Efficacy of mistletoe extract as a complement to standard treatment in advanced pancreatic cancer: study protocol for a multicentre, parallel group, double-blind, randomised, placebo-controlled clinical trial (MISTRAL)
Most pancreatic cancer patients present with advanced stage at diagnosis with extremely short expected survival and few treatment options. A multimodal palliative approach is necessary for symptom relief and o... (Source: Trials)
Source: Trials - September 11, 2020 Category: General Medicine Authors: Kathrin Wode, Johanna H ök Nordberg, Gunver S. Kienle, Nils O. Elander, Britt-Marie Bernhardson, Berit Sunde, Lena Sharp, Roger Henriksson and Per Fransson Tags: Study protocol Source Type: research
Molecules, Vol. 25, Pages 4006: Comprehensive Metabolome Analysis of Fermented Aqueous Extracts of Viscum album L. by Liquid Chromatography −High Resolution Tandem Mass Spectrometry
In this study, a comprehensive metabolome analysis of samples of fermented aqueous extracts of V. album from two host tree species (Malus domestica and Pinus sylvestris), both prepared by two pharmaceutical manufacturing processes, was performed by liquid chromatography−high resolution tandem mass spectrometry (LC-HRMS/MS). A total of 212 metabolites were putatively annotated, including primary metabolites (e.g., amino acids, organic acids, etc.) and secondary metabolites (mostly phenolic compounds). A clear separation between V. album samples according to the host tree species, but not due to manufacturing p...
Source: Molecules - September 1, 2020 Category: Chemistry Authors: Evelyn Pe ñaloza Carla Holandino Claudia Scherr Paula I. P. de Araujo Ricardo M. Borges Konrad Urech Stephan Baumgartner Rafael Garrett Tags: Article Source Type: research
Antioxidant activity of flavonoid rich fraction of Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae).
Antioxidant activity of flavonoid rich fraction of Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae).
Chem Biodivers. 2020 Jul 28;:
Authors: Dobrecky CB, Marchini T, Ricco R, Garcés M, Gadano A, Carballo M, Wagner M, Lucangioli S, Evelson P
Abstract
Ligaria cuneifolia (Ruiz & Pav.) Tiegh (Loranthaceae), the "Argentine mistletoe", is a hemiparasite species largely used in folk medicine. The aim of this study was to evaluate the antioxidant activity using in vitro, ex vivo, and in vivo methods. A screening of phenolics was performed by UV spectroscopy on different fract...
Source: Chemistry and Biodiversity - July 27, 2020 Category: Biochemistry Authors: Dobrecky CB, Marchini T, Ricco R, Garcés M, Gadano A, Carballo M, Wagner M, Lucangioli S, Evelson P Tags: Chem Biodivers Source Type: research
Quality of life in cancer patients treated with mistletoe: a systematic review and meta-analysis
Mistletoe extracts are used as an adjunct therapy for cancer patients, but there is dissent as to whether this therapy has a positive impact on quality of life (QoL). (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 20, 2020 Category: Complementary Medicine Authors: Martin Loef and Harald Walach Tags: Research article Source Type: research
Phytochemical analysis and in vitro anti-proliferative activity of Viscum album ethanolic extracts
Viscum album L. (Santalaceae), commonly known as mistletoe, is a hemiparasitic plant traditionally used in complementary cancer treatment. Its antitumor potential is mostly attributed to the presence of aqueous s... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 9, 2020 Category: Complementary Medicine Authors: Carla Holandino, Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Jo ão Vitor da Costa Batista, Marcia Alves Marques Capella, Rafael Garrett, Mirio Grazi, Hartmut Ramm, Claudia Dalla Torre, Gerhard Schaller, Konrad Urech, Ulrike Weissenstein an Tags: Research article Source Type: research
Transmission studies of the newly described apple chlorotic fruit spot viroid using a combined RT-qPCR and droplet digital PCR approach
AbstractThe transmission of the apscaviroid tentatively named apple chlorotic fruit spot viroid (ACFSVd) was investigated using a one-step reverse-transcription (RT) droplet digital PCR assay for absolute quantification of the viroid, followed by quantification of relative standard curves by RT-qPCR. Our results indicate that ACFSVd is effectively transmitted by grafting, budding and seeds. No transmission has yet been observed to the viroid-inoculated pome fruit speciesPyrus sp. andCydonia sp. ACFSVd was detected in viruliferous aphids (Myzus persicae,Dysaphis plantaginea) and in codling moths (Cydia pomonella). The viroi...
Source: Archives of Virology - July 7, 2020 Category: Virology Source Type: research
Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action.
Abstract
Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro and in vivo studies on the pharmacological activity of Viscum species. Furthermore, we proposed the possible mechanisms of action of this herb, which might include many signalling pathways. Mistletoe could regulate either similar or different targets in various pathways that act on me...
