Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients.
Authors: Verboom MC, Gelderblom H, Kerst JM, Steeghs N, Reyners AKL, Sleijfer S, van der Graaf WTA, van den Hout WB Abstract Trabectedin and ifosfamide are among the few cytostatic agents active in advanced soft tissue sarcomas (STSs). Trabectedin is most potent against so-called L-sarcomas (leiomyosarcoma and liposarcoma). The survival gain and cost-effectiveness of these agents in a second-line setting were analysed in the setting of advanced STS after failure of anthracyclines. A prospective observational trial had previously been performed to assess the use of trabectedin in a Dutch real-world setting. Data on ...
Source: Sarcoma - July 11, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Predictors of Disease-Free and Overall Survival in Retroperitoneal Sarcomas: A Modern 16-Year Multi-Institutional Study from the United States Sarcoma Collaboration (USSC).
Conclusions: The strongest predictors of disease-free and overall survival are tumor-specific characteristics, while surgical factors are less impactful. Nonsurgical therapies are not associated with improved outcomes despite persistent interest and utilization. Complete macroscopic resection (R0/R1) remains a persistent potentially modifiable risk factor associated with improved overall survival in patients with retroperitoneal sarcomas. PMID: 31281208 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 11, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis.
Authors: Andersen S, Mann H, Krarup-Hansen A, Lajer CB, Grønhøj C Abstract Background: Head and neck soft tissue sarcomas (HNSTS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due to the rarity and varied biological behaviour among various subtypes. This systematic review examines the characteristics of tumours and patients with HNSTS. Materials and Methods: A systematic literature review and meta-analysis were performed using the electronic databases PubMed and Embase. Eight eligible studies were identified, and 13 variables were extracted from each study inclu...
Source: Sarcoma - July 4, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Use of Healthcare Services Two Years before Diagnosis in Danish Sarcoma Patients, 2000-2013.
Conclusions: The use of healthcare services among sarcoma patients increased several months before diagnosis in all healthcare sectors. The results reveal a diagnostic time window and a potential to refer, diagnose, and treat sarcoma patients in a timelier manner. PMID: 31205448 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 19, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Role of Radiation Therapy in Adult Extraskeletal Ewing's Sarcoma Patients Treated with Chemotherapy and Surgery.
Authors: Saiz AM, Gingrich AA, Canter RJ, Kirane AR, Monjazeb AM, Randall RL, Thorpe SW Abstract Radiation therapy (RT) is advocated in the multimodal treatment of high-grade soft tissue sarcoma (STS), but its role may be less clear in chemotherapy-sensitive STS such as extraskeletal Ewing sarcoma (EES). The purpose of this study was to determine the role of RT on overall survival (OS) in localized EES adult patients treated with chemotherapy and surgery. Adult patients diagnosed with EES and reported to the National Cancer Database from 2004 to 2014 were evaluated. All patients were treated with surgical resection...
Source: Sarcoma - June 12, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Reconstructive Challenges of Proximal Ulnar Bone Tumors: Our Experience with Biological Osteoarticular Reconstruction Using Extracorporeal Irradiation and Reimplantation.
Conclusion: Biological restoration of elbow anatomy using osteoarticular irradiated graft for proximal ulna reconstruction offers great joint stability and functional outcomes. Although the potential risks of infection and graft failure need to be considered, reconstruction with the size-matched radiated autograft eliminates donor site morbidity, offers a low-cost alternative to endoprosthesis, and provides outcomes superior to any other methods of reconstruction as analyzed from the literature. PMID: 31110466 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 23, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases.
Conclusions: PCS portends a poor prognosis, because of difficulty in obtaining complete resection of sarcoma, advanced stage at diagnosis, and high risk of brain metastases. Providers should be aware of the increased risk of brain metastases and consider brain imaging at diagnosis and follow-up. PMID: 30962762 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 11, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Evaluation of Planned versus Unplanned Soft-Tissue Sarcoma Resection Using PROMIS Measures.
