Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series
CONCLUSION: This case series of advanced HCC indicates that mistletoe extract VF-2 may have potential biological activity against HCC for selected patients. Research is needed to identify the active compound and predictive markers of response.PMID:33776708 | PMC:PMC7983630 | DOI:10.1159/000511566 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2021 Category: Cancer & Oncology Authors: Richard T Lee Peiying Yang Asrar Alahmadi Jennifer McQuade Eric Yuan Analisa Difeo Goutham Narla Ahmed Kaseb Source Type: research
Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series
CONCLUSION: This case series of advanced HCC indicates that mistletoe extract VF-2 may have potential biological activity against HCC for selected patients. Research is needed to identify the active compound and predictive markers of response.PMID:33776708 | PMC:PMC7983630 | DOI:10.1159/000511566 (Source: Ann Oncol)
Source: Ann Oncol - March 29, 2021 Category: Cancer & Oncology Authors: Richard T Lee Peiying Yang Asrar Alahmadi Jennifer McQuade Eric Yuan Analisa Difeo Goutham Narla Ahmed Kaseb Source Type: research
Plant ecology: Macroparasitism in plant communities
Curr Biol. 2021 Mar 22;31(6):R287-R289. doi: 10.1016/j.cub.2021.01.044.ABSTRACTMistletoes, lianas, vines, and epiphytes fulfill many of the population dynamic criteria of animal macroparasites. A new study illustrates elegant ways to quantify cost to the host and how this impacts competition between mistletoe species. It opens the door to a much fuller consideration of plant parasites as macroparasites.PMID:33756139 | DOI:10.1016/j.cub.2021.01.044 (Source: Current Biology)
Source: Current Biology - March 23, 2021 Category: Biology Authors: Andy Dobson Source Type: research
Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series
Conclusion: This case series of advanced HCC indicates that mistletoe extract VF-2 may have potential biological activity against HCC for selected patients. Research is needed to identify the active compound and predictive markers of response.Case Rep Oncol 2021;14:224 –231 (Source: Case Reports in Oncology)
Source: Case Reports in Oncology - March 1, 2021 Category: Cancer & Oncology Source Type: research
Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research
Intraspecific competition for host resources in a parasite
Curr Biol. 2021 Feb 18:S0960-9822(21)00067-1. doi: 10.1016/j.cub.2021.01.034. Online ahead of print.ABSTRACTIntraspecific competition among parasites should, in theory, increase virulence, but we lack clear evidence of this from nature.1-3 Parasitic plants, which are sessile and acquire carbon-based resources through both autotrophy (photosynthesis) and heterotrophy (obtaining carbon from the host), provide a unique opportunity to experimentally study the role of intraspecific competition for nutrients in shaping the biology of both parasite and host.4-6 Here, we manipulated the spatial position of naturally occurring indi...
Source: Current Biology - February 24, 2021 Category: Biology Authors: Paul D Nabity Greg A Barron-Gafford Noah K Whiteman Source Type: research
Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research
Intraspecific competition for host resources in a parasite
Curr Biol. 2021 Feb 18:S0960-9822(21)00067-1. doi: 10.1016/j.cub.2021.01.034. Online ahead of print.ABSTRACTIntraspecific competition among parasites should, in theory, increase virulence, but we lack clear evidence of this from nature.1-3 Parasitic plants, which are sessile and acquire carbon-based resources through both autotrophy (photosynthesis) and heterotrophy (obtaining carbon from the host), provide a unique opportunity to experimentally study the role of intraspecific competition for nutrients in shaping the biology of both parasite and host.4-6 Here, we manipulated the spatial position of naturally occurring indi...
Source: Current Biology - February 24, 2021 Category: Biology Authors: Paul D Nabity Greg A Barron-Gafford Noah K Whiteman Source Type: research
Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research
Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research
Plant-made immunotoxin building blocks: A roadmap for producing therapeutic antibody-toxin fusions.
Abstract
Molecular farming in plants is an emerging platform for the production of pharmaceutical proteins, and host species such as tobacco are now becoming competitive with commercially established production hosts based on bacteria and mammalian cell lines. The range of recombinant therapeutic proteins produced in plants includes replacement enzymes, vaccines and monoclonal antibodies (mAbs). But plants can also be used to manufacture toxins, such as the mistletoe lectin viscumin, providing an opportunity to express active antibody-toxin fusion proteins, so-called recombinant immunotoxins (RITs). Mammal...
Source: Biotechnology Advances - December 26, 2020 Category: Biotechnology Authors: Knödler M, Buyel JF Tags: Biotechnol Adv Source Type: research
Pressurized water extraction – the fast and efficient method for isolation of bioactive proteins from Viscum album leaves
Publication date: Available online 17 December 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Lenka Burdějová, Dana Moravcová, Dana Strouhalová, Kamila Lunerová (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - December 18, 2020 Category: Drugs & Pharmacology Source Type: research
Purified talc/viscum album
(Source: Reactions Weekly)
Source: Reactions Weekly - December 1, 2020 Category: Drugs & Pharmacology Source Type: research
Did Mammals Bring the First Mistletoes into the Treetops?
Abstract
AbstractThe growth habit of mistletoes, the only woody, parasitic plants to infect host canopies, represents a key innovation. How this aerially parasitic habit originated is unknown; mistletoe macrofossils are relatively recent, from long after they adapted to canopy life and evolved showy, bird-pollinated flowers; sticky, bird-dispersed seeds; and woody haustoria diverting water and nutrients from host branches. Since the transition to aerial parasitism predates the origin of mistletoes' contemporary avian seed dispersers by 20-40 million years, this leaves unanswered the question of who the ori...
Source: The American Naturalist - November 21, 2020 Category: Biology Authors: Watson DM Tags: Am Nat Source Type: research
Effects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage model.
CONCLUSION: AHA is a highly effective topical hemostatic agent in a rat tail hemorrhage model, thus may provide for a unique clinically effective option for control of bleeding during surgical operations or other emergencies.
PMID: 33107963 [PubMed - as supplied by publisher] (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - October 1, 2020 Category: Emergency Medicine Authors: Gedar Totuk ÖM, Güzel ŞE, Ekici H, Kumandaş A, Emre Aydıngöz S, Yılmaz EÇ, Kırdan T, Midi A Tags: Ulus Travma Acil Cerrahi Derg Source Type: research
