Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 13, 2020 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 13, 2020 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 13, 2020 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 13, 2020 Category: Radiology Source Type: research

Long-Term Monitoring of Donor Xenogeneic Testis Tissue Grafts and Cell Implants in Recipient Mice Using Ultrasound Biomicroscopy
Testis tissue xenografting and testis cell aggregate implantation from various donor species into recipient mice are novel models for the study and manipulation of testis formation and function in target species. Thus far, the analysis of such studies has been limited to surgical or post-mortem retrieval of samples. Here we used ultrasound biomicroscopy (UBM) to monitor the development of neonatal porcine testis grafts and implants in host mice for 24 wk, and to correlate UBM and (immuno)histologic changes. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 12, 2020 Category: Radiology Authors: Mohammad Amin Fayaz, Awang Hazmi Awang-Junaidi, Jaswant Singh, Ali Honaramooz Tags: Original Contribution Source Type: research

Early Prediction of Blood Loss and Postpartum Hemorrhage after Vaginal Delivery by Ultrasound Measurement of Intrauterine Content
The ability of ultrasound to predict postpartum hemorrhage remains poorly described. The aim of this study was to evaluate whether ultrasound measurement of intrauterine content can predict blood loss and postpartum hemorrhage after vaginal delivery. We used a preliminary prospective monocentric study of 201 women who delivered vaginally after 34 wk of gestation. Measurements were performed 30 –45 min after normal vaginal delivery according to strict ultrasonographic criteria. Analysis of the relationship between ultrasound measurements and hemoglobin loss showed a strong linear correlation (R² = 0.59 and R&...
Source: Ultrasound in Medicine and Biology - August 12, 2020 Category: Radiology Authors: Najeh Hcini, Ali Mchirgui, L éo Pomar, Samuel Beneteau, Véronique Lambert, Gabriel Carles Tags: Clinical Note Source Type: research

Improving Prognostic and Chronicity Evaluation of Chronic Kidney Disease with Contrast ‐Enhanced Ultrasound Index-Derived Peak Intensity
The capability of contrast ‐enhanced ultrasound (CEUS) to assess the prognosis and chronicity of chronic kidney disease (CKD) was evaluated in patients diagnosed with CKD in 2014 at Ren Ji Hospital, Shanghai, China. Time–intensity curves and quantitative indexes were created using QLab quantification software. Kidney biop sies were analyzed with α-smooth muscle actin immunohistochemistry. According to the renal chronicity score, patients were divided into four groups: minimal (n = 14), mild (n = 73), moderate (n = 49) and severe (n = 31). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 9, 2020 Category: Radiology Authors: Yao Xu, Hongli Li, Chunlin Wang, Minfang Zhang, Qin Wang, Yuanyuan Xie, Xinghua Shao, Lei Tian, Yanhong Yuan, Wei Yan, Tienan Feng, Fenghua Li, Zhaohui Ni, Shan Mou Tags: Original Contribution Source Type: research

Ultrasonographic Measurement of Pharyngeal-Airway Dimension and Its Relationship with Obesity and Sleep-Disordered Breathing
Previous studies based on magnetic resonance imaging (MRI) or computed tomography (CT) have shown that pharyngeal airway diameter during wakefulness is different between healthy controls and patients with a high risk of sleep-disordered breathing (SDB). However, MRI and CT are expensive and not easily accessible. Conversely, ultrasonography is more accessible and is getting more attention as a point-of-care technology to assess physiologic systems, such as the pharynx. Thus, we aimed to evaluate the feasibility of ultrasonography in estimating the pharyngeal airway dimension. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Shumit Saha, Anand Rattansingh, Keerthana Viswanathan, Anamika Saha, Rosemary Martino, Azadeh Yadollahi Tags: Original Contribution Source Type: research

Characteristic Blood-Perfusion Reduction of Walker 256 Tumor Induced by Diagnostic Ultrasound and Microbubbles
In this study, we tried to investigate whether the blood perfusion of a malignant tumor can be characteristically interrupted by combining microbubbles and diagnostic ultrasound (US). Twenty-nine Sprague-Dawley (SD) rats with subcutaneous Walker 256 tumors and seven healthy SD rats were included. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Ningshan Li, Yiyi Liao, Jiawei Tang Tags: Original Contribution Source Type: research

Oil-Based Gel Phantoms and the Speed of Sound
Different ultrasound phantom materials have been proposed to overcome the limited temporal stability of commonly used hydrogels. Styrene –ethylene/butylene–styrene (SEBS) polymer mixed with mineral oil is one example of a very stable gel that has been investigated as a tissue substitute for ultrasound imaging for a variety of applications (Oudry et al. 2009; Vieira et al. 2013; Cabrelli et al. 2017b; Hadadian et al. 2018; Suzuki et al. 2019) and complex anatomic structures (Grillo et al. 2018; Maneas et al. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Theo Z. Pavan, Maria Evertsson Tags: Letter to the Editor Source Type: research

