Mistletoe for Bladder Cancer: Call for More Case Reports Using the Intravesical Route
Altern Ther Health Med. 2023 May;29(4):18-19.ABSTRACTNo Abstract Available.PMID:37164031 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 10, 2023 Category: Complementary Medicine Authors: Peter Hinderberger Nasha Winters Source Type: research
Patients ’ and social aspects related to complementary mistletoe therapy in patients with breast cancer: A systematic review commissioned by the German agency for health technology assessment
To mitigate side effects of conventional cancer care and improve quality of life, many patients with breast cancer in German-speaking countries opt for mistletoe therapy in addition to standard treatment. To understand the value for users, we evaluated the domain “Patient and Social aspects” in a health technology assessment on complementary mistletoe therapy in patients with breast cancer. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 7, 2023 Category: Cancer & Oncology Authors: Caroline Steigenberger, Petra Schnell-Inderst, Magdalena Flatscher-Th öni, Lisa-Maria Plank, Uwe Siebert Source Type: research
Patient ’ and social aspects related to complementary mistletoe therapy in patients with breast cancer: A systematic review commissioned by the German agency for Health Technology Assessment
To mitigate side effects of conventional cancer care and improve quality of life, many patients with breast cancer in German-speaking countries opt for mistletoe therapy in addition to standard treatment. To understand the value for users, we evaluated the domain “Patient and Social aspects” in a health technology assessment on complementary mistletoe therapy in patients with breast cancer. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 7, 2023 Category: Cancer & Oncology Authors: Caroline Steigenberger, Petra Schnell-Inderst, Magdalena Flatscher-Th öni, Lisa-Maria Plank, Uwe Siebert Source Type: research
Expression, purification, characterization, and cytotoxic evaluation of the ML1-STxB fusion protein
In this study, we sought to produce and purify a fusion protein containing ML1 fused to STxB and evaluate its cytotoxic activities. The ML1-STxB fusion protein coding sequence was cloned into the pET28a plasmid, then was transformed into E. coli BL21-DE3 cells. Following induction of protein expression, Ni-NTA affinity chromatography was used to purify the protein. Using SDS-PAGE and western blotting, the expression and purification processes were validated. On the SkBr3 cell line, the cytotoxic effects of the recombinant proteins were evaluated. On SDS-PAGE and western blotting membrane, analysis of purified proteins reve...
Source: Archives of Microbiology - May 6, 2023 Category: Microbiology Authors: Mohammad Hasan Yousefi Hamed Afkhami Atefeh Akbari Hossein Honari Source Type: research
Expression, purification, characterization, and cytotoxic evaluation of the ML1-STxB fusion protein
In this study, we sought to produce and purify a fusion protein containing ML1 fused to STxB and evaluate its cytotoxic activities. The ML1-STxB fusion protein coding sequence was cloned into the pET28a plasmid, then was transformed into E. coli BL21-DE3 cells. Following induction of protein expression, Ni-NTA affinity chromatography was used to purify the protein. Using SDS-PAGE and western blotting, the expression and purification processes were validated. On the SkBr3 cell line, the cytotoxic effects of the recombinant proteins were evaluated. On SDS-PAGE and western blotting membrane, analysis of purified proteins reve...
Source: Archives of Microbiology - May 6, 2023 Category: Microbiology Authors: Mohammad Hasan Yousefi Hamed Afkhami Atefeh Akbari Hossein Honari Source Type: research
Computational evaluation of bioactive compounds from < em > Viscum album < /em > (mistletoe) as inhibitors of p63 for pancreatic cancer treatment
This study examines the pancreatic cancer therapeutic potential of the bioactive compounds in the flavonoid and phenolic acid constituents of mistletoe by adopting structural bioinformatics and advanced theoretical chemistry techniques via molecular docking, molecular dynamics simulation, molecular mechanics/generalized Born surface area (MM/GBSA) calculations, pharmacokinetic analysis, and density functional theory analysis. The six best compounds from the flavonoid constituent with the highest binding affinity ranging from -6.8 kcal/mol to -6.7 kcal/mol were selected with the control gemcitabine (-5.5 kcal/mol) for furth...
Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Gbenga Dairo Ayooluwa Ilesanmi Toheeb Balogun Matthew Ward Mette Soendergaard John Determan Source Type: research
Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
CONCLUSIONS: This study is the first reported instance of combined treatments to achieve complete remission for high-grade NMIBC refractory to BCG and MIT-C, using intravesical, subcutaneous, and intravenous mistletoe and intravenous PA. It includes pharmacological information on possible mechanisms. In light of the global shortage of BCG, the high proportion of cases refractory to BCG and MIT-C, the unproven use of costly off-label pharmaceuticals, such as gemcitabine, and the relative cost-effectiveness of mistletoe and PA, clinicians should give serious consideration to employing these combined functional medicine treat...
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Devra Davis Dugald Seely Christopher Morash Jennifer Armstrong Maxwell Meng Phillip Lowe Mikhail Kogan Source Type: research
Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
CONCLUSIONS: This study is the first reported instance of combined treatments to achieve complete remission for high-grade NMIBC refractory to BCG and MIT-C, using intravesical, subcutaneous, and intravenous mistletoe and intravenous PA. It includes pharmacological information on possible mechanisms. In light of the global shortage of BCG, the high proportion of cases refractory to BCG and MIT-C, the unproven use of costly off-label pharmaceuticals, such as gemcitabine, and the relative cost-effectiveness of mistletoe and PA, clinicians should give serious consideration to employing these combined functional medicine treat...