Conclusions: Patients who undergo an unplanned excision followed by a definitive oncologic procedure have similar PROMIS scores compared to patients who undergo an initial planned resection. PMID: 30956533 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 9, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

A Critical Review of the Impact of Sarcoma on Psychosocial Wellbeing.
Conclusion: The published literature does not provide a clear understanding of the impact of sarcoma diagnosis and treatment on psychosocial wellbeing. Instead, the review demonstrates a need for well-designed studies in this area and a more consistent approach to the measurement of patient-reported outcomes, which include psychosocial domains. Recommendations for future research have been proposed. PMID: 30911268 [PubMed] (Source: Sarcoma)
Source: Sarcoma - March 27, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Adjuvant Chemotherapy in Uterine Leiomyosarcoma: Trends and Factors Impacting Usage.
Authors: Patel D, Handorf E, von Mehren M, Martin L, Movva S Abstract Objectives: The benefit of adjuvant chemotherapy in patients with localized uterine leiomyosarcoma (LMS) remains unclear due to a lack of randomized studies and data only from small retrospective series to rely on. We sought to identify factors associated with the administration of chemotherapy and to determine the trends in the usage of adjuvant chemotherapy in patients with nonmetastatic uterine LMS. Methods: Patients diagnosed with nonmetastatic uterine LMS between 2004 and 2014 were identified from the National Cancer Database (NCDB). Mul...
Source: Sarcoma - March 20, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Free Gracilis Muscle Flap for Sarcoma Reconstruction: 19 Years of Clinical Experience.
Conclusions: This series shows that the gracilis is well suited to covering large, compromised wounds across diverse anatomic features, which are the hallmark of sarcoma resections. The high rate of limb salvage and minimal donor-site morbidity further support the use of this flap as a first-line option for sarcoma reconstruction. PMID: 30863198 [PubMed] (Source: Sarcoma)
Source: Sarcoma - March 14, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

An Evaluation of PROMIS Health Domains in Sarcoma Patients Compared to the United States Population.
Conclusion: While physical function was found to be worse in the sarcoma cohorts, we observed significantly improved levels of depression in these patients when compared to the US population. This finding was maintained over time and is an important reminder that a patient's goals and desires change following a cancer diagnosis and must be taken into consideration when planning treatment and determining a successful outcome. PMID: 30799982 [PubMed] (Source: Sarcoma)
Source: Sarcoma - February 27, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib.
Authors: Böhm MJ, Marienfeld R, Jäger D, Mellert K, von Witzleben A, Brüderlein S, Wittau M, von Baer A, Schultheiss M, Mayer-Steinacker R, Rücker FG, Möller P, Bullinger L, Barth TFE Abstract Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight metastases across nine different patients. We identified CDK4 amplification as a recurrent alteration in 5 out of 18 samples (27.8%). It has been previousl...
Source: Sarcoma - February 27, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Using the Spleen as an In Vivo Systemic Immune Barometer Alongside Osteosarcoma Disease Progression and Immunotherapy with α-PD-L1.
In this study, we confirmed that the local and systemic immune profiles of an orthotopic osteosarcoma model with or without luciferase transfection were statistically equivalent. Next, we used flow cytometry to describe systemic immune cell populations influenced by osteosarcoma disease progression. When compared to vehicle-inoculated sham mice, it was found that tumor-bearing mice had significant immunophenotype disturbances at approximately 11 weeks after inoculation (at which time 90% of primary tumor-bearing mice have fulminant pulmonary metastases). Percent populations of natural killer cells and T regulatory cells we...
Source: Sarcoma - January 18, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size.
Authors: Leiting JL, Bergquist JR, Hernandez MC, Merrell KW, Folpe AL, Robinson SI, Nagorney DM, Truty MJ, Grotz TE Abstract Perioperative radiation therapy (RT) has been associated with reduced local recurrence in patients with retroperitoneal sarcomas (RPS); however, selection criteria remain unclear. We hypothesized that perioperative RT would improve survival in patients with RPS and would be associated with pathological factors. The National Cancer Database (NCDB) from 2004 to 2012 was reviewed for patients with nonmetastatic RPS undergoing curative intent resection. Tumor size was dichotomized at 15 cm...
