Machine Learning –Based Ultrasound Radiomics for Evaluating the Function of Transplanted Kidneys
The aim of the study described here was to investigate the value of different machine learning models based on the clinical and radiomic features of 2-D ultrasound images to evaluate post-transplant renal function (pTRF). We included 233 patients who underwent ultrasound examination after renal transplantation and divided them into the normal pTRF group (group 1) and the abnormal pTRF group (group 2) based on their estimated glomerular filtration rates. The patients with abnormal pTRF were further subdivided into the non-severe renal function impairment group (group 2A) and the severe impairment group (group 2B). (Source: ...
Source: Ultrasound in Medicine and Biology - May 19, 2022 Category: Radiology Authors: Lili Zhu, Renjun Huang, Ming Li, Qingmin Fan, Xiaojun Zhao, Xiaofeng Wu, Fenglin Dong Tags: Original Contribution Source Type: research

Individualized References of Carotid Stiffening Quantified With Ultrafast Ultrasound Imaging: Model Construction and Preliminary Validation
To establish and preliminarily validate an individualized reference of carotid stiffness quantified by ultrafast pulse wave velocity (ufPWV), our study included 225 healthy individuals in the modeling cohort and 628 individuals in the validation cohort. All participants underwent assessment of carotid intima –media thickness (cIMT), pulse wave velocity–beginning of systole and pulse wave velocity–end of systole (PWV-ES). A threshold equation of estimated PWV-ES was obtained by multiple linear regression analysis in the modeling cohort as follows: estimated PWV-ES (m/s) = 0.080 × age (y) + 0 .767 × low-densi...
Source: Ultrasound in Medicine and Biology - May 18, 2022 Category: Radiology Authors: Yinping Wang, Zhengqiu Zhu, Xuehui Ma, Wenjun Liu, Xuezhong Jiang, Yiyun Wu, Chong Zou, Bixiao Shen, Hongye Sun, Hui Gao, Yun Luan, Hui Huang Tags: Original Contribution Source Type: research

Computer-Aided Color Parameter Imaging of Contrast-Enhanced Ultrasound Evaluates Hepatocellular Carcinoma Hemodynamic Features and Predicts Radiofrequency Ablation Outcome
Computer-aided color parameter imaging (CPI) is a novel technique for contrast-enhanced ultrasound (CEUS) that can highlight hemodynamic features of focal lesions. The purpose of the study was to investigate the role of CPI in evaluation of hepatocellular carcinoma (HCC) hemodynamic features and prognosis after radiofrequency ablation (RFA). One hundred twenty-one patients with HCC underwent CEUS with CPI analysis before RFA. Eighty-nine patients had pathologically proven well- to moderately differentiated HCC (WM-HCC), and 32 patients had poorly differentiated or undifferentiated HCC (PU-HCC). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 18, 2022 Category: Radiology Authors: Hong Wang, Wen Guo, Wei Yang, Gang Liu, Kun Cao, Yu Sun, Zi-Nan Liang, Xiu-Mei Bai, Song Wang, Wei Wu, Kun Yan, S. Nahum Goldberg Tags: Original Contribution Source Type: research

Osteoporosis Diagnostic Model Using a Multichannel Convolutional Neural Network Based on Quantitative Ultrasound Radiofrequency Signal
In this study, a new method to improve the diagnostic accuracy of QUS was established in which a multichannel convolutional neural network (MCNN) processes the raw radiofrequency (RF) signal of QUS. The improvement in the diagnostic accuracy of osteoporosis using this new method was evaluated by comparison with the conventional speed of sound (SOS) method. Dual-energy  X-ray absorptiometry was used as the diagnostic standard. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 15, 2022 Category: Radiology Authors: Wenqiang Luo, Zhiwei Chen, Qi Zhang, Baiying Lei, Zhong Chen, Yuan Fu, Peidong Guo, Changchuan Li, Teng Ma, Jiang Liu, Yue Ding Tags: Original Contribution Source Type: research

