Striving towards Normality in Daily Life: A Qualitative Study of Patients Living with Metastatic Gastrointestinal Stromal Tumour in Long-Term Clinical Remission.
Conclusions: It is important to focus increased attention on how the daily practical and psychosocial life of patients with chronic cancer, including metastatic GIST, is affected by their disease. Doing so might provide health-care workers with clues regarding how best to guide and support such patients throughout their emotional journey and, therefore, to improve their quality of life. As new medical treatments can also prolong survival and induce long-term clinical remission in relation to several other forms of metastatic cancer, the findings concerning GIST reported in this study might have widespread implications. ...
Source: Sarcoma - October 22, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Diagnostic Differences in Expert Second-Opinion Consultation Cases at a Tertiary Sarcoma Center.
We present our experience with second-opinion (consultation) cases in a specialist tertiary sarcoma center. The aim of this study was to determine areas of diagnostic difficulty in soft tissue pathology. We assessed 581 second-opinion cases which were reviewed by two experienced pathologists in a period of one year. There was 62% concordance between the original and the second-opinion diagnosis, with diagnostic discrepancy in 38%. The largest group of soft tissue neoplasms received for second opinion was fibroblastic/myofibroblastic tumors, and most major diagnostic problems were encountered in adipocytic and so-called &qu...
Source: Sarcoma - October 21, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Time Trends and Prognostic Factors for Overall Survival in Myxoid Liposarcomas: A Population-Based Study.
Conclusions: In this large nationwide cohort, tumor size and tumor location were independent prognostic factors for OS. Furthermore, a higher probability of an RC tumor with increasing age was suggested. An increased use of RT over the years did not translate into improved OS for localized MLS. PMID: 33029074 [PubMed] (Source: Sarcoma)
Source: Sarcoma - October 9, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Pharmacologic Inhibition of Ezrin-Radixin-Moesin Phosphorylation is a Novel Therapeutic Strategy in Rhabdomyosarcoma.
This study investigates the inhibition of ERM phosphorylation using a small molecule pharmacophore NSC668394 as a potential strategy against RMS. Upon in vitro treatment with NSC668394, RMS cells exhibit a dose-dependent decrease in cell viability and proliferation, with induction of caspase-3 cleavage and apoptosis. siRNA-mediated knockdown of individual ERM protein expression revealed that each regulates RMS survival to a different degree. In vivo administration of NSC668394 in RMS xenografts causes significant decrease in tumor growth, with no adverse effect on body weight. Collectively, this study highlights the import...
Source: Sarcoma - October 3, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Angiosarcoma of the Scalp and Face: A Dosimetric Comparison of HDR Surface Applicator Brachytherapy and VMAT.
Conclusions: There may be dosimetric advantages to VMAT over HDR-SA brachytherapy for many patients. However, individual tumor location, patient anatomy, and treatment reproducibility may result in HDR-SA brachytherapy being the preferred technique in a subset of patients. Ultimately, a personalized approach is likely to be the optimal treatment plan. PMID: 32908445 [PubMed] (Source: Sarcoma)
Source: Sarcoma - September 12, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Predicting Pathologic Bone Lesions Using Scout Computed Tomography (CT) Imaging.
This study advocates for the careful review of all scout CT imaging as an essential part of the work up for metastatic disease and encourages all practitioners to utilize this screening tool for the identification of pathologic bony lesions which may help expedite early treatment to reduce patient morbidity. PMID: 32848506 [PubMed] (Source: Sarcoma)
Source: Sarcoma - August 29, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Assessing the Desmoid-Type Fibromatosis Patients' Voice: Comparison of Health-Related Quality of Life Experiences from Patients of Two Countries.
Conclusion: This study identified the most relevant issues for DTF patients, which should be included in a DTF-specific HRQoL questionnaire. Additionally, we identified differences in priority scores between British and Dutch participating patients. Field testing in a large, international cohort is needed to confirm these findings and to devise a comprehensive and specific HRQoL questionnaire for DTF patients. PMID: 32774131 [PubMed] (Source: Sarcoma)
Source: Sarcoma - August 13, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Follow-Up in Bone Sarcoma Care: A Cross-Sectional European Study.
Conclusions: Variations were seen among European bone sarcoma centres with regards to follow-up intervals and use of repeated imaging. The majority of these expert centres follow existing international guidelines and find them sufficient as basis for a follow-up surveillance programme despite lack of evidence. Future research should aim towards evidence-based follow-up with focus on the effects of follow-up strategies on health outcomes, cost-effectiveness, and individualised follow-up algorithms. PMID: 32675939 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Immunohistochemical Analysis of CD99 and PAX8 in a Series of 15 Molecularly Confirmed Cases of Ewing Sarcoma.