Methodological Issue in “Development of an Ultrasound Prediction Model to Discriminate between Malignant and Benign Liver Lesions”
We read with interest the article by Shen et al. (2020) published recently. The aim of the authors was to discriminate between malignant and benign liver lesions. They evaluated the ultrasound features of the target lesions in 266 patients and established a prediction model using a logistic regression algorithm. To evaluate model performance, discrimination and calibration were used. They described that, given its high diagnostic specificity, sensitivity and accuracy, the ultrasound prediction model has potential for use as a diagnostic tool in early detection of malignant tumors of the liver and in reduction of unnecessar...
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Sahar Souri Pilangorgi, Soodeh Shahsavari Tags: Letter to the Editor Source Type: research

Hunting the Vulnerable Carotid Plaque: All That Glitters May Not Be Gold
To the Editor: – (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Dimitrios A. Vrachatis, Theodore G. Papaioannou, Spyridon Deftereos, Bernhard Reimers Tags: Letter to the Editor Source Type: research

Hunting the Vulnerable Carotid Plaque: In Search of a Gold Standard
Vrachatis et al. demonstrated particular interest in our recent review of the literature on the strengths and limitations of contrast-enhanced ultrasound (CEUS) for the detection of carotid intraplaque neovascularization (Schinkel  et al. 2020). I am pleased to have the opportunity to concisely address the two themes they highlighted: the standardization of methods to detect and quantify intraplaque neovascularization, and the correlation of CEUS findings with histopathological results. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 8, 2020 Category: Radiology Authors: Arend F.L. Schinkel Tags: Letter to the Editor Source Type: research

Ultrasound Attenuation Estimation in Harmonic Imaging for Robust Fatty Liver Detection
Accurate detection of liver steatosis is important for liver disease management. Ultrasound attenuation coefficient estimation (ACE) has great potential in quantifying liver fat content. The commonly used ACE methods (e.g., spectral shift methods, reference phantom methods) assume linear tissue response to ultrasound and were developed in fundamental imaging. However, fundamental imaging may be vulnerable to reverberation clutters introduced by the body wall. The clutters superimposed on liver echoes may bias the attenuation estimation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2020 Category: Radiology Authors: Ping Gong, Chenyun Zhou, Pengfei Song, Chengwu Huang, U-Wai Lok, Shanshan Tang, Kymberly Watt, Matthew Callstrom, Shigao Chen Tags: Original Contribution Source Type: research

Correlation Analysis of Conventional Ultrasound Characteristics and Strain Elastography with Ki-67 Status in Breast Cancer
Our objectives were to measure the relationships between conventional ultrasound features, strain elastography in breast cancer and Ki-67 index and to identify parameters that predict Ki-67 index. We included 181 lesions of 178 patients who underwent surgery for breast cancer at Xianyang Central Hospital. In multivariate logistic regression analysis, strain elastography and axillary-node metastasis showed significant Ki-67 index values; the overall theoretical prediction percentage correct was 75.7%. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 4, 2020 Category: Radiology Authors: Jianqiang Fang, Weian Zhao, Qing Li, Binyu Zhang, Cui Pu, Hao Wang Tags: Original Contribution Source Type: research

Low-Frequency (20 kHz) Ultrasonic Modulation of Drug Action
We tested the effect of low-frequency ultrasound (LUS, 20 kHz, 4 W/cm2) on the function of rat mesentery and human pulmonary arteries with wire myography. The vessels were induced to contract with either noradrenaline or physiologic saline solution (PSS) with a high potassium concentration (KPSS) and then incubated with capsaicin (2.1  × 10–7 M, TRPV1 [transient receptor potential vanilloid 1] activator), dopamine (1 × 10–4 M, dopamine and α2-receptor activator), or fenoldopam (dopamineA1 receptor agonist, 1 × 10–4 M) with and without glibenclamide (1 μM, KATP [adeno...
Source: Ultrasound in Medicine and Biology - August 4, 2020 Category: Radiology Authors: Silvijus Abramavi čius, Augusta Volkevičiūtė, Agilė Tunaitytė, Mantas Venslauskas, Algimantas Bubulis, Vytis Bajoriūnas, Edgaras Stankevičius Tags: Original Contribution Source Type: research

Magnetomotive Ultrasound Imaging Systems: Basic Principles and First Applications
This review discusses magnetomotive ultrasound, which is an emerging technique that uses superparamagnetic iron oxide nanoparticles as a contrast agent. The key advantage of using nanoparticle-based contrast agents is their ability to reach extravascular targets, whereas commercial contrast agents for ultrasound comprise microbubbles confined to the blood stream. This also extends possibilities for molecular imaging, where the contrast agent is labeled with specific targeting molecules (e.g., antibodies) so that pathologic tissue may be visualized directly. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2020 Category: Radiology Authors: Sandra Sj östrand, Maria Evertsson, Tomas Jansson Tags: Review Source Type: research

