A New Multimodel Machine Learning Framework to Improve Hepatic Fibrosis Grading Using Ultrasound Elastography Systems from Different Vendors
The purpose of the work described here was to determine if the diagnostic performance of point and 2-D shear wave elastography (pSWE; 2-DSWE) using shear wave velocity (SWV) with a new machine learning (ML) technique applied to systems from different vendors is comparable to that of magnetic resonance elastography (MRE) in distinguishing non-significant ( (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 11, 2019 Category: Radiology Authors: Isabelle Durot, Alireza Akhbardeh, Hersh Sagreiya, Andreas M. Loening, Daniel L. Rubin Tags: Original Contribution Source Type: research

Stiffness and Anisotropy Effect on Shear Wave Elastography: A Phantom and in Vivo Renal Study
Tissue elasticity is related to the pathologic state of kidneys and can be measured using shear wave elastography (SWE). However, SWE quantification has not been rigorously validated. The aim of this study was to evaluate the accuracy of SWE-measured stiffness and the effect of tissue anisotropy on SWE measurements. Point SWE (pSWE), 2-D SWE and dynamic mechanical analysis (DMA) were used to measure stiffness and evaluate the effect of tissue anisotropy on the measurements. SWE and DMA were performed on phantoms of different gelatin concentrations. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 5, 2019 Category: Radiology Authors: Sook Sam Leong, Jeannie Hsiu Ding Wong, Mohammad Nazri Md Shah, Anushya Vijayananthan, Maisarah Jalalonmuhali, Nur Hidayati Mohd Sharif, Nurul Khairyah Abas, Kwan Hoong Ng Tags: Original Contribution Source Type: research

Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Osteoporosis in Ovariectomized Rats: Intensity-Dependent Study
This study investigated the effects of low-intensity pulsed ultrasound (LIPUS) of different spatial-average-temporal-average intensity (ISATA) ranging from 15 –150 mW/cm2 on the treatment of osteoporosis in ovariectomized rats. Healthy 3-mo-old female Sprague–Dawley rats were randomly divided into nine groups (n = 12 per group): sham-ovariectomy (OVX) control group, OVX control group and OVX groups treated with LIPUS at seven different intensities (ISATA: 15, 30, 50, 75, 100, 125 and 150 mW/cm2, respectively). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 4, 2019 Category: Radiology Authors: Shuxin Sun, Lijun Sun, Yiting Kang, Liang Tang, Yi-Xian Qin, Dean Ta Tags: Original Contribution Source Type: research

Distribution and Diffusion of Macromolecule Delivery to the Brain via Focused Ultrasound using Magnetic Resonance and Multispectral Fluorescence Imaging
Focused ultrasound (FUS), in combination with microbubble contrast agents, can be used to transiently open the blood –brain barrier (BBB) to allow intravascular agents to cross into the brain. Often, FUS is carried out in conjunction with magnetic resonance imaging (MRI) to evaluate BBB opening to gadolinium-based MRI contrast agents. Although MRI allows direct visualization of the distribution of gadolinium-bas ed contrast agents in the brain parenchyma, it does not allow measurements of the distribution of other molecules crossing the BBB. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 2, 2019 Category: Radiology Authors: Michael A. Valdez, Elizabeth Fernandez, Terry Matsunaga, Robert P. Erickson, Theodore P. Trouard Tags: Original Contribution Source Type: research

Relationship between Morphologic Characteristics of Ultrasonic Calcification in Thyroid Nodules and Thyroid Carcinoma
The aim of this study was to investigate the relationship between morphologic characteristics of the calcifications detected by ultrasound in thyroid nodules and thyroid carcinoma. Morphologic characteristics of the calcifications on pre-operative ultrasound examinations of thyroids were compared with post-operative pathologic diagnoses in 543 patients undergoing thyroid surgery. Calcifications were divided into microcalcifications ( ≤2 mm) and macrocalcifications (>2 mm), and the latter were divided into eggshell calcifications in a row, eggshell discontinuous calcifications, irregular calcifications and multilayer-...
Source: Ultrasound in Medicine and Biology - October 1, 2019 Category: Radiology Authors: Lu Yin, Wei Zhang, Wenkun Bai, Wen He Tags: Original Contribution Source Type: research