Source: Sarcoma - January 12, 2019 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Adult Primary Bone Sarcoma and Time to Treatment Initiation: An Analysis of the National Cancer Database.
Authors: Lawrenz JM, Curtis GL, Styron JF, George J, Anderson PM, Zahler S, Shepard DR, Rubin BP, Nystrom LM, Mesko NW Abstract Objective: The time to treatment interval (TTI), defined as the period from diagnosis to first definitive treatment, has very limited descriptions toward understanding delays in primary bone sarcoma (PBS) care. Our primary goal was to determine the national standard for time to treatment initiation (TTI) in PBS in adults and to identify characteristics associated with TTI variability. Methods: An analysis of the National Cancer Database identified 15,083 adult patients with PBS diagnos...
Source: Sarcoma - December 13, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

A Cadaveric Comparative Study on the Surgical Accuracy of Freehand, Computer Navigation, and Patient-Specific Instruments in Joint-Preserving Bone Tumor Resections.
This study investigates the surgical accuracy of freehand, CAS- and PSI-assisted joint-preserving tumor resections and tests whether integration of CAS with PSI (CAS + PSI) can further improve accuracy. CT scans of 16 simulated tumors around the knee in four human cadavers were performed and imported into engineering software (MIMICS) for 3D planning of multiplanar joint-preserving resections. The planned resections were transferred to the navigation system and/or used for PSI design. Location accuracy (LA), entry and exit points of all 56 planes, and resection time were measured by postprocedural CT. Both CA...
Source: Sarcoma - December 13, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy.
Conclusions: Myxoid liposarcoma exhibits histological response to chemotherapy and radiation therapy. Tumor size appears to be greatest predictor of long-term disease control and overall survival. We were not able to show that chemotherapy provides a clinical benefit with regard to local control, disease-free survival, or overall survival. However, it is important to note that the selected usage of chemotherapy in the highest risk patients confounds this analysis. Further investigation is needed to help better determine the optimal use of chemotherapy in this group of patients. PMID: 30515050 [PubMed] (Source: Sarcoma)
Source: Sarcoma - December 6, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy.
Authors: Choy E, Ballman K, Chen J, Dickson MA, Chugh R, George S, Okuno S, Pollock R, Patel RM, Hoering A, Patel S Abstract Histone deacetylase inhibitors (HDACi) can reverse chemoresistance, enhance chemotherapy-induced cytotoxicity, and reduce sarcoma proliferation in cell lines and animal models. We sought to determine the safety and toxicity of mocetinostat and its ability to reverse chemoresistance when administered with gemcitabine in patients with metastatic leiomyosarcoma resistant to prior gemcitabine-containing therapy. Participants with metastatic leiomyosarcoma received mocetinostat orally, 70 m...
Source: Sarcoma - November 28, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Periosteal Osteosarcoma: A Single-Institutional Study of Factors Related to Oncologic Outcomes.
Conclusion: These findings add to the available evidence which has failed to find any survival benefit from chemotherapy; patients with this rare disease and their families should be counselled regarding the unclear role of chemotherapy in this rare subtype of osteosarcoma. PMID: 30363676 [PubMed] (Source: Sarcoma)
Source: Sarcoma - October 27, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Health Care Resource Utilization and Costs among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France.
Conclusions: This study provides real-world data on resource utilization and estimated costs in advanced STS and could inform policymakers about treatment burden. PMID: 30297977 [PubMed] (Source: Sarcoma)
Source: Sarcoma - October 10, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Benign Smooth Muscle Tumors (Leiomyomas) of Deep Somatic Soft Tissue.
