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(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 19, 2018 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 19, 2018 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 19, 2018 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 19, 2018 Category: Radiology Source Type: research

Ultrasound Shear Wave Elastography as a Measure of Porcine Hepatic Disease in Right Heart Dysfunction: A Pilot Study
Patients with congenital heart disease with a pressure-overloaded right ventricle can develop liver disease and would benefit from non-invasive diagnostic modalities such as ultrasound shear wave elastography (US SWE). We sought to investigate the ability of US SWE to measure dynamic changes in liver stiffness with an acute fluid bolus in an animal model. Three piglets underwent surgical intervention to create a pressure-overloaded right ventricle and, 12 wk later, underwent US SWE, both pre- and post-intravenous infusion of a saline bolus. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 18, 2018 Category: Radiology Authors: Jessie J. Hu, M. Yasir Qureshi, Matthew W. Urban, Rondell Graham, Meng Yin, Saji Oommen, Kimberly A. Holst, Sarah Edgerton, Luiz Vasconcelos, Ivan Nenadic, Frank Cetta, for the Wanek Program Pre-clinical Pipeline Tags: Technical Note Source Type: research

Ultrasound Measures of Brain Pulsatility Correlate with Subcortical Brain Volumes in Healthy Young Adults
Increasing evidence suggests that brain pulsatility is involved in the pathophysiology of various neurological and psychiatric disorders. However, it remains unclear whether high brain pulsatility is damaging to or protective of the brain in normal conditions, and this could depend on the age of the individual and the methods used to measure brain pulsatility. The goal of our study was to investigate associations between subcortical volumes and brain pulsatility as assessed with ultrasound in healthy young adults using both a conventional method (transcranial Doppler pulsatility index [TCD-PI]) and the innovative method of...
Source: Ultrasound in Medicine and Biology - August 18, 2018 Category: Radiology Authors: Thomas Desmidt, Fr édéric Andersson, Bruno Brizard, Paul-Armand Dujardin, Jean-Philippe Cottier, Frédéric Patat, Jean-Pierre Réméniéras, Valérie Gissot, Wissam El-Hage, Vincent Camus Tags: Original Contribution Source Type: research

Measurement of Left Ventricular Volumes and Ejection Fraction in Patients with Regional Wall Motion Abnormalities Using an Automated 3D Quantification Algorithm
Accurate and rapid left ventricular (LV) ejection fraction (EF) measurement is crucial for patients with wall motion abnormalities (WMAs). Conventional 2D echocardiographic imaging has limitations. The recently developed software HeartModel (HM, Philips Healthcare, Andover, MA, USA) has shown promise in automated 3D quantification. However, the accuracy and detailed features of HM in measurements of LV volume and EF in patients with regional WMAs have not been carefully investigated. In the present study, echocardiographic imaging (EPIQ, X5-1, Philips Healthcare) was performed in 72 patients with WMAs. (Source: Ultrasound ...
Source: Ultrasound in Medicine and Biology - August 17, 2018 Category: Radiology Authors: Qizhe Cai, Jiangtao Wang, Hong Li, Cheng Li, Xiaopeng Wu, Xiuzhang Lu Tags: Original Contribution Source Type: research

Selective Mapping of Deep Brain Stimulation Lead Currents Using Acoustoelectric Imaging
We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1 MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0.70 mm, a detection threshold of 1.75 mA at 1 MPa and a sensitivit...
Source: Ultrasound in Medicine and Biology - August 14, 2018 Category: Radiology Authors: Chet Preston, Willard S. Kasoff, Russell S. Witte Tags: Original Contribution Source Type: research

Ultrasound-Guided Pharmacomechanical Thrombolysis and Angioplasty for Treatment of Acute Thrombotic Prosthetic Arteriovenous Access: 5-Year Experience with 154 Procedures in a Single Center
Pharmacomechanical thrombolysis (PMT) and percutaneous transluminal angioplasty (PTA) for the treatment of acute thrombotic prosthetic arteriovenous access (PAVA) are conventionally guided by radiography, which may cause radiation injury and requires the use of radiographic contrast media. The aim of the present study was to summarize our experience with ultrasound-guided PMT and PTA as an alternative to radiographic guidance. Between December 2012 and October 2016, 114 patients with acute thrombosis of PAVA were treated urgently with ultrasound-guided PMT and PTA to restore blood flow. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 13, 2018 Category: Radiology Authors: Mingxi Lu, Hua Li, Jian Feng, Weiming Hu Tags: Original Contribution Source Type: research

