Treating Porcine Abscesses with Histotripsy: A Pilot Study
Infected abscesses are walled-off collections of pus and bacteria. They are a common sequela of complications in the setting of surgery, trauma, systemic infections and other disease states. Current treatment is typically limited to antibiotics with long-term catheter drainage, or surgical washout when inaccessible to percutaneous drainage or unresponsive to initial care efforts. Antibiotic resistance is also a growing concern. Although bacteria can develop drug resistance, they remain susceptible to thermal and mechanical damage. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 26, 2020 Category: Radiology Authors: Thomas J. Matula, Yak-Nam Wang, Tatiana Khokhlova, Daniel F. Leotta, John Kucewicz, Andrew A. Brayman, Matthew Bruce, Adam D. Maxwell, Brian E. MacConaghy, Gilles Thomas, Valery P. Chernikov, Sergey V. Buravkov, Vera A. Khokhlova, Keith Richmond, Keith Ch Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 21, 2020 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 21, 2020 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 21, 2020 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 21, 2020 Category: Radiology Source Type: research

Correlation of Stiffness of Prostate Cancer Measured by Shear Wave Elastography with Grade Group: A Preliminary Study
The aim of study was to explore the correlation between shear wave elastography (SWE) and grade group (GG) of prostate cancer (PCa). This retrospective study involved prostate-specific antigen elevated patients with elevated prostate-specific antigen levels who underwent SWE before transrectal ultrasound-guided needle biopsy. A total of 49 PCa lesions were reviewed after radical prostatectomy; 3 –7 regions of interest were placed within the cancerous area on axial view compared with the tumor foci outlined on the slides by pathologist. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 21, 2020 Category: Radiology Authors: Wen-Bin Dai, Jun Xu, Bo Yu, Lin Chen, Yue Chen, Jia Zhan Tags: Original Contribution Source Type: research

Microbubble-Mediated Cavitation Promotes Apoptosis and Suppresses Invasion in AsPC-1 Cells
The aim of this study was to identify the potential and mechanisms of microbubble-mediated cavitation in promoting apoptosis and suppressing invasion in cancer cells. AsPC-1 cells were used and divided into four groups: control group, microbubble-only (MB) group, ultrasound-only (US) group and ultrasound plus microbubble (US  + MB) group. Pulse ultrasound was used at a frequency of 360 kHz and a SPPA (spatial peak, pulse average) intensity of 1.4 W/cm2 for 1 min (duty rate = 50%). Then cells in the four groups were cultured for 24 h. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 19, 2020 Category: Radiology Authors: Jing Cao, Chenlu Hu, Hang Zhou, Fuqiang Qiu, Jifan Chen, Jun Zhang, Pintong Huang Tags: Original Contribution Source Type: research

Carotid IMT and Stiffness in the KiGGS 2 National Survey: Third-Generation Measurement, Quality Algorithms and Determinants of Completeness
Carotid intima –media thickness (cIMT) and carotid stiffness (CS) are important markers of atherosclerotic risk in the young. We assessed a novel third-generation method for its applicability in large population-based epidemiologic studies to determine strengths, limitations, completeness and predictors of unsuc cessful measurement. Four thousand seven hundred ninety-eight 14- to 31-y-old participants of the German KiGGS cohort, which is based on a nationally representative sample with 11-y follow-up, underwent B-mode ultrasound examinations of the left and right common carotid artery with semi-automatic ed ge detect...
Source: Ultrasound in Medicine and Biology - November 19, 2020 Category: Radiology Authors: Karsten K önigstein, Ursula von Schenck, Julia Charlotte Büschges, Dieter Schweizer, Felicitas Vogelgesang, Stefan Damerow, Giselle Sarganas, Julia Dratva, Arno Schmidt-Trucksäss, Hannelore Neuhauser Tags: Original Contribution Source Type: research

Ultrasound for Intubation Confirmation: A Randomized Controlled Study among Emergency Medicine Residents
Confirmation of endotracheal tube (ETT) placement during intubation is a critical skill for emergency medicine (EM) residents; airway ultrasonography has been suggested as an accessible and accurate method of ETT confirmation. Here, we investigated the accuracy with which EM residents could identify ETT location in cadavers using different ultrasound modes. EM attendings intubated either the trachea or the esophagus of a cadaver, and blinded residents identified ETT position using either B-mode or B-mode plus color Doppler. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 17, 2020 Category: Radiology Authors: Hooman Hossein-Nejad, Mohammad-Hassan Sadroldini Mehrjerdi, Atefeh Abdollahi, Michael A. Loesche, Sara Schulwolf, Masoud Ghadipasha, Payam Mohammadinejad, Bahar Ataeinia, Hamid Shokoohi Tags: Original Contribution Source Type: research