We present a series of 15 cases of molecularly confirmed ES, in which we found a sensitivity of 100% for CD99 and 80% for PAX8 by immunohistochemistry. This indicates a high sensitivity; however, it is known that both CD99 and PAX8 are also expressed in other tumours. Therefore, molecular confirmation should be performed in all cases. PMID: 32675940 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma.
Authors: Berlow NE, Grasso CS, Quist MJ, Cheng M, Gandour-Edwards R, Hernandez BS, Michalek JE, Ryan C, Spellman P, Pal R, Million LS, Renneker M, Keller C Abstract Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the re...
Source: Sarcoma - June 24, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma.
Authors: Parkes A, Urquiola E, Bhosale P, Lin H, Watson K, Wang WL, Feig B, Torres K, Roland CL, Conley AP, Zarzour M, Livingston JA, Ratan R, Ludwig J, Araujo DM, Ravi V, Benjamin RS, Patel S, Somaiah N Abstract Distinguishing well-differentiated liposarcoma (WDLPS) from dedifferentiated liposarcoma (DDLPS) is essential given distinct treatment paradigms and chemosensitivity. Percutaneous biopsy has a low sensitivity for detecting DDLPS. We sought to identify the diagnostic utility of positron emission tomography/computed tomography (PET/CT) in identifying WDLPS versus DDLPS. An independent radiologist reviewed PE...
Source: Sarcoma - June 24, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Time to Treatment Initiation and Survival in Adult Localized High-Grade Bone Sarcoma.
Authors: Lawrenz JM, Featherall J, Curtis GL, George J, Jin Y, Anderson PM, Shepard DR, Reith JD, Rubin BP, Nystrom LM, Mesko NW Abstract Objective: Few studies have evaluated the prognostic implication of the length of time from diagnosis to treatment initiation in bone sarcoma. The purpose of this study is to determine if time to treatment initiation (TTI) influences overall survival in adults diagnosed with primary bone sarcoma. Methods: A retrospective analysis of the National Cancer Database identified 2,122 patients who met inclusion criteria with localized, high-grade bone sarcoma diagnosed between 2004 ...
Source: Sarcoma - May 28, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung.
Conclusions: Although saracatinib was well tolerated in this patient population, there was no apparent impact of the drug in this double-blinded, placebo-controlled trial on OS, and Src inhibition alone may not be sufficient to suppress metastatic progression in osteosarcoma. There is a suggestion of potential clinical benefit as evidenced by longer PFS in patients randomized to saracatinib based on limited numbers of patients treated. PMID: 32398945 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 15, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Long-Term Follow-up of a Randomized Study of Oral Etoposide versus Viscum album Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse.
Authors: Longhi A, Cesari M, Serra M, Mariani E Abstract Background: In relapsed osteosarcoma, the 5-yr postrelapse disease-free survival (PRDFS) rate after the second relapse is
Source: Sarcoma - May 15, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.
Conclusion: TLE1 is a sensitive and specific marker for synovial sarcoma that can aid in its diagnosis. Due to its involvement in several relevant signaling pathways, TLE1 might have direct relevance to the pathophysiology of the disease. PMID: 32322158 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 25, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Current Approaches for Personalized Therapy of Soft Tissue Sarcomas.
Authors: Kirsanov KI, Lesovaya EA, Fetisov TI, Bokhyan BY, Belitsky GA, Yakubovskaya MG Abstract Soft tissue sarcomas (STS) are a highly heterogeneous group of cancers of mesenchymal origin with diverse morphologies and clinical behaviors. While surgical resection is the standard treatment for primary STS, advanced and metastatic STS patients are not eligible for surgery. Systemic treatments, including standard chemotherapy and newer chemical agents, still play the most relevant role in the management of the disease. Discovery of specific genetic alterations in distinct STS subtypes allowed better understanding of ...
Source: Sarcoma - April 24, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Clinical Outcomes of Osteoarticular Extracorporeal Irradiated Autograft for Malignant Bone Tumor.
Conclusion: Although osteoarticular ECIA is one of the reasonable surgical options for patients with tumors for which reliable prostheses are not available, we do not recommend osteoarticular ECIA as a routine procedure because of high complication rate. PMID: 32317858 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 24, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Clinical Presentation, Natural History, and Therapeutic Approach in Patients with Solitary Fibrous Tumor: A Retrospective Analysis.