Conventional Ultrasound, Immunohistochemical Factors and BRAFV600E Mutation in Predicting Central Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma
The study was aimed at evaluating the correlation between central cervical lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) patients and ultrasound (US) features, immunohistochemical factors and BRAFV600E mutation. A total of 225 consecutive patients (225 PTCs) who had undergone surgery were included. All PTCs were pre-operatively analysed by US with respect to size, components, echogenicity, shape, margins, microcalcification, multiple cancers or not, internal vascularity and capsule contact or involvement. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 10, 2018 Category: Radiology Authors: Jie Chen, Xiao-Long Li, Chong-Ke Zhao, Dan Wang, Qiao Wang, Ming-Xu Li, Qing Wei, Guo Ji, Hui-Xiong Xu Tags: Original Contribution Source Type: research

Power Spectrum Consistency among Systems and Transducers
We describe that the contribution to power spectral density variance among systems and transducers equals that from speckle variance with 59 uncorrelated echo signals. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 7, 2018 Category: Radiology Authors: Quinton W. Guerrero, Liexiang Fan, Shelby Brunke, Andy Milkowski, Ivan M. Rosado-Mendez, Timothy J. Hall Tags: Original Contribution Source Type: research

Remote Echography between a Ground Control Center and the International Space Station Using a Tele-operated Echograph with Motorized Probe
Echography is the most appropriate imaging modality for investigating astronauts. Unfortunately, it requires a great deal of training to perform ultrasound examinations, which can be difficult and time consuming, especially if the astronaut does not have a medical background. We designed a new echography system with motorized probes that allows for the majority of exam functions to be controlled by a ground-based sonographer. Using tele-operation, the sonographer controls the orientation of the transducer (tilt, rotation) and echograph settings (gain, depth, freeze) and triggers ultrasound functions (pulsed wave color Dopp...
Source: Ultrasound in Medicine and Biology - August 7, 2018 Category: Radiology Authors: Philippe Arbeille, Didier Chaput, Kathryn Zuj, Arielle Depriester, Alain Maillet, Olivier Belbis, Patrice Benarroche, Sebastien Barde Tags: Technical Note Source Type: research

Observation of Guided Acoustic Waves in a Human Skull
We report on the first observation of guided acoustic waves in the near field of an ex vivo human skull specimen in the frequency range between 0.2 and 1.5 MHz. In contrast to what was previously observed for guided wave propagation in thin rodent skulls, the guided wave observed in a higher-frequency regime corresponds to a quasi-Rayleigh wave, confined mostly to the cortical bone layer. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2018 Category: Radiology Authors: H éctor Estrada, Sven Gottschalk, Michael Reiss, Volker Neuschmelting, Roland Goldbrunner, Daniel Razansky Tags: Technical Note Source Type: research

Comparison Study of Low-Cost Ultrasound Devices for Estimation of Gestational Age in Resource-Limited Countries
We investigated how accurately low-cost ultrasound devices can estimate gestational age (GA) using both the standard plane and the obstetric sweep protocol (OSP). The OSP can be taught to health care workers without prior knowledge of ultrasound within one day and thus avoid the need to train dedicated sonographers. Three low-cost ultrasound devices were compared with one high-end ultrasound device. GA was estimated with the head circumference (HC), abdominal circumference (AC) and femur length (FL) using both the standard plane and the OSP. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2018 Category: Radiology Authors: Thomas L.A. van den Heuvel, Dagmar de Bruijn, Desir ée Moens-van de Moesdijk, Anette Beverdam, Bram van Ginneken, Chris L. de Korte Tags: Original Contribution Source Type: research

Non-invasive Characterization of Focal Arrhythmia with Electromechanical Wave Imaging in Vivo
The objectives of this initial feasibility study were to determine that EWI is capable of differentiating between endocardial and epicardial sources of focal rhythm and, as a proof-of-concept, that EWI could characterize focal arrhythmia in one patient with premature ventricular contractions (PVCs) before radiofrequency (RF) ablation treatment. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 6, 2018 Category: Radiology Authors: Alexandre Costet, Elaine Wan, Lea Melki, Ethan Bunting, Julien Grondin, Hasan Garan, Elisa Konofagou Tags: Original Contribution Source Type: research