A Pilot Prospective Study to Validate Point-of-Care Ultrasound in Comparison to X-Ray Examination in Detecting Fractures
Despite its limitations, conventional radiography is the method of choice for fracture evaluation in the emergency department. Only a few studies, moreover in limited populations, have evaluated the possible benefits of ultrasound (US), and especially of point-of-care ultrasound (POCUS), in the diagnosis of fractures. We sought to compare the accuracy of POCUS with that of conventional radiography in the diagnosis of bone fractures. This prospective study with a non-randomly allocated convenience sample was conducted at two academic medical centers. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 1, 2019 Category: Radiology Authors: Costantino Caroselli, Eleonora Zaccaria, Michael Blaivas, Giovanni Dib, Romano Fiorentino, Daniele Longo Tags: Original Contribution Source Type: research

Interventional Ultrasound Assisted Early Local Hemostatic Drug Therapy in Traumatic Intracerebral Hemorrhage
This article aims to test a minimally invasive interventional approach by real-time transcranial contrast-enhanced ultrasound (CEUS) through a small bur hole to achieve an early local hemostatic drug therapy in a novel traumatic intracerebral hematoma (ICH) model of pigs with hemostatic abnormalities. The effects of hemostasis in the hemocoagulase atrox (HA) injection group and saline injection group groups were observed by transcranial CEUS at three time points: 0 s, 10 s, 2nd. We successfully established a novel traumatic ICH model of pigs with hemostatic abnormalities by the methods of interventional ultrasound techniqu...
Source: Ultrasound in Medicine and Biology - September 30, 2019 Category: Radiology Authors: Cong Feng, Sai Huang, Xuan Zhou, Lili Wang, Xiang Cui, Li Chen, Faqin Lv, Tanshi Li Tags: Technical Note Source Type: research

Point-of-Care Ultrasound —A New Option for Early Quantitative Assessment of Pulmonary Edema
The aim of the work described here was to investigate the value of point-of-care ultrasound (POCUS) in the early assessment of the severity of pulmonary edema in rabbits. A rabbit oleic acid (OA)-induced pulmonary edema model was used. Thirty-two New Zealand rabbits were randomly divided into four groups: a control group and three pulmonary edema groups (mild, moderate and severe). Features of transthoracic B-line artifacts (BLA), blood pH, PaO2 and PaCO2, serum inflammatory factors, lung coefficient (LC), lung wet-to-dry weight ratio (W/D) and lung histopathology were assessed. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 28, 2019 Category: Radiology Authors: Zhixing Zhu, Xihua Lian, Yiming Zeng, Weijing Wu, Zhirong Xu, Yongjian Chen, Jingyun Li, Xiaoshan Su, Liqing Zeng, Guorong Lv Tags: Original Contribution Source Type: research

Cerebrovascular Pulsatility During Rest and Exercise Reflects Hemodynamic Impairment in Stroke and Cerebral Small Vessel Disease
This study tested the hypothesis that older adults with chronic stroke or cerebral small vessel disease (SVD) exhibit a greater increase in pulsatile hemodynamics during exercise compared with young and age-matched healthy adults. Middle cerebral artery blood flow velocity was acquired during 20 min of moderate intensity cycling in 51 participants from four groups (young, old, SVD and stroke). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 28, 2019 Category: Radiology Authors: Andrew D. Robertson, Sarah Atwi, Kyriaki Kostoglou, Nicolaas Paul L.G. Verhoeff, Paul I. Oh, Georgios D. Mitsis, Susan Marzolini, Bradley J. MacIntosh Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 27, 2019 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 27, 2019 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 27, 2019 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 27, 2019 Category: Radiology Source Type: research

Ultrasound Detection of Abnormal Cerebrovascular Morphology in a Mouse Model of Sickle Cell Disease Based on Wave Reflection
Sickle cell disease (SCD) is associated with a high risk of stroke, and affected individuals often have focal brain lesions termed silent cerebral infarcts. The mechanisms leading to these types of injuries are at present poorly understood. Our group has recently demonstrated a non-invasive measurement of cerebrovascular impedance and wave reflection in mice using high-frequency ultrasound in the common carotid artery. To better understand the pathophysiology in SCD, we used this approach in combination with micro-computed tomography to investigate changes in cerebrovascular morphology in the Townes mouse model of SCD. (So...
Source: Ultrasound in Medicine and Biology - September 26, 2019 Category: Radiology Authors: Lindsay S. Cahill, Jesper Pilmeyer, Lisa X. Yu, Joe Steinman, Gregory M.T. Hare, Andrea Kassner, Christopher K. Macgowan, John G. Sled Tags: Original Contribution Source Type: research

