Mohamed Tantawi, Dennis B. Leeper, Margaret A. Wheatley, John R. Eisenbrey Tags: Original Contribution Source Type: research

The Possibilities of Using Ultrasonically Activated Streams to Reduce the Risk of Foodborne Infection from Salad
In this study, we investigated the effects of an ultrasonically activated stream (UAS) on the removal of microbial contaminants from spinach leaves. The microbial loads on samples cleaned with and without UAS were enumerated using the cell culture method and compared against unwashed samples on day 0 and day 6 after cleaning. The effects of UAS cleaning on leaf quality were also examined through both macroscopic and microscopic inspection, as well as measurement of the electrolyte leakage rate. Results showed that the microbial load on samples cleaned with UAS for 2 min was significantly lower on day 6 after cleaning than ...
Source: Ultrasound in Medicine and Biology - February 25, 2021 Category: Radiology Authors: Weng Yee Chong, Thomas J. Secker, Craig N. Dolder, Charles W. Keevil, Timothy G. Leighton Tags: Original Contribution Source Type: research

Effects of Lung Ultrasonography-Guided Management on Cumulative Fluid Balance and Other Clinical Outcomes: A Systematic Review
Lung ultrasonography is accurate in detecting pulmonary edema and overcomes most limitations of traditional diagnostic modalities. Whether use of lung ultrasonography-guided management has an effect on cumulative fluid balances and other clinical outcomes remains unclear. In this systematic review, we included 12 studies using ultrasonography guided-management with a total of 2290 patients. Four in-patient studies found a reduced cumulative fluid balance (ranging from –0.3 L to –2.4 L), whereas three out-patient studies found reduction in dialysis dry weight (ranging from –2.6 kg to –0.2 kg) compare...
Source: Ultrasound in Medicine and Biology - February 23, 2021 Category: Radiology Authors: Micah L.A. Heldeweg, Ameet R. Jagesar, Mark E. Haaksma, Jasper M. Smit, Frederique Paulus, Marcus J. Schultz, Pieter R. Tuinman Tags: Original Contribution Source Type: research

Evaluation of Schistosomiasis Mansoni Morbidity by Hepatic and Splenic Elastography
This study aimed to evaluate the morbidity of schistosomiasis by hepatic and splenic point shear-wave elastography (pSWE) and relate this to US parameters. The PPF pattern, the diameter of the portal and splenic veins and the size of the spleen were evaluated by US. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 20, 2021 Category: Radiology Authors: Caroline Louise Diniz Pereira, Joelma Carvalho Santos, Raissa Melo Arruda, Milena Lima Rodrigues, Eduardo Sampaio Siqueira, Roberto Souza Lemos, Andrea D ória Batista, Ana Lúcia Coutinho Domingues, Edmundo Pessoa Lopes Tags: Original Contribution Source Type: research

Transcranial Focused Ultrasound Enhances Sensory Discrimination Capability through Somatosensory Cortical Excitation
In this study, healthy human subjects (N  = 9) were asked to perform tactile vibration frequency discrimination tasks while tFUS was directed onto the primary somatosensory cortex. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 20, 2021 Category: Radiology Authors: Chang Liu, Kai Yu, Xiaodan Niu, Bin He Tags: Original Contribution Source Type: research

Mutual Information Reveals Non-linear Relationships between Electrocardiographic Conduction or Repolarization Indices and Mechanical Dispersion by Speckle-Tracking Echocardiography in the General Population
Electrical inhomogeneities can lead to regional heterogeneity in left ventricular contraction. We investigated the correlation between electrocardiographic parameters of conduction and/or repolarization and myocardial longitudinal strain-derived parameters in a general population. Mean and dispersion (maximum –minimum) values were calculated for the electrocardiographic indices: QT interval, Tpeak–Tend interval (Tpe), JTpeak interval (JTp), JTend interval (JTe), QTpeak interval (QTp). Mechanical dispersion was assessed using the standard deviation (SD) of time-to-peak longitudinal strains (MDSD) and the differe...
Source: Ultrasound in Medicine and Biology - February 20, 2021 Category: Radiology Authors: Ana Ciobanu, Gabriela Silvia Gheorghe, Oana Mihaela In ţă, Jiandong Zhou, Qingpeng Zhang, Gary Tse Tags: Original Contribution Source Type: research