Longitudinal Movement of the Common Carotid Artery Wall: New Information on Cardiovascular Aging
Putative changes in the multiphasic pattern of longitudinal movement of the common carotid artery wall in the normal aging process are unknown. The aim of this study was to explore the phases, and resulting patterns, of the longitudinal movement of the intima –media complex of the human common carotid artery with respect to age and gender. One hundred thirty-five healthy non-smoking patients of different ages were investigated using in-house-developed ultrasound methods. The patterns of longitudinal movement seen in middle-aged and older patients were markedly different from those commonly seen in young patients, inc...
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Magnus Cinthio, John Albinsson, Tobias Erl öv, Niclas Bjarnegård, Toste Länne, Åsa Rydén Ahlgren Tags: Original Contribution Source Type: research

Contrast Transthoracic Echocardiography Using 50% Glucose as a Contrast Agent for Screening of a Patent Foramen Ovale
A patent foramen ovale (PFO) is considered a risk factor for neurologic events. The goal of the study described here was to assess the feasibility, advantages, diagnostic sensitivity and accuracy of contrast transthoracic echocardiography examination (cTTE) using 50% glucose as a contrast agent in comparison with the use of agitated saline as contrast to screen for PFO. In our study, we found that the peak time, effective duration and duration of microbubbles produced by 50% glucose were all longer than those produced by the physiologic saline. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Xin Li, Yun-Hua Gao, Sheng-Zheng Wu, Hong-Mei Xia Tags: Original Contribution Source Type: research

A lung phantom model to study pulmonary edema using lung ultrasound surface wave elastography
Lung ultrasound surface wave elastography (LUSWE) is a novel technique used to measure superficial lung tissue stiffness. A phantom study was carried out in the study described here to evaluate the application of LUSWE to assess lung water for pulmonary edema. A lung phantom model with cellulose sponge was used; various volumes of water were injected into the sponge to model lung water. Shaker-generated surface wave propagation on the sponge surface was recorded by a 10-MHz ultrasound probe at three shaker frequencies: 100, 150 and 200 Hz. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Jinling Zhou, Xiaoming Zhang Tags: Technical Note Source Type: research

Comparison of [18F]Fluorodeoxyglucose Positron Emission Tomography and Contrast-Enhanced Ultrasound for Evaluation of Hepatic Alveolar Echinococcosis Activity
The mean gray-scale ratio of the infiltrating zone of a lesion to the surrounding normal liver tissue was evaluated on the basis of contrast enhancement of the infiltration and proliferation zones of a hepatic alveolar echinococcosis lesion. The results were compared with the maximum standardized uptake value (SUVmax) of [18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET-CT), and the application of contrast-enhanced ultrasound in evaluating hepatic alveolar echinococcosis activity is discussed. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Juan Li, Jian Dong, Lei Yang, Xiaohong Li, Tao Song Tags: Original Contribution Source Type: research

Sequential Payload Release from Acoustically-Responsive Scaffolds Using Focused Ultrasound
Regenerative processes, such as angiogenesis and osteogenesis, often require multiple growth factors with distinct spatiotemporal patterns and expression sequences. Within tissue engineering, hydrogel scaffolds are commonly used for exogenous growth factor delivery. However, direct incorporation of growth factors within conventional hydrogels does not afford spatiotemporally controlled delivery because release is governed by passive mechanisms that cannot be actively controlled after the scaffold is implanted. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Alexander Moncion, Melissa Lin, Oliver D. Kripfgans, Renny T. Franceschi, Andrew J. Putnam, Mario L. Fabiilli Tags: Original Contribution Source Type: research

The B-Mode Image-Guided Ultrasound Attenuation Parameter Accurately Detects Hepatic Steatosis in Chronic Liver Disease
The purpose of our study was to evaluate the diagnostic accuracy of the ultrasound-guided attenuation parameter (UGAP) for the detection of hepatic steatosis in comparison with the controlled attenuation parameter (CAP), using histopathology as the reference standard. We prospectively analyzed 163 consecutive chronic liver disease patients who underwent UGAP, CAP, computed tomography and a liver biopsy on the same day between April 2016 and July 2017. Radiofrequency signals corresponding to the images were compensated by the reference signal previously measured from the uniform phantom with known attenuation (0.44 dB/cm/MH...
Source: Ultrasound in Medicine and Biology - August 2, 2018 Category: Radiology Authors: Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Kazuyuki Ishida, Takuma Oguri, Sachiyo Noguchi, Tamotsu Sugai, Naohisa Kamiyama, Yasuhiro Takikawa Tags: Original Contribution Source Type: research