Carotid Intraplaque Neovascularization on Contrast-Enhanced Ultrasound Correlates with Cardiovascular Events and Poor Prognosis: A Systematic Review and Meta-analysis
The goal of this meta-analysis is to investigate whether carotid intraplaque neovascularization (IPN) on contrast-enhanced ultrasound (CEUS) correlates with past cardiovascular events (CVEs) and prognosis. The present meta-analysis included 22 studies involving 3232 patients. The pooled analysis revealed that the presence of IPN was significantly associated with a higher incidence of future CVEs (pooled relative risk  = 3.28, 95% confidence interval [CI]: 2.28–4.73) and a lower event-free probability (pooled hazard ratio = 2.51, 95% CI: 1.48–4.27). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 17, 2020 Category: Radiology Authors: Hualin Yan, Xian Wu, Ying He, Daniel Staub, Xiaorong Wen, Yan Luo Tags: Review Article Source Type: research

Clinical Utility of Qualitative Elastography Using Acoustic Radiation Force Impulse for Differentiating Benign from Malignant Salivary Gland Tumors
The goal of the work described here was to evaluate the utility of acoustic radiation force impulse (ARFI) imaging, a novel elastography technique, for differentiating benign from malignant salivary gland tumors. With the use of conventional strain elastography (SE) and ARFI imaging with a four-pattern scoring system, 185 tumors were examined (163 benign/22 malignant). When a score of ≥3 was used to define malignancy, the sensitivity, specificity and accuracy were higher for ARFI imaging (77.3%, 63.8% and 65.4%, respectively) than for conventional SE (54.5%, 56.4% and 56.2%, respectively). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 11, 2020 Category: Radiology Authors: Eriko Matsuda, Takahiro Fukuhara, Ryohei Donishi, Kenkichiro Taira, Satoshi Koyama, Tsuyoshi Morisaki, Kazunori Fujiwara, Hiromi Takeuchi Tags: Original Contribution Source Type: research

Reliability and Validity of Panoramic Ultrasound Imaging for Evaluating Muscular Quality and Morphology: A Systematic Review
Panoramic ultrasound (US) is a novel method used to assess linear dimensions, cross-sectional area, fatty infiltrate and echo-intensity features of muscles that cannot be measured with B-mode US. However, a structured overview of its validity and reliability is lacking. MEDLINE, PubMed, SCOPUS and Web of Science databases were systematically searched for studies evaluating reliability or validity data on panoramic US imaging to determine the muscular morphology and/or quality of skeletal muscles. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 11, 2020 Category: Radiology Authors: Juan Antonio Valera-Calero, Cristina Ojedo-Mart ín, César Fernández-de-las-Peñas, Joshua A. Cleland, José Luis Arias-Buría, Juan Pablo Hervás-Pérez Tags: Review Article Source Type: research

Importance of the Ultrasound Probe Angle on the Rotation Fill-in Signature in Ultrasound Axial-Shear Strain Imaging
The rotation fill-in is a signature of tumor benignity in rotation elastograms and has been used for breast tumor classification. It is a consequence of the bonding condition at the tumor –tissue interface. In vivo studies have revealed the presence of fluctuations when inclined uniaxial external compression is applied. However, the physical meaning of these fluctuations is not yet fully understood. In this article we present an experimental and numerical study of the rotation fill -in signature as a function of the probe's tilt angle. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 7, 2020 Category: Radiology Authors: Belfor Galaz, Esteban Donoso, Miguel Trejo Tags: Original Contribution Source Type: research

Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density
We studied the characteristics of contrast-enhanced ultrasound (CEUS) in renal pelvic urothelial carcinomas and explored its performance in assessing microvessel density (MVD) of tumor tissues. We retrospectively analyzed the characteristics of 125 cases, which were confirmed pathologically to be renal pelvic urothelial carcinomas using CEUS. We performed CEUS and found that most tumors presented with an enhanced mode of “slow-in (mean = 16.7 ± 2.6 s, range: 12–25 s), hypo-enhancement and fast-out (mean = 69.3 ± 16.2 s, range: 42–113 s).” However, the wash-in pattern, homogenei...
Source: Ultrasound in Medicine and Biology - November 3, 2020 Category: Radiology Authors: Bo Zhang, Jing Li, Zhouliang Wu, Chenyun Li, Tong Sun, Na Zhuo, Jixiang Liang, Qing Duan, Hailong Hu, Jing Tian Tags: Original Contribution Source Type: research