Conclusion: SFT is an orphan malignancy with a highly variable clinical course and a considerable risk of local failure and metachronous metastasis. Surgery is the only curative option; palliative systemic therapy is used in inoperable/metastatic cases but achieves low response rates. The highest response rates are seen with pazopanib in second/third line. PMID: 32300277 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Axillary Lymph Node Dissection in Angiosarcomas of the Breast: An Asian Institutional Perspective.
Authors: Ragavan S, Lim HJ, Tan JW, Hendrikson J, Chan JY, Farid M, Chia CS, Tan GHC, Soo KC, Teo MCC, Ong CJ Abstract Angiosarcomas of the breast (ASB) are rare, making up to less than 8% of all angiosarcomas. The surgical management for this disease continues to vary throughout centres worldwide due to the current limited evidence. We aim to examine the necessity of axillary lymph node dissection in this pathology through a retrospective study of axillary metastasis and recurrence patterns in patients treated at our institution. A retrospective review of a prospectively-maintained database was performed. All adul...
Source: Sarcoma - April 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Prognostic Factors for Development of Subsequent Metastases in Localized Osteosarcoma: A Systematic Review and Identification of Literature Gaps.
Conclusions: Several prognostic factors seemed to be consistent amongst the studies, but the heterogeneity and smaller sizes of the study populations made pooling of results difficult. Standardization of larger patient populations and consistent definitions/cutoffs for prognostic factors are needed to further assess for consistent prognostic factors and potential predictive models to be developed. PMID: 32300279 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Induction of Myogenic Differentiation Improves Chemosensitivity of Chemoresistant Cells in Soft-Tissue Sarcoma Cell Lines.
In this study, we investigated the myogenic determination factor 1 (MYOD1) and Noggin (NOG) markers in an embryonal RMS (ERMS) cell line and an RT cell line and the differential response of the MYOD1 and NOG expressing subpopulations to chemotherapy. Importantly, we found that these markers together identify a subpopulation of cells (MYOD1+ NOG+ cells) with primary resistance to Vincristine and Doxorubicin, two commonly used chemotherapies for ERMS and RT. The chemoresistant MYOD1+ NOG+ cells express markers of undifferentiated cells such as myogenin and ID1. Combination of Vincristine with TPA/GSK126, a drug combination s...
Source: Sarcoma - April 18, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Treatment Patterns and Healthcare Resource Utilization among Patients with Advanced or Metastatic Soft Tissue Sarcoma in US Community Practices.
Conclusions: While demographic and clinical characteristics were similar, treatment patterns changed in 2016. Future research should evaluate the impact of changing drug approvals and clinical trial results on future treatment patterns. PMID: 32256184 [PubMed - as supplied by publisher] (Source: Sarcoma)
Source: Sarcoma - April 8, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Oncological Treatment Considerations Differ across Surgical Subspecialties Treating Malignant Peripheral Nerve Sheath Tumors: An International Survey.
Conclusion: Surgical oncologists generally agree on preoperative diagnostics; other subspecialties do not. Considering the preservation of function differed among all subspecialties. Surgeons do agree on some indications for radiotherapy, yet the use of chemotherapy in localized MPNSTs lacks consensus. A preferred sequence of multimodal therapy differs between and within surgical subspecialties, but surgical oncologists prefer neoadjuvant radiotherapy. PMID: 32189989 [PubMed] (Source: Sarcoma)
Source: Sarcoma - March 21, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma.
Authors: Bücklein V, Limmroth C, Kampmann E, Schuebbe G, Issels R, Roeder F, Angele M, Dürr HR, Knösel T, Abdel-Rahman S, Di Gioia D, Lindner LH Abstract Patients with localized relapse of soft-tissue sarcoma (STS) after anthracycline-based chemotherapy have a dismal prognosis, particularly when surgery is not possible. To facilitate resection and improve long-term tumor control, we applied an intensified perioperative treatment consisting of ICE (ifosfamide 6 g/m2, carboplatin 400 mg/m2, and etoposide 600 mg/m2) in combination with regional hyperthermia (RHT) to maximize local c...
Source: Sarcoma - March 21, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis.
