Nasopharyngeal Metastasis from Breast Carcinoma: A Case Report and a Review of the Literature
We report the case of a 50-year-old woman with a history of a confirmed breast carcinoma under chemotherapy who presented to our department with a unilateral hearing loss and tinnitus. Nasal endoscopy revealed a small bulging mass at the posterior wall of the nasopharynx. The biopsy of the lesion showed an infiltration of the nasopharyngeal mucosa by a mammary adenocarcinoma that was positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Computed tomography scan revealed a thickening of the nasopharyngeal mucosa, a pleural and pericardial effusion and diffused secondary ...
Source: Ear, Nose and Throat Journal - August 9, 2022 Category: ENT & OMF Authors: Moncef Sellami Souha Kallel Mariam Ben Ayed Manel Mellouli Tahya Sellami Boudawara Malek Mnejja Bouthaina Hammami Imen Achour Ilhem Charfeddine Source Type: research

[68Ga]Ga-FAPI PET/CT Improves the T Staging of Patients with Newly Diagnosed Nasopharyngeal Carcinoma: A Comparison with [18F]F-FDG
Conclusion[68Ga]Ga-FAPI PET/CT outperformed [18F]F-FDG PET/CT in detecting the cavernous sinus and bony structure involvement of primary NPC tumours, suggesting its value in improving T staging and therapeutic regimen selection. However, the performance of [68Ga]Ga-FAPI PET/CT is less promising for N staging because it detected fewer positive CLNs than [18F]F-FDG PET/CT. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 9, 2022 Category: Molecular Biology Source Type: research

Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host
Front Microbiol. 2022 Jul 22;13:955603. doi: 10.3389/fmicb.2022.955603. eCollection 2022.ABSTRACTEpstein-Barr virus (EBV) is a double-stranded DNA virus of the Herpesviridae family. This virus preferentially infects human primary B cells and persists in the human B cell compartment for a lifetime. Latent EBV infection can lead to the development of different types of lymphomas as well as carcinomas such as nasopharyngeal and gastric carcinoma in immunocompetent and immunocompromised patients. The early phase of viral infection is crucial for EBV to establish latency, but different viral components are sensed by cellular se...
Source: Cancer Control - August 8, 2022 Category: Cancer & Oncology Authors: Manuel Albanese Takanobu Tagawa Wolfgang Hammerschmidt Source Type: research

Selection and validation of chemotherapy beneficiaries among elderly nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT): a large real-world study
Using real-world evidence, this study aimed to identify elderly nasopharyngeal carcinoma (NPC) patients who would benefit from chemotherapy. (Source: Radiation Oncology)
Source: Radiation Oncology - August 8, 2022 Category: Cancer & Oncology Authors: Yan-Ling Wu, Kai-Bin Yang, Ying Huang, Jing-Rong Shi, Qing-Shui He, Lei Chen, Wen-Fei Li, Xiao-Dan Huang, Li Lin, Yu-Pei Chen, Yan-Ping Mao, Ling-Long Tang and Jun Ma Tags: Research Source Type: research

The prognostic value of the ratio of standard uptake value of lymph node to primary tumor before treatment of locally advanced nasopharyngeal carcinoma
ConclusionsHigh NTR before treatment indicates a poor prognosis for patients with nasopharyngeal carcinoma. This can serve as a reference value for the reasonable treatment and prognosis monitoring of such patients. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - August 6, 2022 Category: ENT & OMF Source Type: research

Cancers, Vol. 14, Pages 3804: Hospital-Treated Infections and Increased Risk of Two EBV-Related Malignancies: A Nested Case-Control Study
Conclusions: These findings suggest that infections requiring hospital treatment might contribute to the carcinogenesis of malignancies potentially related to EBV. (Source: Cancers)
Source: Cancers - August 5, 2022 Category: Cancer & Oncology Authors: Yanping Yang Li Yin Qianwei Liu Jiangwei Sun Hans-Olov Adami Weimin Ye Zhe Zhang Fang Fang Tags: Article Source Type: research

Epithelial –myoepithelial carcinoma of the nasopharynx: A case report and review of the literature
ConclusionTo the best of our knowledge, this is the third reported case of EMCa in the nasopharynx and the only case of EMCa in the nasopharynx treated with CCRT, and a partial response was achieved. Therefore, to improve the quality of life and prognosis of patients with unresectable tumors, we believe that CCRT is a suitable option. Further clinical observations are required to elucidate the pathophysiology and prognosis of EMCa. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 5, 2022 Category: Cancer & Oncology Source Type: research

Sensors, Vol. 22, Pages 5875: Lightweight Compound Scaling Network for Nasopharyngeal Carcinoma Segmentation From MR Images
n Liu Nasopharyngeal carcinoma (NPC) is a category of tumours with a high incidence in head-and-neck. To treat nasopharyngeal cancer, doctors invariably need to perform focal segmentation. However, manual segmentation is time consuming and laborious for doctors and the existing automatic segmentation methods require large computing resources, which makes some small and medium-sized hospitals unaffordable. To enable small and medium-sized hospitals with limited computational resources to run the model smoothly and improve the accuracy of structure, we propose a new LW-UNet network. The network utilises lightweight modul...
Source: Sensors - August 5, 2022 Category: Biotechnology Authors: Yi Liu Guanghui Han Xiujian Liu Tags: Article Source Type: research

Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy
CONCLUSION: CAIX remarkably expresses in human NPCs and stratifies patient prognosis. In preclinical studies, CAIX-800-based imaging successfully identifies occult LNMs and tracks early stage of pathological ENE. This attractive method shows potential in clinic, allowing medical workers to longitudinally monitor nodal status and helping to reduce unnecessary nodal biopsy for patients with NPC. The schematic diagram for the study. CAIX, carbonic anhydrase IX; NPC, nasopharyngeal carcinoma; US, ultrasonography; sPA, spectroscopic photoacoustic.PMID:35925443 | DOI:10.1007/s00259-022-05922-6 (Source: Molecular Medicine)
Source: Molecular Medicine - August 4, 2022 Category: Molecular Biology Authors: Wenhui Huang Kun Wang Weiyuan Huang Zicong He Jingming Zhang Bin Zhang Zhiyuan Xiong Kelly McCabe Gillen Wenzhe Li Feng Chen Xing Yang Shuixing Zhang Jie Tian Source Type: research

Improved overall survival is associated with adjuvant chemotherapy after definitive concurrent chemoradiotherapy for N3 nasopharyngeal cancer
Sci Rep. 2022 Aug 4;12(1):13390. doi: 10.1038/s41598-022-16422-w.ABSTRACTConcurrent chemoradiotherapy is the established treatment for locally advanced nasopharyngeal carcinoma (NPC). However, there is no evidence supporting routine adjuvant chemotherapy. We aimed to demonstrate the effect of adjuvant chemotherapy on survival and distant metastasis in high-risk N3 NPC patients. We linked the Taiwan Cancer Registry and Cause of Death database to obtain data. Clinical N3 NPC patients were divided as those receiving definitive concurrent chemoradiotherapy (CCRT) with adjuvant 5-fluorouracil and platinum (PF) chemotherapy and ...
Source: Cancer Control - August 4, 2022 Category: Cancer & Oncology Authors: Mu-Hung Tsai Shang-Yin Wu Hsi-Huei Lu Tsung Yu Sen-Tien Tsai Yuan-Hua Wu Source Type: research

Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy
CONCLUSION: CAIX remarkably expresses in human NPCs and stratifies patient prognosis. In preclinical studies, CAIX-800-based imaging successfully identifies occult LNMs and tracks early stage of pathological ENE. This attractive method shows potential in clinic, allowing medical workers to longitudinally monitor nodal status and helping to reduce unnecessary nodal biopsy for patients with NPC. The schematic diagram for the study. CAIX, carbonic anhydrase IX; NPC, nasopharyngeal carcinoma; US, ultrasonography; sPA, spectroscopic photoacoustic.PMID:35925443 | DOI:10.1007/s00259-022-05922-6 (Source: Molecular Medicine)
Source: Molecular Medicine - August 4, 2022 Category: Molecular Biology Authors: Wenhui Huang Kun Wang Weiyuan Huang Zicong He Jingming Zhang Bin Zhang Zhiyuan Xiong Kelly McCabe Gillen Wenzhe Li Feng Chen Xing Yang Shuixing Zhang Jie Tian Source Type: research

A Joint Model Considering Measurement Errors for Optimally Identifying Tumor Mutation Burden Threshold
We report a multi-endpoint joint model as a generalized method for inferring the TMB thresholds, facilitating consistent statistical inference using an iterative numerical estimation procedure considering mis-specified covariates. The model optimizes the division by combining objective response rate and time-to-event outcomes, which may be interrelated due to some shared traits. We augment previous works by enabling subject-specific random effects to govern the communication among distinct endpoints. Our simulations show that the proposed model has advantages over the standard model in terms of precision and stability in p...
Source: Frontiers in Genetics - August 4, 2022 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 14, Pages 3795: Clinical Characteristics and Predictive Outcomes of Recurrent Nasopharyngeal Carcinoma & mdash;A Lingering Pitfall of the Long Latency
Conclusion: Long-latent NPC recurrence is not rare, and the survival outcome is poor. Regular follow-up for early detection of NPC recurrence is necessary even after five years of disease-free period. (Source: Cancers)
Source: Cancers - August 4, 2022 Category: Cancer & Oncology Authors: Yung-Hsuan Chen Sheng-Dean Luo Shao-Chun Wu Ching-Nung Wu Tai-Jan Chiu Yu-Ming Wang Yao-Hsu Yang Wei-Chih Chen Tags: Article Source Type: research

Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy
ConclusionCAIX remarkably expresses in human NPCs and stratifies patient prognosis. In preclinical studies, CAIX-800-based imaging successfully identifies occult LNMs and tracks early stage of pathological ENE. This attractive method shows potential in clinic, allowing medical workers to longitudinally monitor nodal status and helping to reduce unnecessary nodal biopsy for patients with  NPC.Graphical abstractThe schematic diagram for the study. CAIX, carbonic anhydrase IX; NPC, nasopharyngeal carcinoma; US, ultrasonography; sPA, spectroscopic photoacoustic. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 4, 2022 Category: Nuclear Medicine Source Type: research