Pan ‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma
In conclusion, the PIV was a powerful predictor of survival outcomes and outperformed the SII in patients with NPC treated with chemoradiotherapy. Prospective validation of the PIV should be performed to better stratify radical treatment of patients with NPC.PMID:38646495 | PMC:PMC11027095 | DOI:10.3892/ol.2024.14385 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhen Su Jie Tang Yan He Wei Hua Zeng Qian Yu Xiao Long Cao Guo Rong Zou Source Type: research
Comments on "Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study"
Radiother Oncol. 2024 Apr 20:110292. doi: 10.1016/j.radonc.2024.110292. Online ahead of print.NO ABSTRACTPMID:38648993 | DOI:10.1016/j.radonc.2024.110292 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 22, 2024 Category: Radiology Authors: Caglayan Selenge Beduk Esen Gizem Nur Can Berna Akkus Yildirim Source Type: research
Pan ‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma
In conclusion, the PIV was a powerful predictor of survival outcomes and outperformed the SII in patients with NPC treated with chemoradiotherapy. Prospective validation of the PIV should be performed to better stratify radical treatment of patients with NPC.PMID:38646495 | PMC:PMC11027095 | DOI:10.3892/ol.2024.14385 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhen Su Jie Tang Yan He Wei Hua Zeng Qian Yu Xiao Long Cao Guo Rong Zou Source Type: research
KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma
Oncogene, Published online: 22 April 2024; doi:10.1038/s41388-024-03033-0KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma (Source: Oncogene)
Source: Oncogene - April 22, 2024 Category: Cancer & Oncology Authors: Zhenyu Yang Yanfu Peng Yaqin Wang Panyang Yang Zhuohui Huang Tingqiu Quan Xudong Xu Peng Sun Ying Sun Jiawei Lv Denghui Wei Guan-Qun Zhou Source Type: research
A deep learning-based method for the prediction of temporal lobe injury in patients with nasopharyngeal carcinoma
Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC) and demonstrates a satisfactory 5-year overall survival [1]. However, the emergence of radiation-induced complications or late RT toxicities cannot be overlooked [2]. Temporal lobe injury (TLI) induced by radiotherapy is a severe late sequela that typically manifests 6 –47 months post-treatment, leading to symptoms such as dizziness, memory loss, personality changes, cognitive impairment, temporal lobe epilepsy, or necrosis. (Source: Physica Medica: European Journal of Medical Physics)
Source: Physica Medica: European Journal of Medical Physics - April 22, 2024 Category: General Medicine Authors: Wenting Ren, Bin Liang, Chao Sun, Runye Wu, Kuo Men, Huan Chen, Xin Feng, Lu Hou, Fei Han, Junlin Yi, Jianrong Dai Tags: Original paper Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Correction: Predictive progression outcomes and risk stratification in patients with recurrent or metastatic nasopharyngeal carcinoma who received first ‑line immunochemotherapy
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Comments on “Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study”
We read the article entitled “Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study” by Zhang et al [1] with great interest. The findings of the study indicated that adding concurrent chemotherapy to r adiotherapy did not contribute to improved survival rates in patients with stage II and T3N0 nasopharyngeal carcinoma (NPC) with adverse factors. This is a substantial study as it comprehensively evaluates this controversial issue with a large number of patients and propensity score-matching analysi...
Source: Radiotherapy and Oncology - April 19, 2024 Category: Radiology Authors: Caglayan Selenge Beduk Esen, Gizem Nur Can, Berna Akkus Yildirim Tags: Letter to the Editor Source Type: research
TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples
In this study, we introduce TMBstable, an innovative method that dynamically selects optimal variant calling strategies for specific genomic regions using a meta-learning framework, distinguishing it from traditional callers with uniform sample-wide strategies. The process begins with segmenting the sample into windows and extracting meta-features for clustering, followed by using a pre-trained meta-model to select suitable algorithms for each cluster, thereby addressing strategy-sample mismatches, reducing performance fluctuations and ensuring consistent performance across various samples. We evaluated TMBstable using bot...
Source: Briefings in Bioinformatics - April 18, 2024 Category: Bioinformatics Authors: Shenjie Wang Xiaoyan Zhu Xuwen Wang Yuqian Liu Minchao Zhao Zhili Chang Xiaonan Wang Yang Shao Jiayin Wang Source Type: research
Using the genomic adjusted radiation dose (GARD) to personalize the radiation dose in nasopharyngeal cancer
CONCLUSION: GARD is independently associated with locoregional control in radiotherapy-treated NPC patients from a Phase 3 clinical trial. GARD may be a potential framework to personalize radiotherapy dose for NPC patients.PMID:38636709 | DOI:10.1016/j.radonc.2024.110287 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2024 Category: Radiology Authors: Chi Leung Chiang Kenneth Sik Kwan Chan Huaping Li Wai Tong Ng James Chung Hang Chow Horace Cheuk Wai Choi Ka On Lam Victor Ho Fun Lee Roger Kai Cheong Ngan Anne Wing Mui Lee Steven A Eschrich Javier F Torres-Roca Jason Wing Hon Wong Source Type: research
Re-irradiation versus systemic therapy for the management of local-regionally recurrent head and neck cancer
CONCLUSION: Although re-irradiation improved overall survival compared to systemic therapy for appropriately selected patients with local-regionally recurrent head and neck cancer, the relatively high risk of toxicity must be considered.PMID:38636710 | DOI:10.1016/j.radonc.2024.110278 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2024 Category: Radiology Authors: Allen M Chen Jeremy P Harris Rupali Nabar Tjoson Tjoa Yarah Haidar William B Armstrong Source Type: research
TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples
In this study, we introduce TMBstable, an innovative method that dynamically selects optimal variant calling strategies for specific genomic regions using a meta-learning framework, distinguishing it from traditional callers with uniform sample-wide strategies. The process begins with segmenting the sample into windows and extracting meta-features for clustering, followed by using a pre-trained meta-model to select suitable algorithms for each cluster, thereby addressing strategy-sample mismatches, reducing performance fluctuations and ensuring consistent performance across various samples. We evaluated TMBstable using bot...
Source: Briefings in Bioinformatics - April 18, 2024 Category: Bioinformatics Authors: Shenjie Wang Xiaoyan Zhu Xuwen Wang Yuqian Liu Minchao Zhao Zhili Chang Xiaonan Wang Yang Shao Jiayin Wang Source Type: research
Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2
Cell Death & Disease, Published online: 18 April 2024; doi:10.1038/s41419-024-06671-0Cancer-associated fibroblasts secrete FGF5 to inhibit ferroptosis to decrease cisplatin sensitivity in nasopharyngeal carcinoma through binding to FGFR2 (Source: Cell death and disease)
Source: Cell death and disease - April 18, 2024 Category: Internal Medicine Authors: Feng Liu Ling Tang Huai Liu Yanzhu Chen Tengfei Xiao Wangning Gu Hongmin Yang Hui Wang Pan Chen Source Type: research
Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer
Head and neck cancers (HNC) are among the most prevalent malignant tumors worldwide. They encompass malignancies of the upper respiratory tract and gastrointestinal system, including nasopharyngeal carcinoma, laryngeal carcinoma, tongue carcinoma, parotid gland carcinoma, and others [1]. The development of HNC is closely related to smoking, excessive drinking, chewing of betel nuts, and viral infection (HBV/HPV). The treatment of HNC includes surgery, radiotherapy (RT), chemotherapy, and immunotherapy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Zhuangzhuang Zheng, Yingying Shen, Jing Su, Xiaorui Ji, Qiang Zhang, Qin Zhao, Xin Jiang Tags: Original Article Source Type: research
