Work Stress and the Risk of Cancer: a Meta ‐analysis of Observational Studies
This study aimed to investigate the association between work stress and the risk of cancer and in relation to major potential confounding and modifying factors. We systematically searched three electronic databases, hand ‐searched references and citations of retrieved articles, and consulted experts to identify studies on assessing the association between work stress and the risk of cancer. The relative risks (RRs) of cancer associated with work stress were estimated using a random‐effects model, and stratified by exposure measurement, study design, gender, study location, cancer site, smoking, drinking, body mass inde...
Source: International Journal of Cancer - November 28, 2018 Category: Cancer & Oncology Authors: Tingting Yang, Yan Qiao, Siyun Xiang, Wenzhen Li, Yong Gan, Yongchun Chen Tags: Research Article Source Type: research

The role of microbiota in the development of colorectal cancer
This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Zhujiang Dai, Jingqiu Zhang, Qi Wu, Juan Chen, Jun Liu, Lu Wang, Chaowu Chen, Jiaming Xu, Hongpeng Zhang, Chunfeng Shi, Zhen Li, Huiwen Fang, Chaobiao Lin, Dong Tang, Daorong Wang Tags: Mini Review Source Type: research

Issue Information
International Journal of Cancer, Volume 143, Issue 12, Page 3282-3283, 15 December 2018. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

Issue Information
International Journal of Cancer, Volume 143, Issue 12, Page 3043-3049, 15 December 2018. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

A functional ex vivo assay to detect PARP1 ‐EJ repair and radiosensitization by PARP‐inhibitor in prostate cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Authors: S. K öcher, B. Beyer, T. Lange, L. Nordquist, J. Volquardsen, S. Burdak‐Rothkamm, T. Schlomm, C. Petersen, K. Rothkamm, W.Y. Mansour Tags: Research Article Source Type: research

Large scale in ‐vivo micro‐RNA loss of function screen identified miR‐29a, miR‐100 and miR‐155 as modulators of radioresistance and tumor‐stroma communication
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Azadeh Fahim Golestaneh, Laura S.M. Lecker, Julian Schlegel, Ali Nowrouzi, Christian Schwager, Sarah Meister, Wilko Weichert, J ürgen Debus, Amir Abdollahi Tags: Research Article Source Type: research

Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Kamal Pandey, Hee ‐Jung An, Seung Ki Kim, Seung Ah Lee, Sewha Kim, Sun Min Lim, Gun Min Kim, Joohyuk Sohn, Yong Wha Moon Tags: Mini Review Source Type: research

The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers
International Journal of Cancer, Volume 0, Issue ja, -Not available-. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 26, 2018 Category: Cancer & Oncology Authors: Kristina Klaschik, Jan Hauke, Guido Neidhardt, Christian Tr änkle, Harald M. Surowy, Stefanie Heilmann‐Heimbach, Gunter Rappl, Elisabeth Mangold, Norbert Arnold, Dieter Niederacher, Christian Sutter, Barbara Burwinkel, Christoph Engel, Bar Tags: Letter to the Editor Source Type: research

Response to: The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers
International Journal of Cancer, Volume 0, Issue ja, -Not available-. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 25, 2018 Category: Cancer & Oncology Authors: Daria R. Bulanova, Mikko Helenius, Anna P. Sokolenko, Sergey G. Kuznetsov, Evgeny N. Imyanitov Tags: Letter to the Editor Source Type: research

Increasing risk of uterine cervical cancer among young Japanese women: Comparison of incidence trends in Japan, South Korea and Japanese ‐Americans between 1985 and 2012
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 25, 2018 Category: Cancer & Oncology Authors: Mai Utada, Pavel Chernyavskiy, Won Jin Lee, Silvia Franceschi, Catherine Sauvaget, Amy Berrington de Gonzalez, Diana R. Withrow Tags: Research Article Source Type: research

