Prognostic value of pre-treatment [18F] FDG PET/CT in recurrent nasopharyngeal carcinoma without distant metastasis
[18 F]-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has the ability to detect local and/or regional recurrence as well as distant metastasis. We aimed to evaluate the prog... (Source: BMC Cancer)
Source: BMC Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Zhe Dong, Gao-Yuan Wang, Dong-Yu Dai, Guan-Jie Qin, Ling-Long Tang, Cheng Xu and Jun Ma Tags: Research Source Type: research
Impact of chrono-radiotherapy on the prognosis and treatment-related toxicity in patients with locally advanced nasopharyngeal carcinoma: A multicenter propensity-matched study
Chronobiol Int. 2024 Apr 12:1-11. doi: 10.1080/07420528.2024.2337887. Online ahead of print.ABSTRACTThe timing of radiotherapy (RT) delivery has been reported to affect both cancer survival and treatment toxicity. However, the association among the timing of RT delivery, survival, and toxicity in locally advanced nasopharyngeal carcinoma (LA-NPC) has not been investigated. We retrospectively reviewed patients diagnosed with LA-NPC who received definitive RT at multiple institutions. The median RT delivery daytime was categorized as morning (DAY) and night (NIGHT). Seasonal variations were classified into the darker half of...
Source: Chronobiology International - April 12, 2024 Category: Biology Authors: Jie Lin Xiantao Lin Rong Zheng Kehai Lin Muhammad Khan Xiuting Huang Yunhong Tian Baiyao Wang BenHua Xu Yawei Yuan Zhong Huang Source Type: research
Impact of chrono-radiotherapy on the prognosis and treatment-related toxicity in patients with locally advanced nasopharyngeal carcinoma: A multicenter propensity-matched study
Chronobiol Int. 2024 Apr 12:1-11. doi: 10.1080/07420528.2024.2337887. Online ahead of print.ABSTRACTThe timing of radiotherapy (RT) delivery has been reported to affect both cancer survival and treatment toxicity. However, the association among the timing of RT delivery, survival, and toxicity in locally advanced nasopharyngeal carcinoma (LA-NPC) has not been investigated. We retrospectively reviewed patients diagnosed with LA-NPC who received definitive RT at multiple institutions. The median RT delivery daytime was categorized as morning (DAY) and night (NIGHT). Seasonal variations were classified into the darker half of...
Source: Chronobiology International - April 12, 2024 Category: Biology Authors: Jie Lin Xiantao Lin Rong Zheng Kehai Lin Muhammad Khan Xiuting Huang Yunhong Tian Baiyao Wang BenHua Xu Yawei Yuan Zhong Huang Source Type: research
Correlation of the biological clock gene PER1 with ferroptosis in nasopharyngeal carcinoma
(Source: Biological Rhythm Research)
Source: Biological Rhythm Research - April 12, 2024 Category: Research Authors: Zeng Wang Jin Long Chen Zhang Tang Luo Ye Wu Source Type: research
Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis
CONCLUSION: The combination of HDW and AP targets 16 key genes to impede the development of NPC, primarily by modulating AKT1 and VEGFA pathways.PMID:38603854 | DOI:10.1016/j.intimp.2024.111866 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Chengyu Ye Baofan Zhang Zhongjie Tang Cuiping Zheng Qiongzhang Wang Xiangmin Tong Source Type: research
Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis
CONCLUSION: The combination of HDW and AP targets 16 key genes to impede the development of NPC, primarily by modulating AKT1 and VEGFA pathways.PMID:38603854 | DOI:10.1016/j.intimp.2024.111866 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Chengyu Ye Baofan Zhang Zhongjie Tang Cuiping Zheng Qiongzhang Wang Xiangmin Tong Source Type: research
Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma
ConclusionThis study presents a prognostic model utilizing IMRGs in NPC, which could assist in assessing patient prognosis and provide insights into new therapeutic targets for NPC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 11, 2024 Category: Cancer & Oncology Source Type: research
A minimalist cancer cell membrane-shielded biomimetic nanoparticle for nasopharyngeal carcinoma active-targeting therapy
Colloids Surf B Biointerfaces. 2024 Apr 8;238:113909. doi: 10.1016/j.colsurfb.2024.113909. Online ahead of print.ABSTRACTNasopharyngeal carcinoma (NPC) is a common head and neck malignancy, which is characterized by high incidence and aggression with poor diagnosis and limited therapeutic opportunity. The innovative strategy for achieving precise NPC active-targeting drug delivery has emerged as a prominent focus in clinical research. Here, a minimalist cancer cell membrane (CCM) shielded biomimetic nanoparticle (NP) was designed for NPC active-targeting therapy. Chemotherapeutant model drug doxorubicin (DOX) was loaded in...