Ultrasound-Based Carotid Plaque Characteristics Help Predict New Cerebral Ischemic Lesions after Endarterectomy
The aim of this study was to identify the ultrasound-based carotid plaque characteristics associated with new cerebral ischemic lesions after carotid endarterectomy (CEA). Between January 2013 and December 2018, carotid duplex ultrasound was performed in 1061 patients who underwent CEA. Brain magnetic resonance diffusion-weighted imaging (DWI) was performed pre-operatively and within 30 d after CEA. New cerebral ischemic lesions on DWI were observed in 169 patients. The cutoff value gray-scale median (GSM) used to distinguish DWI-positive from DWI-negative patients was 30.5, with an area under the receiver operating charac...
Source: Ultrasound in Medicine and Biology - November 3, 2020 Category: Radiology Authors: Fubo Zhou, Yang Hua, Xunming Ji, Lingyun Jia, Ke Zhang, Qing Li, Qiuping Li, Jie Yang, Jingzhi Li, Liqun Jiao Tags: Original Contribution Source Type: research

Combination of Lymphatic and Intravenous Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis from Papillary Thyroid Carcinoma: A Preliminary Study
The aim of this prospective study was to evaluate the value of the combination of lymphatic contrast-enhanced ultrasound (LCEUS) and intravenous contrast-enhanced ultrasound (IVCEUS) for the identification of cervical lymph node metastasis (CLNM) from papillary thyroid carcinoma (PTC). From November 2018 to March 2019, 24 consecutive patients with PTC were evaluated. All patients underwent routine US, LCEUS and IVCEUS. Pathology was used as the gold standard. After injection of a contrast agent into the thyroid parenchyma, lymphatic vessels and lymph nodes (LNs) could be exclusively displayed as hyper-enhancement on LCEUS....
Source: Ultrasound in Medicine and Biology - November 3, 2020 Category: Radiology Authors: Ying Wei, Ming-an Yu, Yun Niu, Ying Hao, Jin-xi Di, Zhen-Long Zhao, Xiao-Jing Cao, Li-li Peng, Yan Li Tags: Original Contribution Source Type: research

In memoriam: harvey l. nisenbaum (1943 –2020)
Dr. Harvey L. Nisenbaum, 77, of Wynnewood, Pennsylvania, past president of the American Institute of Medicine (AIUM) and the World Federation for Ultrasound in Medicine and Biology (WFUMB), died Thursday, October 8, 2020, of complications from glioblastoma at Penn Hospice at Rittenhouse, Philadelphia, Pennsylvania. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 3, 2020 Category: Radiology Authors: Jacques S. Abramowicz, Maria Cristina Chammas, Seung Hyup Kim, Christian P állson Nolsøe Tags: In Memoriam Source Type: research

Therapeutic Ultrasound Parameter Optimization for Drug Delivery Applied to a Murine Model of Hepatocellular Carcinoma
Ultrasound and microbubble (USMB)-mediated drug delivery is a valuable tool for increasing the efficiency of the delivery of therapeutic agents to cancer while maintaining low systemic toxicity. Typically, selection of USMB drug delivery parameters used in current research settings are either based on previous studies described in the literature or optimized using tissue-mimicking phantoms. However, phantoms rarely mimic in vivo tumor environments, and the selection of parameters should be based on the application or experiment. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 2, 2020 Category: Radiology Authors: Arsenii V. Telichko, Huaijun Wang, Sunitha Bachawal, Sukumar U. Kumar, Jagathesh C. Bose, Ramasamy Paulmurugan, Jeremy J. Dahl Tags: Original Contribution Source Type: research

Application of Hepatic Transit Time and Shear Wave Velocity in Assessing Portal Pressure in Patients with Cirrhotic Portal Hypertension
The aim of the study described here was to explore the value of hepatic transit time (HTT) and shear wave velocity (SWV) in diagnosing cirrhotic portal hypertension. Fifty-seven patients had undergone esophagogastric varicose vein embolization (group OBS) and 50 healthy controls (group CON) were retrospectively compared with respect to HTT (arterial –hepatic vein [HA-HVTT], portal vein–hepatic vein [PV-HVTT], liver parenchyma–hepatic vein [PA-HVTT]) and SWV to analyze their efficacy in diagnosing cirrhotic portal hypertension. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - November 2, 2020 Category: Radiology Authors: Yuanqiang Lin, Yan Liu, Bo Jiang, Wenhui Li, Hequn Li, Hui Wang Tags: Original Contribution Source Type: research