Different characteristics and survival in non ‐small cell lung cancer patients with primary and acquired EGFR T790M mutation
Primary epidermal growth factor receptor (EGFR) T790M mutation can be occasionally identified in previous untreated non ‐small cell lung cancer (NSCLC) patients. To compare clinical characteristics and outcomes in patients with primary and acquired EGFR T790M mutation, we collected the data of patients diagnosed with EGFR mutation from 2012 to 2017 in Shanghai Chest Hospital. Primary EGFR T790M mutation was identif ied in 61 patients (1.1%; 95% confidence interval (CI): 0.8%‐1.3%) of 5685 TKI‐naive EGFR mutant patients. Acquired T790M mutation was detected in 98 patients (50.3%; 95%CI: 43.2%‐57.3%) of 195 TKI‐tre...
Source: International Journal of Cancer - November 25, 2018 Category: Cancer & Oncology Authors: Shuyuan Wang, Bo Yan, Yanwei Zhang, Jianlin Xu, Rong Qiao, Yu Dong, Bo Zhang, Yiming Zhao, Lele Zhang, Jie Qian, Jun Lu, Ruiying Zhao, Baohui Han Tags: Research Article Source Type: research

Strong associations of a healthy lifestyle with all stages of colorectal carcinogenesis: results from a large cohort of participants of screening colonoscopy
The risk of developing colorectal cancer (CRC) is associated with a wide range of dietary and lifestyle factors. The individual contribution of single modifiable factors, such as alcohol consumption, physical activity, smoking, body mass index (BMI) or dietary components, to the development of CRC has been investigated extensively, but evidence on their combined effect at various stages of colorectal carcinogenesis is sparse. The aim of this study was to analyze the association of a healthy lifestyle pattern with prevalence of early and advanced colorectal neoplasms. A total of 13,600 participants of screening colonoscopy ...
Source: International Journal of Cancer - November 23, 2018 Category: Cancer & Oncology Authors: Vanessa Erben, Prudence R Carr, Bernd Holleczek, Christa Stegmaier, Michael Hoffmeister, Hermann Brenner Tags: Research Article Source Type: research

A controlled trial of HNSCC patient ‐derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor alterations in the PI3K/AKT/mTOR signalling axis, particularly in thePIK3CA gene. PI3K ‐targeted agents have therefore gained considerable preclinical and clinical interest as emerging therapies for HNSCC. Identification of predictive biomarkers of response would advance the clinical application of PI3K‐targeted drugs for patients in order to achieve maximal benefit. To date, stud ies of drug biomarkers have largely focused on screening cell lines, with much more limitedin vivo testing, usually only as validation. This approach has rarely enabled accurat...
Source: International Journal of Cancer - November 23, 2018 Category: Cancer & Oncology Authors: Kara M. Ruicci, Jalna Meens, Ren X. Sun, Giananthony Rizzo, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Paul C. Boutros, Laurie Ailles, Anthony C. Nichols Tags: Short Report Source Type: research

Selective BTK inhibition improves bendamustine therapy response and normalizes immune effector functions in chronic lymphocytic leukemia
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 23, 2018 Category: Cancer & Oncology Authors: Eriong Lee ‐Vergés, Bola S. Hanna, Haniyeh Yazdanparast, Vanina Rodríguez, Marta Leonor Rodríguez, Ariadna Giró, Anna Vidal‐Crespo, Laia Rosich, Virginia Amador, Marta Aymerich, Neus Villamor, Julio Delgado, Peter Lichter, Patricia P Tags: Research Article Source Type: research

CLPTM1L/CRR9 Ectodomain Interaction with GRP78 at the Cell Surface Signals for Survival and Chemoresistance upon ER Stress in Pancreatic Adenocarcinoma Cells
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 23, 2018 Category: Cancer & Oncology Authors: William R. Clarke, Laufey Amundadottir, Michael A. James Tags: Research Article Source Type: research

Management of HPV ‐Positive Women in Cervical Screening Using Results from Two Consecutive Screening Rounds
We studied whether triage of human papillomavirus (HPV) ‐positive women participating in an HPV‐based screening programme can be improved by including the HPV result at the previous screen in the triage algorithm.We analyzed data of a subgroup of 366 women from the POBASCAM trial, screened by cytology and HPV co ‐testing. Women were included if they tested HPV‐positive in the second HPV‐based screening round. We evaluated the clinical performance of sixteen strategies, consisting of cytology, HPV genotyping, and/or previous screen HPV result. The clinical endpoint was cervical precancer or cancer (CIN 3+).The cur...
Source: International Journal of Cancer - November 22, 2018 Category: Cancer & Oncology Authors: Nicole J. Polman, Nienke J. Veldhuijzen, Dani ëlle. A.M. Heideman, Peter J.F. Snijders, Chris J.L.M. Meijer, Johannes Berkhof Tags: Research Article Source Type: research