MR versus CEUS LI-RADS for Distinguishing Hepatocellular Carcinoma from other Hepatic Malignancies in High-Risk Patients
This study evaluated the performance of the Liver Imaging Reporting and Data System (LI-RADS) using magnetic resonance imaging (MRI) versus contrast-enhanced ultrasonography (CEUS) for differentiating HCC from OMs in patients at high risk for HCC. This retrospective study consecutively enrolled 106 high-risk patients with HCC and 52 high-risk patients with OMs. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 18, 2021 Category: Radiology Authors: Zhe Huang, PingPing Zhou, ShanShan Li, Kaiyan Li Tags: Original Contribution Source Type: research

Masthead
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Source: Ultrasound in Medicine and Biology - February 16, 2021 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 16, 2021 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 16, 2021 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 16, 2021 Category: Radiology Source Type: research

Focused Ultrasound and Microbubble Treatment Increases Delivery of Transferrin Receptor-Targeting Liposomes to the Brain
The blood-brain barrier (BBB) is a major obstacle to treating several brain disorders. Focused ultrasound (FUS) in combination with intravascular microbubbles increases BBB permeability by opening tight junctions, creating endothelial cell openings, improving endocytosis and increasing transcytosis. Here we investigated whether combining FUS and microbubbles with transferrin receptor-targeting liposomes would result in enhanced delivery to the brain of post-natal rats compared with liposomes lacking the BBB-targeting moiety. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 16, 2021 Category: Radiology Authors: Marieke Olsman, Viktoria Sereti, Melina M ühlenpfordt, Kasper Bendix Johnsen, Thomas Lars Andresen, Andrew James Urquhart, Catharina de Lange Davies Tags: Original Contribution Source Type: research

Estimating Arterial Wall Deformations from Automatic Key-Point Detection and Matching
Assessing arterial-wall motion and deformations may reveal pathologic alterations in biomechanical properties of the parietal tissues and, thus, contribute to the detection of vascular disease onset. Ultrasound image sequences allow the observation of this motion and many methods have been developed to estimate temporal changes in artery diameter and wall thickness and to track 2-D displacements of selected points. Some methods enable the assessment of shearing or stretching within the wall, but none of them can estimate all these deformations simultaneously. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 15, 2021 Category: Radiology Authors: Sami Qorchi, Didier Vray, Maciej Orkisz Tags: Original Contribution Source Type: research

Evaluation of Stone Features That Cause the Color Doppler Ultrasound Twinkling Artifact
The color Doppler ultrasound twinkling artifact is a rapid color shift that appears on 43% –96% of kidney stones. Surface microbubbles on kidney stones are theorized to cause twinkling as exposure to elevated static pressures of 0.41–1.13 MPa (approximately 0.5–1 times diagnostic ultrasound pressure and 5–10 times ambient pressure) reduced twinkling. However, it is unclear what ex ternal and internal stone features support bubbles. Thirteen ex vivo kidney stones were scanned with color Doppler ultrasound at 2.5, 5 and 18.5 MHz. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 15, 2021 Category: Radiology Authors: Eric Rokni, Scott Zinck, Julianna C. Simon Tags: Original Contribution Source Type: research

Myocardial Strain Measured by Epicardial Transducers —Comparison Between Velocity Estimators
This study describes results from an experimental ultrasound system with miniature transducers sutured directly onto the epicardial surface and used to measure heart contractions continuously. This system was used to find velocity distributions through the myocardium. The resulting velocities were used to track the motion of four layers at different depths through the myocardium and to find the regional strain in each of the four layers. Velocities inside the myocardium vary from the epicardial to the endocardial borders. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 13, 2021 Category: Radiology Authors: Thuy Thu Nguyen, Andreas W. Espinoza, Stefan Hyler, Espen W. Remme, Jan D'hooge, Lars Hoff Tags: Original Contribution Source Type: research