Contrast-Enhanced Ultrasonography versus Contrast-Enhanced Magnetic Resonance Imaging in the Diagnosis of Mediastinal Tumors
The aim of the study was to evaluate and compare contrast-enhanced ultrasound (CEUS) and contrast-enhanced magnetic resonance imaging (CE-MRI) with respect to their value in the differential diagnosis between benign and malignant mediastinal tumors. Forty-two patients with mediastinal tumor underwent CEUS and CE-MRI respectively. The sensitivity, specificity, diagnostic coincidence rate, positive predictive value (PPV) and negative predictive value of the two methods were compared. The value of different enhancement patterns in the differential diagnosis of benign and malignant mediastinal tumors was analyzed. (Source: Ult...
Source: Ultrasound in Medicine and Biology - November 2, 2020 Category: Radiology Authors: Juhong Pan, Wenwei Chen, Haidong Zhang, Xingyue Huang, Xin Huang Tags: Original Contribution Source Type: research

Advances of Contrast-Enhanced Ultrasonography and Elastography in Kidney Transplantation: From Microscopic to Microcosmic
Kidney transplantation is the best choice for patients with end-stage renal disease. To date, allograft biopsy remains the gold standard for revealing pathologic changes and predicting long-term outcomes. However, the invasive nature of transplant biopsy greatly limits its application. Ultrasound has been a first-line examination for evaluating kidney allografts for a long time. Advances in ultrasound in recent years, especially the growing number of studies in elastography and contrast-enhanced ultrasonography (CEUS), have shed new light on its application in kidney transplantation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 31, 2020 Category: Radiology Authors: Ruochen Qi, Cheng Yang, Tongyu Zhu Tags: Review Article Source Type: research

Temporal Artery Ultrasound to Diagnose Giant Cell Arteritis: A Practical Guide
The diagnostic modalities for giant cell arteritis (GCA) have evolved significantly in recent years. Among the different diagnostic tools developed, Doppler ultrasound of the temporal arteries, with a sensitivity and specificity reaching 69% and 82%, respectively, is now recognized as superior and, therefore, is a first-line diagnostic tool in GCA. Moreover, with the increasing development of new ultrasound technologies, the accuracy of Doppler ultrasound in GCA seems to be constantly improving. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 31, 2020 Category: Radiology Authors: Steve Raoul Noumegni, Cl ément Hoffmann, Divi Cornec, Simon Gestin, Luc Bressollette, Sandrine Jousse-Joulin Tags: Review Article Source Type: research

Tissue Characterization by Low-Frequency Acoustic Waves Generated by a Single High-Frequency Focused Ultrasound Beam
The mechanical properties of biological tissues are fingerprints of certain pathologic processes. Ultrasound systems have been used as a non-invasive technique to both induce kilohertz-frequency mechanical vibrations and detect waves resulting from interactions with biological structures. However, existing methodologies to produce kilohertz-frequency mechanical vibrations using ultrasound require the use of variable-frequency, dual-frequency and high-power systems. Here, we propose and demonstrate the use of bursts of megahertz- frequency acoustic radiation to observe kilohertz-frequency mechanical responses in biological ...
Source: Ultrasound in Medicine and Biology - October 29, 2020 Category: Radiology Authors: Guilherme A. Braz, Andre L. Baggio, Paulo M. Agnollitto, Felipe W. Grillo, Theo Z. Pavan, Francisco J.A. Paula, Marcello H. Nogueira-Barbosa, George C. Cardoso, Antonio A.O. Carneiro Tags: Original Contribution Source Type: research

Ultrasound Detection of Liver Fibrosis in Individuals with Hepatic Steatosis Using the Homodyned K Distribution
This study proposed using ultrasound parametric imaging based on the parameter α of the homodyned K (HK) distribution for staging liver fibrosis in patients with significant hepatic steatosis. Raw ultrasound image data were acquired from patients (n = 237) to construct B-mode and HK α parametric images, which were compared with the focal disturbance (FD) ratio obtained f rom ASQ on the basis of histologic evidence (METAVIR fibrosis score and hepatic steatosis severity). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 24, 2020 Category: Radiology Authors: Yu-Wei Tsai, Zhuhuang Zhou, Cihun-Siyong Alex Gong, Dar-In Tai, Anca Cristea, Yu-Ching Lin, Ya-Chun Tang, Po-Hsiang Tsui Tags: Original Contribution Source Type: research