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Devra Davis Dugald Seely Christopher Morash Jennifer Armstrong Maxwell Meng Phillip Lowe Mikhail Kogan Source Type: research
Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
CONCLUSIONS: This study is the first reported instance of combined treatments to achieve complete remission for high-grade NMIBC refractory to BCG and MIT-C, using intravesical, subcutaneous, and intravenous mistletoe and intravenous PA. It includes pharmacological information on possible mechanisms. In light of the global shortage of BCG, the high proportion of cases refractory to BCG and MIT-C, the unproven use of costly off-label pharmaceuticals, such as gemcitabine, and the relative cost-effectiveness of mistletoe and PA, clinicians should give serious consideration to employing these combined functional medicine treat...
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Devra Davis Dugald Seely Christopher Morash Jennifer Armstrong Maxwell Meng Phillip Lowe Mikhail Kogan Source Type: research
Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
CONCLUSIONS: This study is the first reported instance of combined treatments to achieve complete remission for high-grade NMIBC refractory to BCG and MIT-C, using intravesical, subcutaneous, and intravenous mistletoe and intravenous PA. It includes pharmacological information on possible mechanisms. In light of the global shortage of BCG, the high proportion of cases refractory to BCG and MIT-C, the unproven use of costly off-label pharmaceuticals, such as gemcitabine, and the relative cost-effectiveness of mistletoe and PA, clinicians should give serious consideration to employing these combined functional medicine treat...
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Devra Davis Dugald Seely Christopher Morash Jennifer Armstrong Maxwell Meng Phillip Lowe Mikhail Kogan Source Type: research
Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study
Lung cancer (LC) is associated with high mortality and poor quality of life (QoL). The disease as well as oncological treatments such as radiation and chemotherapy with adverse effects can impair the QoL of pa... (Source: Radiation Oncology)
Source: Radiation Oncology - March 6, 2023 Category: Cancer & Oncology Authors: Friedemann Schad, Diana Steinmann, Shiao Li Oei, Anja Thronicke and Christian Grah Tags: Research Source Type: research
Toxicity test of flavonoid compounds from the leaves of < em > Dendrophthoe pentandra < /em > (L.) Miq. using < em > in vitro < /em > culture cell models
CONCLUSION: Flavonoid compounds from BD were safely used for topical treatment of cancer cells at a concentration <2.491 μg/mL, whereas for non-cancerous cells, a concentration <2.582 μg/mL was sufficient (p < 0.05).PMID:36718322 | PMC:PMC9880835 | DOI:10.14202/vetworld.2022.2896-2902 (Source: Cancer Control)
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: Mochamad Lazuardi Suharjono Suharjono Chi-Hsien Chien Jie-Long He Chi-Wen Lee Chia-Kang Peng Mohammad Sukmanadi Rahmi Sugihartuti Lilik Maslachah Source Type: research
IJERPH, Vol. 20, Pages 2565: Safety of Combined Targeted and Helixor & reg; & nbsp;Viscum album L. Therapy in Breast and Gynecological Cancer Patients, a Real-World Data Study
Conclusions: The present study is the first of its kind showing the applicability of Helixor&reg; VA in combination with targeted therapies. The results indicate that add-on Helixor&reg; VA does not negatively alter the safety profile of targeted therapies in breast and gynaecological cancer patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - January 31, 2023 Category: Environmental Health Authors: Friedemann Schad Anja Thronicke Tags: Article Source Type: research
Horner's Syndrome and Lymphocele Following Thyroid Surgery
J Clin Med. 2023 Jan 6;12(2):474. doi: 10.3390/jcm12020474.ABSTRACTHorner's syndrome (HS), caused by lesions of the 3-neuron oculosympathetic nerve pathway (ONP), includes the triad: blepharoptosis, miosis and anhidrosis (ipsilateral with ONP damage). Thyroid-related HS represents an unusual entity underling thyroid nodules/goiter/cancer-HS (T-HS), and post-thyroidectomy HS (Tx-HS). We aim to overview Tx-HS. This is a narrative review. We revised PubMed published, full-length, English papers from inception to November 2022. Additionally, we introduced data on post-thyroidectomy lymphocele/chylous leakage (Tx-L), and introd...
Source: Clinical Breast Cancer - January 21, 2023 Category: Cancer & Oncology Authors: Mara Carsote Claudiu-Eduard Nistor Florina Ligia Popa Mihaela Stanciu Source Type: research
Horner's Syndrome and Lymphocele Following Thyroid Surgery
J Clin Med. 2023 Jan 6;12(2):474. doi: 10.3390/jcm12020474.ABSTRACTHorner's syndrome (HS), caused by lesions of the 3-neuron oculosympathetic nerve pathway (ONP), includes the triad: blepharoptosis, miosis and anhidrosis (ipsilateral with ONP damage). Thyroid-related HS represents an unusual entity underling thyroid nodules/goiter/cancer-HS (T-HS), and post-thyroidectomy HS (Tx-HS). We aim to overview Tx-HS. This is a narrative review. We revised PubMed published, full-length, English papers from inception to November 2022. Additionally, we introduced data on post-thyroidectomy lymphocele/chylous leakage (Tx-L), and introd...
Source: Clinical Genitourinary Cancer - January 21, 2023 Category: Cancer & Oncology Authors: Mara Carsote Claudiu-Eduard Nistor Florina Ligia Popa Mihaela Stanciu Source Type: research