Reproducibility of Natural Shear Wave Elastography Measurements
For the quantification of myocardial function, myocardial stiffness can potentially be measured non-invasively using shear wave elastography. Clinical diagnosis requires high precision. In 10 healthy volunteers, we studied the reproducibility of the measurement of propagation speeds of shear waves induced by aortic and mitral valve closure (AVC, MVC). Inter-scan was slightly higher but in similar ranges as intra-scan variability (AVC: 0.67 m/s (interquartile range [IQR]: 0.40 –0.86 m/s) versus 0.38 m/s (IQR: 0.26–0.68 m/s), MVC: 0.61 m/s (IQR: 0.26–0.94 m/s) versus 0.26 m/s (IQR: 0.15–0.46 m/s)). (S...
Source: Ultrasound in Medicine and Biology - September 26, 2019 Category: Radiology Authors: Lana B.H. Keijzer, Mihai Strachinaru, Dan J. Bowen, Marcel L. Geleijnse, Antonius F.W. van der Steen, Johan G. Bosch, Nico de Jong, Hendrik J. Vos Tags: Original Contribution Source Type: research

Diagnostic Performance Using Automated Breast Ultrasound System for Breast Cancer in Chinese Women Aged 40 Years or Older: A Comparative Study
The purpose of this study was to investigate the diagnostic performance of the automated breast ultrasound system (ABUS) compared with hand-held ultrasonography (HHUS) and mammography (MG) for breast cancer in women aged 40 y or older. A total of 594 breasts in 385 patients were enrolled in the study. HHUS, ABUS and MG exams were performed for these patients. Follow-up and pathologic findings were used as the reference standard. Based on the reference standard, 519 units were benign or normal and 75 were malignant. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2019 Category: Radiology Authors: Li Zhang, Ling-Yun Bao, Yan-Juan Tan, Luo-Qian Zhu, Xiao-Jing Xu, Qing-Qing Zhu, Yan-Na Shan, Jing Zhao, Le-Si Xie, Jan Liu Tags: Original Contribution Source Type: research

Acoustic Droplet Vaporization in Acoustically Responsive Scaffolds: Effects of Frequency of Excitation, Volume Fraction and Threshold Determination Method
Ultrasound-induced vaporization of liquid perfluorocarbon (PFC) droplets into microbubbles, termed acoustic droplet vaporization (ADV), has potential therapeutic and diagnostic applications. Recently, we demonstrated how ADV —a threshold-based phenomenon—can modulate the release of biomolecules from composite hydrogels, thereby stimulating regenerative processes, such as angiogenesis. These composite hydrogels, called acoustically responsive scaffolds (ARSs), consist of monodispersed, micron size PFC emulsions embed ded within a fibrin matrix. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2019 Category: Radiology Authors: Mitra Aliabouzar, Xiaofang Lu, Oliver D. Kripfgans, J. Brian Fowlkes, Mario L. Fabiilli Tags: Original Contribution Source Type: research

Safety and Efficacy of Ultrasound-Guided High-Intensity Focused Ultrasound Treatment for Uterine Fibroids and Adenomyosis
The objective of this study was to assess the tolerability and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation using a Haifu JC Focused Ultrasound Tumor Therapeutic System (operating transducer frequency: 0.8 MHz, 300 –400 W/cm2) under real-time ultrasound guidance (2.5- to 5.0-MHz imaging probe) for uterine fibroids and adenomyosis in 1807 patients (928 with fibroids and 889 with adenomyosis). Volume change and clinical symptom improvement after treatment were evaluated based on symptom severity scores and hea lth-related quality of life scores using the Uterine Fibroid Symptom and...
Source: Ultrasound in Medicine and Biology - September 25, 2019 Category: Radiology Authors: Jae-Seong Lee, Gi-Youn Hong, Kye-Hwa Lee, Jung-Hwa Song, Tae-Eung Kim Tags: Original Contribution Source Type: research

Acoustic Histology with Specific Dyes and Antibodies
The present study aims to identify specific staining methods for acoustic histology. We compared attenuation-of-sound (AOS) images from scanning acoustic microscopy (SAM) with light microscopy (LM) images. Ethanol-fixed tissue or cytology samples and formalin-fixed surgical or autopsy specimens were examined. Nuclei, collagen, elastic fibers and polysaccharides and various antigens, including cell surface, cytoplasmic, nuclear and stromal substances, were observed. Samples with various fixation methods were used. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2019 Category: Radiology Authors: Katsutoshi Miura, Kanna Yamashita Tags: Original Contribution Source Type: research

