Dosimetric parameters predict radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma patients: A systematic review and meta-analysis
Nasopharyngeal carcinoma (NPC) is a prevalent disease in Southeast Asia, particularly in southern China, and is closely associated with Epstein-Barr virus infection [1]. Radiotherapy (RT) is an essential part of NPC treatment but careful planning is required as RT can cause damage to surrounding healthy tissues, including the temporal lobe [2 –4]. Temporal lobe necrosis (TLN) is a potentially debilitating irreversible late complication following RT for NPC. It manifests with symptoms such as dizziness, headaches, cognitive impairment, and seizures [5,6]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 25, 2024 Category: Radiology Authors: Jun Dong, Wai Tong Ng, Charlene H.L. Wong, Ji-Shi Li, Heleen Bollen, James C.H. Chow, Avraham Eisbruch, Anne W.M. Lee, Victor H.F. Lee, Sweet Ping Ng, Sandra Nuyts, Robert Smee, Alfio Ferlito Tags: Original Article Source Type: research
Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients
CONCLUSION: This study found an association between oral cavity and pharyngeal cancer outcomes among patients in persistent poverty indicating a multidimensional strategy to improve survival.PMID:38520565 | DOI:10.1007/s10552-024-01867-3 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Shama Karanth Shilpi Mistry Meghann Wheeler Tomi Akinyemiju Joel Divaker Jae Jeong Yang Hyung-Suk Yoon Dejana Braithwaite Source Type: research
Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients
ConclusionThis study found an association between oral cavity and pharyngeal cancer outcomes among patients in persistent poverty indicating a multidimensional strategy to improve survival. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - March 23, 2024 Category: Cancer & Oncology Source Type: research
Higher area deprivation index is associated with poorer local control and overall survival in non-metastatic nasopharyngeal carcinoma
CONCLUSIONS: NPC patients from more disadvantaged neighborhoods undergoing radiotherapy had worse local control and survival outcomes. Interventions to address structural determinants of health and neighborhood disparities may improve these outcomes.PMID:38517113 | DOI:10.1002/hed.27751 (Source: Cancer Control)
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Nauman H Malik Mackenzie Montero Jie Jane Chen Sumi Sinha Sue S Yom Jason W Chan Source Type: research
Randomized controlled trial of an app for cancer pain management
CONCLUSIONS: The primary obstacle encountered in the development of applications for managing cancer-related discomfort lies in the sensitive nature of the subject matter, potentially leading to patient apprehension regarding application usage for pain management. Consequently, meticulous attention to user preferences and anticipations is imperative, necessitating the creation of an application characterized by user-friendliness and medical efficacy.TRIAL REGISTRATION: Chinese Clinical Trials Registry ChiCTR1800016066; http://www.chictr.org.cn/showproj.aspx?proj=27153 . Date of Registration: 2018-05-09.PMID:38517559 | DOI:...
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Lizhu Weng Wanlong Lin Xiuxian Lin Maobai Liu Jing Yang Source Type: research
Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study
CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.PMID:38517817 | DOI:10.3233/THC-231173 (Source: Cancer Control)
Source: Cancer Control - March 22, 2024 Category: Cancer & Oncology Authors: Qiuyang Wang Peng An Lina Song Junjie Liu Jisheng Liu Source Type: research
Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study
CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.PMID:38517817 | DOI:10.3233/THC-231173 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Qiuyang Wang Peng An Lina Song Junjie Liu Jisheng Liu Source Type: research
ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma
CONCLUSIONS: The study provided pioneering insights that ADAM22 had the potential to act as an oncogene by promoting EMT and metastasis of NPC through the RAC2-mediated PI3K/Akt signaling pathway. Thus, ADAM22 could serve as a novel prognostic indicator in NPC.PMID:38518731 | DOI:10.1016/j.prp.2024.155264 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 22, 2024 Category: Pathology Authors: Kaixiong Xu Ping Jiang Zui Chen Xiaoqiong Gu Ting Zhang Source Type: research
Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study
CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.PMID:38517817 | DOI:10.3233/THC-231173 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Qiuyang Wang Peng An Lina Song Junjie Liu Jisheng Liu Source Type: research
ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma
CONCLUSIONS: The study provided pioneering insights that ADAM22 had the potential to act as an oncogene by promoting EMT and metastasis of NPC through the RAC2-mediated PI3K/Akt signaling pathway. Thus, ADAM22 could serve as a novel prognostic indicator in NPC.PMID:38518731 | DOI:10.1016/j.prp.2024.155264 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 22, 2024 Category: Pathology Authors: Kaixiong Xu Ping Jiang Zui Chen Xiaoqiong Gu Ting Zhang Source Type: research
Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study
CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.PMID:38517817 | DOI:10.3233/THC-231173 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Qiuyang Wang Peng An Lina Song Junjie Liu Jisheng Liu Source Type: research
Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study
CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.PMID:38517817 | DOI:10.3233/THC-231173 (Source: Technology and Health Care)
Source: Technology and Health Care - March 22, 2024 Category: Medical Devices Authors: Qiuyang Wang Peng An Lina Song Junjie Liu Jisheng Liu Source Type: research
Long-term survival, toxicities, and the role of chrono-chemotherapy with different infusion rates in locally advanced nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy: a retrospective study with a 5-year follow-up
ConclusionLong-term analysis confirmed that in CCRT, cisplatin administration with sinusoidal chrono-modulated infusion was not superior to the constant infusion rate in terms of long-term toxicity and prognosis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Randomized controlled trial of an app for cancer pain management
ConclusionsThe primary obstacle encountered in the development of applications for managing cancer-related discomfort lies in the sensitive nature of the subject matter, potentially leading to patient apprehension regarding application usage for pain management. Consequently, meticulous attention to user preferences and anticipations is imperative, necessitating the creation of an application characterized by user-friendliness and medical efficacy.Trial registrationChinese Clinical Trials Registry ChiCTR1800016066;http://www.chictr.org.cn/showproj.aspx?proj=27153. Date of Registration: 2018 –05-09. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - March 22, 2024 Category: Cancer & Oncology Source Type: research
Hsa-miR-92b-3p Targeting FHL2 to Enhance Radiosensitivity of Nasopharyngeal Carcinoma
In this study, we found that the expression level of miR-92b-3p was significantly higher in radiotherapy-sensitive NPC patients than in radiotherapy-resistant patients. High expression of miR-92b-3p was associated with good prognosis in patients with NPC, and high expression of FHL2 was associated with poor prognosis in patients with NPC. It was predicted that miR-92b-3p could directly target and bind FHL2. Overexpression of miR-92b-3p significantly inhibited FHL2 expression at the mRNA as well as protein levels, while inhibition of miR-92b-3p expression significantly upregulated FHL2 expression. Overexpression of miR-92b-...
Source: Biochemical Genetics - March 21, 2024 Category: Genetics & Stem Cells Authors: Can Zeng Shuangni Duan Lin Zhao Jing Jiang Source Type: research
