The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research

Correction: Predictive progression outcomes and risk stratification in patients with recurrent or metastatic nasopharyngeal carcinoma who received first ‑line immunochemotherapy
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research

TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples
In this study, we introduce TMBstable, an innovative method that dynamically selects optimal variant calling strategies for specific genomic regions using a meta-learning framework, distinguishing it from traditional callers with uniform sample-wide strategies. The process begins with segmenting the sample into windows and extracting meta-features for clustering, followed by using a pre-trained meta-model to select suitable algorithms for each cluster, thereby addressing strategy-sample mismatches, reducing performance fluctuations and ensuring consistent performance across various samples. We evaluated TMBstable using bot...
Source: Briefings in Bioinformatics - April 18, 2024 Category: Bioinformatics Authors: Shenjie Wang Xiaoyan Zhu Xuwen Wang Yuqian Liu Minchao Zhao Zhili Chang Xiaonan Wang Yang Shao Jiayin Wang Source Type: research

Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2
Cell Death & Disease, Published online: 18 April 2024; doi:10.1038/s41419-024-06671-0Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2 (Source: Cell death and disease)
Source: Cell death and disease - April 18, 2024 Category: Internal Medicine Authors: Feng Liu Ling Tang Huai Liu Yanzhu Chen Tengfei Xiao Wangning Gu Hongmin Yang Hui Wang Pan Chen Source Type: research

Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer
Head and neck cancers (HNC) are among the most prevalent malignant tumors worldwide. They encompass malignancies of the upper respiratory tract and gastrointestinal system, including nasopharyngeal carcinoma, laryngeal carcinoma, tongue carcinoma, parotid gland carcinoma, and others [1]. The development of HNC is closely related to smoking, excessive drinking, chewing of betel nuts, and viral infection (HBV/HPV). The treatment of HNC includes surgery, radiotherapy (RT), chemotherapy, and immunotherapy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Zhuangzhuang Zheng, Yingying Shen, Jing Su, Xiaorui Ji, Qiang Zhang, Qin Zhao, Xin Jiang Tags: Original Article Source Type: research

Comorbidity profiling identifies potential subtype of elderly patients with nasopharyngeal carcinoma
CONCLUSION: Our study shed light on the potential comorbidity patterns in elderly patients with NPC, thereby providing valuable insights into the development of comprehensive health management strategies for this specific population.PMID:38625619 | DOI:10.1093/oncolo/oyae063 (Source: The Oncologist)
Source: The Oncologist - April 16, 2024 Category: Cancer & Oncology Authors: Ying Li Yuhui Pan Zongwei Huang Lishui Wu Wenxi Wu Siqi Xu Zihan Chen Xin Chen Jun Lu Sufang Qiu Source Type: research

Comorbidity profiling identifies potential subtype of elderly patients with nasopharyngeal carcinoma
CONCLUSION: Our study shed light on the potential comorbidity patterns in elderly patients with NPC, thereby providing valuable insights into the development of comprehensive health management strategies for this specific population.PMID:38625619 | DOI:10.1093/oncolo/oyae063 (Source: The Oncologist)
Source: The Oncologist - April 16, 2024 Category: Cancer & Oncology Authors: Ying Li Yuhui Pan Zongwei Huang Lishui Wu Wenxi Wu Siqi Xu Zihan Chen Xin Chen Jun Lu Sufang Qiu Source Type: research

Electrophysiological Changes on Laryngeal Motor Neuropathways Cause Voice Disorders for Postradiotherapy Patients with Nasopharyngeal Carcinoma
This study explored electrophysiological changes in the laryngeal motor neuropathway and determined whether lesions in the laryngeal motor cortex (LMC) and its descending tract contribute to voice deterioration and peripheral nerve palsy in patients with nasopharyngeal carcinoma (NPC) postradiotherapy (RT). (Source: Journal of Voice)
Source: Journal of Voice - April 16, 2024 Category: ENT & OMF Authors: Cui He, Libing Guo, Mingfen Zheng, Hong Peng, Xuhui Zhang, Changhe Fan, Xiangdong Zhao, Pinggui Gong, Zeyi Deng, Guang Xu, Cuijie Chen Source Type: research