Assessment of Left Ventricular Global Myocardial Work in Patients With Different Degrees of Coronary Artery Stenosis by Pressure-Strain Loops Analysis
Global myocardial work (MW) analysis by pressure ‐strain loops (PSL) allows the non‐invasive assessment of left ventricular (LV) function. We aimed to investigate the relationship between LV global MW and the degree of coronary artery stenosis in suspected coronary artery disease (CAD) patients with normal LV ejection fraction and regional wal l motion. A total of 164 suspected CAD patients were divided into four groups according to coronary artery angiography. The results showed that global work efficiency (GWE) as the most significant predictor in all MW parameters had the optimal cut-off value of 94.5% for detecting...
Source: Ultrasound in Medicine and Biology - October 24, 2020 Category: Radiology Authors: Ran-ran Wang, Tian Tian, Shou-qiang Li, Xiao-ping Leng, Jia-wei Tian Tags: Original Contribution Source Type: research

Breast Elasticity Imaging Techniques: Comparison of Strain Elastography and Shear-Wave Elastography in the Same Population
Our purpose was to compare the diagnostic performances of strain elastography (SE) and shear-wave elastography (SWE) in differentiating breast lesions by combining with conventional ultrasound (US). A total of 198 patients with 203 breast lesions underwent conventional US, SE and SWE examination using MyLab 90 and Aixplorer US systems. The SE parameters were SEscore, fat-to-lesion ratio, gland-to-lesion ratio, muscle-to-lesion ratio and SEmean, and the SWE parameters were Emax, Emean, Emin and Esd. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 24, 2020 Category: Radiology Authors: WanRu Jia, Ting Luo, YiJie Dong, XiaoXiao Zhang, WeiWei Zhan, JianQiao Zhou Tags: Original Contribution Source Type: research

3-D Ultrasound Imaging Reliability of Measuring Dysplasia Metrics in Infants
Developmental dysplasia of the hip is a hip abnormality that ranges from mild acetabular dysplasia to irreducible femoral head dislocations. While 2-D B-mode ultrasound (US)-based dysplasia metrics or disease metrics are currently used clinically to diagnose developmental dysplasia of the hip, such estimates suffer from high inter-exam variability. In this work, we propose and evaluate 3-D US-derived dysplasia metrics that are automatically computed and demonstrate that these automatically derived dysplasia metrics are considerably more reproducible. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 23, 2020 Category: Radiology Authors: Niamul Quader, Antony J. Hodgson, Kishore Mulpuri, Anthony Cooper, Rafeef Garbi Tags: Original Contribution Source Type: research

Diagnostic Performance of Ultrasound Computer-Aided Diagnosis Software Compared with That of Radiologists with Different Levels of Expertise for Thyroid Malignancy: A Multicenter Prospective Study
The aim of the work described here was to evaluate the diagnostic performance of ultrasound thyroid computer-aided diagnosis (CAD) software. This multicenter prospective study included 494 patients (565 thyroid nodules) who underwent surgery or biopsy after ultrasonography at four hospitals from January 2019 to September 2019. The diagnostic performance metrics of different readers were calculated and compared with the pathologic results. The sensitivity of CAD was outstanding and was equivalent to that of a senior radiologist (90.51% vs. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 23, 2020 Category: Radiology Authors: Feng-Ying Ye, Guo-Rong Lyu, Shang-Qing Li, Jian-Hong You, Kang-Jian Wang, Ming-Li Cai, Qi-Chen Su Tags: Original Contribution Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 22, 2020 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 22, 2020 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 22, 2020 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 22, 2020 Category: Radiology Source Type: research

Contrast-Enhanced Ultrasound for Monitoring Non-surgical Treatments of Uterine Fibroids: A Systematic Review
Non-surgical treatment options for uterine fibroids are uterine artery embolization (UAE), high-intensity focused ultrasound ablation (HIFUA), and percutaneous microwave ablation (PMWA). Magnetic resonance imaging (MRI) is the reference standard imaging method before and after these procedures. Contrast-enhanced ultrasound (CEUS) has been studied as an alternative to MRI for evaluating the fibroids ’ characteristics and responses to non-surgical treatments. PubMed, Ovid MEDLINE and Scopus databases were searched for literature published from January 2000 through June 7, 2020, that investigated the application of CEUS...
Source: Ultrasound in Medicine and Biology - October 22, 2020 Category: Radiology Authors: Mehnoosh Torkzaban, Priscilla Machado, Ipshita Gupta, Yang Hai, Flemming Forsberg Tags: Original Contribution Source Type: research

Accuracy of Point-of-Care Ultrasound in Detecting Fractures in Children: A Validation Study
This study sought to compare point-of-care ultrasound (POCUS) and conventional X-rays for detecting fractures in children. This was a prospective, non-randomized, convenience-sample study conducted in five medical centers. It evaluated pediatric patients with trauma. POCUS and X-ray examination results were treated as dichotomous variables with fracture either present or absent. Descriptive statistics were calculated in addition to prevalence, sensitivity, specificity, positive predictive value and negative predictive value, including 95% confidence intervals (CIs). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 20, 2020 Category: Radiology Authors: Costantino Caroselli, Irene Raffaldi, Stefania Norbedo, Niccol ò Parri, Francesca Poma, Michael Blaivas, Eleonora Zaccaria, Giovanni Dib, Romano Fiorentino, Daniele Longo, Paolo Biban, Antonio Francesco Urbino Tags: Original Contribution Source Type: research