Blood Flow Visualization and Wall Shear Stress Measurement of Carotid Arteries Using Vascular Vector Flow Mapping
This study aimed to visualize the blood flow of carotid arteries and measured WSS using vector flow mapping (VFM) developed specifica lly for vascular use. Patients with cerebrovascular diseases were prospectively enrolled and examined with carotid ultrasound using VFM Vascular. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2020 Category: Radiology Authors: Kozue Saito, Soichiro Abe, Masaya Kumamoto, Yuto Uchihara, Akito Tanaka, Kazuma Sugie, Masafumi Ihara, Masatoshi Koga, Hiroshi Yamagami Tags: Original Contribution Source Type: research

Ultrasound Imaging of Injections in Masseter Muscle without Contrast Agent Using Strain Elastography and a Novel B-Mode Spatiotemporal Filter
Botulinum toxin type A (BTX-A) injections in masseter muscle can alleviate muscle tightness and aching pain caused by idiopathic masticatory myalgia, a subform of the myofascial pain syndrome. Yet the injection procedure (number, amount) is currently empirical. In this ex vivo study, we determined the feasibility of using contrast-free ultrasound imaging to visualize the short-term injectate propagation. Ultrasound annotations of BTX-A injectate spread in N  = 12 porcine masseter muscles were compared with the histopathology of the excised masseter. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2020 Category: Radiology Authors: Sergio J. Sanabria, Lisa Ruby, Jasmine Kuonen, Susanne Dettwiler, Vera Colombo, Thomas Frauenfelder, Dominik Ettlin, Marga B. Rominger Tags: Original Contribution Source Type: research

Feasibility of High-Intensity Focused Ultrasound for Hepatocellular Carcinoma after Stereotactic Body Radiation Therapy: Initial Experience
The purpose of this initial clinical observation was to investigate the safety and effect of high-intensity focused ultrasound (HIFU) for patients with hepatocellular carcinoma (HCC) after stereotactic body radiation therapy (SBRT). Twenty patients who had been treated with SBRT, with 24 local residuals, received HIFU ablation. The changes of periphery blood cell count and serum biochemistry were observed before HIFU and 1 week after. Contrast-enhanced magnetic resonance imaging before HIFU and 2 weeks after was performed to assess the effect of HIFU. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 31, 2020 Category: Radiology Authors: Chengbing Jin, Wei Yang, Lifeng Ran, Jun Zhang, Hui Zhu Tags: Original Contribution Source Type: research

Change in Carotid Blood Flow and Carotid Corrected Flow Time Assessed by Novice Sonologists Fails to Determine Fluid Responsiveness in Spontaneously Breathing Intensive Care Unit Patients
Measurement of carotid blood flow (CBF) and corrected carotid flow time (ccFT) has been proposed as a non-invasive means of determining fluid responsiveness. We evaluated the ability of CBF and ccFT as assessed by novice sonologists to determine fluid responsiveness in intensive care unit patients. Three novice physician sonologists performed carotid ultrasounds before and after a fluid bolus and calculated changes in CBF and ccFT. Fluid responsiveness was defined as a ≥10% increase in cardiac index as measured using bioreactance. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 31, 2020 Category: Radiology Authors: Adeel Abbasi, Nader Azab, Mohammed Nayeemuddin, Alexandra Schick, Thomas Lopardo, Gary S. Phillips, Roland C. Merchant, Mitchell M. Levy, Michael Blaivas, Keith A. Corl Tags: Original Contribution Source Type: research

Feasibility of Non-invasive Pulse Pressure Measurement Using the Phased-Tracking Method
Phased tracking (PT) is a high-precision ultrasonic technology that enables measurements of pulse pressure (PP). The aim of this study was to verify the accuracy of estimated PP using PT. Estimated PPs were compared with measured PPs in three sheep fetuses that were connected to an artificial placenta system. Similarly, estimated and measured PPs of 30 human neonates were compared. PP was calculated using the Water –Hammer equation (PP = ρ × PWV (pulse wave velocity) × ΔU). PWV was estimated by measuring the transit times of pulse waves at two sites along the aorta using the PT metho...
Source: Ultrasound in Medicine and Biology - July 28, 2020 Category: Radiology Authors: Shusaku Kobori, Jun Murotsuki, Shimpei Watanabe, Hideyuki Hasegawa, Hiroshi Kanai, Nobuo Yaegashi, Masatoshi Saito Tags: Original Contribution Source Type: research