Attenuation Coefficients of the Individual Components of the International Electrotechnical Commission Agar Tissue-Mimicking Material
This study was aimed at evaluating whether the overall attenuation coefficient of the IEC agar-TMM is the linear sum of the attenuation coefficients of each of its ingredients. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2018 Category: Radiology Authors: Adela Rabell-Montiel, Tom Anderson, Steve D. Pye, Carmel M. Moran Tags: Original Contribution Source Type: research

Acoustic Transmission Factor through the Rat Skull as a Function of Body Mass, Frequency and Position
In this study, we measured acoustic transmission factors through 13 excised skulls of male Sprague-Dawley rats weighing between 90 and 520 g, at different positions on each skull and at 1, 1.25, 1.5, 1.75 and 2 MHz. Our results revealed that insertion loss through rat skull increases linearly with both body mass and frequency and strongly depends on the position, decreasing from the front to the back and from the midline to the lateral sides. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2018 Category: Radiology Authors: Matthieu Gerstenmayer, Benjamin Fellah, R émi Magnin, Erwan Selingue, Benoit Larrat Tags: Original Contribution Source Type: research

New Ultrasound Techniques Challenge the Diagnosis of Sinusoidal Obstruction Syndrome
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation. Clinically, SOS/VOD is characterized by hepatomegaly, right upper quadrant pain, jaundice and ascites, most often occurring within the first 3 wk after hematopoietic cell transplantation. Early therapeutic intervention is pivotal for survival in SOS/VOD. Thus, a rapid and reliable diagnosis has to be made. Diagnosis of SOS/VOD is based on clinical criteria, such as the Seattle, Baltimore or recently issued European Society for Blood and Ma...
Source: Ultrasound in Medicine and Biology - August 1, 2018 Category: Radiology Authors: Christoph F. Dietrich, Corinna Trenker, Teresa Fontanilla, Christian G örg, Andreas Hausmann, Stefan Klein, Nathalie Lassau, Rosa Miquel, Dagmar Schreiber-Dietrich, Yi Dong Tags: Review Source Type: research

Normal reference values for assessing diastolic function using the parameterized diastolic filling formalism method in patients with normal results of rest and stress echocardiography
This study retrospectively recruited patients with normal results on rest and stress echocardiography and no diabetes or hypertension (n=138, 45% female). DICOM images of the resting E-wave from transmitral pulsed wave Doppler flow velocities were analyzed using freely available software. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2018 Category: Radiology Authors: Martin G. Sundqvist, Anders Sahl én, Zee Pin Ding, Martin Ugander Tags: Original Contribution Source Type: research

Persistent Enhancement on Contrast-Enhanced Ultrasound Studies of Severe Crohn's Disease: Stuck Bubbles?
A small population of patients with severe Crohn's disease (CD) exhibit atypical lack of intensity decline on intestinal contrast-enhanced ultrasound. From a retrospective CD cohort examined with contrast-enhanced ultrasound, 104 patients were identified. Twenty study patients with severe active disease exhibited high peak enhancement (>23 dB) and minimal decline. From the same cohort, 84 control patients also exhibited high peak enhancement>23 dB, but with typical intensity decline. Patient outcomes were assessed. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - August 1, 2018 Category: Radiology Authors: Rune Wilkens, Alexandra Wilson, Peter N. Burns, Subrata Ghosh, Stephanie R. Wilson Tags: Original Contribution Source Type: research

Acoustic characterization of a miniature matrix transducer for pediatric 3D transesophageal echocardiography
This paper presents the design, fabrication and characterization of a miniature PZT-on-CMOS matrix transducer for real-time pediatric 3-dimensional (3D) transesophageal echocardiography (TEE). This 3D TEE probe consists of a 32  × 32 array of PZT elements integrated on top of an Application Specific Integrated Circuit (ASIC). We propose a partitioned transmit/receive array architecture wherein the 8 × 8 transmitter elements, located at the centre of the array, are directly wired out and the remaining receive elem ents are grouped into 96 sub-arrays of 3 × 3 elements. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 30, 2018 Category: Radiology Authors: Verya Daeichin, Deep Bera, Shreyas Raghunathan, Maysam Shabani Motlagh, Zhao Chen, Chao Chen, Emile Noothout, Hendrik J. Vos, Michiel Pertijs, Johan G. Bosch, Nico de Jong, Martin Verweij Tags: Original Contribution Source Type: research