Microbubble-Facilitated Ultrasound Catheter Ablation Causes Microvascular Damage and Fibrosis
High-intensity ultrasound (US) ablation produces deeper myocardial lesions than radiofrequency ablation. The presence of intravascular microbubble (MB) contrast agents enhances pulsed-wave US ablation via cavitation-related histotripsy, potentially facilitating ablation in persistently perfused/conducting myocardium. US ablation catheters were developed and tested in the presence of MBs using ex vivo and in vivo models. High-frame-rate videomicroscopy and US imaging of gel phantom models confirmed MB destruction by inertial cavitation. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 20, 2020 Category: Radiology Authors: Babak Nazer, David Giraud, Yan Zhao, Yue Qi, O'Neil Mason, Peter D. Jones, Chris J. Diederich, Edward P. Gerstenfeld, Jonathan R. Lindner Tags: Original Contribution Source Type: research

Effect of Calcifications on Shear-Wave Elastography in Evaluating Breast Lesions
This study aimed to investigate the effect of calcifications on shear-wave elastography in evaluating breast lesions. We retrospectively reviewed ultrasound images of 673 breast lesions and compared the elasticity between lesions with and without calcifications in three subgroups: benign lesions, in situ carcinomas and invasive carcinomas. Breast lesions were confirmed histologically (n  = 401) or by follow-up images for more than 2 y (n = 272). Calcifications were present in 25.3% (170/673) of the lesions. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 20, 2020 Category: Radiology Authors: Seung Hee Choi, Eun Young Ko, Boo-Kyung Han, Eun Sook Ko, Ji Soo Choi, Ko Woon Park Tags: Original Contribution Source Type: research

Biomechanical Evaluation of Intercostal Muscles in Healthy Children and Adolescent Idiopathic Scoliosis: A Preliminary Study
Spine deformity during adolescent idiopathic scoliosis can induce a rib-cage deformity. This bone deformity can have direct consequences on the chest-wall muscles, including intercostal muscles, leading to respiratory impairments in individuals with severe cases. The aim of this study was to determine whether shear-wave elastography can be used to measure intercostal-muscle shear-wave speed (SWS) in healthy children and those with adolescent idiopathic scoliosis (AIS). Nineteen healthy participants and 16 with AIS took part. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 17, 2020 Category: Radiology Authors: Rapha ël Pietton, Mercedes David, Alisa Hisaund, Tristan Langlais, Wafa Skalli, Raphaël Vialle, Claudio Vergari Tags: Original Contribution Source Type: research

Femoral Cartilage Ultrasound Echo Intensity Associates with Arthroscopic Cartilage Damage
This study compared quantitative cartilage ultrasound metrics between people with (n  = 12) and without (n = 12) arthroscopic cartilage damage after anterior cruciate ligament injury (age, 24.9 ± 3.7 y; sex, 33% female, 67% male; days since injury = 50 ± 52). A transverse suprapatellar ultrasound assessment imaged the femoral cartilage in participants’ injured knees before a clinical arthroscopy. A custom program automatically separated a manual cartilage segmentation into standardized medial and lateral femoral regions and calculated mean thickness (i.e., cross-sectional area/length of cart...
Source: Ultrasound in Medicine and Biology - October 17, 2020 Category: Radiology Authors: Matthew S. Harkey, Erin Little, Mikaela Thompson, Ming Zhang, Jeffrey B. Driban, Matthew J. Salzler Tags: Original Contribution Source Type: research

“Double-Flash”: An Innovative Method to Diagnose Papillary Thyroid Microcarcinomas
The aim of the study was to investigate the diagnostic ability of an innovative method called “Double-Flash” during contrast-enhanced ultrasound (CEUS) examination in papillary thyroid microcarcinomas. A total of 43 nodules measuring (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 17, 2020 Category: Radiology Authors: Tiantong Zhu, Jingwen Shi, Bo Wang, Yue Yu, Ying Huang Tags: Original Contribution Source Type: research