Monitoring Canine Myocardial Infarction Formation and Recovery via Transthoracic Cardiac Strain Imaging
Myocardial elastography (ME) is an ultrasound-based strain imaging method that aims to determine the degree of ischemia or infarction as a result of the change in the elastic properties of the myocardium. A survival canine model (n  = 11) was employed to investigate the ability of ME to image myocardial infarction formation and recovery. Infarcts were generated by ligation of the left anterior descending coronary artery. Canines were survived and imaged for 4 days (n = 7) or 4 weeks (n = 4), allowing sufficient tim e for recovery via collateral perfusion. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 27, 2020 Category: Radiology Authors: Vincent Sayseng, Rebecca A. Ober, Christopher S. Grubb, Rachel A. Weber, Elisa Konofagou Tags: Original Contribution Source Type: research

Investigating the Accumulation of Submicron Phase-Change Droplets in Tumors
Submicron phase-change droplets are an emerging class of ultrasound contrast agent. Compared with microbubbles, their relatively small size and increased stability offer the potential to passively extravasate and accumulate in solid tumors through the enhanced permeability and retention effect. Under exposure to sufficiently powerful ultrasound, these droplets can convert into in situ gas microbubbles and thus be used as an extravascular-specific contrast agent. However, in vivo imaging methods to detect extravasated droplets have yet to be established. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 27, 2020 Category: Radiology Authors: Brandon L. Helfield, Kimoon Yoo, Jingjing Liu, Ross Williams, Paul S. Sheeran, David E. Goertz, Peter N. Burns Tags: Technical Note Source Type: research

Lung Ultrasound Score in Evaluating The Severity Of Coronavirus Disease 2019 (COVID-19) Pneumonia
The purpose of this study is to observe the potential of lung ultrasound in evaluating the severity of COVID-19 pneumonia. Lung ultrasound of patients was performed in ten zones of the chest walls. The features of the ultrasound images were observed, and a lung ultrasound score (LUS) was recorded. The ultrasound features and scores were compared between the refractory group (PaO2/FiO2 ≤100 mmHG or on ECMO) and the nonrefractory group. The prediction value of the LUS was studied by receiver operating characteristic (ROC) curve analysis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 24, 2020 Category: Radiology Authors: Lina Zhao, Kanglong Yu, Qi Zhao, Rui Tian, Hui Xie, Lijun Xie, Puyu Deng, Guogang Xie, Aihua Bao, Kanglong Yu, Jiang Du Source Type: research

Guidelines and Good Clinical Practice Recommendations for Contrast-Enhanced Ultrasound (CEUS) in the Liver –Update 2020 WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS
The present, updated document describes the fourth iteration of recommendations for the hepatic use of contrast-enhanced ultrasound, first initiated in 2004 by the European Federation of Societies for Ultrasound in Medicine and Biology. The previous updated editions of the guidelines reflected changes in the available contrast agents and updated the guidelines not only for hepatic but also for non-hepatic applications. The 2012 guideline requires updating as, previously, the differences in the contrast agents were not precisely described and the differences in contrast phases as well as handling were not clearly indicated....
Source: Ultrasound in Medicine and Biology - July 23, 2020 Category: Radiology Authors: Christoph F. Dietrich, Christian P állson Nolsøe, Richard G. Barr, Annalisa Berzigotti, Peter N. Burns, Vito Cantisani, Maria Cristina Chammas, Nitin Chaubal, Byung Ihn Choi, Dirk-André Clevert, Xinwu Cui, Yi Dong, Mirko D'Onofrio, J. Brian Fowlkes, Od Tags: Review Article Source Type: research

Carotid Wall Longitudinal Motion in Ultrasound Imaging: An Expert Consensus Review
Motion extracted from the carotid artery wall provides unique information for vascular health evaluation. Carotid artery longitudinal wall motion corresponds to the multiphasic arterial wall excursion in the direction parallel to blood flow during the cardiac cycle. While this motion phenomenon has been well characterized, there is a general lack of awareness regarding its implications for vascular health assessment or even basic vascular physiology. In the last decade, novel estimation strategies and clinical investigations have greatly advanced our understanding of the bi-axial behavior of the carotid artery, necessitati...
Source: Ultrasound in Medicine and Biology - July 21, 2020 Category: Radiology Authors: Fereshteh Yousefi Rizi, Jason Au, Heikki Yli-Ollila, Spyretta Golemati, Monika Mak ūnaitė, Maciej Orkisz, Nassir Navab, Maureen MacDonald, Tiina Marja Laitinen, Hamid Behnam, Zhifan Gao, Aimilia Gastounioti, Rytis Jurkonis, Didier Vray, Tomi Laitinen, A Tags: Review Article Source Type: research

Attention-Enriched Deep Learning Model for Breast Tumor Segmentation in Ultrasound Images
Incorporating human domain knowledge for breast tumor diagnosis is challenging because shape, boundary, curvature, intensity or other common medical priors vary significantly across patients and cannot be employed. This work proposes a new approach to integrating visual saliency into a deep learning model for breast tumor segmentation in ultrasound images. Visual saliency refers to image maps containing regions that are more likely to attract radiologists ’ visual attention. The proposed approach introduces attention blocks into a U-Net architecture and learns feature representations that prioritize spatial regions w...
Source: Ultrasound in Medicine and Biology - July 21, 2020 Category: Radiology Authors: Aleksandar Vakanski, Min Xian, Phoebe E. Freer Tags: Original Contribution Source Type: research