3-D Ultrasound and Thyroid Cancer Diagnosis: A Prospective Study
This study tests the hypothesis that evaluation of thyroid nodule (TN) margin irregularities by three-dimensional ultrasound (3-D-US) distinguishes benign from malignant TNs with greater sensitivity and specificity than two-dimensional ultrasound (2-D-US). We prospectively evaluated 344 TNs using both 2-D-US and 3-D-US followed by fine needle aspiration biopsy. TNs were divided into four groups based on the 3-D-US appearance of the margins. Bi-variate and multi-variate analyses were used. Surgical pathology confirmed 44 thyroid cancers in 40 patients. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 12, 2021 Category: Radiology Authors: Ghobad Azizi, Kirk Faust, Lorna Ogden, Laura Been, Michelle L. Mayo, Kele Piper, Carl Malchoff Tags: Original Contribution Source Type: research

Influence of Bias in the Assessment of Patellar Tendon Stiffness: A Systematic Review and Meta-analysis
The aim of the present study was to provide a systematic review and meta-analysis of the main biases in practical applications of the different types of elastography in assessment of the stiffness of healthy patellar tendons. A literature search on four databases (Scopus, Web of Science, Pubmed and SportDiscus) was conducted on March 25, 2020. After analysis of 1,052 resultant articles, studies were included if they met two inclusion criteria: (1) studies were observational or randomized controlled trials; (2) studies included outcomes of patellar tendon stiffness. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 12, 2021 Category: Radiology Authors: Alfredo Bravo-S ánchez, Pablo Abián, Jorge Sánchez-Infante, Fernando Jimenez, Javier Abián-Vicén Tags: Review Source Type: research

Multiparametric Ultrasound Evaluation of the Thyroid: Elastography as a Key Tool in the Risk Prediction of Undetermined Nodules (Bethesda III and IV) —Histopathological Correlation
The purpose of this study was to select thyroid nodules most at risk for malignancy among those cytologically undetermined by fine-needle aspiration biopsy (FNAB), using B-mode, color duplex Doppler and 2-D shear wave shear wave elastography (2-D-SWE). This was a prospective diagnostic accuracy study with 62 Bethesda III/IV nodules according to FNAB (atypia/follicular lesion of undetermined significance or follicular neoplasia/H ürthle cell neoplasm). Ultrasonography (US) data were compared with resection histologic results, revealing 35 of 62 benign nodules (56.4%) and 27 of 62 carcinomas (43.6%). (Source: Ultrasound...
Source: Ultrasound in Medicine and Biology - February 12, 2021 Category: Radiology Authors: Pedro H.M. Moraes, Marcelo Straus Takahashi, Felipe A.B. Vanderlei, Marcelo V. Schelini, Danielle A. Chacon, Marcos Roberto Tavares, Maria Cristina Chammas Tags: Original Contribution Source Type: research

Corrigendum to ‘Screening of Embolic Sources by Point-of-Care Ultrasound in the Acute Phase of Ischemic Stroke’ [Ultrasound in Med. & Biol. 46 (2020) 2173 –2180]
The authors regret that the affiliation details for Teresa Gonzalez-Alujas and Arturo Evangelista were incomplete. The correct affiliation details for all authors are shown above. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 12, 2021 Category: Radiology Authors: Jes ús Juega, Jorge Pagola, Teresa Gonzalez-Alujas, David Rodriguez-Luna, Marta Rubiera, Noelia Rodriguez-Villatoro, Álvaro García-Tornel, Manuel Requena, Matias Deck, Laia Seró, Sandra Boned, Marc Ribo, Marian Muchada, Marta Olivé, Estela Sanjuan, J Tags: Corrigendum Source Type: research

The Diagnostic Value of the American College of Radiology Thyroid Imaging Reporting and Data System Classification and Shear-Wave Elastography for the Differentiation of Thyroid Nodules
This study aimed to determine the diagnostic accuracy of the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) classification and shear-wave elastography (SWE) for the diagnosis of benign and malignant thyroid nodules. This retrospective study enrolled 141 patients (18 –84 y of age) undergoing thyroidectomy between January 2015 and August 2020. All statistical analysis was based on pathologic results of patients. The cut-off value was found as category 4 for ACR TI-RADS classification and 5 m/s for shear-wave velocity (Vs) by the receiver operator characteristic curve analysis (are...
Source: Ultrasound in Medicine and Biology - February 12, 2021 Category: Radiology Authors: G ül Bora Makal, Aydın Aslan Tags: Original Contribution Source Type: research