Authors: McCarthy AJ, Chetty R Abstract Leiomyomas of deep soft tissue are extremely rare and should only be diagnosed following adherence to stringent histological criteria, namely, the absence of nuclear atypia and of coagulative tumor necrosis. Whether extremely low counts of, or even any, mitotic activity are acceptable when making a diagnosis of leiomyoma in deep soft tissue sites is controversial. The morphology and immunophenotype of smooth muscle tumors in deep soft tissue are similar to their counterparts irrespective of topography. It is interesting to note that leiomyomas of deep soft tissue (extremity a...
Source: Sarcoma - October 3, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Comparison of Epidemiology, Clinical Features, and Outcomes of Patients with Reported Ewing Sarcoma and PNET over 40 Years Justifies Current WHO Classification and Treatment Approaches.
Authors: Campbell K, Shulman D, Janeway KA, DuBois SG Abstract Background: As of 2013, the WHO has classified peripheral primitive neuroectodermal tumors (PNETs) within the umbrella of Ewing sarcoma family of tumors (ESFTs) given their shared biology. Histologic features differ between PNET and Ewing sarcoma (ES), and potential clinical differences between PNET and ES have not been fully elucidated. Methods: Through the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database, we identified 3,575 patients identified with histologic diagnosis of ES or PNET from 1973 to 2014. We use...
Source: Sarcoma - August 31, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy.
Authors: Raj S, Miller LD, Triozzi PL Abstract Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as "Coley's toxins." However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumor and immune cells in the tumor microenvironment play a crucial role in response to immunotherapy. There is a dynamic equilibrium created by the immune cells infiltrating the tumor, and this forms the basis of tumor evasion. Manipulating the intratumoral microenvir...
Source: Sarcoma - August 31, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

The Volume-Outcome Relationship in Retroperitoneal Soft Tissue Sarcoma: Evidence of Improved Short- and Long-Term Outcomes at High-Volume Institutions.
Authors: Bagaria SP, Neville M, Gray RJ, Gabriel E, Ashman JB, Attia S, Wasif N Abstract Background: We sought to study the association between RPS case volume and outcomes. Although a relationship has been demonstrated between case volume and patient outcomes in some cancers, such a relationship has not been established for retroperitoneal sarcomas (RPSs). Study Design: The National Cancer Database (NCDB) was queried for patients undergoing treatment for primary RPS diagnosed between 2004 and 2013. Mean annual patient volume for RPS resection was calculated for all hospitals and divided into low volume (10 cas...
Source: Sarcoma - August 26, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

A Longitudinal Study of Functional Outcomes in Patients with Limb Salvage Surgery for Soft Tissue Sarcoma.
Authors: Oh E, Seo SW, Han KJ Abstract Background: Many studies have reported on the surgical outcomes of soft tissue sarcoma. However, there was no longitudinal cohort study. Because time is the most valuable factor for functional recovery, adjusting time value was the key for finding the causal relationship between other risk factors and postoperative function. Therefore, existing cross-sectional studies can neither fully explain the causal relationship between the risk factors and the functional score nor predict functional recovery. The aim of this study was to determine important predictive factors that affect...
Source: Sarcoma - August 21, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands.
This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies. Patients and Methods: From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed. Results: Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 19...
Source: Sarcoma - July 25, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Safety and Accuracy of Core Needle Biopsy for Soft Tissue Masses in an Ambulatory Setting.
Authors: Walker JB, Stockwell E, Worhacz K, Kang P, Decomas A Abstract Background: Percutaneous needle biopsy has been found to be a safe and accurate method for the initial investigation of soft tissue masses. The notion exists that needle biopsies should be performed in specialized sarcoma centers, which can place a financial burden on patients without a sarcoma center near their place of residence. There is no consensus in the current literature regarding the diagnostic accuracy and clinical utility of clinic-based percutaneous core needle biopsy performed by community orthopedic surgeons with fellowship trainin...
Source: Sarcoma - July 18, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France.
Conclusions: In real-world clinical practice, advanced STS is most commonly treated with older therapies in the United Kingdom, Spain, Germany, and France. New therapies that improve overall survival in advanced STS are needed. PMID: 29977133 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 8, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Role of High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation for Children and Young Adults with Relapsed Ewing's Sarcoma: A Systematic Review.