Evaluation of Myocardial Stiffness in Hypertensive Patients by Intrinsic Wave Propagation of the Myocardial Stretch
The objective of the study was to evaluate myocardial stiffness in hypertensive patients by measuring the intrinsic velocity propagation (IVP) of the myocardial stretch and to explore the correlation between IVP and cardiac systolic and diastolic functions. Eighty-one hypertensive patients and 53 healthy patients were prospectively enrolled in this study. IVP was measured using high-frame rate tissue Doppler (350 −450 frames per second). IVP was significantly higher in hypertensive patients than in the control group (1.53 ± 0.39 m/s vs. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 21, 2020 Category: Radiology Authors: Jun Zhang, Youbin Deng, Qiaoying Tang, Jie Sun, Lingying Huang, Pengfei Song, Xiaojun Bi Tags: Original Contribution Source Type: research

Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review
Cancerous tumor growth is associated with the development of tortuous, chaotic microvasculature, and this aberrant microvascular morphology can act as a biomarker of malignant disease. Acoustic angiography is a contrast-enhanced ultrasound technique that relies on superharmonic imaging to form high-resolution 3-D maps of the microvasculature. To date, acoustic angiography has been performed with dual-element transducers that can achieve high contrast-to-tissue ratio and resolution in pre-clinical small animal models. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 20, 2020 Category: Radiology Authors: Isabel G. Newsome, Paul A. Dayton Tags: Review Article Source Type: research

Renal Resistive Index of the Main Renal Arteries and Transmitral Flow in Hypertensive Patients
In hypertensive patients, diastolic dysfunction is related to increased resistive index (RI) of parenchymal renal arteries. To determine the existence of a link between RI of the main renal arteries (RRI) and diastolic dysfunction, a group of 127 hypertensive patients, with glomerular filtration rates>50 mL/min (mean estimated glomerular filtration rate: 88.6 ± 15.2 mL/min) and no comorbidities, was studied. RRI and transmitral flow were evaluated using the deceleration time (DT) and E/A ratio. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 20, 2020 Category: Radiology Authors: Michele Antonio Prencipe, Andrea Fontana, Chiara Di Giorgio, Angela Maria Pellegrino, Antonio Mangiacotti, Massimiliano Coppetti, Filippo Aucella Tags: Original Contribution Source Type: research

Lung ultrasound may support diagnosis and monitoring of COVID-19 pneumonia
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) is characterized by a severe pneumonia and/or acute respiratory distress syndrome (ARDS) in about 20% of infected patients. Computed tomography (CT) is the routine imaging technique for diagnosis and monitoring of COVID-19 pneumonia. Chest CT has high sensitivity for diagnosis of COVID-19, but is not universally available, requires infected or unstable patient to be moved to the Radiology unit with potential exposure of several people, CT room needs proper sanification after use, and is underutilized in children and pregnant women for radio...
Source: Ultrasound in Medicine and Biology - July 19, 2020 Category: Radiology Authors: Allinovi Marco, Parise Alberto, Giacalone Martina, Amerio Andrea, Delsante Marco, Odone Anna, Franci Andrea, Gigliotti Fabrizio, Amadasi Silvia, Delmonte Davide, Parri Niccol ò, Mangia Angelo Source Type: research

Lung Ultrasound Findings Are Associated with Mortality and Need for Intensive Care Admission in COVID-19 Patients Evaluated in the Emergency Department
Lung ultrasound (LUS) has recently been advocated as an accurate tool to diagnose coronavirus disease 2019 (COVID-19) pneumonia. However, reports on its use are based mainly on hypothesis studies, case reports or small retrospective case series, while the prognostic role of LUS in COVID-19 patients has not yet been established. We conducted a prospective study aimed at assessing the ability of LUS to predict mortality and intensive care unit admission of COVID-19 patients evaluated in a tertiary level emergency department. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 15, 2020 Category: Radiology Authors: Nicola Bonadia, Annamaria Carnicelli, Alfonso Piano, Danilo Buonsenso, Emanuele Gilardi, Cristina Kadhim, Enrico Torelli, Martina Petrucci, Luca Di Maurizio, Daniele Guerino Biasucci, Mariella Fuorlo, Evelina Forte, Raffaella Zaccaria, Francesco Francesch Tags: Original Contribution Source Type: research