Technique Success, Technique Efficacy and Complications of HIFU Ablation for Palliation of Pain in Patients With Bone Lesions: A Meta-Analysis of 28 Feasibility Studies
Several feasibility studies have reported that high-intensity focused ultrasound (HIFU) ablation can be applied to ease patients ’ bone pain. However, the effect of HIFU ablation to palliate bone pain remains unclear. To evaluate the technique's success, efficacy, minor complication and major complication on patients suffering from bone pain, we searched the PubMed, MEDLINE, EMBASE and Cochrane Library databases from Januar y 1998 to March 2019. Clinical studies that have assessed the association between bone pain and HIFU ablation were involved. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 11, 2021 Category: Radiology Authors: Xiaoti Lin, Weiyu Chen, Fengqin Wei Tags: Review Source Type: research

Reliability of Shear Wave Elastography and Ultrasound Measurement in Children with Unilateral Spastic Cerebral Palsy
In clinical practice, few data exist on the feasibility of performing reliable shear wave elastography (SWE) and ultrasonography (US) measurements in spastic muscles of children with cerebral palsy (CP). Ten children with unilateral CP took part in SWE and US assessment of the tibialis anterior and medialis gastrocnemius muscles during two sessions separated by a 1-wk interval. Intra- and inter-investigator reliability of shear modulus ( µ) and muscle thickness (MT) measurements, at neutral and maximal dorsiflexion angles on both legs, was assessed by two investigators with different levels of experience. (Source: Ul...
Source: Ultrasound in Medicine and Biology - February 9, 2021 Category: Radiology Authors: Cl ément Boulard, Laure Mathevon, Louis Florian Arnaudeau, Vincent Gautheron, Paul Calmels Tags: Original Contribution Source Type: research

A Model for Predicting Malignant Sub-pleural Solid Masses Using Grayscale Ultrasound and Ultrasound Elastography
This article aimed to establish a prediction model of grayscale sonography and ultrasound elastography for malignant sub-pleural solid masses and evaluate its diagnostic value. The study included 153 patients, including 89 patients with malignant tumors and 64 patients with benign diseases. Statistical differences between the malignant and benign groups were found in the factors of age, air bronchogram, borderline, shape and elasticity score (p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 8, 2021 Category: Radiology Authors: Wanbin Li, Mengjun Shen, Yi Zhang, Yang Cong, Huiming Zu, Hongwei Chen, Yin Wang Tags: Original Contribution Source Type: research

Re: “Contrast-Enhanced Ultrasound Evaluation of Renal Blood Perfusion Changes After Percutaneous Transluminal Renal Angioplasty and Stenting for Severe Atherosclerotic Renal Artery Stenosis” (Ran et al. Ultrasound Med Biol 2020;46:1872–1879)
I read with interest the article by Ran et al. (2020) in a recent issue of Ultrasound in Medicine& Biology. However, some considerations are mandatory. The authors used contrast-enhanced ultrasound to evaluate renal cortical blood flow changes in 21 patients with ≥70% renal artery stenosis treated with percutaneous transluminal renal angioplasty and stenting (PTRAS). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 5, 2021 Category: Radiology Authors: Rosario Cianci Tags: Letter to the Editor Source Type: research

Reply to the letter to the Editor from Professor Cianci Rosario
We are honored that you have read our article (Ran  et al. 2020) and are interested in our study. We thank you for raising these important issues, especially considering your extensive professional background in nephrology. We have read all the documents you mentioned in your letter, and after serious consideration, we reply here. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 4, 2021 Category: Radiology Authors: Xu Ran, Luzeng Chen, Letao Lin, Yinghua Zou Tags: Letter to the Editor Source Type: research