Ultrasound Parameters for Human Osteoarthritic Subchondral Bone ex Vivo: Comparison with Micro-Computed Tomography Parameters
The aim of this study was to identify ultrasound parameters reflecting subchondral porosity (Po), subchondral plate thickness (Tpl) and bone volume fraction at the trabecular bone region (BV/TVTb). Sixteen osteoarthritic human lateral femoral condyles were evaluated ex vivo using a 15-MHz pulsed-echo ultrasound 3-D scanning system. The cartilage –subchondral bone (C-B) surface region (layer 1) and inner subchondral bone region (layer 2) were analyzed; we newly introduced entropy (ENT) and correlation (COR) of ultrasound texture parameters of the parallel (x) or perpendicular (z) direction to the C-B interface for thi...
Source: Ultrasound in Medicine and Biology - July 29, 2018 Category: Radiology Authors: Wataru Kiyan, Yasuaki Nakagawa, Akira Ito, Hirotaka Iijima, Kohei Nishitani, Momoko Tanima-Nagai, Shogo Mukai, Junichi Tajino, Shoki Yamaguchi, Akihiro Nakahata, Jue Zhang, Tomoki Aoyama, Hiroshi Kuroki Tags: Original Contribution Source Type: research

Real-Time in Vivo Photoacoustic Imaging in the Assessment of Myocardial Dynamics in Murine Model of Myocardial Ischemia
Photoacoustic imaging (PAI) is an evolving real-time imaging modality that combines the higher contrast of optical imaging with the higher spatial resolution of ultrasound imaging. We utilized dual-wavelength PAI for the diagnosis and monitoring of myocardial ischemia by assessing variations in blood oxygen saturation estimated in a murine model. The use of high-frequency ultrasound in conjunction with PAI enabled imaging of anatomic and functional changes associated with ischemia. Myocardial ischemia was established in eight mice by ligating the left anterior descending artery (LAD). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 28, 2018 Category: Radiology Authors: Rashid Al Mukaddim, Allison Rodgers, Timothy A Hacker, Andrew Heinmiller, Tomy Varghese Tags: Original Contribution Source Type: research

Fast, Low-Frequency Plane-Wave Imaging for Ultrasound Contrast Imaging
Plane-wave ultrasound contrast imaging offers a faster, less destructive means for imaging microbubbles compared with traditional ultrasound imaging. Even though many of the most acoustically responsive microbubbles have resonant frequencies in the lower-megahertz range, higher frequencies (>3 MHz) have typically been employed to achieve high spatial resolution. In this work we implement and optimize low-frequency (1.5-4 MHz) plane-wave pulse inversion imaging on a commercial, phased-array imaging transducer in vitro and illustrate its use in vivo by imaging a mouse xenograft model. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 26, 2018 Category: Radiology Authors: Jiro Kusunose, Charles F. Caskey Tags: Original Contribution Source Type: research

Reply
We appreciate the interest of Ertan Yetkin and Selcuk Ozturk in our published article "Characteristic Echocardiographic Manifestations of Behcet's Disease" and thank them for their comments. Consistent with most of the previous studies (Han  et al. 2009), the most common cardiac involvement in patients with Behçet's disease (BD) in our study was severe aortic regurgitation. Some distinctive echocardiographic features of severe aortic insufficiency caused by BD are redundant motion of elongated aortic cusps or prolapsed aortic cusps with aneurysmal changes, vegetation-like mobile lesions and ...
Source: Ultrasound in Medicine and Biology - July 26, 2018 Category: Radiology Authors: Rongjuan Li, Lihong Pu Tags: Letter to the Editor Source Type: research

Non-enhanced Pattern on Contrast-Enhanced Ultrasound in the Local Efficacy Assessment of Irreversible Electroporation Ablation of Pancreatic Adenocarcinoma
The objective was to evaluate the diagnostic value of contrast-enhanced ultrasound in the assessment of the local efficacy after irreversible electroporation (IRE) ablation of pancreatic adenocarcinoma 1 mo after ablation. Fifteen patients with pancreatic adenocarcinoma were treated with IRE and then examined by contrast-enhanced ultrasound 1 mo after ablation. The contrast agent was SonoVue. Technical efficacy was assessed at 3 mo after IRE and classified as technical efficiency (TE) and technical inefficiency (TIE). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 25, 2018 Category: Radiology Authors: Manxia Lin, Xiaoyan Xie, Ming Xu, Shiting Feng, Wenshuo Tian, Bowen Zhuang, Liya Su, Jieyi Ye, Jinhua Lin, Ping Liang, Jie Yu, Ming Kuang Tags: Original Contribution Source Type: research