Corrigendum to ‘Breast elastography early experiences’ [Ultrasound Med Biol 45 (2019) S21-S22]
The author regrets that Sandra O'Hara was listed in error as a co-author of the above conference abstract. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2019 Category: Radiology Authors: Natalie Clements Tags: Corrigendum Source Type: research

Large-Strain 3-D in Vivo Breast Ultrasound Strain Elastography Using a Multi-compression Strategy and a Whole-Breast Scanning System
In this study, a multi-compression strategy was utilized to produce large tissue deformation, and a method to estimate 3-D motion of tissue under large deformation was introduced. Given multiple volumes of ultrasound data, the proposed method first estimates volume-to-volume incremental displacements using a 3-D region-growing motion-tracking method. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 21, 2019 Category: Radiology Authors: Yuqi Wang, Matthew Bayer, Jingfeng Jiang, Timothy J. Hall Tags: Original Contribution Source Type: research

Acoustic Radiation Force Impulse and Conventional Ultrasound in the Prediction of Cirrhosis Complicating Fatty Liver: Does Body Mass Index Independently Alter the Results?
We investigated whether ultrasound (US) could quantify steatosis and fibrosis in non-alcoholic fatty liver disease (NAFLD). Estimates of fat by gray-scale, hepatorenal index (HRI) and fibrosis by acoustic radiation force impulse (ARFI) were made using the interquartile range (IQR)/median for ARFI quality. Biopsy was the gold standard. US fat assessment correlated with histologic grade and predicted steatosis. HRI predicted steatosis but did not improve accuracy. ARFI of good quality was highly sensitive toward severe fibrosis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 19, 2019 Category: Radiology Authors: Alexandra Medellin, Glen Pridham, Stefan J. Urbanski, Saumya Jayakumar, Stephanie R. Wilson Tags: Original Contribution Source Type: research

Sonoporation as an Approach for siRNA delivery into T cells
Delivery of small interfering RNAs (siRNAs) into primary T cells is quite challenging because they are non-proliferating cells and are difficult to transfect with non-viral approaches. Because sonoporation is independent of the proliferation status of cells and siRNA acts in the cell cytoplasm, we investigated whether sonoporation could be used to deliver siRNA into mouse and human T cells. Cells mixed with Definity microbubbles and siRNA were sonicated with a non-focused transducer of center frequency 2.20 MHz producing ultrasound at a 10% duty cycle, pulse repetition frequency of 2.20 kHz and spatial average temporal ave...
Source: Ultrasound in Medicine and Biology - September 17, 2019 Category: Radiology Authors: Alina Karki, Emily Giddings, Ana Carreras, Devin Champagne, Karen Fortner, Mercedes Rincon, Junru Wu Tags: Original Contribution Source Type: research

Mechanical Function of Internal Jugular Vein Valve: Post-analysis of M-Mode Imaging under Cardiac Monitoring
Because the internal jugular vein (IJV) valve is the only protective valve between the brain and heart, recent studies have focused on the dynamic behaviour of the valve and its importance in regulating the cerebral blood outflow pathway. However, the mechanism underlying valve opening and closure, as well as the normal opening time, has not been investigated before. The aim of the study described here was to investigate IJV physiology in healthy young adults by means of ultrasound imaging. Twenty-four normal young adults (16 male, 8 female, 21.79 ± 0.79 y of age) were enrolled in this study. (Source: Ultrasound in ...
Source: Ultrasound in Medicine and Biology - September 17, 2019 Category: Radiology Authors: Nadiya Y. Mohammed, Giovanni Di Domenico, Erica Menegatti, Francesco Sisini, Maria Elena Vannini, Mauro Gambaccini, Mirko Tessari, Paolo Zamboni Tags: Original Contribution Source Type: research

Mechanical Weakness of Thoracic Aorta Related to Aging or Dissection Predicted by Speed of Sound with Collagenase
Scanning acoustic microscopy reveals information on histology and speed of sound (SOS) through tissues. Slower SOS corresponds to lower stiffness. The aim of the present study was to investigate whether SOS values reflect the degree of degeneration with aging or dissection and whether enzymatic digestion susceptibility is distinct. The SOSs of media other than the atheromatous areas of normal and surgical dissections were measured and compared using medial degeneration grade (MDG) scores. To evaluate the damage rate, SOS was assessed after collagenase digestion. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 16, 2019 Category: Radiology Authors: Katsutoshi Miura, Kanna Yamashita Tags: Original Contribution Source Type: research