Quantifiable Contrast-Enhanced Ultrasound Explores the Role of Protection, Rest, Ice (Cryotherapy), Compression and Elevation (PRICE) Therapy on Microvascular Blood Flow
The aim of this randomized controlled laboratory study was to evaluate the role of standardized protection, rest, ice (cryotherapy), compression and elevation (PRICE) therapy on microvascular blood flow in human skeletal muscle. Quantifiable contrast-enhanced ultrasound was used to analyze intramuscular tissue perfusion (ITP) of  the rectus femoris (RF) and vastus intermedius (VI) muscles in 20 healthy athletes who were randomly assigned to PRICE or control groups. Baseline perfusion measurements (resting conditions, T0) were compared with cycling exercise (T1), intervention (PRICE or control, T2) and follow-up at 60 ...
Source: Ultrasound in Medicine and Biology - February 4, 2021 Category: Radiology Authors: Thilo Hotfiel, Matthias Wilhelm Hoppe, Rafael Heiss, Christoph Lutter, Thomas Tischer, Raimund Forst, Christian Manfred Hammer, J ürgen Freiwald, Martin Engelhardt, Casper Grim Tags: Original Contribution Source Type: research

Associations of Renal Augmented Velocity Index with Arterial Stiffness, Carotid Intima –Media Thickness and Blood Pressure, in Comparison with Renal Resistive Index
We examined associations of renal Avi with blood pressure (BP), aortic stiffness and carotid intima –media thickness (IMT), and compared its performance with that of resistive index (RI). One hundred forty-seven volunteers were recruited. Renal Avi had significant positive correlations with systolic BP (r = 0.37, p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 4, 2021 Category: Radiology Authors: Kin Hung Liu, Ming Chung Lee, Alice Pik Shan Kong, Ling Chen, Juliana Chung Ngor Chan, Winnie Chiu Wing Chu Tags: Original Contribution Source Type: research

Advances in Ultrasound-Guided Vacuum-Assisted Biopsy of Breast Microcalcifications
Microcalcification is one of the significant indications for or can even be the sole mammographic feature of breast cancer, especially occult breast cancer. Biopsy and pathologic examination are the most important methods used to identify the nature of suspicious microcalcifications. Stereotactic vacuum-assisted breast biopsy (S-VAB) is the most commonly used biopsy method for microcalcifications currently because of the high detection rate of mammography for microcalcifications. However, in recent years, several clinical studies have gradually found that ultrasound-guided vacuum-assisted breast biopsy (US-VAB) could be an...
Source: Ultrasound in Medicine and Biology - February 4, 2021 Category: Radiology Authors: Juan Wu, Rong Kong, Shen Tian, Hao Li, Jia-shuo Liu, Zhou Xu, Bao-shan Zou, Kai-nan Wu, Ling-quan Kong Tags: Review Article Source Type: research

Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing accumulation and penetration. We used a subcutaneous prostate cancer xenograft model in mice to investigate the effect of free and nanoparticle-encapsulated cabazitaxel in combination with ultrasound and microbubbles with a lipid shell or a shell of nanoparticles. Sonopermeation reduced tumor growth and prolonged survival (26% –100%), whether the free drug was co-injected with lipid-shelled microbubble...
Source: Ultrasound in Medicine and Biology - February 3, 2021 Category: Radiology Authors: Sofie Snipstad, Ýrr Mørch, Einar Sulheim, Andreas Åslund, André Pedersen, Catharina de Lange Davies, Rune Hansen, Sigrid Berg Tags: Original Contribution Source Type: research

Systematic Analysis of Combined Thrombolysis Using Ultrasound and Different Fibrinolytic Drugs in an in Vitro Clot Model of Intracerebral Hemorrhage
Adequate removal of blood clots by minimally invasive surgery seems to correlate with a better clinical outcome in patients with intracerebral hemorrhages (ICHs). Moreover, neurotoxic effects of recombinant tissue plasminogen activator have been reported. The aim of this study was to improve fibrinolysis using an intra-clot ultrasound application with tenecteplase and urokinase in our established ICH clot model. One hundred thirty clots were produced from 25 or 50 mL of human blood, incubated for different periods and equipped with drainage, through which an ultrasound catheter was placed in 65 treatment clots for 1 h, ran...
Source: Ultrasound in Medicine and Biology - February 3, 2021 Category: Radiology Authors: Julia Masomi-Bornwasser, Oliver Fabrig, Harald Krenzlin, Jochem K önig, Yasemin Tanyildizi, Oliver Kempski, Florian Ringel, Naureen Keric Tags: Original Contribution Source Type: research