Histotripsy Using Fundamental and Second Harmonic Superposition Combined with Hundred-Microsecond Ultrasound Pulses
A novel histotripsy approach based on fundamental and second harmonic superposition and incorporating hundred-microsecond-long pulses and two-stage pulse protocol is proposed in this study to rapidly generate mechanically homogenized lesions. Two pulse stages were applied: stage 1, pulses with a pulse duration of 500 –600 μs and pulse repetition frequency of 100 Hz, and stage 2, multiple periods, each composed of multiple pulses with the same pulse duration and pulse repetition frequency as those in stage 1, but with an off-time of 600 ms between periods. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 24, 2018 Category: Radiology Authors: Yujiao Li, Rui Wang, Mingzhu Lu, Linglu Zhang, Yanshan Liu, Dan Han, Xuan Wang, Yizhe Geng, Mingxi Wan Tags: Original Contribution Source Type: research

Cardiac Complications in Beh çet's Disease
We have read the article “Characteristic Echocardiographic Manifestations of Behcet's Disease” by Pu et al. with great enthusiasm. In their retrospective study, they reported echocardiographic findings in patients with Behçet's disease (BD). Of the 63 patients enrolled in the study, aortic valve regurgitation (65.1%) was the most common pathology, followed by aortic dilation (20.6%) and mitral valve regurgitation (4.8%). On the basis of this study, we believe that several issues need to be discussed. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 24, 2018 Category: Radiology Authors: Ertan Yetkin, Selcuk Ozturk Tags: Letter to the Editor Source Type: research

Reactive Oxygen Species Mediate Therapeutic Ultrasound-Induced, Mitogen-Activated Protein Kinase Activation in C28/I2 Chondrocytes
In this study, we hypothesized that LIPUS activates mitogen-activated protein kinases through generation of reactive oxygen species. C28/I2 cells were stimulated with LIPUS for 10 and 20min, while the control group was treated using a sham LIPUS transducer. Through quantitative reverse transcription polymerase chain reaction and immunoblot analyses, we determined that LIPUS application increased reactive oxygen species generation and cell viability in C28/I2 cells. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 21, 2018 Category: Radiology Authors: Harmanpreet Kaur, Arno G. Siraki, Monika Sharma, Hasan Uluda ğ, Douglas N. Dederich, Patrick Flood, Tarek El-Bialy Tags: Original Contribution Source Type: research

Fast Volumetric Imaging Using a Matrix Transesophageal Echocardiography Probe with Partitioned Transmit –Receive Array
We describe a 3-D multiline parallel beamforming scheme for real-time volumetric ultrasound imaging using a prototype matrix transesophageal echocardiography probe with diagonally diced elements and separated transmit and receive arrays. The elements in the smaller rectangular transmit array are directly wired to the ultrasound system. The elements of the larger square receive aperture are grouped in 4  × 4-element sub-arrays by micro-beamforming in an application-specific integrated circuit. We propose a beamforming sequence with 85 transmit–receive events that exhibits good performance for a volume sector...
Source: Ultrasound in Medicine and Biology - July 20, 2018 Category: Radiology Authors: Deep Bera, Franc van den Adel, Nikola Radeljic-Jakic, Boris Lippe, Mehdi Soozande, Michiel A.P. Pertijs, Martin D. Verweij, Pieter Kruizinga, Verya Daeichin, Hendrik J. Vos, Antonius F.W. van der Steen, Johan G. Bosch, Nico de Jong Tags: Original Contribution Source Type: research

Classification of Tendon Matrix Change Using Ultrasound Imaging: A Systematic Review and Meta-analysis
Ultrasound imaging (US) is an accurate and reliable method used to diagnose tendinopathy. This systematic review was aimed at identifying common criteria and parameters used to diagnose tendinopathy, the methodological quality of studies and the predictive value of US. Nineteen studies met the inclusion criteria, with the Achilles, quadriceps and patella tendons being investigated. Overall, there was significant heterogeneity between the criteria used to diagnose tendinopathy utilising US. The methodological quality of included studies was "good. ” Additionally, meta-analysis revealed that US-identified abnormal...
Source: Ultrasound in Medicine and Biology - July 11, 2018 Category: Radiology Authors: Wesley Matthews, Richard Ellis, James Furness, Wayne Hing Tags: Review Source Type: research