Source: Colloids and Surfaces - April 10, 2024 Category: Biotechnology Authors: Shuo Sun Rongrong Han Yanju Sun Wenqiang Chen Limin Zhao Xiuwen Guan Weifen Zhang Source Type: research
A minimalist cancer cell membrane-shielded biomimetic nanoparticle for nasopharyngeal carcinoma active-targeting therapy
Colloids Surf B Biointerfaces. 2024 Apr 8;238:113909. doi: 10.1016/j.colsurfb.2024.113909. Online ahead of print.ABSTRACTNasopharyngeal carcinoma (NPC) is a common head and neck malignancy, which is characterized by high incidence and aggression with poor diagnosis and limited therapeutic opportunity. The innovative strategy for achieving precise NPC active-targeting drug delivery has emerged as a prominent focus in clinical research. Here, a minimalist cancer cell membrane (CCM) shielded biomimetic nanoparticle (NP) was designed for NPC active-targeting therapy. Chemotherapeutant model drug doxorubicin (DOX) was loaded in...
Source: Colloids and Surfaces - April 10, 2024 Category: Biotechnology Authors: Shuo Sun Rongrong Han Yanju Sun Wenqiang Chen Limin Zhao Xiuwen Guan Weifen Zhang Source Type: research
High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma
Cell Death & Differentiation, Published online: 08 April 2024; doi:10.1038/s41418-024-01287-5High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 8, 2024 Category: Cytology Authors: Ping Feng Ying Wang Na Liu Yanming Chen Yujun Hu Zilu Huang Ya Liu Shuohan Zheng Tongchao Jiang Xiang Xiao Wei Dai Peng Huang Yunfei Xia Source Type: research
Long-term efficacy analysis of radiotherapy and local management of metastases in patients with newly diagnosed oligometastatic nasopharyngeal carcinoma: A prospective, single-arm, single-center clinical study
CONCLUSION: Patients with newly diagnosed oligometastatic NPC can achieve long-term survival after receiving radical radiotherapy to the primary site and local treatment for metastases.PMID:38583720 | DOI:10.1016/j.radonc.2024.110265 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 7, 2024 Category: Radiology Authors: Huang Shuang Jiang Feng Cao Caineng Jin Qifeng Jin Ting Hua Yonghong Chen Xiaozhong Source Type: research
Long-term efficacy analysis of radiotherapy and local management of metastases in patients with newly diagnosed oligometastatic nasopharyngeal carcinoma: A prospective, single-arm, single-center clinical study
CONCLUSION: Patients with newly diagnosed oligometastatic NPC can achieve long-term survival after receiving radical radiotherapy to the primary site and local treatment for metastases.PMID:38583720 | DOI:10.1016/j.radonc.2024.110265 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 7, 2024 Category: Radiology Authors: Huang Shuang Jiang Feng Cao Caineng Jin Qifeng Jin Ting Hua Yonghong Chen Xiaozhong Source Type: research
New hopes for the breast cancer treatment: perspectives on the oncolytic virus therapy
Front Immunol. 2024 Mar 21;15:1375433. doi: 10.3389/fimmu.2024.1375433. eCollection 2024.ABSTRACTOncolytic virus (OV) therapy has emerged as a promising frontier in cancer treatment, especially for solid tumours. While immunotherapies like immune checkpoint inhibitors and CAR-T cells have demonstrated impressive results, their limitations in inducing complete tumour regression have spurred researchers to explore new approaches targeting tumours resistant to current immunotherapies. OVs, both natural and genetically engineered, selectively replicate within cancer cells, inducing their lysis while sparing normal tissues. Rec...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Hanna Chowaniec Antonina Ślubowska Magdalena Mroczek Martyna Borowczyk Ma łgorzata Braszka Grzegorz Dworacki Paula Dobosz Mateusz Wichtowski Source Type: research
Addition of nimotuzumab to concurrent chemoradiotherapy after induction chemotherapy improves outcomes of patients with locally advanced nasopharyngeal carcinoma
CONCLUSION: The addition of nimotuzumab to CCRT after IC in LANPC has shown promising results in improving treatment outcomes and acceptable toxicities.PMID:38576484 | PMC:PMC10991775 | DOI:10.3389/fphar.2024.1366853 (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Run-Jie Wang Rui-Quan Ke Yi-Feng Yu Guan-Zhong Lu San-Gang Wu Source Type: research
Patterns of failure in patients with nasopharyngeal cancer of Northeastern region of India: a retrospective observational study
CONCLUSIONS: For NPC patients who undergo curative IMRT, primary tumour and nodal volumes are independent prognostic indicators. GTVp and GTVn are highly predictive of local control, distant metastases, disease-free survival, and overall survival. This justifies their use as quantitative prognostic indicator for NPC.PMID:38578506 | DOI:10.1007/s00405-024-08624-x (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Mouchumee Bhattacharyya Partha Pratim Medhi Prashasti Sharma Jyotiman Nath Apurba Kumar Kalita Partha Sarathi Roy Tashnin Rahman Yanpothung Yanthan Source Type: research