Conclusions: Most studies using HDCT/ASCT as consolidation regimen showed improved survival benefits compared to CC. Randomized controlled studies are needed to determine true clinical benefits of HDCT followed by ASCT in patients with RES. PMID: 29973774 [PubMed] (Source: Sarcoma)
Source: Sarcoma - July 7, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients.
Authors: Schuster AJ, Kager L, Reichardt P, Baumhoer D, Csóka M, Hecker-Nolting S, Lang S, Lorenzen S, Mayer-Steinacker R, von Kalle T, Kevric M, Werner M, Windhager R, Wirth T, Bielack SS Abstract Osteosarcoma of the foot is a very rare presentation of a rare tumor entity. In a retrospective analysis, we investigated tumor- and treatment-related variables and outcome of patients registered in the Cooperative Osteosarcoma Study Group (COSS) database between January 1980 and April 2016 who suffered from primary high-grade osteosarcoma of the foot. Among the 23 eligible patients, median age was 32 years (range...
Source: Sarcoma - June 3, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

High-Dose Chemotherapy with Stem Cell Rescue in Desmoplastic Small Round Cell Tumor: A Single-Institution Experience and Review of the Literature.
Conclusion: Given the poor prognosis in DSRCT, this study supports further prospective research into the possible benefit of consolidation of autologous SCT in patients with DSRCT who are in remission, with the alternative inference that these patients in remission may fare well without SCT. Our retrospective review of the literature does not support SCT for patients who are not in remission. PMID: 29853779 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 3, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Sister Chromatid Exchange and Genomic Instability in Soft Tissue Sarcomas: Potential Implications for Response to DNA-Damaging Treatments.
Authors: Salawu A, Wright K, Al-Kathiri A, Wyld L, Reed M, Sisley K Abstract Sarcomas are rare heterogeneous malignancies of mesenchymal origin characterised by complex karyotypes but no specific abnormalities. Recurrence is common, and metastatic disease carries poor survival despite standard DNA-damaging radiotherapy or chemotherapy. DNA double-strand breaks (DSBs) are either repaired by mechanisms such as homologous recombination (HR) or result in cell death by apoptosis. Endogenous γH2AX formation and SCE formation are early and late events, respectively, and their levels are considered surrogate measures...
Source: Sarcoma - June 3, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Retrospective Analysis of Spectrum of Presentation and Treatment Outcome in Extremity Sarcomas: A Single-Centre Experience.
Conclusion: This study depicts single-center experience of extremity STS. The population analyzed was from sub-Himalayan region with significant lost to follow-up. Pooling of data from different centers has been advocated to derive conclusive results. PMID: 29808079 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Multiple Soft Tissue Sarcomas in a Single Patient: An International Multicentre Review.
Authors: Lex JR, Aoude A, Stevenson JD, Wunder JS, Evans S, Ferguson PC, Stavropoulos NA, Jeys L, Goulding K, Turcotte RE Abstract Developing multiple soft tissue sarcomas (STSs) is a rare process, sparsely reported in the literature to date. Little is known about the pattern of disease development or outcomes in these patients. Patients were identified from three tertiary orthopaedic oncology centres in Canada and the UK. Patients who developed multiple extremity STSs were collated retrospectively from prospective oncology databases. A literature review using MEDLINE was also performed. Six patients were identifie...
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy.
Conclusion: Stereotactic body radiotherapy is an effective and safe treatment for the ablation of pulmonary metastasis from sarcoma. Further work is needed to evaluate the optimal role of SBRT relative to surgery or chemotherapy for treatment of metastatic sarcoma. PMID: 29808081 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Epidemiology of Adult Soft-Tissue Sarcomas in Germany.