Evaluation of Gastric Emptying by Transabdominal Ultrasound after Oral Administration of Semisolid Cellulose-Based Gastric Ultrasound Contrast Agents
Many previous studies have found that transabdominal ultrasound may allow precise measurement of gastric emptying of liquid meals. However, the clinical use of this technique has been hampered by the limitation that transabdominal ultrasound might not accurately measure gastric emptying of solid meals. It is more important to measure gastric emptying of solids instead of liquids, as gastric emptying of solids is more often delayed than gastric emptying of liquids in gastric motility disorders. Recently, transabdominal ultrasound after oral administration of a cellulose-based gastric contrast agents (TUS-OSCA) has been sugg...
Source: Ultrasound in Medicine and Biology - July 10, 2018 Category: Radiology Authors: Zhijun Liu, Zhining Liu, Yuhong Li, Jintao Guo, Jianmin Li, Weidong Ren, Shaoshan Tang, Limei Xie, Ying Huang, Liping Huang, Siyu Sun, Ying Zhao Tags: Original Contribution Source Type: research

High-Frequency Micro-Ultrasound Imaging and Optical Topographic Imaging for Spinal Surgery: Initial Experiences
High frequency micro-ultrasound ( µUS) transducers with central frequencies up to 50 MHz facilitate dynamic visualization of patient anatomy with minimal disruption of the surgical work flow. Micro-ultrasound improves spatial resolution over conventional ultrasound imaging from millimeter to micrometer, but compromises depth pene tration. This trade-off is sufficient during an open surgery in which the bone is removed and the ultrasound probe can be placed into the surgical cavity. By fusing µUS with pre-operative imaging and tracking the ultrasound probe intra-operatively using our optical topographic i...
Source: Ultrasound in Medicine and Biology - July 10, 2018 Category: Radiology Authors: Raphael Jakubovic, Joel Ramjist, Shaurya Gupta, Daipayan Guha, Arjun Sahgal, F. Stuart Foster, Victor X.D. Yang Tags: Clinical Note Source Type: research

Photoacoustic Oxygenation Quantification in Patients with Raynaud's: First-in-Human Results
The purpose of this study was to investigate the use of photoacoustic imaging for quantifying fingertip oxygenation as an approach to diagnosing and monitoring Raynaud's phenomenon. After 30  min of acclimation to room temperature, 22 patients (7 patients with secondary Raynaud's associated to Scleroderma and 15 healthy controls) provided informed consent to undergo fingertip Doppler imaging and high-frequency photoacoustic imaging before and 5, 15 and 30 min after cold stimulus (su bmerged hand in a 15 °C water bath for 1 min). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 6, 2018 Category: Radiology Authors: John R. Eisenbrey, Maria Stanczak, Flemming Forsberg, Fabian A. Mendoza-Ballesteros, Andrej Lyshchik Tags: Original Contribution Source Type: research

Application of ARFI-SWV in Stiffness Measurement of the Abdominal Wall Musculature: A Pilot Feasibility Study
The purpose of this study was to assess the feasibility of acoustic radiation force impulse shear wave velocity and textural features for characterizing abdominal wall musculature and to identify subject-related and technique-related factors that can potentially affect measurements. Median shear wave velocity measurements for the right external abdominal oblique were the same (1.89 ± 0.16 m/s) for both the active group (healthy volunteers with active lifestyles) and the control group (age and body mass index–matched volunteers from an ongoing hernia study). (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 3, 2018 Category: Radiology Authors: David A. Gabrielsen, Martin J. Carney, Jason M. Weissler, Michael A. Lanni, Jorge Hernandez, Laith R. Sultan, Fabiola Enriquez, Chandra M. Sehgal, John P. Fischer, Anil Chauhan Tags: Original Contribution Source Type: research

Postoperative chest ultrasound findings and effectiveness after thoracic surgery: A pilot study
The aim of this study was to analyze the information from post-operative chest ultrasound (CU) to evaluate the possibility to use this method instead of chest X-ray (CXR) after thoracic surgery. Patients who underwent thoracic surgery were evaluated with CU blinded to CXR after surgery, deciding if it was useful or CU was exhaustive. Twenty-four patients were enrolled prospectively. The CU allowed a further discrimination of the lung abnormalities, discriminating between atelectasis, infections or hematoma. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 3, 2018 Category: Radiology Authors: Marco Chiappetta, Elisa Meacci, Alfredo Cesario, Andrea Smargiassi, Riccardo Inchingolo, Leonardo Petracca Ciavarella, Stefania Lopatriello, Andrea Contegiacomo, Maria Teresa Congedo, Stefano Margaritora Tags: Original Contribution Source Type: research

