Mistletoe and Immunomodulation: Insights and Implications for Anticancer Therapies.
Authors: Oei SL, Thronicke A, Schad F
Abstract
In early tumor development, cancer cells develop a plethora of strategies to escape surveillance from the adaptive and innate immune system. Cancer immunotherapies, in particular immune checkpoint inhibitors, are becoming a highly promising cancer therapeutic approach that has remarkable increased progress in combating various cancer types. Unfortunately, their mechanisms of action induce some complications, such as inflammatory reactions and immune-related adverse events. In the management of side effects during anticancer therapy, complementary and integrati...
Source: Evidence-based Complementary and Alternative Medicine - May 25, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Biochemical and morphological changes in mouse liver induced by mistletoe toxins.
The objective of this study was to investigate short-term effects (up to 48 h) of mistletoe toxins on mouse hepatocytes. Standardized mistletoe extract Iscador P was given to female mice as a single injection (0.1 mg/kg b.w., 1 mg/kg b.w., or 2 mg/kg b.w). Activities of lysosomal hydrolases: acid phosphatase, cathepsins D and L, N-acetyl-β-D-hexosaminidase, β-D-glucuronidase, β-D-glucosidase and cytosolic proteases: arginine and leucine aminopeptidases were analyzed in the liver fractions 24 and 48 h after the injection. The morphology of hepatocytes was examined by light and transmission electron microscopy. ...
Source: Food and Chemical Toxicology - April 25, 2019 Category: Food Science Authors: Wieczorek A, Lysek-Gladysinska M, Krol T, Kordos K, Kosińska K, Atanasov AG, Strzalkowska N, Jozwik A Tags: Food Chem Toxicol Source Type: research
The Pulse-Respiration Quotient: A Powerful but Untapped Parameter for Modern Studies About Human Physiology and Pathophysiology
This study only analyzed the PRQ phases that showed a constant PRQ over a specific period (frequency coupling) and also a phase entrainment between HR and RR (phase coupling) during this time. During sleep, a complex correlation between the HR and the RR is evident with the PRQ capturing one specific aspect. In a study investigating the N-rs-PRQ with a detailed division of the sleep stages (five stages), Zerm et al. (2008) showed that there is a positive correlation between the N-rs-PRQ and the sleep depth, i.e., the higher the depth of sleep, the lower the N-rs-PRQ. In this study, sleep depth was defined according...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research
ERRATUM TO: Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report.
Authors: Werthmann PG, Kempenich R, Kienle GS
PMID: 30939264 [PubMed - in process] (Source: The Permanente journal)
Source: The Permanente journal - April 4, 2019 Category: General Medicine Tags: Perm J Source Type: research
Long-term survival of a patient with advanced pancreatic cancer under adjunct treatment with Viscum album extracts: A case report.
CONCLUSION: We present the case of a patient with aPC with R1-resection with development of liver metastasis during the course of treatment who showed an overall survival of 63 mo and a relapse-free survival of 39 mo under increasing VAE therapy. The possible synergistic effect on tumor control of RFA treatment and immune-stimulatory effects of VAE should be further investigated.
PMID: 30948915 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 27, 2019 Category: Gastroenterology Authors: Werthmann PG, Kempenich R, Lang-Avérous G, Kienle GS Tags: World J Gastroenterol Source Type: research