Authors: Saltus CW, Calingaert B, Candrilli S, Lorenzo M, D'yachkova Y, Otto T, Wagner U, Kaye JA Abstract We conducted a retrospective cohort study using data compiled from the regional German cancer registries by the Centre for Cancer Registry Data (ZfKD) at the Robert Koch Institut (RKI) to describe the epidemiology of adult soft-tissue sarcomas (STS) in Germany in 2003-2012, focusing on advanced STS. We identified 33,803 incident adult cases of STS (other than the Kaposi sarcoma and gastrointestinal stromal tumors). The incidence of STS was 6.05 (95% confidence interval (CI), 5.82-6.29) per 100,000 in 2012 (4,0...
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Improving Long-Term Outcomes for Patients with Extra-Abdominal Soft Tissue Sarcoma Regionalization to High-Volume Centers, Improved Compliance with Guidelines or Both?
Authors: Bagaria SP, Chang YH, Gray RJ, Ashman JB, Attia S, Wasif N Abstract Introduction: Optimization of outcomes of extra-abdominal STS is not clearly understood. We sought to determine whether hospital surgical volume and adherence to NCCN guidelines, or both, are associated with outcomes in the treatment of extra-abdominal soft tissue sarcoma (STS). Methods: The National Cancer Database (NCDB) was queried for patients undergoing surgery for extra-abdominal STS diagnosed from 2003 to 2007. Mean annual hospital volume for STS surgery was divided into volume terciles (1T ≤3, 2T 4-10, and 3T ≥11 cases/ye...
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Outcome for Advanced or Metastatic Soft Tissue Sarcoma of Nonextremities Treated with Doxorubicin-Based Chemotherapy: A Retrospective Study from a Single Cancer Institution.
Conclusions: Combination therapy showed better response and TTF than monotherapy but did not show better OS. Possible prognostic factors for OS were indicated. This retrospective study was approved by the institutional review board. This trial is registered with UMIN000028787. PMID: 29849480 [PubMed] (Source: Sarcoma)
Source: Sarcoma - June 1, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Cost-Effectiveness of Olaratumab in Combination with Doxorubicin for Patients with Soft Tissue Sarcoma in the United States.
Conclusion: Olara + Dox is cost-effective for STS treatment compared with Dox and other standard-of-care regimens at willingness-to-pay thresholds of $150,000 per LY and above. PMID: 29785170 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 25, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

The Value of MRI in Distinguishing Subtypes of Lipomatous Extremity Tumors Needs Reassessment in the Era of MDM2 and CDK4 Testing.
Conclusion: The accuracy of both our readers and the formula suggests that MRI remains unreliable for distinguishing between lipoma and WDLs. PMID: 29755284 [PubMed] (Source: Sarcoma)
Source: Sarcoma - May 15, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma.
Authors: Koenig JL, Tsai CJ, Sborov K, Horst KC, Pollom EL Abstract Private insurance is associated with better outcomes in multiple common cancers. We hypothesized that insurance status would significantly impact outcomes in primary breast sarcoma (PBS) due to the additional challenges of diagnosing and coordinating specialized care for a rare cancer. Using the National Cancer Database, we identified adult females diagnosed with PBS between 2004 and 2013. The influence of insurance status on overall survival (OS) was evaluated using the Kaplan-Meier estimator with log-rank tests and Cox proportional hazard models....
Source: Sarcoma - May 9, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Limb-Salvage Surgery of Soft Tissue Sarcoma with Sciatic Nerve Involvement.
Conclusion: In a cohort of carefully selected patients with STS and sciatic nerve involvement, the extent of sciatic nerve resection had no significant impact on disease recurrence or survival. Precise classification of neural involvement may therefore be useful in selecting the appropriate degree of nerve resection, without compromising oncological outcome or unnecessarily sacrificing leg function. PMID: 29692655 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 27, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

When Do Orthopaedic Oncologists Consider the Implantation of Expandable Prostheses in Bone Sarcoma Patients?
