Detectable Circulating Tumor Tissue Modified Viral (TTMV)-HPV DNA in Non-Oropharyngeal Head and Neck Cancers
Plasma ctHPVDNA is detectable prior to treatment in ∼90% of patients with HPV-OPSCC and has shown utility in the dynamic monitoring of treatment response and detecting recurrences (4, 5, 6). Recent data has demonstrated ctHPVDNA to be detectable in patients with sinonasal and nasopharyngeal primary tumors (7). Herein, we present our early experienc e of ctHPVDNA detection in non-oropharyngeal HPV-associated head and neck cancers using an ultrasensitive multianalyte droplet polymerase chain reaction assay that tests for cell free tumor tissue modified viral (TTMV)-HPV DNA (liquid biopsies). (Source: International Journal ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: E.W. Duffy, J. Kaczmar, W. Albergotti, A. Kejner, J.G. Newman, E.M. Graboyes, A. Tamblyn, B.S. Chera Tags: 132 Source Type: research
Phase II Trial of Quality-of-Life Outcomes after Proton Beam for Nasopharyngeal Carcinoma
Radiotherapy is a primary treatment modality for nasopharyngeal cancer (NPC). Advances in radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) have shown less detriment in quality of life (QOL). Proton beam therapy (PBT) has potential to further reduce detriment in QOL due to reduced exposure of normal tissues to low-dose radiation. The purpose of this study was to assess patient-reported QOL outcomes after PBT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Slater, E.A. Weyman, A.W. Chan Tags: 190 Source Type: research
Patient-Reported and Dosimetric Determinants of Trismus after Chemoradiation for Nasopharyngeal Carcinoma: A Prospective Study
Trismus is a common side effect following radiation therapy for head and neck cancer and may be most severe for patients with nasopharyngeal carcinoma. To date, prospective efforts investigating patient reported outcomes combined with dosimetric predictors are lacking. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.S. Gentile, A.A. Aizer, T. Goldsmith, E.A. Weyman, A. Holman, J.A. Adams, A.W. Chan Tags: 181 Source Type: research
The Microbiome is Associated with Responses to Neoadjuvant Therapy in Primary Nasopharyngeal Carcinoma
The microbiome has been noted to be altered in a variety of malignancies including nasopharyngeal carcinoma (NPC). Microbiome dysbiosis is postulated to affect the tumor immune microenvironment and potentially responses to radiotherapy, chemotherapy and immunotherapy. Here we sought to elucidate the role of the microbiome in predicting responses to neoadjuvant therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Chan, J. Chen, D. Yeung, Z. Chen Tags: 238 Source Type: research
Toripalimab: A Next Generation Designed Anti-PD-1 Antibody for Treatment of Nasopharyngeal Carcinoma
Toripalimab is a PD-1 targeting humanized IgG4 monoclonal antibody (mAb) that is currently under review by US Food and Drug Administration (FDA) for first-line treatment of nasopharyngeal carcinoma (NPC) in combination with chemotherapy. Currently approved PD-1 monoclonal antibodies (mAbs) have demonstrated significant clinical benefit particularly in patients with PD-L1 expressing tumors. However, in three multicenter on-going phase 3 trials (including NPC, Jupiter-02), toripalimab in combination with chemotherapy has demonstrated good clinical efficacy irrespective of the PD-L-1 status. (Source: International Journal of ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N. Rajasekaran, S. Ravindranathan, X. Wang, D.J. Chin, S.Y. Tseng, S. Klakamp, K. Widmann, G. Young, B. Yu, V. Kapoor, V. Vexler, P. Keegan, S. Yao, S.D. Khare, T. LaVallee Tags: 260 Source Type: research
A real-world evaluation of tislelizumab in patients with head and neck cancer
CONCLUSIONS: Tislelizumab demonstrated promising efficacy and tolerability in patients with HNSCC or NPC in a real-world setting, consistent with previous reports.PMID:38482433 | PMC:PMC10928599 | DOI:10.21037/tcr-23-1502 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Baomin Zheng Zhou Huang Weixin Liu Dan Zhao Xiaolong Xu Shaowen Xiao Yan Sun Weihu Wang Source Type: research
Salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma in a non-endemic area
ConclusionNER appeared as a safe and effective treatment for recurrent uNK-NPC. The adequate selection of patients eligible for NER is essential, to maximize the chances to cure and minimize the risk of local complications. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - March 14, 2024 Category: ENT & OMF Source Type: research
Epidermodysplasia verruciformis –associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features
We report here a distinctive form of EDV-associated eccrine neoplasia. Seven tumors from two patients were analyzed and show highly uniform features including multiple clustered clinical lesions, multifocal epidermal origin, eccrine differentiation with close association with the acrosyringium, an anastomosing growth pattern, and a bland monotonous poroid-to-basaloid cytomorphology. Clinical follow-up for one patient has been benign to date. These tumors show strong similarity to two previously reported cases, suggesting that this type of EDV-associated eccrine neoplasia may represent a rare but reproducible form of skin a...
