Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization
Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells is one of the major risks in its clinical application, and we therefore propose to encapsulate ML1 in a nanocarrier that can specifically release its cargo intratumorally, thus improving the efficacy to toxicity ratio of the cytotoxin. We investigated the encapsulation of ML1 in ultrasound-sensitive liposomes (USL) and studied its release by high-intensity focused ultrasound (HAccessedIFU). USL were prepared by entrapment of perfluorocarbon nanodroplets in pegylate...
Source: Frontiers in Pharmacology - December 4, 2019 Category: Drugs & Pharmacology Source Type: research
Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives.
Abstract
Biologically active molecules obtained from plant sources, mostly including secondary metabolites, have been considered to be of immense value with respect to treatment of various human diseases. However, some inevitable limitations associated with these secondary metabolites like high cytotoxicity, low bio-availability, poor absorption, low abundance, improper metabolism etc. , have forced the scientific community to explore medicinal plants for alternate biologically active molecules. In this context, therapeutically active proteins/peptides from medicinal plants have been promoted as a promisin...
Source: Current Protein and Peptide Science - November 17, 2019 Category: Biochemistry Authors: Wani SS, Dar PA, Zargar SM, Dar TA Tags: Curr Protein Pept Sci Source Type: research
Time and dose-dependent effects of viscum album quercus on rabbit spermatozoa motility and viability in vitro.
Abstract
The target of this study was to evaluate the effect of extract of the European mistletoe - Viscum album quercus L. on spermatozoa motility and viability in vitro. The CASA system was used to determine the spermatozoa motility parameters at different time intervals (0, 1, 2 and 3 h) and spermatozoa viability was determined in five different doses of Viscum album quercus L [10 (QA), 6.6 (QB), 3.3 (QC), 2.5 (QD) and 2 (QE) mg/ml]. Results in experimental groups detected a significant deterioration on rabbit spermatozoa after 1, 2 and 3 hours, compared to the control. The initial total spermatozoa mot...
Source: Physiological Research - October 24, 2019 Category: Physiology Authors: Halo M, Massanyi P, Gren A, Lasak A, Slanina T, Ondruska L, Muchacka R, Galbavy D, Ivanic P, Schneir ER, Formicki G Tags: Physiol Res Source Type: research
Molecules, Vol. 24, Pages 3762: Correction: Saha, C., et al. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses. Molecules 2016, 21, 912
i V. Kaveri
The authors wish to make the following corrections to this paper [...] (Source: Molecules)
Source: Molecules - October 17, 2019 Category: Chemistry Authors: Chaitrali Saha Mrinmoy Das Emmanuel Stephen-Victor Alain Friboulet Jagadeesh Bayry Srini V. Kaveri Tags: Correction Source Type: research
Preclinical Evaluation of Antitumoral and Cytotoxic Properties of Viscum album Fraxini Extract on Pediatric Tumor Cells
Planta Med DOI: 10.1055/a-1013-0382In Europe, especially in German-speaking countries, administration of mistletoe extracts is the most common and popular complementary and alternative therapy approach reported in oncology. Mistletoe therapy is applied to children with cancer for curative and palliative therapeutic regimes with increasing frequency, but at the same time, there are only a few studies on the effectiveness of this therapy. Therefore, we have investigated the response of various pediatric cell lines (acute myeloid leukemia, Ewingʼs sarcoma, hepatocellular carcinoma, medulloblastoma, neuroblastoma, and osteosa...
Source: Planta Medica - October 6, 2019 Category: Drugs & Pharmacology Authors: Menke, Katrin Schwermer, Melanie Schramm, Alexander Zuzak, Tycho J. Tags: Original Papers Source Type: research
Biochemical analysis of European mistletoe (Viscum album L.) foliage and fruit settled on Persian ironwood (Parrotia persica C. A. Mey.) and hornbeam (Carpinus betulus L.)
In this study, mistletoe plant parts were collected from three bases of each host species in Daeiz forest of Hyrcanian forests of Iran. The samples were extracted with ethyl acetate and analyzed by HPLC. The results indicated that the host species had no significant effect on the amount of triterpene acids in the mistletoes. But the organ type (foliage and fruit), had significant effect on the BA content meanwhile it didn't show any significant effect on the OA. The highest level of BA was significantly detected in foliage of mistletoes on P. persica and C. betulus (1.23 and 0.97 mg/g dry weight) respectively. Independen...