The Application of Contrast Enhanced Ultrasound for Core Needle Biopsy of Subpleural Pulmonary Lesions: Retrospective Analysis in 92 Patients
The purpose of this study was to investigate the role of contrast-enhanced ultrasound (CEUS) in determining the viable target area in patients with subpleural pulmonary lesions before ultrasound-guided transthoracic core biopsy. In this retrospective study, we analyzed 92 patients with subpleural pulmonary lesions (63 males and 29 females; mean age: 65.17 ± 11.72 y). All patients underwent B-mode ultrasound, color Doppler and CEUS. Color Doppler was performed to identify the major vessels. The time to enhancement of the contrast agents, homogeneity of enhancement and the presence of areas without enhancement were re...
Source: Ultrasound in Medicine and Biology - February 2, 2021 Category: Radiology Authors: Wen Xu, Qing Wen, Xinjian Zhang, MinQiang Pan, Chunmei Liu, Lijing Zha, Pintong Huang Tags: Original Contribution Source Type: research

A Wavelet Approach to the Estimation of Left Ventricular Early Filling Wave Propagation Velocity from Color M-Mode Echocardiograms
A new approach to calculating left ventricular (LV) early filling propagation velocity (VP) from color M-mode echocardiograms using wavelet analysis is described. Current methods for measuring VP do not account for the spatiotemporal variation in VP. They are confined by empirical assumptions and user inputs that hinder the accuracy of VP, limiting its clinical utility. We evaluated three methods for measuring LV early filling: conventional VP, the strength of propagation (VS) and wavelet propagation velocity (VW) determined from the most energetically significant wave (peak VW). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 2, 2021 Category: Radiology Authors: Sreyashi Chakraborty, Brett A. Meyers, Hiroyuki Iwano, Michael E. Hall, Pavlos P. Vlachos Tags: Original Contribution Source Type: research

Can Ultrasound in Combination with Virtual Touch Imaging Quantification Predict the Dignity of a Parotid Tumor?
This study evaluates the diagnostic performance of B-mode ultrasound in combination with Virtual Touch imaging quantification (VTIQ) in the assessment of parotid lesions. A prospective study of 268 patients with parotid lesions was conducted. Pre-operative ultrasound findings and VTIQ data were compared against histologic results. Ill-defined margins on ultrasound were associated with a significantly higher risk of malignancy (odds ratio [OR]  = 1224.0, 95 % confidence interval [CI]: 151.8–9872.7). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 1, 2021 Category: Radiology Authors: Monika Jering, Johannes Zenk, Rubens Th ölken, Holger Rüger, Georgios Psychogios Tags: Original Contribution Source Type: research

Impact of Patent Foramen Ovale Anatomic Features on Right-to-Left Shunt in Patients with Cryptogenic Stroke
The purpose of this study was to investigate the impact of the morphologic characteristics of patent foramen ovale (PFO) on right-to-left shunt (RLS) in patients with PFO and cryptogenic stroke using transesophageal echocardiography and saline contrast transthoracic echocardiography (c-TTE). Of the 165 patients with PFO stroke, both the height and the length of PFO in the provoked RLS group were smaller than those in the constant RLS group. PFO height, interatrial septum mobility and proportion of atrial septal aneurysms were greater in the severe RLS group than in the mild and moderate RLS groups. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - February 1, 2021 Category: Radiology Authors: Ying Zhu, Jun Zhang, Bo Huang, Yani Liu, Youbin Deng, Yahui Weng, Ruiying Sun Tags: Original Contribution Source Type: research