Speckle Tracking-Derived Longitudinal Strain: Validation and Influence of Scanner Settings
Speckle tracking-based strain analysis is an evolving technique for the assessment of left ventricular function. We evaluated the influence of machine settings on global longitudinal peak systolic strain (GLPSS) values in an everyday patient population (n  = 35). In each patient, the four-chamber view was recorded multiple times with different machine parameters. Ejection fraction ranged between 10% and 76% and correlated well with GLPSS (r = –0.778). GLPSS was not altered systematically by modifications of gain and frame rate. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 16, 2020 Category: Radiology Authors: Hermann Blessberger, Jutta Bergler-Klein, Senta Graf, Bonni Syeda, Helga Wagner, Juergen Kammler, Clemens Steinwender, Thomas Binder Tags: Original Contribution Source Type: research

Transcranial Color-Coded Sonography Criteria for Moderate and Severe Middle Cerebral Artery Stenosis
This study aimed to establish optimal criteria for evaluation of moderate (50% –69%) and severe (70%–99%) middle cerebral artery (MCA) stenosis with transcranial color-coded sonography (TCCS). A total of 375 cases provided 409 TCCS/digital subtraction angiography vessel pairs. Peak systolic velocity (PSV), end-diastolic velocity (EDV) and mean flow velocity (MFV) of the MC A were measured. The stenotic/distal MFV ratios (SDRs) were calculated. With digital subtraction angiography as a reference, for 50%–69% MCA stenosis, the optimal combined criteria were PSV ≥180 cm/s (sensitivity 95.7%, specificity 6...
Source: Ultrasound in Medicine and Biology - October 14, 2020 Category: Radiology Authors: Ran Liu, Jingzhi Li, Yang Hua, Jie Yang, Yue Zhao, Xiaojie Tian, Yan Ma, Wenbo Zhao Tags: Original Contribution Source Type: research

Spleen and Liver Stiffness for Predicting High-Risk Varices in Patients with Compensated Liver Cirrhosis
The study evaluates the utility of spleen (SS) and liver stiffness (LS) associated with spleen size (SSZ) as non-invasive markers for predicting high-risk varices (HRV). One hundred thirty-two patients with compensated liver cirrhosis who underwent abdominal ultrasound SS (SSM) and LS measurements (LSM) using a 2-D shear wave elastography (2-D-SWE) technique from General Electric and upper endoscopy were included. Similar rates of reliable SSM and LSM were obtained (95.4% and 97.7% respectively); therefore, 124 patients were included in the final analysis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 13, 2020 Category: Radiology Authors: Renata Fofiu, Felix Bende, Alina Popescu, Roxana Şirli, Raluca Lupușoru, Ana-Maria Ghiuchici, Ioan Sporea Tags: Original Contribution Source Type: research

Chinese Expert Consensus on Protection for Ultrasound Healthcare Workers against COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become worldwide pandemic and posed a serious public health risk. It was proved that lung ultrasound (LUS) can be extremely valuable in the diagnosis and treatment of the disease, which could also minimize number of exposed healthcare workers and equipment. Since in the department of ultrasound, the healthcare workers are close contacted with patients who might be infected or virus carrying, it is extremely important to offer sufficient protection of them. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 12, 2020 Category: Radiology Authors: Luo Yukun, Yuan Jianjun, Liu Minghui, Nie Fang, Bai Jiao, Fei Xiang, Deng Yujiao, Yu Tengfei, Mao Juan, Zhu Haohui, Li Chuang, Peng Qinghai, Zhang Ming, Zeng Shi, Xu Ganqiong, Niu Chengcheng, Dong Tiantian, He Wen, Tang Jie, Chinese Ultrasound Doctors Ass Source Type: research

Consistency of Indices Obtained via Hip Medial Ultrasound and Magnetic Resonance Imaging in Reduction and Spica Cast Treatment for Developmental Dysplasia of the Hip
This study explored the hip medial ultrasonography method and anatomic structure sonograms. Twenty-eight children with DDH were enrolled. A total of 51 hips (24 left hips /27 right hips) were measured, including 30 affected hips and 21 normal hips. Various indices, including femoral head diameter (DIA), triradiate cartilage –femoral distance (TFD), acetabular–femoral distance (AFD) and ilium–femoral distance (IFD), were measured in the acetabular median coronal plane of ultrasound and the median coronal plane of MRI. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 8, 2020 Category: Radiology Authors: Jingmiao Yu, Fangfang Duan, Wen Guo, Dandan Wang, Xiaoting Qin, Gang Fu, Tao Chen Tags: Original Contribution Source Type: research