Lung Ultrasound findings are associated with mortality and need of intensive care admission in COVID-19 patients evaluated in the Emergency Department
Lung Ultrasound (LUS) has been recently advocated as an accurate tool to diagnose COVID-19 pneumonia. However, reports on its use are mainly based on hypotheses studies, case reports or small retrospective case series, while the prognostic role of LUS in COVID-19 patients has not yet been established. We conducted a prospective study aiming to assess the ability of LUS in predicting mortality and intensive care unit admission of COVID-19 patients evaluated in a tertiary level emergency department. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 15, 2020 Category: Radiology Authors: Nicola Bonadia, Annamaria Carnicelli, Alfonso Piano, Danilo Buonsenso, Emanuele Gilardi, Cristina Kadhim, Enrico Torelli, Martina Petrucci, Luca Di Maurizio, Daniele Guerino Biasucci, Mariella Fuorlo, Evelina Forte, Raffaella Zaccaria, Francesco Francesch Tags: Original Contribution Source Type: research

Correlation between chest computed tomography and lung ultrasonography in patients with coronavirus disease 2019 (covid-19)
There is growing evidence regarding the imaging findings of Coronavirus Disease 2019 (COVID-19), in chest X-ray and Computed Tomography scan (CT). At this moment, the role of Lung Ultrasonography (LUS) has yet to be explored. The main purpose of this study is to evaluate the correlation between LUS findings and chest CT in confirmed (positive RT-PCR) or clinically highly suspicious (dyspnea, fever, myasthenia, gastrointestinal symptoms, dry cough, ageusia or anosmia) of COVID-19 patients. This prospective study was carried out in the emergency department (ED), confirmed or clinically highly suspicious COVID-19 patients wer...
Source: Ultrasound in Medicine and Biology - July 13, 2020 Category: Radiology Authors: Yale Tung Chen, Milagros Mart í de Gracia, Aurea Díez-Tascón, Rodrigo Alonso-González, Pablo Rodríguez-Fuertes, Maria Luz Parra-Gordo, Silvia Ossaba-Vélez, Sergio Agudo-Fernández, Rafael Llamas Fuertes Source Type: research

Left Ventricular Pressure –Strain Loop-Based Quantitative Examination of the Global and Regional Myocardial Work of Patients with Dilated Cardiomyopathy
The aim of our prospective pilot study was to explore the distribution characteristics of myocardial work (MW) of patients with dilated cardiomyopathy (DCM) and their clinical value in evaluation of therapeutic effects. Thirty patients with DCM were enrolled in the case group, and 30 healthy patients were randomly allocated to the control group. Global myocardial work (GMW) and regional myocardial work (RMW) of the control and case groups before and after therapy were evaluated by using left ventricular pressure –strain loops and then compared. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 10, 2020 Category: Radiology Authors: Cunying Cui, Lin Liu, Yanan Li, Yuanyuan Liu, Danqing Huang, Yanbin Hu, Lianzhong Zhang Tags: Clinical Note Source Type: research

Urinary Bladder Test Device to Integrate Basic Ultrasound Training for Nurses
Ultrasound is a useful tool for integrating clinical assessment with a bedside reliable imaging technique, but it requires adequate training. Ultrasonographic training involves examination performed on human models, in which many pathologic findings are not always readily available for the trainee to observe. The possibility of creating test objects that reproduce pathologic images allows the provision of training courses with those elements that are not always available. Our aims were to describe how to create a urinary bladder test object and to test its image quality and usefulness. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 10, 2020 Category: Radiology Authors: Andrea Colombo, Andrea Stella, Filippo Lombardi, Sabina Gulino, Sandro Pregnolato, Silvia Bonaiti, Giulia Salve, Francesco Mojoli, Silvia Mongodi Tags: Technical Note Source Type: research

Development of 64Cu-loaded Perfluoropentane Nanodroplet: A Potential Tumor Theragnostic Nano-carrier and Dual-Modality PET-Ultrasound Imaging Agents
The purpose of this study was to develop and preliminarily evaluate phospholipid-shelled nanodroplets (NDs) encapsulating perfluoropentane (PFP) and radioactive 64Cu as a hybrid positron emission tomography (PET)-ultrasound (US) probe.  PFP NDs were fabricated by mixing liquid-phase PFP with a phospholipid solution. The 64Cu was encapsulated into the NDs in a size-controlled manner by exploiting the hydrophobicity of 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) using a vial mixer and an extruder. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 9, 2020 Category: Radiology Authors: Unchol Shin, Jungyoung Kim, Jiwoong Lee, Donghee Park, Changmoon Lee, Hyon Chel Jung, Jiae Park, Kyochul Lee, Min Woo Lee, Suhng Wook Kim, Jongbum Seo Tags: Original Contribution Source Type: research