Conclusions: Our survey confirmed the literature with 3-4 cm as the minimum estimated growth deficit. The minimum age for the implantation of a growing prosthesis is approx. 6.6 years, and therefore the patients are younger than those reported in previous publications. One-quarter of orthopaedic surgeons do not use growing prostheses at all. It remains unclear whether growing prostheses are indicated in patients with metastatic disease. PMID: 29681761 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 25, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation.
Conclusions: PRE biomarker expression did not predict survival outcomes. Expression pattern changes after neoadjuvant chemoradiation supports the concepts of tumor reoxygenation, altered HIF-1α signaling, and a p53 nuclear accumulation DNA damage response. Clinical Trial Registration: NRG Oncology RTOG 9514 is registered with ClinicalTrials.gov. The ClinicalTrials.gov Identifier is NCT00002791. PMID: 29681762 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 25, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing.
Conclusion: These data indicate that initiating aerosol GCB postoperatively may kill residual lung metastases thereby preventing relapse and improve survival. PMID: 29610563 [PubMed] (Source: Sarcoma)
Source: Sarcoma - April 5, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Single-Centre Experience of Systemic Treatment with Vincristine, Ifosfamide, and Doxorubicin Alternating with Etoposide, Ifosfamide, and Cisplatin in Adult Patients with Ewing Sarcoma.
In this report, we describe our experience with the alternating use of triple combination therapies based on vincristine, ifosfamide, and doxorubicin (VIA) and an etoposide, ifosfamide, and cisplatin combination (VIP). We retrospectively evaluated the response rates, outcome, and tolerance of adult patients (n = 64) treated with VIA/VIP between 1990 and 2014. The patients included were treated with perioperative chemotherapy (53.1% neoadjuvant therapy and 17.2% adjuvant therapy) or had synchronous metastases at diagnosis (29.7%). Five-year overall survival rate was 52.2% for all patients, 72.2% for patients w...
Source: Sarcoma - March 15, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Treatment of Recurrent or Metastatic Uterine Adenosarcoma.
Conclusion: These results suggest that surgery is an important treatment modality for recurrent or metastatic uterine adenosarcoma, and the most effective chemotherapeutics are doxorubicin/ifosfamide and gemcitabine/docetaxel. PMID: 29445312 [PubMed] (Source: Sarcoma)
Source: Sarcoma - February 17, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Ovary-Sparing Radiation Planning Techniques Can Achieve Ovarian Dose Reduction for Soft Tissue Sarcoma of the Buttock and Thigh.
Authors: Kovtun KA, Yeo WP, Phillips CH, Viswanathan A, Baldini EH Abstract Background and Objectives: Attention to ovary dose is important for premenopausal women undergoing radiation therapy (RT) and must not be overlooked when treating extremity sarcoma. We assessed whether ovary-sparing RT plans could decrease ovary dose without compromising target coverage. Methods: Standard sarcoma target volumes and organs at risk (OAR) were contoured by a sarcoma dedicated radiation oncologist on CT planning scans for 23 women with thigh or buttock sarcoma. IMRT plans (50 Gy) with and without attempted ovary-spar...
Source: Sarcoma - January 11, 2018 Category: Cancer & Oncology Tags: Sarcoma Source Type: research

Desmoplastic Small Round Blue Cell Tumor: A Review of Treatment and Potential Therapeutic Genomic Alterations.
Authors: Bulbul A, Fahy BN, Xiu J, Rashad S, Mustafa A, Husain H, Hayes-Jordan A Abstract Desmoplastic small round blue cell tumors (DSRCTs) originate from a cell with multilineage potential. A molecular hallmark of DSRCT is the EWS-WT1 reciprocal translocation. Ewing sarcoma and DSRCT are treated similarly due to similar oncogene activation pathways, and DSRCT has been represented in very limited numbers in sarcoma studies. Despite aggressive therapy, median survival ranges from 17 to 25 months, and 5-year survival rates remain around 15%, with higher survival reported among those undergoing removal of at least 90...
Source: Sarcoma - December 13, 2017 Category: Cancer & Oncology Tags: Sarcoma Source Type: research