Ultrasound-induced cavitation and passive acoustic mapping: SonoTran platform performance and short-term safety in a large-animal model
Ultrasound-induced cavitation is currently under investigation for several potential applications in cancer treatment. Among these, the use of low-intensity ultrasound, coupled with the systemic administration of various cavitation nuclei, has been found to enhance the delivery of co-administered therapeutics into solid tumors. Effective pharmacological treatment of solid tumors is often hampered, among various factors, by the limited diffusion of drugs from the bloodstream into the neoplastic mass and through it, and SonoTran holds the potential to tackle this clinical limitation by increasing the amount of drug and its d...
Source: Ultrasound in Medicine and Biology - May 13, 2022 Category: Radiology Authors: Massimo Masiero, Paul Boulos, Calum Crake, Cliff Rowe, Christian M. Coviello Tags: Technical Note Source Type: research

Blood Flow Quantification with High-Frame-Rate, Contrast-Enhanced Ultrasound Velocimetry in Stented Aortoiliac Arteries: In Vivo Feasibility
Local flow patterns influence stent patency, while blood flow quantification in stents is challenging. The aim of this study was to investigate the feasibility of 2-D blood flow quantification using high-frame-rate, contrast-enhanced ultrasound (HFR-CEUS) and particle image velocimetry (PIV), or echoPIV, in patients with aortoiliac stents. HFR-CEUS measurements were performed at 129 locations in 62 patients. Two-dimensional blood flow velocity fields were obtained using echoPIV. Visual inspection was performed by five observers to evaluate feasibility. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 13, 2022 Category: Radiology Authors: Stefan Engelhard, Majorie van Helvert, Jason Voorneveld, Johan G. Bosch, Guillaume Lajoinie, Erik Groot Jebbink, Michel M.P.J. Reijnen, Michel Versluis Tags: Original Contribution Source Type: research

Contrast-enhanced ultrasound –based nomogram for predicting malignant involvements among sonographically indeterminate/suspicious cervical lymph nodes in patients with differentiated thyroid carcinoma
This prospective study was aimed at assessing the value of nomograms based on conventional and contrast-enhanced ultrasound (CEUS) features in the pre-operative diagnosis of sonographically indeterminate/suspicious lymph node metastasis (LNM) in patients with differentiated thyroid carcinoma (DTC). A total of 72 cervical LNs from 47 patients with DTC from January to June 2018 were included in the primary data set, and 30 LNs from 15 patients with DTC from July to August 2018 were included in the external validation data set. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 13, 2022 Category: Radiology Authors: Qianqian Guo, Chao Sun, Qing Chang, Yong Wang, Yu Chen, Qian Wang, Zhengjiang Li, Lijuan Niu Tags: Original Contribution Source Type: research

Freeze-Dried Microfluidic Monodisperse Microbubbles as a New Generation of Ultrasound Contrast Agents
We succeeded in freeze-drying monodisperse microbubbles without degrading their performance, that is, their monodispersity in size and echogenicity. We used microfluidic technology to generate cryoprotected highly monodisperse microbubbles (coefficient of variation [CV] (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 11, 2022 Category: Radiology Authors: Ugur Soysal, Pedro N. Azevedo, Flavien Bureau, Alexandre Aubry, Marcio S. Carvalho, Amanda C.S.N. Pessoa, Lucimara G. De La Torre, Olivier Couture, Arnaud Tourin, Mathias Fink, Patrick Tabeling Tags: Original Contribution Source Type: research

Quantitative Ultrasound Assessment of Early Osteoarthritis in Human Articular Cartilage Using a High-Frequency Linear Array Transducer
The objective of this ex vivo study was to assess the performance of QUS in detecting early OA using a high-frequency linear array transducer. Osteochondral plugs (n  = 26) of human articular cartilage were scanned with ExactVu Micro-Ultrasound using an EV29L side-fire transducer. For comparison, the samples were also imaged with SAM200Ex, a custom 40-MHz scanning acoustic microscope with a single-element, focused transducer. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 7, 2022 Category: Radiology Authors: Theresa H. Lye, Omar Gachouch, Lisa Renner, Sefer Elezkurtaj, Hannes Cash, Daniel Messroghli, Kay Raum, Jonathan Mamou Tags: Original Contribution Source Type: research