Clinical Significance of Twinkling Artifact in the Diagnosis of Urinary Stones
The twinkling artifact is a color Doppler artifact, but it could be used in the confirmation of urinary stones. Conventionally, gray-scale criteria (echogenic foci with acoustic shadowing) is used in the diagnosis of urinary stones, but unfortunately, its reliability is very low. If the color Doppler twinkling artifact is applied in conjunction with other provocative measures, then its overall reliability exceeds 95%. To determine the clinical significance of twinkling artifact in the diagnosis of urinary stones, this cross-sectional observational study was conducted at Gilani Ultrasound Center, Lahore, Pakistan. (Source: ...
Source: Ultrasound in Medicine and Biology - September 16, 2019 Category: Radiology Authors: Raham Bacha, Iqra Manzoor, Syed Amir Gilani, Amjad Iqbal Khan Tags: Original Contribution Source Type: research

Ultrasensitive Ultrasound Microvessel Imaging for Characterizing Benign and Malignant Breast Tumors
Tumor angiogenesis plays an important role during breast tumor growth. However, conventional Doppler has limited sensitivity to detect small blood vessels, resulting in a large overlap of Doppler features between benign and malignant tumors. An ultrasensitive ultrasound microvessel imaging (UMI) technique was recently developed. To evaluate the performance of UMI, we studied 44 patients with 51 breast masses. Tumor pathology served as the gold standard: 28 malignancies and 23 benignities. UMI provided a significant improvement in depicting smaller vessels compared with conventional Doppler. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 14, 2019 Category: Radiology Authors: Ping Gong, Pengfei Song, Chengwu Huang, U-Wai Lok, Shanshan Tang, Yue Yu, Duane D. Meixner, Kathryn J. Ruddy, Karthik Ghosh, Robert T. Fazzio, Wenwu Ling, Shigao Chen Tags: Original Contribution Source Type: research

The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models
Non-ablative pulsed focused ultrasound (pFUS) targets non-thermal forces that activate local molecular and cellular immune responses. Optimal parameters to stimulate immunotherapeutic tumor microenvironments (TME) and responses in different tumor types remain uninvestigated. Flank B16 murine melanoma and 4T1 breast tumors received 1 MHz pFUS at 1 –8 MPa peak negative pressures (PNP) and were analyzed 24 hr post-sonication. Necrosis or hemorrhage were unaltered in both tumors, but pFUS induced DNA strand breaks in tumor cells at PNP ≥6 MPa. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 14, 2019 Category: Radiology Authors: Omer Aydin, Parwathy Chandran, Rebecca R. Lorsung, Gadi Cohen, Scott R. Burks, Joseph A. Frank Tags: Original Contribution Source Type: research

Focused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions
An experimental arrangement that allows in vitro exposure of cells to focused ultrasound-mediated hyperthermia (43 °C–55°C) in a tissue-mimicking phantom with biological, acoustic and thermal properties comparable to those of human soft tissue is described. Cells were embedded in a compressed collagen gel, which was sandwiched between 6-mm-thick slices of biocompatible, acoustically absorbing and thermally t issue mimicking poly(vinyl alcohol) cryo-gel. To illustrate the system's potential, cells were exposed using a 1.66-MHz focused ultrasound beam (spatial-peak temporal-average intensities (ISPTA) = 900...
Source: Ultrasound in Medicine and Biology - September 6, 2019 Category: Radiology Authors: Sarah C. Br üningk, Ian Rivens, Petros Mouratidis, Gail ter Haar Tags: Technical Note Source Type: research

Oxytocin-Augmented and Non-Sedating High-Intensity –Focused Ultrasound (HIFU) for Uterine Fibroids Showed Promising Outcome As Compared To HIFU Alone or Uterine Artery Embolization
The objective of this study was to evaluate the safety and treatment effectiveness of this new protocol. The treat ment outcomes of 9 consecutive patients (study group) were compared with those of 51 patients (control group) who had been randomized (1:1) to receive HIFU (n = 24) or uterine artery embolization ([UAE] n = 27). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 4, 2019 Category: Radiology Authors: Simon Chun-Ho Yu, Eva Chun-Wai Cheung, Vivian Yee-Fong Leung, Linda Wen-Ying Fung Tags: Original Contribution Source Type: research