Overweight in midlife and risk of cancer in late life: a nationwide Swedish twin study
In conclusion, midlife overweight is associated with increased risk of late‐life colon, liver, and uterine cancer but reduced risk of late‐life non‐melanoma skin cancer. Further investigations are warranted t o explore the role of genetic and early‐life environmental factors in these associations.This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 22, 2018 Category: Cancer & Oncology Authors: Cuiping Bao, Rongrong Yang, Nancy L Pedersen, Weige Xu, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu Tags: Research Article Source Type: research

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion ‐positive and fusion‐negative rhabdomyosarcoma
In conclusion, these findings highlight the interaction of epigenetic changes with mutational alterations and transcriptional organizati on in RMS tumors, and contribute to improved molecular categorization of these tumors.This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 22, 2018 Category: Cancer & Oncology Authors: Wenyue Sun, Bishwanath Chatterjee, Jack F. Shern, Rajesh Patidar, Young Song, Yonghong Wang, Robert L. Walker, Bruce R. Pawel, Corinne M. Linardic, Peter Houghton, Stephen M. Hewitt, Daniel C. Edelman, Javed Khan, Paul S. Meltzer, Frederic G Tags: Research Article Source Type: research

Alterations in the Gut Microbiota and Metabolite Profiles of Thyroid Carcinoma Patients
The aim of this study was to investigate the relationship among the gut microbiota community, metabolite profiles and thyroid carcinoma (TC). First, 30 TC patients and 35 healthy controls (HCs) fecal samples were applied to characterize the gut microbial community using 16S rRNA gene sequencing. Differential microbiota compositions were observed, with significant enrichment of 19 and depletion of 8 genera in TC samples compared with those in HCs (Q value
Source: International Journal of Cancer - November 22, 2018 Category: Cancer & Oncology Authors: Jing Feng, Fuya Zhao, Jiayu Sun, Baiqiang Lin, Lei Zhao, Yang Liu, Ye Jin, Shengda Li, Aidong Li, Yunwei Wei Tags: Research Article Source Type: research

An effective dendritic cell ‐based vaccine containing glioma stem‐like cell lysate and CpG adjuvant for an orthotopic mouse model of glioma
This study aimed to assess the therapeutic efficacy of a glioma vaccine called STDENVANT. This vaccine, comprising glioma stem ‐like cell (GSC) lysate, dendritic cells (DCs), and Toll‐like receptor (TLR) 9 agonist CpG motif‐containing oligodeoxynucleotides (CpG ODNs), was assessed using a GL261‐C57BL/6 orthotopic mouse model of glioma. STDENVANT markedly improved survival and tumor regression by enhancing anti‐tum or immune function. Moreover, STDENVANT upregulated programmed death 1 (PD‐1) and its ligand PD‐L1 on effector T cells, DCs, and glioma tissues, resulting in the accumulation of regulatory T (Treg) ...
Source: International Journal of Cancer - November 22, 2018 Category: Cancer & Oncology Authors: Shan Zhu, Xinping Lv, Xuhao Zhang, Tete Li, Guoxia Zang, Ning Yang, Xue Wang, Jing Wu, Wei Chen, Yong ‐Jun Liu, Jingtao Chen Tags: Research Article Source Type: research

Fecal microbiota transplantation in cancer management: Current status and perspectives
This article would help to better understand this new therapeutic approach for cancer patients by targeting gut microbiota.This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 20, 2018 Category: Cancer & Oncology Authors: Danfeng Chen, Jingyi Wu, Duochen Jin, Bangmao Wang, Hailong Cao Tags: Mini Review Source Type: research

Molecular and cellular basis of mammary gland fibrosis and cancer risk
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 19, 2018 Category: Cancer & Oncology Authors: Jianchun Wu, David L. Crowe Tags: Research Article Source Type: research