Source: Biocatalysis and Agricultural Biotechnology - September 26, 2019 Category: Biotechnology Source Type: research
Three new bioactive flavonoid glycosides from Viscum album
Publication date: July 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 7Author(s): Jia-Kun DAI, Duo CAO, Cui-Hua LI, Jing GAO, Meng-Qing LI, Na FAN, Ya-Hui WEI, Zheng-Liang SUN, Meng-Yang HOUABSTRACTTwo new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4−10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory ...
Source: Chinese Journal of Natural Medicines - September 11, 2019 Category: Complementary Medicine Source Type: research
Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice.
Conclusion: Our results suggest that an adjuvant treatment of glioma patients with ML-containing drugs might be beneficial.
PMID: 31354846 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 30, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
How far we have gone in realizing true potential of Viscum album as versatile regulator of cell signaling pathways.
Authors: Farooqi AA, Sabitaliyevich UY
PMID: 31304899 [PubMed - in process] (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - July 17, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Unraveling the rapid assembly process of stiff cellulosic fibers from mistletoe berries.
Abstract
The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fold increase in length, providing a relevant role model for efforts to produce advanced composites from cellulose-based structures such as cellulose nanocrystals (CNCs) or cellulose nanofibrils (CNF). Using a combination of in situ polarized light microscopy (PLM), synchrotron X-r...
Source: Biomacromolecules - July 16, 2019 Category: Biochemistry Authors: Horbelt N, Eder M, Bertinetti L, Fratzl P, Harrington MJ Tags: Biomacromolecules Source Type: research
Answer to the letter to the editors by Matthes and colleagues regarding our systematic reviews on mistletoe
(Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 12, 2019 Category: Cancer & Oncology Source Type: research
Answer to the letter to the editors by Matthes and colleagues regarding our systematic reviews on mistletoe.
PMID: 31302756 [PubMed - as supplied by publisher] (Source: Clin Med Res)
Source: Clin Med Res - July 12, 2019 Category: Research Authors: Huebner J, Freuding M, Keinki C, Micke O, Buentzel J Tags: J Cancer Res Clin Oncol Source Type: research
Molecules, Vol. 24, Pages 2549: Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis
Kooyeon Lee
The abnormal regulation of melanin synthesis leads to a wide range of pigmentary disorders. Although various melanin biosynthesis inhibitors have been developed, their efficacy and long-term safety needs to be further improved, and thus the goal of this study is to develop promising natural compound inhibitors of melanin biosynthesis. Here, we obtained aglycone flavonoid extract through the microwave-assisted hydrolysis of glycoside extract from Korean mistletoe in acidic condition. The aglycone extract inhibited tyrosinase activity more efficiently with better antioxidant activity than glycoside extract ...
Source: Molecules - July 11, 2019 Category: Chemistry Authors: Se-Hui Jung Jaehyun Kim Juneyong Eum Jung Won Choe Hak Hyun Kim Yun Kee Kooyeon Lee Tags: Article Source Type: research
3-O-Methyl-alkylgallates inhibit fatty acid desaturation in Mycobacterium tuberculosis.
Abstract
In the quest for new antibacterial lead structures, activity screening against Mycobacterium tuberculosis identified antitubercular effects of gallic acid derivatives isolated from the Nigerian mistletoe Loranthus micranthus Structure-activity relationship studies indicated that 3-O-methyl-alkylgallates comprising aliphatic ester chains with four to eight carbon atoms result in strongest growth inhibition in vitro against M. tuberculosis with a minimal inhibitory concentration (MIC) of 6.25 μM. Furthermore, the most active compounds (3-O-methyl-butyl-, 3-O-methyl-hexyl- and 3-O-methyl-octylgallat...
Source: Antimicrobial Agents and Chemotherapy - June 16, 2019 Category: Microbiology Authors: Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R Tags: Antimicrob Agents Chemother Source Type: research
Herb-drug interactions: a novel algorithm-assisted information system for pharmacokinetic drug interactions with herbal supplements in cancer treatment
ConclusionsThe novel algorithm allows to transparently generate and dynamically display herb-drug interaction risks based on the available evidence from clinical and laboratory pharmacologic studies. It provides health professionals with readily available and easy updatable information about the risk of pharmacokinetic interactions between herbs and oncologic drugs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 31, 2019 Category: Drugs & Pharmacology Source Type: research