Does Magnetic Resonance Imaging Provide Superior Reliability for Achilles and Patellar Tendon Cross-Sectional Area Measurements Compared with Ultrasound Imaging?
This study investigated the reliability of Achilles and patellar tendon cross-sectional area (CSA) measurement using ultrasound imaging (USI) and magnetic resonance imaging (MRI). Fifteen healthy adults were imaged twice on two occasions, interrupted by a tendon loading protocol. Tendon CSA segmentations were conducted by an experienced and an inexperienced rater blinded to information regarding subject, session and loading status. USI provided good test-retest reliability (intra-class correlation coefficient [ICC] 2,1> 0.85, standard error of measurement [SEM] 5% –6%), while with MRI it was excellent (ICC 2,1>...
Source: Ultrasound in Medicine and Biology - September 4, 2019 Category: Radiology Authors: Lauri Stenroth, Sandra Sefa, Jari Arokoski, Juha T öyräs Tags: Original Contribution Source Type: research

2-D Shear Wave Elastography for Focal Lesions in Liver Phantoms: Effects of Background Stiffness, Depth and Size of Focal Lesions on Stiffness Measurement
The aim of this study was to determine the factors influencing stiffness and conspicuity of focal lesions in deep organs by focusing on target properties using 2-D shear wave elastography (SWE). Two normal (4 ± 1 kPa) and cirrhotic (16 ± 2 kPa) liver-mimicking phantoms with spherical inclusions (23 ± 3 kPa) were used. Inclusions of three sizes (20, 15 and 10 mm in diameter) were arranged in a row at depths of 3, 5 and 7 cm. Two observers acquired quantitative stiffness values and a qualitative five-gr ade morphologic score at each inclusion using SWE. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 4, 2019 Category: Radiology Authors: Jeong Ah Hwang, Woo Kyoung Jeong, Kyoung Doo Song, Kyung A Kang, Hyo K. Lim Tags: Original Contribution Source Type: research

Median Nerve Transverse Mobility and Outcome after Carpal Tunnel Release
Nerve movement is decreased in patients with carpal tunnel syndrome and can be assessed with ultrasound. In addition to morphologic features, this study describes a novel approach in which nerve movement and the association with short-term patient-reported outcome are assessed. Ultrasound images at the carpal tunnel inlet were acquired during finger and wrist flexion. Linear regression models were used with the Boston Carpal Tunnel Questionnaire as main outcome. Eighty-five patients were included; 93% completed the 3-mo follow-up. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 2, 2019 Category: Radiology Authors: Verena J.M.M. Schrier, Stefanie Evers, Jennifer R. Geske, Walter K. Kremers, Hector R. Villarraga, Sanjeev Kakar, Ruud W. Selles, Steven E.R. Hovius, Russell Gelfman, Peter C. Amadio Tags: Original Contribution Source Type: research

High-Performance Ultrasonic Tweezers for Manipulation of Motile and Still Single Cells in a Droplet
The manipulation of motile and still single cells with the simultaneous features of selective trapping, 3-D path free transport, position-controllable release and little heat damage has been a significant challenge. We developed an ultrasonic method for capturing motile and still single cells with the aforementioned features in a droplet. During manipulation, a micromanipulation probe (MMP), which vibrated linearly with a trajectory parallel to a silicon substrate, was immersed in the droplet and was not in contact with the substrate. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 31, 2019 Category: Radiology Authors: Qingyang Liu, Junhui Hu, Igor V. Minin, Oleg V. Minin Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Source Type: research

Sonographic Assessment of Oropharynx Movement During Deep Breathing
To investigate the feasibility of ultrasonography in detecting the oropharynx movement during deep breathing and to quantitatively analyze oropharynx airway lumen changes during deep breathing. The motions of oropharynx were monitored, and sonographic measurements of airway lumen were obtained during deep breathing in 448 healthy volunteers. Adequate visualization of oropharynx movement was obtained on all healthy volunteers. The anterior-posterior (AP) diameters and AP/transverse (T) diameter ratios were greater at the end of deep inspiration than that at the end of deep expiration for each sex (p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Authors: Hai-Mei Lun, Shang-Yong Zhu, Qiao Hu, Yao-Li Liu, Li-si Wei Tags: Original Contribution Source Type: research

Effect of Ultrasound on the Vasculature and Extravasation of Nanoscale Particles Imaged in Real Time
Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect of acoustic pressure on extravasation and penetration of nanoscale particles into the extracellular matrix, real-time intravital multiphoton microscopy was performed during sonication of tumors growing in dorsal window chambers. The impact of vessel diameter, vessel structure and blood flow was characterized. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Authors: Petros T. Yemane, Andreas K.O. Åslund, Sofie Snipstad, Astrid Bjørkøy, Kristin Grendstad, Sigrid Berg, Yrr Mørch, Sverre H. Torp, Rune Hansen, Catharina de Lange Davies Tags: Original Contribution Source Type: research