CTCs ‐derived xenograft development in a Triple Negative breast cancer case
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 19, 2018 Category: Cancer & Oncology Authors: Tais Pereira ‐Veiga, Manuel Abreu, Diego Robledo, Xavier Matias‐Guiu, María Santacana, Laura Sánchez, Juan Cueva, Patricia Palacios, Ihab Abdulkader, Rafael López‐López, Laura Muinelo‐Romay, Clotilde Costa Tags: Research Article Source Type: research

Erratum
International Journal of Cancer, EarlyView. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 18, 2018 Category: Cancer & Oncology Tags: Erratum Source Type: research

Long non ‐coding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell‐intrinsic properties
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 17, 2018 Category: Cancer & Oncology Authors: Peter W. Eide, Ina A. Eilertsen, Anita Sveen, Ragnhild A. Lothe Tags: Research Article Source Type: research

Measurement of Tumor Mutational Burden (TMB) in routine molecular diagnostics: in ‐silico and real‐life analysis of three larger gene panels
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 17, 2018 Category: Cancer & Oncology Authors: Volker Endris, Ivo Buchhalter, Michael Allg äuer, Eugen Rempel, Amelie Lier, Anna‐Lena Volckmar, Martina Kirchner, Moritz Winterfeld, Jonas Leichsenring, Olaf Neumann, Roland Penzel, Wilko Weichert, Hanno Glimm, Stefan Fröhling, Hauke Wi Tags: Research Article Source Type: research

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia
In conclusion, we report that DNA methylation profiles may vary even among CLL patients with similar somatic hypermutation status, supporting a compartmentalized approach to dissecting CLL biology. Furthermore, we highlight p63 as a novel prosurvival factor in CLL, thus identifying ano ther piece of the complex puzzle of clinical aggressiveness.This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 16, 2018 Category: Cancer & Oncology Authors: Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, Theodoros Moysiadis, Sujata Bhoi, Andigoni Malousi, Fotis Psomopoulos, Larry Mansouri, Stamatia Laidou, Despoina Papazoglou, Maria Gounari, Konstantinos Pasentsis, Karla Plevova, V Tags: Research Article Source Type: research

Challenges in Assessing the Sunscreen ‐Melanoma Association
Whether sunscreen use affects melanoma risk has been widely studied with contradictory results. To answer this question we performed a systematic review of all published studies, accounting for sources of heterogeneity and bias. We searched for original articles investigating the sunscreen ‐melanoma association in humans to 28.02.2018. We then used random‐effects meta‐analysis to combine estimates of the association, stratified by study design. Stratified meta‐analysis and meta‐regression were used to identify sources of heterogeneity. We included 21'069 melanoma cases from 28 studies published 1979‐2018: 23 ca...
Source: International Journal of Cancer - November 16, 2018 Category: Cancer & Oncology Authors: Corina S Rueegg, Jo S Stenehjem, Matthias Egger, Reza Ghiasvand, Eunyoung Cho, Eiliv Lund, Elisabete Weiderpass, Adele C Green, Marit B Veier ød Tags: Research Article Source Type: research

Issue Information
International Journal of Cancer, Volume 143, Issue 11, Page 3041-3042, 1 December 2018. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 14, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

Issue Information
International Journal of Cancer, Volume 143, Issue 11, Page 2617-2627, 1 December 2018. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 14, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

Progression ‐free survival and one‐year milestone survival as surrogates for overall survival in previously treated advanced non‐small cell lung cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Shen Zhao, Zhonghan Zhang, Yaxiong Zhang, Shaodong Hong, Ting Zhou, Yunpeng Yang, Wenfeng Fang, Hongyun Zhao, Li Zhang Tags: Research Article Source Type: research

Connecting the dots between metformin and high ‐grade glioma
International Journal of Cancer, Volume 0, Issue ja, -Not available-. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Victor M. Lu Tags: Letter to the Editor Source Type: research