Contrast-Enhanced Ultrasound of the Pleural Cavity: A Method to Locate Pleural Catheters and Identify Fibrous Septa
We aimed to explore the value of contrast-enhanced ultrasound (CEUS) of the pleural cavity in locating catheters and identifying fibrous septa and to compare CEUS with multiple existing methods. We included 304 participants whose pleural effusion could not continue to be drained and compared the catheter-localization capabilities of empirical diagnosis, B-mode ultrasound with normal saline and CEUS, with computed tomography as the reference standard. CEUS performed the best (accuracy, 100%; sensitivity, 100%; specificity, 100%), followed by B-mode ultrasound with normal saline (accuracy, 77.78%; sensitivity, 62.5%; specifi...
Source: Ultrasound in Medicine and Biology - February 1, 2021 Category: Radiology Authors: Ke Bi, Bin Wang, Yi Zhang, Meng-jun Shen, Hong-wei Chen, Hui-ming Zhu, Chun-hong Tang, Yin Wang Tags: Original Contribution Source Type: research

Reliability of Sonoelastography Measurements of Lower Limb Tendon Properties: A Systematic Review
This study investigated the reliability of sonoelastography techniques in quantifying lower limb tendon elasticity. A literature search was conducted using PubMed, Web of Science and CINAHL. The quality of the selected papers was evaluated using the Guidelines for Reporting Reliability and Agreement Studies and the Quality Appraisal Tool for Studies of Diagnostic Reliability checklist. Reliability values were extracted and synthesized. Twenty-four studies were included and were divided by the two main technologies used: strain and shear-wave elastography. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 27, 2021 Category: Radiology Authors: Alessandro Schneebeli, Anna Folli, Deborah Falla, Marco Barbero Tags: Original Contribution Source Type: research

Indexing Cerebrovascular Health Using Transcranial Doppler Ultrasound
Transcranial Doppler (TCD) blood flow velocity has been extensively used in biomedical research as it provides a cost-effective and relatively simple approach to assess changes in cerebral blood flow dynamics and track cerebrovascular health status. In this article we introduce a new TCD-based timing index, TITCD, as an indicator of vascular stiffening and vascular health. We investigate the correlations of the new index and the existing indices, namely the pulsatility index and the augmentation index, with age, cardiorespiratory fitness (CRF) and magnetic resonance imaging (MRI) blood flow pulsatility index (PIMRI). (Sour...
Source: Ultrasound in Medicine and Biology - January 22, 2021 Category: Radiology Authors: Rashid Afkhami, Rachel Wong, Saadallah Ramadan, Frederick Rohan Walker, Sarah Johnson Tags: Original Contribution Source Type: research

Clinical Utility of Contrast-enhanced Ultrasound for the Diagnosis of Lymphadenopathy
This meta-analysis aimed to evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in identifying lymphazdenopathy. PubMed, Web of Science, Embase and the Cochrane Library were searched for relevant articles through September 2020. A total of 16 articles, which included 1787 participants, were analyzed. The summary sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio of CEUS for diagnosing lymphadenopathy were 0.88 (0.86 –0.90), 0.90 (0.88–0.92), 6.04 (3.67–9.95), 0.15 (0.10–0.21) and 47.38 (23.45–95.66), respectively. (Source: U...
Source: Ultrasound in Medicine and Biology - January 21, 2021 Category: Radiology Authors: Siyang Huang, Yunuo Zhao, Xian Jiang, Nan Lin, Mingxuan Zhang, Hang Wang, Aiping Zheng, Xuelei Ma Tags: Review Source Type: research

Reliability of Human Achilles Tendon Stiffness Measures Using Freehand 3-D Ultrasound
Achilles tendon (AT) stiffness is an important property of both human locomotor performance and injury mechanics. Freehand 3-D ultrasound (3-DUS) is a promising method for measuring stiffness of the Achilles tendon, particularly the free AT (2 –6 cm proximal to calcaneus), which is commonly injured. The aim of this study was to investigate the test–retest reliability of freehand 3-DUS in measuring free AT stiffness in humans. The free Achilles tendon length of healthy participants (n = 10) was scanned on the same day on two consec utive occasions (1 h apart) during rest and isometric plantar flexion contrac...
Source: Ultrasound in Medicine and Biology - January 21, 2021 Category: Radiology Authors: Eman Merza, Stephen Pearson, Glen Lichtwark, Alessandro Garofolini, Peter Malliaras Tags: Original Contribution Source Type: research