Usefulness of Left Ventricular Vortex Flow Analysis for Predicting Clinical Outcomes in Patients with Chronic Heart Failure: A Quantitative Vorticity Imaging Study Using Contrast Echocardiography
The goal of the study described here was to evaluate whether left ventricular vortex flow parameters, as assessed by contrast echocardiography, enhance prediction of major adverse cardiac events (MACE) in patients with chronic heart failure and systolic dysfunction. A total of 75 patients with contrast echocardiography and systolic dysfunction (ejection fraction ≤45%) were prospectively enrolled and underwent vortex flow analysis with particle image velocimetry using contrast echocardiography. Vortex flow parameters, including kinetic energy fluctuation (KEF), were evaluated. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 3, 2018 Category: Radiology Authors: In-Cheol Kim, Geu-Ru Hong, Gianni Pedrizzetti, Chi Young Shim, Seok-Min Kang, Namsik Chung Tags: Original Contribution Source Type: research

Meal Ingestion and Hemodynamic Interactions Regarding Renal Blood Flow on Duplex Sonography: Potential Diagnostic Implications
Splanchnic blood flow changes dramatically after meal ingestion. The present study evaluated physiologic interactions between meal ingestion and hemodynamics with respect to renal blood flow on duplex sonography, assessing the possible influence on Doppler parameters used as diagnostic criteria for renal artery stenosis. Subjects comprised 26 healthy young men (mean age: 22 ± 2 y). Sonographic measurements were made shortly after breakfast and every 1 h thereafter and were compared with values measured before the meal. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 3, 2018 Category: Radiology Authors: Tomonori Kishino, Keiichiro Harashima, Shigeki Hashimoto, Naoya Fukuta, Masayo Seki, Hiroaki Ohnishi, Takashi Watanabe, Junichi Otaki Tags: Technical Note Source Type: research

Masthead
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 28, 2018 Category: Radiology Source Type: research

Editorial Advisory Board
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 28, 2018 Category: Radiology Source Type: research

Contents
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 28, 2018 Category: Radiology Source Type: research

Calendar
(Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 28, 2018 Category: Radiology Source Type: research

Respiratory variability of peak velocities in the common femoral vein estimated with vector flow imaging and Doppler ultrasound
Respiratory variability of peak velocities (RVPV) in the common femoral vein measured with ultrasound can reveal venous outflow obstruction. Pulse wave (PW) Doppler is the gold standard for venous velocity estimation of the lower extremities. PW Doppler measurements are angle dependent, whereas vector flow imaging (VFI) can yield angle-independent measures. The hypothesis of the present study was that VFI can provide RVPV estimations without the angle dependency of PW Doppler for an improved venous disease assessment. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 27, 2018 Category: Radiology Authors: Thor Bechsgaard, Kristoffer Lindskov Hansen, Andreas Hjelm Brandt, Ramin Moshavegh, Julie Lyng Forman, Pia F øgh, Lotte Klitfod, Niels Bækgaard, Lars Lönn, Michael Bachmann Nielsen, Jørgen Arendt Jensen Tags: Original Contribution Source Type: research

Inactivation of Planktonic Escherichia coli by Focused 1-MHz Ultrasound Pulses with Shocks: Efficacy and Kinetics Upon Volume Scale-Up
This study addresses inactivation of E. coli in either 5- or 10-mL volumes, which were 50- to 100-fold greater than used in an earlier study (Brayman et al. 2017). Cells were treated with 1-MHz pulsed high-intensity focused ultrasound (10 cycles, 2-kHz repetition frequency, +65/ –12.8 MPa focal pressures). The surviving fraction was assessed by coliform assay, and inactivation demonstrated curvilinear kinetics. The reduction of surviving fraction to 50% required 2.5 or 6 min in 5- or 10-mL samples, respectively. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - June 22, 2018 Category: Radiology Authors: Andrew A. Brayman, Brian E. MacConaghy, Yak-Nam Wang, Keith T. Chan, Wayne L. Monsky, Valery P. Chernikov, Sergey V. Buravkov, Vera A. Khokhlova, Thomas J. Matula Tags: Original Contribution Source Type: research