Identification of Polyphenolics from < em > Loranthus globosus < /em > as Potential Inhibitors of Cholinesterase and Oxidative Stress for Alzheimer's Disease Treatment
We report that the crude methanol extract (CME) of the plant contains a good amount of polyphenolics and possesses antioxidant and cholinesterase inhibitory activity. Fractionation of CME with solvents of varying polarity revealed the highest activity and polyphenolic content in the ethylacetate fraction (EAF). Correlation analysis revealed a significant (P < 0.05) association of polyphenolics with the antioxidant and cholinesterase inhibitory properties. Using column chromatography with diaion resin, the polyphenolics (EAF-PP) were isolated from the EAF that displayed the potent antioxidant and cholinesterase inhibitor...
Source: Biomed Res - November 22, 2021 Category: Research Authors: Netish Kumar Kundo Md Imran Nur Manik Kushal Biswas Riniara Khatun Md Yusuf Al-Amin A H M K Alam Toshihisa Tanaka Golam Sadik Source Type: research
Identification of Polyphenolics from < em > Loranthus globosus < /em > as Potential Inhibitors of Cholinesterase and Oxidative Stress for Alzheimer's Disease Treatment
We report that the crude methanol extract (CME) of the plant contains a good amount of polyphenolics and possesses antioxidant and cholinesterase inhibitory activity. Fractionation of CME with solvents of varying polarity revealed the highest activity and polyphenolic content in the ethylacetate fraction (EAF). Correlation analysis revealed a significant (P < 0.05) association of polyphenolics with the antioxidant and cholinesterase inhibitory properties. Using column chromatography with diaion resin, the polyphenolics (EAF-PP) were isolated from the EAF that displayed the potent antioxidant and cholinesterase inhibitor...
Source: Biomed Res - November 22, 2021 Category: Research Authors: Netish Kumar Kundo Md Imran Nur Manik Kushal Biswas Riniara Khatun Md Yusuf Al-Amin A H M K Alam Toshihisa Tanaka Golam Sadik Source Type: research