Ultrasound-Mediated Microbubble Cavitation Transiently Reverses Acute Hindlimb Tissue Ischemia through Augmentation of Microcirculation Perfusion via the eNOS/NO Pathway
Ultrasound-mediated microbubble cavitation improves perfusion in chronic limb and myocardial ischemia. The purpose of this study was to determine the effects of ultrasound-mediated microbubble cavitation in acute limb ischemia and investigate the mechanism of action. The animal with acute hindlimb ischemia was established using male Sprague-Dawley rats. The rats were randomly divided into three groups: intermittent high-mechanical-index ultrasound pulses combined with microbubbles (ultrasound [US]  + MB group), US alone (US group) and MB alone (MB group). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 21, 2021 Category: Radiology Authors: Shifeng Qiu, Danxia Li, Yuegang Wang, Jiancheng Xiu, Chuangye Lyu, Shelby Kutty, Daogang Zha, Juefei Wu Tags: Original Contribution Source Type: research

Multifrequency Phased Tracking Method for Estimating Velocity in Heart Wall
Local high-accuracy velocity estimation is important for the ultrasound-based evaluation of regional myocardial function. The ultrasound phase difference at the center frequency of the transmitted signal has been conventionally used for velocity estimation. In the conventional method, spatial averaging is necessary owing to the frequency-dependent attenuation and interference of backscattered waves. Here, we propose a method for suppressing these effects using multifrequency phase differences. The resulting improvement in velocity estimation in the heart wall was validated by in vivo experiments. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 20, 2021 Category: Radiology Authors: Yu Obara, Shohei Mori, Mototaka Arakawa, Hiroshi Kanai Tags: Original Contribution Source Type: research

Evaluation of Left Ventricular Diastolic Function by 2-D Speckle Tracking Echocardiography in Patients with Connective Tissue Disease-Associated Pulmonary Artery Hypertension
The purpose of this study was to evaluate the role of 2-D speckle tracking imaging in assessing left ventricular diastolic function in patients with connective tissue disease (CTD). A total of 98 CTD patients and 32 healthy controls were prospectively recruited. Early (E) and late (A) diastolic velocities of the transmitral flow were measured by pulsed Doppler echocardiography. Peak early diastolic myocardial velocity (E') was calculated on tissue Doppler echocardiography. The longitudinal strain rate (SR) was calculated as the average of three apical views, while circumferential and radial SRs were measured in three short...
Source: Ultrasound in Medicine and Biology - January 19, 2021 Category: Radiology Authors: Hong Ma, Xian-Fang Liu, Xiao-Qing Qi, Ying-Heng Huang, Xiao-Xuan Sun, Lei Zhou, Hong-Ping Wu Tags: Original Contribution Source Type: research

Non-invasive Assessment of Liver Fat in ob/ob Mice Using Ultrasound-Induced Thermal Strain Imaging and Its Correlation with Hepatic Triglyceride Content
In this study, US-TSI was used to quantify lipid composition of fatty livers in ob/ob mice (n  = 28) at various steatosis stages. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 16, 2021 Category: Radiology Authors: Waqas B. Khalid, Nadim Farhat, Linda Lavery, Josh Jarnagin, James P. Delany, Kang Kim Tags: Original Contribution Source Type: research

Improved Ultrasound Microvessel Imaging Using Deconvolution with Total Variation Regularization
Singular value decomposition-based clutter filters can robustly reject tissue clutter, allowing for detection of slow blood flow in imaging microvasculature. However, to identify microvessels, high ultrasound frequency must be used to increase the spatial resolution at the expense of shorter depth of  penetration. Deconvolution using Tikhonov regularization is an imaging processing method widely used to improve spatial resolution. The ringing artifact of Tikhonov regularization, though, can produce image artifacts such as non-existent microvessels, which degrade image quality. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 16, 2021 Category: Radiology Authors: U-Wai Lok, Joshua D. Trzasko, Chengwu Huang, Shanshan Tang, Ping Gong, Yohan Kim, Fabrice Lucien, Matthew R. Lowerison, Pengfei Song, Shigao Chen Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 15, 2021 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 15, 2021 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 15, 2021 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - January 15, 2021 Category: Radiology Source Type: research