Monodisperse versus Polydisperse Ultrasound Contrast Agents: In Vivo Sensitivity and safety in Rat and Pig
Recent advances in the field of monodisperse microbubble synthesis by flow focusing allow for the production of foam-free, highly concentrated and monodisperse lipid-coated microbubble suspensions. It has been found that in vitro, such monodisperse ultrasound contrast agents (UCAs) improve the sensitivity of contrast-enhanced ultrasound imaging. Here, we present the first in vivo study in the left ventricle of rat and pig with this new monodisperse bubble agent. We systematically characterize the acoustic sensitivity and safety of the agent at an imaging frequency of 2.5 MHz as compared with three commercial polydisperse U...
Source: Ultrasound in Medicine and Biology - September 28, 2020 Category: Radiology Authors: Alexandre Helbert, Emmanuel Gaud, Tim Segers, Catherine Botteron, Peter Frinking, Victor Jeannot Tags: Original Contribution Source Type: research

Acoustic Coupling Quantification in Ultrasound-Guided Focused Ultrasound Surgery: Simulation-Based Evaluation and Experimental Feasibility Study
Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided FUS. In this work, a quantitative method was developed and a related metric was introduced: the acoustic coupling coefficient. This metric associates the adequacy of the acoustic coupling with the reflected signals recorded through an imaging probe during a low-energy sonication. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 27, 2020 Category: Radiology Authors: Laura Morchi, Andrea Mariani, Alessandro Diodato, Selene Tognarelli, Andrea Cafarelli, Arianna Menciassi Tags: Original Contribution Source Type: research

Multiparametric Ultrasound for Targeting Prostate Cancer: Combining ARFI, SWEI, QUS and B-Mode
Diagnosing prostate cancer through standard transrectal ultrasound (TRUS)-guided biopsy is challenging because of the sensitivity and specificity limitations of B-mode imaging. We used a linear support vector machine (SVM) to combine standard TRUS imaging data with acoustic radiation force impulse (ARFI) imaging data, shear wave elasticity imaging (SWEI) data and quantitative ultrasound (QUS) midband fit data to enhance lesion contrast into a synthesized multiparametric ultrasound volume. This SVM was trained and validated using a subset of 20 patients and tested on a second subset of 10 patients. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2020 Category: Radiology Authors: D. Cody Morris, Derek Y. Chan, Theresa H. Lye, Hong Chen, Mark L. Palmeri, Thomas J. Polascik, Wen-Chi Foo, Jiaoti Huang, Jonathan Mamou, Kathryn R. Nightingale Tags: Original Contribution Source Type: research

Comprehensive Viscoelastic Characterization of Tissues and the Inter-relationship of Shear Wave (Group and Phase) Velocity, Attenuation and Dispersion
We report shear wave phase and group velocity, dispersion and attenuation in oil-in-gelatin viscoelastic phantoms and in vivo liver data. Moreover, we measured the power law coefficient from each dispersion curve and used it, together with the shear wave velocity, to calculate an approximate value for attenuation that agrees with independent attenuation measurements. Results in phantoms exhibit good agreement for all parameters with respect to independent mechanical measurements. For in vivo data, the livers of 20 patients were scanned. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2020 Category: Radiology Authors: Juvenal Ormachea, Kevin J. Parker Tags: Original Contribution Source Type: research

A Trimodal Ultrasound, Photoacoustic and Magnetic Resonance Imaging Approach for Longitudinal Post-operative Monitoring of Stem Cells in the Spinal Cord
Longitudinal monitoring of stem cells in the spinal cord could unveil critical information needed to understand regenerative processes, thereby expediting therapy development and translation. We introduce a post-operative trimodal imaging approach to monitor stem cells in the spinal cord over time. A key aspect of the approach is to label the stem cells with Prussian blue nanocubes (PBNCs), which simultaneously possess optical and magnetic properties for ultrasound-guided photoacoustic (US/PA) and magnetic resonance imaging (MRI) contrast. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - September 25, 2020 Category: Radiology Authors: Kelsey P. Kubelick, Stanislav Y. Emelianov Tags: Technical Note Source Type: research

Multi-directional Assessment of Respiratory and Cardiac Pulsatility of the Inferior Vena Cava From Ultrasound Imaging in Short Axis
The pulsatility of the inferior vena cava (IVC) reflects the volume status of patients. It can be investigated by ultrasounds (US), offering an important non-invasive tool supporting fluid management. However, the method has limitations attributable to many confounding factors, e.g., related to IVC movements and non-regular shapes. Short- or long-axis views have been used, both having advantages and limitations in counteracting such confounding factors, depending on the specific condition. The aim of this study is to investigate IVC pulsatility in the different directions on the transverse plane and to assess its variabili...
Source: Ultrasound in Medicine and Biology - September 25, 2020 Category: Radiology Authors: Luca Mesin, Paolo Pasquero, Silvestro Roatta Tags: Technical Note Source Type: research