Conclusion: Approximately 1 in 11 pediatric patients will experience a complication in the first thirty days following surgery. However, perioperative mortality remains low. This study represents the first comprehensive review of pediatric bone and soft tissue sarcoma surgery in the NSQIP-P database. As the case volume of NSQIP-P continues to grow, NSQIP-P has the potential to become a powerful tool for pediatric orthopedic oncology research. PMID: 32148435 [PubMed] (Source: Sarcoma)
Source: Sarcoma - March 11, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Analysis of the Chemotherapy-Free Interval following Image-Guided Ablation in Sarcoma Patients.
In conclusion, ablation of sarcoma metastases can provide an extended systemic chemotherapy-free interval of greater than 1 year. Ablation of sarcoma metastases may improve patient quality of life by extending the chemotherapy-free interval. PMID: 32148436 [PubMed] (Source: Sarcoma)
Source: Sarcoma - March 11, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023).
Conclusion: Despite promising preclinical rationale and tolerability of the combination therapy, no responses were observed, and the study did not meet parameters for further evaluation in MPNSTs. This trial was registered with (NCT02008877). PMID: 32089640 [PubMed] (Source: Sarcoma)
Source: Sarcoma - February 25, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Does Reconstruction with Reimplantation of Sterilized Tumor Bone Provide Survival Benefit in Diaphyseal Osteosarcoma?
Authors: Nayak P, Gulia A, Puri A Abstract Does reimplantation of sterilized tumor bone for reconstruction provide outcome benefits in intercalary osteosarcoma based on the potential immunogenic effect of reimplanted sterilized tumor tissue? Of 720 cases of surgically treated high-grade osteosarcoma patients treated at our institute from 2006 to 2013, 61 had predominantly diaphyseal disease. All patients were nonmetastatic at presentation. Patient and tumor characteristics, treatment details, and local recurrence-free, metastasis-free, and overall survival were compared for 24 patients who had reconstruction with s...
Source: Sarcoma - February 15, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Radiomics and Machine Learning Differentiate Soft-Tissue Lipoma and Liposarcoma Better than Musculoskeletal Radiologists.
Authors: Malinauskaite I, Hofmeister J, Burgermeister S, Neroladaki A, Hamard M, Montet X, Boudabbous S Abstract Distinguishing lipoma from liposarcoma is challenging on conventional MRI examination. In case of uncertain diagnosis following MRI, further invasive procedure (percutaneous biopsy or surgery) is often required to allow for diagnosis based on histopathological examination. Radiomics and machine learning allow for several types of pathologies encountered on radiological images to be automatically and reliably distinguished. The aim of the study was to assess the contribution of radiomics and machine learn...
Source: Sarcoma - February 1, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Optimization of the Therapeutic Approach to Patients with Sarcoma: Delphi Consensus.
Authors: Álvarez Álvarez R, Cruz Jurado J, Del Muro Solans XG, Giner JL, López Pousa A, Martín-Broto J, Valverde CM Abstract Soft tissue sarcomas (STS) constitute a heterogeneous group of rare solid tumors associated with significant morbidity and mortality. The evaluation and treatment of STS require a multidisciplinary team with extensive experience in the management of these types of tumors. National and international clinical practice guidelines for STS do not always provide answers to a great many situations that specialists have to contend with in their everyday practice. This cons...
Source: Sarcoma - January 26, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution.
Conclusions: The prognosis of DDCS is poor. Complete resection remains a significant prognostic factor for local control. Chemotherapy with doxorubicin and cisplatin seems to have better PFS. More prognostic, multicenter trials are warranted to further explore the effectiveness of chemotherapy in selected DDCS patients. PMID: 31915413 [PubMed] (Source: Sarcoma)
Source: Sarcoma - January 11, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Comparison of MRI and Histopathology with regard to Intramedullary Extent of Disease in Bone Sarcomas.
Authors: Gulia A, Puri A, Subi TS, Gupta SM, Juvekar SL, Rekhi B Abstract In today's era, limb salvage surgery is the procedure of choice and current standard of care in appropriately selected patients of bone sarcomas. For adequate oncologic clearance, preoperative evaluation of the extent of tumor is mandatory. The present study was done to compare measurements of bone sarcomas (osteosarcoma, Ewing's sarcoma, and chondrosarcoma) as determined by magnetic resonance imaging (MRI) with the histopathological extent seen on resected specimens. We prospectively evaluated 100 consecutive patients with a diagnosis of bon...
Source: Sarcoma - January 1, 2020 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Efficacy and Safety of Nanosomal Docetaxel Lipid Suspension-Based Chemotherapy in Sarcoma: A Multicenter, Retrospective Study.