Source: Virchows Archiv - March 14, 2024 Category: Pathology Source Type: research
Impact of plasma Epstein –Barr virus DNA in posttreatment nasopharyngeal carcinoma patients after SARS-CoV-2 infection
Nasopharyngeal carcinoma (NPC) is prevalent in southern China. EBV DNA is the most useful biomarker in NPC. However, the value of EBV DNA in posttreatment NPC patients infected with severe acute respiratory sy... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Cheng Lin, Meifang Li, Yingying Lin, Yu Zhang, Hanchuan Xu, Bijuan Chen, Xia Yan and Yun Xu Tags: Research Source Type: research
Mesenchymal Stem Cell-derived Exosome; An Interesting Nanocarrier to Improve Allergen-specific Intranasal Immunotherapy
In conclusion, the Exo-OVA improved the INIT efficacy compared to free OVA. Therefore, this formulation could be introduced as an effective approach for immunomodulatory purposes with a shorter treatment duration and reduced side effects.PMID:38477953 | DOI:10.18502/ijaai.v22i6.14645 (Source: Cancer Control)
Source: Cancer Control - March 13, 2024 Category: Cancer & Oncology Authors: Sajad Dehnavi Maryam Dadmanesh Negin Hosseini Rouzbahani Mahmood Karimi Ali Asadirad Mohammad Gholami Khodayar Ghorban Source Type: research
Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide
Cancers (Basel). 2024 Feb 26;16(5):936. doi: 10.3390/cancers16050936.ABSTRACTThe Epstein-Barr virus (EBV) is accepted as a primary risk factor for certain nasopharyngeal carcinoma (NPC) subtypes, where the virus persists in a latent stage which is thought to contribute to tumorigenesis. Current treatments are sub-optimal, and recurrence occurs in many cases. An alternative therapeutic concept is aimed at triggering the lytic cycle of EBV selectively in tumor cells as a means to add clinical benefit. While compounds able to stimulate the lytic cascade have been identified, their clinical application so far has been limited....
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Hannah Hartman-Houstman Steve Swenson Radu O Minea Uttam K Sinha Ming-Fu Chiang Thomas C Chen Axel H Sch önthal Source Type: research
Dynamic monitoring of radiation-induced white matter microstructure injury in nasopharyngeal carcinoma via high-angular resolution diffusion imaging
CONCLUSIONS: White matter tract changes detected by HARDI are potential biomarkers for monitoring radiotherapy-related brain damage in NPC patients.PMID:38479491 | DOI:10.1016/j.brainres.2024.148851 (Source: Brain Research)
Source: Brain Research - March 13, 2024 Category: Neurology Authors: Tiansheng Li Yihao Guo Xin Jin Tao Liu Gang Wu Weiyuan Huang Feng Chen Source Type: research
Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide
Cancers (Basel). 2024 Feb 26;16(5):936. doi: 10.3390/cancers16050936.ABSTRACTThe Epstein-Barr virus (EBV) is accepted as a primary risk factor for certain nasopharyngeal carcinoma (NPC) subtypes, where the virus persists in a latent stage which is thought to contribute to tumorigenesis. Current treatments are sub-optimal, and recurrence occurs in many cases. An alternative therapeutic concept is aimed at triggering the lytic cycle of EBV selectively in tumor cells as a means to add clinical benefit. While compounds able to stimulate the lytic cascade have been identified, their clinical application so far has been limited....
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Hannah Hartman-Houstman Steve Swenson Radu O Minea Uttam K Sinha Ming-Fu Chiang Thomas C Chen Axel H Sch önthal Source Type: research
GSE169589 N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/ β-Catenin pathway in nasopharyngeal carcinoma
Contributors : Hao Peng ; Shuibin LinSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensTreatment selections are very limited for patients with advanced nasopharyngeal carcinoma (NPC) experiencing disease progression. Uncovering the potential mechanism underlying NPC progression is crucial for identify novel treatments. Here we show that N7-methylguanosine (m7G) tRNA modification enzyme METTL1 and its partner WDR4 are significantly elevated in NPC and associated with poor prognosis. Loss-of-function and gain-of-function assays demonstrated that METTL1/WDR4 mediated m7G tRNA mod...
Source: GEO: Gene Expression Omnibus - March 13, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
BPIFB1, Serving as a Downstream Effector of EBV-miR-BART4, Blocks Immune Escape of Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression
This study provided a comprehensive understanding of the molecular mechanism for the upstream and downstream pathway of BPIFB1 related with immune escape, indicating a novel approach for the treatment of NPC.PMID:38467887 | DOI:10.1007/s10528-024-10719-3 (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 12, 2024 Category: Genetics & Stem Cells Authors: Jiaodi Cai Li Xiao Jiao Liu Dan Wang Yadong Zhou Zhiming Liao Guoqun Chen Source Type: research