Source: Archives of Pharmacal Research - July 2, 2020 Category: Drugs & Pharmacology Authors: Szurpnicka A, Kowalczuk A, Szterk A Tags: Arch Pharm Res Source Type: research
Molecules, Vol. 25, Pages 2562: Transiently Expressed Mistletoe Lectin II in Nicotiana benthamiana Demonstrates Anticancer Activity In Vitro
kam
Mistletoe (Viscum album) extracts have been used as alternative and complementary therapeutic preparations in multiple cancers for decades. Mistletoe lectins (ML-I, ML-II, and ML-III) are considered to be the main anticancer components of such preparations. In the present study, ML-II was transiently expressed in Nicotiana benthamiana using the pEAQ-HT expression system. Expression levels of up to 60 mg/kg of the infiltrated plant tissue were obtained, and a three-fold increase was achieved by adding the endoplasmic reticulum (ER) retention signal KDEL to the native ML-II sequence. The native protein containing His...
Source: Molecules - May 30, 2020 Category: Chemistry Authors: Milena Mazalovska J. Calvin Kouokam Tags: Article Source Type: research
Long-Term Follow-up of a Randomized Study of Oral Etoposide versus Viscum album Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse.
Conclusions: After 12 years from the start of the trial, the patients in the Viscum arm continue to show a considerably longer PRDFS compared to oral etoposide, and a trend for an advantage in OS is evident even if the number of treated patients is too small to draw conclusions. Viscum as maintenance treatment after complete surgical remission in relapsed osteosarcoma should be further investigated and compared with other drugs.
PMID: 32398946 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 15, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research
Establishment of conventional PCR and real-time PCR assays for accurate, rapid and quantitative authentication of four mistletoe species
Publication date: August 2020Source: Phytochemistry, Volume 176Author(s): Wook Jin Kim, Sungyu Yang, Goya Choi, Inkyu Park, Pureum Noh, A. Yeong Lee, Hyo Seon Kim, Byeong Cheol Moon (Source: Phytochemistry)
Source: Phytochemistry - May 12, 2020 Category: Chemistry Source Type: research
Cost-Effectiveness of Real-World Administration of Concomitant Viscum album L. Therapy for the Treatment of Stage IV Pancreatic Cancer.
Conclusion: Based on this CEA analysis, from the hospital's point of view, the costs per mean month of OS and per mean hospital stay were lower for patients under combinational standard of care plus VA compared to patients receiving standard of care alone for the treatment of stage IV pancreatic cancer. Further prospective cost-effectiveness studies are mandatory to reevaluate our findings.
PMID: 32256640 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Construction of eco-biosensor and its potential application for highly selective, sensitive and fast detection of viscumin.
Abstract
Viscum album lectin 1 (Viscumin) is one of the most important plant-based protein of potential adjuvant in cancer treatment. Therefore, the use of nano-biosensor technology as a novel emerges of biosensors is crucial to detect this modal agent in pharmacological study. Molecular imprinted polymer using 9-mer peptides sequence (epitope) was applied as a template. Using ultraviolet light, hydrogen bonding attained between the functional monomer and epitope, leading to the formation of a molecularly imprinted polymer. In the following, the epitope was derived from the surface of the polymer by sodium...
Source: Analytica Chimica Acta - March 24, 2020 Category: Chemistry Authors: Nasirahmadi S, Akbari-Adergani B, Shoeibi S Tags: Anal Chim Acta Source Type: research
[Mistletoe in the treatment of cancer patients].
Abstract
Mistletoe (Viscum album L.) continues to be the medical herb prescribed most frequently for cancer patients in German-speaking countries. Demand for this therapy often comes from patients themselves and requires careful consideration by the attending physician during consultation.In German-speaking countries, mistletoe extracts are available as approved drugs (based on monographs of the commissions C and E of the German Federal Institute for Drugs and Medical Devices). In Switzerland, treatment costs are generally covered by statutory health insurance. In Germany, coverage is limited to palliat...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - March 23, 2020 Category: International Medicine & Public Health Authors: Rostock M Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
Statement to an Insufficient Systematic Review on Viscum album L. Therapy.
Conclusion: In view of the approaching release of a new guideline in the field of complementary therapies in oncology, the present statement draws attention to a lack of profound methodology of conductance of a recently released systematic review on mistletoe. In consequence, a comprehensive overview of published mistletoe studies, i.e., a meta-analysis with a sound methodology of conductance, is necessary.
PMID: 32148549 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 11, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Long-term survival of a patient with an inoperable thymic neuroendocrine tumor stage IIIa under sole treatment with Viscum album extract: A CARE compliant clinical case report
We report the case of this patient who declined chemotherapy and was treated instead with sole subcutaneous VAE 3 times per week for 85 months. No other tumor-specific intervention was applied.
Outcomes
Quality of life (QoL) improved substantially. The patient returned to work, and the tumor remained stable for 71 months. Thereafter, the tumor progressed, and the patient died 90 months after initial diagnosis. Besides self-limited local skin reactions around the application site, no side effects occurred.
Lessons
This is an exceptionally good course of disease of an inoperable, large, obstructing, and invasive TNET w...
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