Conclusion: Nanosomal docetaxel lipid suspension-based chemotherapy was efficacious and well tolerated in the treatment of sarcoma. Further prospective trials are needed to confirm the data. PMID: 31827370 [PubMed] (Source: Sarcoma)
Source: Sarcoma - December 13, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.
Conclusions: Despite the suggested radioresistance of CS, modern radiotherapies may present a treatment option for certain patients. Our results support a role for high-dose, advanced radiation therapies in selected high-risk CS patients with tumors in surgically challenging locations or unplanned positive margins. While there is an associated survival rate benefit, further, prospective studies are needed for validation. PMID: 31736653 [PubMed] (Source: Sarcoma)
Source: Sarcoma - November 20, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear.
Conclusions: The rate of LR for patients with myxofibrosarcoma was high. The impact of RT on local tumor control was unclear. The surgical margin was important for both local and distant tumor control. Large tumor size was a risk factor for distant metastasis. PMID: 31662702 [PubMed] (Source: Sarcoma)
Source: Sarcoma - October 31, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Changes in Soft-Tissue Sarcoma Treatment Patterns over Time: A Population-Based Study in a Country with Universal and Centralized Healthcare.
Conclusion: This is the first population-level study reporting of 7 different STS treatment regimens in a country with universal and centralized healthcare. Radiation therapy for local disease control and chemotherapy for Stage 4 patients have recently become more utilized. Survival from STS is highly dependent on stage at presentation. Other population-based studies from other countries are needed to establish the current international treatment patterns. PMID: 31636505 [PubMed] (Source: Sarcoma)
Source: Sarcoma - October 24, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Safety and Efficacy of Hepatic Artery Embolization in Treating Solitary Fibrous Tumor Metastatic to the Liver.
Authors: Velayati S, Erinjeri JP, Brody LA, Ziv E, Boas FE, Brown KT, Covey AM, Getrajdman GI, Solomon SB, Kingham PT, Tap WD, Jarnagin WR, Yarmohammadi H Abstract The aim of this study was to evaluate safety and survival following hepatic artery embolization (HAE) for metastatic solitary fibrous tumor (SFT) in the liver. All patients with SFT metastatic to liver treated with HAE were retrospectively analyzed. Tumor response was evaluated using mRECIST. Objective response, overall survival (OS), and progression-free survival (PFS) were evaluated using Kaplan-Meier and multivariate Cox proportional hazard ratio. Adv...
Source: Sarcoma - October 1, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Corrigendum to "SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy".
Corrigendum to "SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy". Sarcoma. 2019;2019:7608743 Authors: Choy E, Ballman K, Chen J, Dickson MA, Chugh R, George S, Okuno S, Pollock R, Patel RM, Hoering A, Patel S Abstract [This corrects the article DOI: 10.1155/2018/2068517.]. PMID: 31534435 [PubMed - in process] (Source: Sarcoma)
Source: Sarcoma - September 20, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

A Retrospective Case Series of Synovial Sarcoma of the Upper Extremity.
Conclusion: While we were unable to find a significant difference in outcomes or amputation rates between those who underwent reexcision of a previously unplanned excision and those who underwent an initial planned resection, the high rate of unplanned excision is troubling and should remind practitioners to consider sarcoma in the differential of all upper extremity masses. PMID: 31467480 [PubMed] (Source: Sarcoma)
Source: Sarcoma - August 31, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.
Authors: Chen M, Xu ES, Leisenring NH, Cardona DM, Luo L, Ma Y, Ventura A, Kirsch DG Abstract Myxoid liposarcoma is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. Here, we report the generation and characterization of a spatially and temporally restricted mouse model of sarcoma driven by FUS-CHOP. Using different Cre drivers in the adipocyte lineage, we initiated in vivo tumorigenesis by expressing FUS-CHOP in ...
Source: Sarcoma - August 21, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).
Conclusion: With a CBR of 12% (3/25), the combination of everolimus and bevacizumab did not reach the study's target response rate and is not considered active in refractory MPNST. PMID: 31427883 [PubMed] (Source: Sarcoma)
Source: Sarcoma - August 21, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy.
Authors: Mandell JB, Lu F, Fisch M, Beumer JH, Guo J, Watters RJ, Weiss KR Abstract Although many cancer cells have significantly higher copper concentrations compared with normal cells and tissues, the role of copper in cancer biology and metastatic disease remains poorly understood. Here, we study the importance of copper in osteosarcoma, which frequently metastasizes to the lungs and is often chemoresistant. K12 and K7M2 are murine OS cells with differing metastatic phenotypes: K7M2 is highly metastatic, whereas K12 is much less so. Intracellular copper levels were determined using atomic absorption. Copper tran...
