Malignant Fibrous Histiocytoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

[Soft tissue tumors : Epidemiology, classification and staging].
Abstract Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. g. undifferentiated sarcomas have been formed into a new subgroup and are no longer assigned to the fibrohistiocytic tumors. The term malignant fibrous histiocytoma has been replaced by the undifferentiated sarcoma. Furthermore, two new subgroups were incorporat...
Source: Der Radiologe - October 26, 2017 Category: Radiology Authors: Fenzl L, Mehrmann M, Kremp K, Schneider G Tags: Radiologe Source Type: research

Asymptomatic giant retroperitoneal mass detected at a medical checkup
Key Clinical Message The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosis than other soft tissue sarcomas. Soft tissue sarcoma of retroperitoneal origin often remains asymptomatic until tumor enlargement, leading to diagnosis at advanced stages. The differential diagnosis of retroperitoneal mass includes liposarcoma, leiomyosarcoma, malignant fibrous histiocytoma, neurofibroma, stromal tumor, teratoma, and lymphoma. Leiomyosarcoma is rare with poorer prognosi...
Source: Clinical Case Reports - October 16, 2017 Category: General Medicine Authors: Tsutomu Takeda, Daisuke Asaoka, Yuki Fukumura, Sumio Watanabe Tags: Clinical Image Source Type: research

Malignant fibrous histiocytoma in the right portion of the mandible with metastasis in pancreas
Conclusion Malignant fibrous histiocytoma is a potentially curable disease. The most important part of the treatment is complete surgical removal, usually followed by adjuvant radiation therapy. Chemotherapy is a treatment usually used only on those patients with higher recurrence risk or on those showingrecurrence or who have already showed recurrence. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 13, 2017 Category: Surgery Source Type: research

Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
CONCLUSION: ILP and ILI for extremity STS can be safely performed with appreciable response rates and significant limb salvage rates. Further study is needed to identify optimal treatment regimens by histology. PMID: 29022281 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 11, 2017 Category: Cancer & Oncology Authors: Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC Tags: Ann Surg Oncol Source Type: research

Malignant fibrous histiocytoma: Database review suggests a favorable prognosis in the head and neck
ConclusionHead and neck malignant fibrous histiocytoma presents at a smaller size and lower grade, likely due to earlier presentation in this region. Because of this, head and neck malignant fibrous histiocytoma represents a more favorable survival prognosis compared with trunk and extremity disease. Level of Evidence4. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - October 8, 2017 Category: ENT & OMF Authors: Robert B. Borucki, David M. Neskey, Eric J. Lentsch Tags: Head and Neck Source Type: research

Malignant fibrous histiocytoma: Database review suggests a favorable prognosis in the head and neck
The Laryngoscope,Volume 128, Issue 4, Page 885-888, April 2018. (Source: The Laryngoscope)
Source: The Laryngoscope - October 8, 2017 Category: ENT & OMF Source Type: research

Primary pulmonary malignant fibrous histiocytoma: case report and literature review.
Authors: Li X, Liu R, Shi T, Dong S, Ren F, Yang F, Ren D, Fan H, Wei S, Chen G, Chen J, Xu S Abstract Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature...
Source: Journal of Thoracic Disease - September 23, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Treatment outcomes of malignant fibrous histiocytoma of the maxillary sinus
Conclusions: Surgical resection is the mainstay of treatment for MFH of the maxillary sinus. A radical resection with clear margins is essential for excellent local control and long-term survival. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 13, 2017 Category: Cancer & Oncology Authors: Hui Huang Dezhi Li Xiaolei Wang Yuehuang Wu Shaoyan Liu Zhengang Xu Source Type: research

Identifying actionable variants using next generation sequencing in patients with a historical diagnosis of undifferentiated pleomorphic sarcoma
This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re‐evaluation by a pathologist specializing in sarcoma. Tumor DNA was isolated from archived fresh frozen tissue samples and genotyped using NGS with the Illumina MiSeq TruSeq Amplicon Cancer Panel (48 genes, 212 amplicons). In total, 95 patients initially classified with UPS were identified. Following pathology re‐review the histological subtypes were reclassified to include: Myxofibrosarcoma (MFS, N=44); UPS(N=18); a...
Source: International Journal of Cancer - September 10, 2017 Category: Cancer & Oncology Authors: Jeremy Lewin, Swati Garg, Beatrice Y Lau, Brendan C Dickson, Frank Traub, Nalan Gokgoz, Anthony M Griffin, Peter C Ferguson, Irene L Andrulis, Hao ‐Wen Sim, Suzanne Kamel‐Reid, Tracy L Stockley, Lillian Siu, Jay S Wunder, Albiruni RA Razak Tags: Research Article Source Type: research