Presence of Deep Fascial Fluid in Imaging Necrotizing Fasciitis: Importance of This Feature in Diagnosing Necrotizing Fasciitis without Imaging Manifestations of Soft Tissue Gas
I read with great interest the important original contribution by Lin et al. (2019), “The Relationship between Fluid Accumulation in Ultrasonography, Diagnosis, and Prognosis of Patients with Necrotizing Fasciitis,” in which the authors profile a retrospective cohort of 48 patients with clinically suspected necrotizing fasciitis (NF) in the upper or lower extremities who receive d an ultrasound examination of the suspected limb with NF performed by three emergency physicians. Their study details that the degree of deep fascial fluid accumulation can help diagnose and determine the prognostic effects of NF. (Sou...
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Authors: David H. Ballard Tags: Letter to the Editor Source Type: research

Contrast Agent Microbubble Jetting during Initial Interaction with 200-kHz Focused Ultrasound
The initial response of microbubbles flowing through a 500- μm polycarbonate capillary to a burst of 200-kHz focused ultrasound, at peak-negative pressure amplitudes from 0.7–1.5 MPa, was investigated with dual-perspective high-speed imaging. Directed jetting through the acoustic focus is demonstrated according to the pressure gradients acting across the cavitating microbubbles. At lower amplitudes, repeated microbubble-jetting is accompanied by sudden, intermittent translation. At higher amplitudes a rebound jet also forms, before disintegration into a cavitation cloud. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 30, 2019 Category: Radiology Authors: Sarah Cleve, Claude Inserra, Paul Prentice Tags: Technical Note Source Type: research

Magnetic Resonance Imaging and Freehand 3-D Ultrasound Provide Similar Estimates of Free Achilles Tendon Shape and 3-D Geometry
The purpose of this study was to assess the similarity of free Achilles tendon shape and 3-D geometry between magnetic resonance imaging (MRI) and freehand 3-D ultrasound (3-DUS) imaging methods. Fourteen elite/sub-elite middle-distance runners participated in the study. MRI and 3-DUS scans of the Achilles tendon were acquired on two separate imaging sessions, and all 3-D reconstructions were performed using identical methods. Shape similarity of free Achilles tendon reconstructed from MRI and 3-DUS data was assessed using Jaccard index, Hausdorff distance and root mean square error (RMSE). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 27, 2019 Category: Radiology Authors: Daniel Devaprakash, David G. Lloyd, Rod S. Barrett, Steven J. Obst, Ben Kennedy, Kahlee L. Adams, Adam Hunter, Nicole Vlahovich, David L. Pease, Claudio Pizzolato Tags: Original Contribution Source Type: research

Corrigendum to ‘LOW-ECHO SPHERE PHANTOMS AND METHODS FOR ASSESSING IMAGING PERFORMANCE OF MEDICAL ULTRASOUND SCANNERS’ [ULTRASOUND MED BIOL 40 (2014) 1697-1717]
The authors regret that there was a miscommunication between the programmer (Song) and Madsen regarding Eq. (5) and the sentence in lines 18-23 in the right –hand on page 1707. That sentence describes a restriction which was not included in the data analyses and indeed should not have been included. That sentence should be replaced with the following: (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 26, 2019 Category: Radiology Authors: Ernest L. Madsen, Chihwa Song, Gary R. Frank Tags: Corrigendum Source Type: research

Investigating the Accuracy of Ultrasound-Ultrasound Fusion Imaging for Evaluating the Ablation Effect via Special Phantom-Simulated Liver Tumors
The goal of this study was to investigate the accuracy of ultrasound-ultrasound (US-US) fusion imaging for evaluating the ablation effect via phantom-simulated liver tumors. Twenty special phantom models were established, ablated and divided into a complete ablation group (n  = 10) and an incomplete ablation group (n = 10). US-US fusion imaging was performed to evaluate the ablation effect. Gross specimens were observed as a standard reference. In this US-US fusion imaging study, the registration success rate was 100% (20/20), and the assessment time was 3.8 ± 0.9 min. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2019 Category: Radiology Authors: Shumin Lv, Yinglin Long, Zhongzhen Su, Rongqin Zheng, Kai Li, Huichao Zhou, Chen Qiu, Tinghui Yin, Erjiao Xu Tags: Technical Note Source Type: research