Effect of Ultrasound Therapy on Expression of Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor Receptors, CD31 and Functional Recovery After Facial Nerve Injury
This study was aimed at determining the effect of ultrasound treatment on the expression of vascular endothelial growth factor (VEGF), its receptors and new vessel formation after facial nerve injury. Sixty-four Wistar rats were divided into four groups: control (group 1), sham (group 2), facial-facial coaptation (group 3), and facial-facial coaptation and ultrasound treatment (group 4). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 6, 2022 Category: Radiology Authors: Arzu Hizay, Umut Ozsoy, Kamil Savas, Sezin Yakut-Uzuner, Ozlem Ozbey, Simla Su Akkan, Pinar Bahsi Tags: Original Contribution Source Type: research

A Multilayered, Lesion-Embedded Ultrasound Breast Phantom with Realistic Visual and Haptic Feedback for Needle Biopsy
This study aimed to develop a breast tissue-mimicking phantom that offers realistic haptic feedback and ultrasound imaging during needle insertion. We investigated the tunability of the mechanical and acoustic properties of breast tissue-mimicking materials (TMMs) to emulate fat, glandular and tumor tissues. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 6, 2022 Category: Radiology Authors: Si Yen Ng, Chi-Lun Lin Tags: Original Contribution Source Type: research

Optimizing Lung Ultrasound: The Effect of Depth, Gain and Focal Position on Sonographic B-Lines
Ultrasonographic B-lines are artifacts present in alveolar-interstitial syndromes. We prospectively investigated optimal depth, gain, focal position and transducer type for B-line visualization and image quality. B-Lines were assessed at a single rib interspace with curvilinear and linear transducers. Video clips were acquired by changing parameters: depth (6, 12, 18 and 24 cm for curvilinear transducer, 4 and 8 cm for linear transducer), gain (10%, 50% and 90%) and focal position (at the pleural line or half the scanning depth). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 5, 2022 Category: Radiology Authors: Nicole M. Duggan, Andrew J. Goldsmith, Ahad Alhassan Al Saud, Irene W.Y. Ma, Hamid Shokoohi, Andrew S. Liteplo Tags: Original Contribution Source Type: research

Blood Flow Changes Associated with Spinal Cord Injury Assessed by Non-linear Doppler Contrast-Enhanced Ultrasound
Contrast-enhanced ultrasound (CEUS) is clinically used to image the microcirculation at lower imaging frequencies ( (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - May 4, 2022 Category: Radiology Authors: Matthew Bruce, Dane DeWees, Jonah Harmon, Lindsay Cates, Zin Z. Khaing, Christoph P. Hofstetter Tags: Original Contribution Source Type: research

Comparison of High-Frequency Contrast-Enhanced Ultrasound With Conventional High-Frequency Ultrasound in Guiding Pleural Lesion Biopsy
The goal of the work described here was to compare high-frequency contrast-enhanced ultrasound (HF-CEUS) and conventional high-frequency ultrasound (HFU) with respect to performance and safety during ultrasound-guided biopsy of pleural lesions. We performed a retrospective study on patients with pleural lesions who received the puncture biopsy under the guidance of conventional HFU or HF-CEUS between August 2018 and August 2021. These patients received either a conventional HF-U (HF-U group) or HF-CEUS (HF-CEUS group) examination. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - April 30, 2022 Category: Radiology Authors: Fuyong Ye, Yuwen Yang, Jianhua Liu Tags: Original Contribution Source Type: research

Toward Fluoro-Free Interventions: Using Radial Intracardiac Ultrasound for Vascular Navigation
Transcatheter cardiovascular interventions have the advantage of patient safety, reduced surgery time and minimal trauma to the patient's body. Transcathether interventions, which are performed percutaneously, are limited by the lack of direct line of sight with the procedural tools and the patient anatomy. Therefore, such interventional procedures rely heavily on image guidance for navigating toward and delivering therapy at the target site. Vascular navigation via the inferior vena cava, from the groin to the heart, is an imperative part of most transcatheter cardiovascular interventions including heart valve repair surg...
Source: Ultrasound in Medicine and Biology - April 26, 2022 Category: Radiology Authors: Hareem Nisar, Leah Groves, Leandro Cardarelli-Leite, Terry M. Peters, Elvis C.S. Chen Tags: Original Contribution Source Type: research