Malignant fibrous histiocytoma arising from renal capsule: An extremely rare entity.
Abstract Malignant fibrous histiocytoma (MFH) usually presents in the extremities or retroperitoneum. MFH arising from renal parenchyma or renal capsule is extremely rare, only few cases have been reported in literature and portend a poor prognosis. Renal MFH is differentiated from renal cell carcinoma, renal sarcoma, and sarcomatoid renal tumor only by histological and immunohistochemical studies. Since the therapeutic options for MFH are different, its early diagnosis is imperative. Herein, we report a case of a primary renal MFH in a 35-year-old male. PMID: 28937382 [PubMed - in process] (Source...
Source: Indian Journal of Pathology and Microbiology - July 1, 2017 Category: Pathology Authors: Bairwa S, Sangwaiya A, Ansari M, Jindal A, Singla S, Yadav A Tags: Indian J Pathol Microbiol Source Type: research

Superficial CD34-positive fibroblastic tumor: A new entity; case report and review of literature.
Abstract Earlier, categorized under low grade malignant fibrous histiocytoma and low grade sarcomas, 'superficial CD34 positive fibroblastic tumor', a newly proposed entity, is a low grade mesenchymal tumor of intermediate malignant potential. Morphological features include monomorphic neoplastic spindle cells arranged in a fascicular to storiform pattern along with sheets of pleomorphic epithelioid cells, and multinucleated giant cells with glassy cytoplasm. Diffuse vimentin and characteristic diffuse CD34 positivity is seen in all cases with few showing focal cytokeratin expression. Rest of the melanocyt...
Source: Indian Journal of Pathology and Microbiology - July 1, 2017 Category: Pathology Authors: Sood N, Khandelia BK Tags: Indian J Pathol Microbiol Source Type: research

An Analysis of Tumor- and Surgery-Related Factors that Contribute to Inadvertent Positive Margins Following Soft Tissue Sarcoma Resection
ConclusionsIPMs after STS resection results in substantial LR risk. While demonstrating distinct surgery- and tumor-related contributions, there was no between-group difference in LR or OS. These results may aid in avoiding IPMs.Level of EvidenceTherapeutic Level III, retrospective comparative study (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 29, 2017 Category: Cancer & Oncology Source Type: research

Soft Tissue Tumors Rarely Presenting Primary in Bone; Diagnostic Pitfalls
Primary bone sarcomas represent extremely rare entities. The use of now abolished labels, such as malignant fibrous histiocytoma and hemangiopericytoma, has significantly hampered the chance of identifying specific entities. It is now accepted that a broad variety of mesenchymal malignancies most often arising on the soft tissue may actually present as primary bone lesions. A more accurate morphologic partition is justified based on availability of distinct therapeutic options. An integrated diagnostic approach represents the only way to achieve a correct classification. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - June 29, 2017 Category: Pathology Authors: Marta Sbaraglia, Alberto Righi, Marco Gambarotti, Daniel Vanel, Piero Picci, Angelo P. Dei Tos Source Type: research

MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239
This study investigated the role of MFHAS1 in TLR4 signaling pathway and the possible mechanisms implicated. The results indicated that the expression of MFHAS1 was significantly increased in cells stimulated with LPS. Up-regulation of MFHAS1 effectively suppressed inflammatory cytokine expression in cells exposed to LPS, whereas down-regulation of MFHAS1 markedly increased inflammatory cytokines expression. Co-immunoprecipitation, pull-down and immunofluorescence tests demonstrated that MFHAS1 combined with the B and C subunits of PP2A and induced cytoplasm translocation of the C subunit, leading to decrease dephosphoryla...
Source: Molecular Immunology - June 11, 2017 Category: Allergy & Immunology Source Type: research

Primary hepatic malignant fibrous histiocytoma combined with invasion of inferior vena cava: A case report and literature review
Rationale: Malignant fibrous histiocytoma (MFH), primary presented in liver, was very rare and displayed a poor prognosis because of high aggression. As a few of cases had been reported merely, we shared the case of primary hepatic MFH combined with invasion of inferior vena cava (IVC). Patients concerns: A 69-year-old women presented with abdominal pain. Diagnoses: Abdominal computed tomography and magnetic resonance imaging indicated a soft mass about 5.4 × 4.2 cm in the caudate lobe, accompanied with IVC invaded. Interventions: After the multidisciplinary consultation, laparotomy was performed, followed by che...
Source: Medicine - June 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research