Estimating Regional Myocardial Contraction Using Miniature Transducers on the Epicardium
This paper describes an ultrasound system to monitor cardiac motion using miniature transducers attached directly to the epicardial surface. Our aim was to develop both a research tool for detailed studies of cardiac mechanics and a continuous, real time system for peri-operative evaluation of heart function. The system was tested on a porcine model. Two 3 mm diameter, 10 MHz ultrasound transducers were sutured to the epicardial surface. As the epicardial surface was the reference for the velocity and strain estimations, this procedure compensated for the motion of the heart. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2019 Category: Radiology Authors: Thuy Thu Nguyen, Andreas W. Espinoza, Stefan Hyler, Espen W. Remme, Jan D'hooge, Lars Hoff Tags: Original Contribution Source Type: research

Real-Time Contrast-Enhanced –Guided Biopsy Compared with Conventional Ultrasound–Guided Biopsy in the Diagnosis of Hepatic Tumors on a Background of Advanced Chronic Liver Disease: A Prospective, Randomized, Clinical Trial
We aimed to compare contrast-enhanced –guided liver biopsy (CEUSLB) and ultrasound-guided liver biopsy (USLB) in the diagnosis of focal liver lesions (FLLs) developed on a background of advanced chronic liver disease (ACLD). Between 2011 and 2019, patients diagnosed with liver tumors on a background of ACLD were evaluated for inclusio n in the study. Patients were randomly assigned to the CEUSLB or USLB group. In total, 144 patients were randomly assigned to either CEUSLB (n = 79) or USLB (n = 65). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2019 Category: Radiology Authors: Zeno Sparchez, Tudor Mocan, Claudia Hagiu, Gabriel Kacso, Toader Zaharie, Ioana Rusu, Nadim Al Hajjar, Daniel Corneliu Leucuta, Mihaela Sparchez Tags: Original Contribution Source Type: research

Potential Value of Conventional Ultrasound in Estimation of Bone Age in Patients from Birth to Near Adulthood
We aimed to assess the relationship between standard bone age (BA) stratification obtained using plain radiography and that obtained using ultrasound determination of ossification ratio (OR) as a novelty in patients from birth to near adulthood. The ratio of diameters of the ossification center and epiphysis was calculated to evaluate the OR of bones. The ORs of the bones assigned to different weight coefficient were then summed as the skeletal maturity score (SMS). Pearson's correlation r between SMSs derived from ORs and BAs was 0.97 in girls (p (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2019 Category: Radiology Authors: Jie Wan, Ying Zhao, Qunqun Feng, Ziyan Sun, Chao Zhang Tags: Original Contribution Source Type: research

Usefulness of Ultrasound in Differentiating Xanthogranulomatous Cholecystitis from Gallbladder Carcinoma
Our study was aimed at finding the ultrasound (US) features of xanthogranulomatous cholecystitis (XGC) and evaluating the usefulness of US in differentiating XGC from gallbladder carcinoma (GBC). Through use of an electronic medical record system and the picture archiving and communication system, 31 cases of XGC and 52 cases of GBC with both sonograms and pathologic results were identified. Sonographic features of the abnormal gallbladder were evaluated. The smooth and intact interface between gallbladder lumen and mucosa was observed in most XGC cases (23/31, 74.2%) but in no GBC cases. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 22, 2019 Category: Radiology Authors: Fan Zhang, Wen Chen, Lingfu Zhang, Chunsheng Hou, Ming Zhang Tags: Original Contribution Source Type: research

Quantitative Ultrasound Image Analysis of Axillary Lymph Nodes to Diagnose Metastatic Involvement in Breast Cancer
This study aimed to assess the potential of state-of-the-art ultrasound analysis techniques to non-invasively diagnose axillary lymph nodes involvement in breast cancer. After exclusion criteria, 105 patients were selected from two different hospitals. The 118 lymph node ultrasound images taken from these patients were divided into 53 cases and 65 controls, which made up the study series. The clinical outcome of each node was verified by ultrasound-guided fine needle aspiration, core needle biopsy or surgical biopsy. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 20, 2019 Category: Radiology Authors: David Coronado-Guti érrez, Gorane Santamaría, Sergi Ganau, Xavier Bargalló, Stefania Orlando, M. Eulalia Oliva-Brañas, Alvaro Perez-Moreno, Xavier P. Burgos-Artizzu Tags: Original Contribution Source Type: research