Source: Sarcoma - August 7, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

How Effective Are Noninvasive Tests for Diagnosing Malignant Peripheral Nerve Sheath Tumors in Patients with Neurofibromatosis Type 1? Diagnosing MPNST in NF1 Patients.
Conclusions: MRI and PET were more effective at diagnosing MPNST than clinical features. We created an algorithm for preoperative evaluation of peripheral nerve sheath tumors in NF1 patients, for which additional validation will be indicated. PMID: 31354382 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 31, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Psychosocial Distress Scores and Needs among Newly Diagnosed Sarcoma Patients: A Provincial Experience.
Discussion: Up to 45% of sarcoma patients experience some form of psychological distress at disease presentation. Patients desire information about their diagnosis and treatment. Tailored interventions to individual psychological comorbidity and improved patient education resources would be beneficial. PMID: 31354383 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 31, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients.
Authors: Verboom MC, Gelderblom H, Kerst JM, Steeghs N, Reyners AKL, Sleijfer S, van der Graaf WTA, van den Hout WB Abstract Trabectedin and ifosfamide are among the few cytostatic agents active in advanced soft tissue sarcomas (STSs). Trabectedin is most potent against so-called L-sarcomas (leiomyosarcoma and liposarcoma). The survival gain and cost-effectiveness of these agents in a second-line setting were analysed in the setting of advanced STS after failure of anthracyclines. A prospective observational trial had previously been performed to assess the use of trabectedin in a Dutch real-world setting. Data on ...
Source: Sarcoma - July 11, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Predictors of Disease-Free and Overall Survival in Retroperitoneal Sarcomas: A Modern 16-Year Multi-Institutional Study from the United States Sarcoma Collaboration (USSC).
Conclusions: The strongest predictors of disease-free and overall survival are tumor-specific characteristics, while surgical factors are less impactful. Nonsurgical therapies are not associated with improved outcomes despite persistent interest and utilization. Complete macroscopic resection (R0/R1) remains a persistent potentially modifiable risk factor associated with improved overall survival in patients with retroperitoneal sarcomas. PMID: 31281208 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 11, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis.
Authors: Andersen S, Mann H, Krarup-Hansen A, Lajer CB, Grønhøj C Abstract Background: Head and neck soft tissue sarcomas (HNSTS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due to the rarity and varied biological behaviour among various subtypes. This systematic review examines the characteristics of tumours and patients with HNSTS. Materials and Methods: A systematic literature review and meta-analysis were performed using the electronic databases PubMed and Embase. Eight eligible studies were identified, and 13 variables were extracted from each study inclu...
Source: Sarcoma - July 4, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Use of Healthcare Services Two Years before Diagnosis in Danish Sarcoma Patients, 2000-2013.
Conclusions: The use of healthcare services among sarcoma patients increased several months before diagnosis in all healthcare sectors. The results reveal a diagnostic time window and a potential to refer, diagnose, and treat sarcoma patients in a timelier manner. PMID: 31205448 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 19, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Role of Radiation Therapy in Adult Extraskeletal Ewing's Sarcoma Patients Treated with Chemotherapy and Surgery.
Authors: Saiz AM, Gingrich AA, Canter RJ, Kirane AR, Monjazeb AM, Randall RL, Thorpe SW Abstract Radiation therapy (RT) is advocated in the multimodal treatment of high-grade soft tissue sarcoma (STS), but its role may be less clear in chemotherapy-sensitive STS such as extraskeletal Ewing sarcoma (EES). The purpose of this study was to determine the role of RT on overall survival (OS) in localized EES adult patients treated with chemotherapy and surgery. Adult patients diagnosed with EES and reported to the National Cancer Database from 2004 to 2014 were evaluated. All patients were treated with surgical resection...
Source: Sarcoma - June 12, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Reconstructive Challenges of Proximal Ulnar Bone Tumors: Our Experience with Biological Osteoarticular Reconstruction Using Extracorporeal Irradiation and Reimplantation.
Conclusion: Biological restoration of elbow anatomy using osteoarticular irradiated graft for proximal ulna reconstruction offers great joint stability and functional outcomes. Although the potential risks of infection and graft failure need to be considered, reconstruction with the size-matched radiated autograft eliminates donor site morbidity, offers a low-cost alternative to endoprosthesis, and provides outcomes superior to any other methods of reconstruction as analyzed from the literature. PMID: 31110466 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 23, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research