Spatial structure and oligomerization of viscotoxin A3 in detergent micelles: Implication for mechanisms of ion channel formation and membrane lysis
Biochem Biophys Res Commun. 2021 Nov 9;585:22-28. doi: 10.1016/j.bbrc.2021.11.022. Online ahead of print.ABSTRACTThionins are the family of small (∼5 kDa) cationic cysteine-rich peptides involved in the immune response in plants. Viscotoxin A3 (VtA3) is the thionin from mistletoe (Viscum album) demonstrating antimicrobial and cytotoxic activity against cancer cells in vitro. VtA3 (charge +6) interacts with the membranes containing anionic lipids and forms cation-selective ion channels. Here we studied the VtA3 structure in membrane-mimicking media by NMR spectroscopy. Spatial structure of VtA3, consisting of a helical ha...
Source: Biochemical and Biophysical Research communications - November 15, 2021 Category: Biochemistry Authors: Alexander S Paramonov Ekaterina N Lyukmanova Alexander G Tonevitsky Alexander S Arseniev Zakhar O Shenkarev Source Type: research
Molecules, Vol. 26, Pages 4986: Green Synthesis of Silver Nanoparticles Using Natural Extracts with Proven Antioxidant Activity
ołodziej
Natural extracts are a rich source of biomolecules that are useful not only as antioxidant drugs or diet supplements but also as complex reagents for the biogenic synthesis of metallic nanoparticles. The natural product components can act as strong reducing and capping substrates guaranteeing the stability of formed NPs. The current work demonstrates the suitability of extracts of Camellia sinensis, Ilex paraguariensis, Salvia officinalis, Tilia cordata, Levisticum officinale, Aegopodium podagraria, Urtica dioica, Capsicum baccatum, Viscum album, and marine algae Porphyra Yezoensis for green synthesis of AgNP...
Source: Molecules - August 17, 2021 Category: Chemistry Authors: Jolanta Flieger Wojciech Franus Rafa ł Panek Monika Szyma ńska-Chargot Wojciech Flieger Micha ł Flieger Przemys ław Kołodziej Tags: Article Source Type: research
The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation
J Immunol Res. 2021 Jun 29;2021:2183427. doi: 10.1155/2021/2183427. eCollection 2021.ABSTRACTKorean mistletoe has anti-inflammatory and antioxidant functions and may be a useful training supplement. We investigated the effect of Korean mistletoe extract (KME) on inflammatory markers after high-intensity exercise by 20 university male rowers (KME group vs. CON group) consuming 110 mL KME/dose (2 times a day over 8 weeks). Blood samples were collected for measurement of serum cytokine levels at baseline, immediately after exercise, and following 30 minutes of recovery. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-Î...
Source: Journal of Immunology Research - July 26, 2021 Category: Allergy & Immunology Authors: Soo-Min Ha Ji-Hyeon Kim Jong-Won Kim Do-Yeon Kim Min-Seong Ha Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Gender dimorphism in the virulence of a dioecious mistletoe
Int J Parasitol. 2021 Jul 14:S0020-7519(21)00217-4. doi: 10.1016/j.ijpara.2021.05.007. Online ahead of print.ABSTRACTParasite virulence often differs between male and female hosts. However, less is known about how virulence might differ between male and female parasites. Here, I show that female plants of the dioecious mistletoe Misodendrum quadrifolium (Misodendraceae) grow larger than male plants. Correspondingly, females reduce the photosynthetic capacity of infected host branches more than males. Results indicate that in addition to playing an important role in determining host susceptibility to parasitism, gender can ...
Source: International Journal for Parasitology - July 17, 2021 Category: Parasitology Authors: K C Burns Source Type: research
Molecules, Vol. 26, Pages 3741: Impact of Harvest Conditions and Host Tree Species on Chemical Composition and Antioxidant Activity of Extracts from Viscum album L.
wak
The content of plant secondary metabolites is not stable, and factors such as the region/location effect and seasonal variations have an impact on their chemical composition, especially in parasitic plants. Research in this area is an important step in the development of quality parameter standards of medicinal plants and their finished products. The effects of the time and place of harvest and the host tree species on the chemical composition and antioxidant activity of mistletoe extracts were investigated. Statistical tools were used to evaluate the results of the spectrophotometric and LC-ESI-MS/MS studies of th...
Source: Molecules - June 19, 2021 Category: Chemistry Authors: Wioleta Pietrzak Renata Nowak Tags: Article Source Type: research
Complementary medicine in uro-oncology
Urologe A. 2021 Jun 15. doi: 10.1007/s00120-021-01584-8. Online ahead of print.ABSTRACTComplementary and alternative medicine (CAM) is widespread in oncology patients with a user rate of approximately 40-50%. An accompanying supportive effect can arise through improved adherence, especially in long-term (e.g. endocrine) therapies through active patient involvement. When assessing the evidence on frequently requested methods, there is no high-quality evidence that homeopathy or anthroposophy leads to an improved prognosis. Mistletoe therapy can be considered to improve the quality of life, although the data quality is weak....
Source: Der Urologe. Ausg. A - June 15, 2021 Category: Urology & Nephrology Authors: Jutta H übner Ralph M ücke Oliver Micke Christian Keinki Source Type: research
Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: a cohort study
Mistletoe extract, used as a complementary chemotherapeutic agent for cancer patients, has anticancer effects against various malignancies. The aim of the present study was to evaluate the effect of mistletoe ... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - June 15, 2021 Category: Cancer & Oncology Authors: Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung and Kyung-Ok Kim Tags: Research Source Type: research