Comparison of [18F]FDG and [68  Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
Conclusions[68 Ga]pentixafor is a promising imaging tracer for detecting primary and metastatic NPC. [68 Ga]pentixafor PET/CT is comparable to [18F]FDG PET/CT in the detection rate of primary tumors and metastatic cervical lymph nodes in nasopharyngeal carcinoma, but [68 Ga]pentixafor uptake was heterogeneous. [68 Ga]pentixafor PET/CT may help select patients most likely to benefit from CXCR4-directed endoradiotherapy.Clinical trial registration No.: ChiCTR2200065902 (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 16, 2024 Category: Molecular Biology Source Type: research

Using the genomic adjusted radiation dose (GARD) to personalize the radiation dose in nasopharyngeal cancer
Radiotherapy (RT) is an integral component of nasopharyngeal cancer (NPC) management. Advanced RT techniques such as intensity-modulated radiotherapy (IMRT) have improved the anatomical precision of local treatment for primary NPC.[1] Despite this, around 20 –30 % of patients develop local recurrence and/or distant metastases.[2] Additionally, up to 50 % of patients in remission experience RT-induced late toxicities.[3] Current radiation dose protocols are uniformly standardized at 66–70 Gy for gross disease and 54–60 Gy for elective nodal regions, despite substantial heterogeneity in treatment response. (Sou...
Source: Radiotherapy and Oncology - April 16, 2024 Category: Radiology Authors: Chi Leung Chiang, Kenneth Sik Kwan Chan, Huaping Li, Wai Tong Ng, James Chung Hang Chow, Horace Cheuk Wai Choi, Ka On Lam, Victor Ho Fun Lee, Roger Kai Cheong Ngan, Anne Wing Mui Lee, Steven A Eschrich, Javier F Torres-Roca, Jason Wing Hon Wong Tags: Original Article Source Type: research

An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model
Adoptive transfer of T cell receptor–engineered T cells (TCR-T) is a promising strategy for immunotherapy against solid tumors. However, the potential of CD4+ T cells in mediating tumor regression has been neglected. Nasopharyngeal cancer is consistently associated with EBV. Here, to evaluate the therapeutic potential of CD4 TCR-T in nasopharyngeal cancer, we screened for CD4 TCRs recognizing EBV nuclear antigen 1 (EBNA1) presented by HLA-DP5. Using mass spectrometry, we identified EBNA1567–581, a peptide naturally processed and presented by HLA-DP5. We isolated TCR135, a CD4 TCR with high functional avidity, that can ...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Chenwei Wang, Jiewen Chen, Jingyao Li, Zhihong Xu, Lihong Huang, Qian Zhao, Lei Chen, Xiaolong Liang, Hai Hu, Gang Li, Chengjie Xiong, Bin Wu, Hua You, Danyi Du, Xiaoling Wang, Hongle Li, Zibing Wang, Lin Chen Source Type: research

Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research

Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
CONCLUSION: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.PMID:38619029 | DOI:10.34172/aim.2024.11 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Bahareh Vakili Parisa Shoaei Kiana Shahzamani Seyed Davar Siadat Hasan Shojaei Zahra Esfandiari Elahe Nasri Shiva Shabani Ali Zamani Moghadam Behrooz Ataei Source Type: research

Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1
Conclusion: Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.PMID:38617001 | PMC:PMC11008478 | DOI:10.7150/ijms.93128 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Jinhai Chen Min Mao Zhaoen Ma Jie Liu Minqiong Jiang Guangui Chen Yali Xu Source Type: research

Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
CONCLUSION: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.PMID:38619029 | PMC:PMC11017262 | DOI:10.34172/aim.2024.11 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Bahareh Vakili Parisa Shoaei Kiana Shahzamani Seyed Davar Siadat Hasan Shojaei Zahra Esfandiari Elahe Nasri Shiva Shabani Ali Zamani Moghadam Behrooz Ataei Source Type: research