Influence of Ultrasound and Magnetic Field Treatment Time on Carcinoma Cell Inhibition with Drug Carriers: An in Vitro Study
The influence of exposing carcinoma cells to a static magnetic field (SMF) and low-intensity pulsed ultrasound (LIPUS), for different durations (15 –45 min/d), in the presence of magnetic and non-magnetic drug carriers, on their in vitro inhibition is examined. Increasing the exposure time by 15 min/d decreased the culture duration by 24 h to achieve the same level of inhibition in colon (HCT116) and hepatocellular (HepG2) cells. Cell cycle a nalysis revealed enhanced cellular blockage in G1 and S phases with SMF + LIPUS exposure, and exposure for 45 min/d completely suppressed the S → G2 transition. (So...
Source: Ultrasound in Medicine and Biology - July 9, 2020 Category: Radiology Authors: Somoshree Sengupta, Chandra Khatua, Aniruddha Pal, Subhadip Bodhak, Vamsi Krishna Balla Tags: Original Contribution Source Type: research

3-D H-Scan Ultrasound Imaging and Use of a Convolutional Neural Network for Scatterer Size Estimation
H-Scan ultrasound (US) is a new imaging technology that estimates the relative size of acoustic scattering objects and structures. The purpose of this study was to introduce a three-dimensional (3-D) H-scan US imaging approach for scatterer size estimation in volume space. Using a programmable research scanner (Vantage 256, Verasonics Inc, Kirkland, WA, USA) equipped with a custom volumetric imaging transducer (4 DL7, Vermon, Tours, France), raw radiofrequency (RF) data was collected for offline processing to generate H-scan US volumes. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 8, 2020 Category: Radiology Authors: Haowei Tai, Mawia Khairalseed, Kenneth Hoyt Tags: Original Contribution Source Type: research

Evaluation of the Uncertainty of Passive Cavitation Measurements for Blood –Brain Barrier Disruption Monitoring
Exposure to ultrasound combined with intravenous injection of microbubbles is a technique that can be used to temporarily disrupt the blood –brain barrier. Transcranial monitoring of cavitation can be done with one or more passive cavitation detectors (PCDs). However, the positioning of the PCDs relative to the cavitation site and the attenuation of these signals by the skull are two sources of error in the quantification of cavitatio n activity. The aim of this study was to evaluate in vitro the amplitude variation of cavitation signals that can be expected for an excised porcine skull model. (Source: Ultrasound in ...
Source: Ultrasound in Medicine and Biology - July 8, 2020 Category: Radiology Authors: Nicolas Asquier, Jean-Yves Chapelon, Cyril Lafon Tags: Original Contribution Source Type: research

Automatic Midline Identification in Transverse 2-D Ultrasound Images of the Spine
Effective epidural needle placement and injection involves accurate identification of the midline of the spine. Ultrasound, as a safe pre-procedural imaging modality, is suitable for epidural guidance because it offers adequate visibility of the vertebral anatomy. However, image interpretation remains a key challenge, especially for novices. A deep neural network is proposed to automatically classify the transverse ultrasound images of the vertebrae and identify the midline. To distinguish midline images from off-center frames, the proposed network detects the left –right symmetric anatomic landmarks. (Source: Ultras...
Source: Ultrasound in Medicine and Biology - July 7, 2020 Category: Radiology Authors: Mehran Pesteie, Vickie Lessoway, Purang Abolmaesumi, Robert Rohling Tags: Technical Note Source Type: research

Multimodal Ultrasound Including Virtual Touch Imaging Quantification for Differentiating Cervical Lymph Nodes
Defining the entity of cervical lymph nodes (LNs) is essential for the diagnosis and staging of head and neck malignancies. Virtual Touch imaging quantification (VTIQ) is a relatively new method of elastography that measures tissue stiffness quantitatively. A prospective study was conducted that included 108 patients (57 benign and 51 metastatic lymph nodes [MLNs]). Shear wave velocities (SWVs) were analyzed using VTIQ and were compared with the histopathological results. Both maximum and minimum SWVs within the LNs significantly differed between benign masses and MLNs (p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 7, 2020 Category: Radiology Authors: Holger R üger, Georgios Psychogios, Monika Jering, Johannes Zenk Tags: Original Contribution Source Type: research

Stable Low-Dose Oxygen Release Using H2O2/Perfluoropentane Phase-Change Nanoparticles with Low-Intensity Focused Ultrasound for Coronary Thrombolysis
After the onset of myocardial infarction, extensive coronary thrombus and oxygen supply insufficiency lead to severe myocardial damage and heart failure. Recently, ultrasound-irradiated phase-change nanoparticles have been recognized for their cardiovascular thrombolysis potential. Therefore, we sought to establish a novel treatment method using hydrogen peroxide (H2O2)/perfluoropentane (PFP) phase-change nanoparticles with low-intensity focused ultrasound (LIFU) for the simulation of acute coronary thrombolysis and myocardial preservation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 6, 2020 Category: Radiology Authors: Nan Jiang, Bo Hu, Sheng Cao, Shunji Gao, Qingqiong Cao, Jinling Chen, Qing Zhou, Ruiqiang Guo Tags: Original Contribution Source Type: research

Automated Quantitative Assessment of Coronary Calcification Using Intravascular Ultrasound
Coronary calcification represents a challenge in the treatment of coronary artery disease by stent placement. It negatively affects stent expansion and has been related to future adverse cardiac events. Intravascular ultrasound (IVUS) is known for its high sensitivity in detecting coronary calcification. At present, automated quantification of calcium as detected by IVUS is not available. For this reason, we developed and validated an optimized framework for accurate automated detection and quantification of calcified plaque in coronary atherosclerosis as seen by IVUS. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 4, 2020 Category: Radiology Authors: Shengnan Liu, Tara Neleman, Eline M.J. Hartman, Jurgen M.R. Ligthart, Karen T. Witberg, Antonius F.W. van der Steen, Jolanda J. Wentzel, Joost Daemen, Gijs van Soest Tags: Original Contribution Source Type: research

Image Processing Pipeline for Liver Fibrosis Classification Using Ultrasound Shear Wave Elastography
The purpose of this study was to develop an automated method for classifying liver fibrosis stage ≥F2 based on ultrasound shear wave elastography (SWE) and to assess the system's performance in comparison with a reference manual approach. The reference approach consists of manually selecting a region of interest from each of eight or more SWE images, computing the mean tissue stiffness within each of the regions of interest and computing a resulting stiffness value as the median of the means. The 527-subject database consisted of 5526 SWE images and pathologist-scored biopsies, with data collected from a single system a...
Source: Ultrasound in Medicine and Biology - July 2, 2020 Category: Radiology Authors: Laura J. Brattain, Arinc Ozturk, Brian A. Telfer, Manish Dhyani, Joseph R. Grajo, Anthony E. Samir Tags: Original Contribution Source Type: research

Vascular Shear Wave Elastography in Atherosclerotic Arteries: A Systematic Review
Ischemic stroke is a leading cause of death and disability worldwide, so adequate prevention strategies are crucial. However, current stroke risk stratification is based on epidemiologic studies and is still suboptimal for individual patients. The aim of this systematic review was to provide a literature overview on the feasibility and diagnostic value of vascular shear wave elastography (SWE) using ultrasound (US) in (mimicked) human and non-human arteries affected by different stages of atherosclerotic diseases or diseases related to atherosclerosis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 30, 2020 Category: Radiology Authors: Judith T. Pruijssen, Chris L. de Korte, Iona Voss, Hendrik H.G. Hansen Tags: Review Article Source Type: research

3-D Intravascular Characterization of Blood Flow Velocity Fields with a Forward-Viewing 2-D Array
Risk stratification in coronary artery disease is an ongoing challenge for which few tools are available for quantifying physiology within coronary arteries. Recently, anatomy-driven computational fluid dynamic modeling has enabled the mapping of local flow dynamics in coronary stenoses, with derived parameters such as WSS exhibiting a strong capability for predicting adverse clinical events on a patient-specific basis. As cardiac catheterization is common in patients with coronary artery disease, minimally invasive technologies capable of identifying pathologic flow in situ in real time could have a significant impact on ...
Source: Ultrasound in Medicine and Biology - June 30, 2020 Category: Radiology Authors: Brooks D. Lindsey, Bowen Jing, Saeyoung Kim, Graham C. Collins, Muralidhar Padala Tags: Technical Note Source Type: research

Direct Activation of Cortical Neurons in the Primary Somatosensory Cortex of the Rat in Vivo Using Focused Ultrasound
We address the recent controversy over whether focused ultrasound (FUS) activates cortical neurons directly or indirectly by initially activating auditory pathways. We obtained two types of evidence that FUS can directly activate cortical neurons. The depth profile of the local field potential (LFP) in the barrel cortex of the rat in vivo indicated a generator was located within the cortical gray matter. The onset and peak latencies of the initial component p1 were 3.2 ± 0.25 ms (mean ± standard error of the mean) and 7.6 ± 0.12 ms, respectively, for the direct cortical response (DCR), 6.8 ± 0.4...
Source: Ultrasound in Medicine and Biology - June 30, 2020 Category: Radiology Authors: Kush Tripathi, Tongsheng Zhang, Nathan McDannold, Yong-Zhi Zhang, G östa Ehnholm, Yoshio Okada Tags: Original Contribution Source Type: research

Magnetorheological Gel Mimicking Cervical Ripening as a Potential Model for Evaluating Shear Wave Elastography
The mechanical characteristics of tissue can reflect its biochemical content and, therefore, be a powerful tool in the diagnosis of diseases. Many different methods have been developed for testing the mechanical properties of tissue, such as aspiration, indentation and shear wave elastography. Soft tissues are, however, more complex in behaviour than current commercial tissue-mimicking materials and the models used in measurement methods. Complex behaviours of the tissue include anisotropy and heterogeneous elasticity. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 29, 2020 Category: Radiology Authors: Weirong Ge, Graham Brooker, Joyce Woo, Will Rae, Yu Liu, Jon Hyett Tags: Original Contribution Source Type: research