Circulating mir ‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Orazio Fortunato, Cristina Borzi, Massimo Milione, Giovanni Centonze, Davide Conte, Mattia Boeri, Carla Verri, Massimo Moro, Federica Facchinetti, Francesca Andriani, Luca Roz, Laura Caleca, Veronica Huber, Agata Cova, Chiara Camisaschi, Ch Tags: Research Article Source Type: research

Assessment of herd effects among women and heterosexual men following girls ‐only HPV16/18 vaccination in the Netherlands: a repeated cross‐sectional study
Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls ‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross‐sectional study, the HPV prevalence among 16‐ to 24‐year‐old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE...
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Petra J Woestenberg, Johannes A Bogaards, Audrey J King, Suzan Leussink, Marianne AB Sande, Christian JPA Hoebe, Birgit HB Benthem, on behalf of the Medical Microbiological Laboratories and the Public Health Services Tags: Research Article Source Type: research

Reply to Lu: Connecting the dots between metformin and high ‐grade glioma
International Journal of Cancer, Volume 0, Issue ja, -Not available-. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Corinna Seliger, Michael Gerken, Michael F. Leitzmann, Peter Hau Tags: Letter to the Editor Source Type: research

Serum Copper and Zinc levels at Diagnosis and Hepatocellular Carcinoma Survival in the Guangdong Liver Cancer Cohort
Copper and zinc are essential micronutrients, whose imbalance may be involved in the development and progression of cancer. However, the role of copper and/or zinc imbalance in the prognosis of hepatocellular carcinoma (HCC) is currently unclear. Our objective was to investigate the association between serum levels of copper, zinc and their ratio (copper/zinc) at diagnosis with HCC survival. We included 989 patients with incident HCC in this prospective cohort study, who were enrolled in the Guangdong Liver Cancer Cohort (GLCC) study within 30 days of diagnosis between September 2013 and February 2017. Serum copper and zin...
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Ai ‐Ping Fang, Pei‐Yan Chen, Xiao‐Yan Wang, Zhao‐Yan Liu, Dao‐Ming Zhang, Yun Luo, Gong‐Cheng Liao, Jing‐An Long, Rong‐Huan Zhong, Zhong‐Guo Zhou, Yan‐Jun Xu, Xiao‐Jun Xu, Wen‐Hua Ling, Min‐Shan Chen, Yao‐Jun Zhan Tags: Research Article Source Type: research

Coffee and pancreatic cancer risk among never ‐smokers in the UK prospective Million Women Study
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Charlie D Zhou, Ai Seon Kuan, Gillian K Reeves, Jane Green, Sarah Floud, Valerie Beral, Tie nYu Owen Yang, on behalf of the Million Women Study Collaborators Tags: Short Report Source Type: research

Epidemiology and outcomes of acute kidney injury in hospitalized cancer patients in China
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Yichun Cheng, Sheng Nie, Lu Li, Yanqin Li, Diankun Liu, Mengqi Xiong, Long Wang, Shuwang Ge, Gang Xu, on behalf of the EACH study investigators Tags: Research Article Source Type: research

A plasma metabolite panel as biomarkers for early primary breast cancer detection
In conclusion, using a metabolomics approach, we identified metabolites that have potential value for development of a multimarker blood ‐based test to complement and improve early breast cancer detection. The panel identified herein might be part of a prescreening tool, especially for younger women or for closely observing women with certain risks, to facilitate decision making regarding which individuals should undergo further di agnostic tests. In the future, the combination of metabolites and other blood‐based molecular marker sets, such as DNA methylation, microRNA, and cell‐free DNA mutation markers, will be an...
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Baowen Yuan, Simon Schafferer, Qiuqiong Tang, Matthias Scheffler, Juliane Nees, J örg Heil, Sarah Schott, Michael Golatta, Markus Wallwiener, Christof Sohn, Therese Koal, Barbara Wolf, Andreas Schneeweiß, Barbara Burwinkel Tags: Research Article Source Type: research

The identification of pathogenic variants in BRCA1/2 negative, high risk, hereditary breast and/or ovarian cancer patients: high frequency of FANCM pathogenic variants
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Stephanie Schubert, Jana L. Luttikhuizen, Bernd Auber, Gunnar Schmidt, Winfried Hofmann, Judith Penkert, Colin F. Davenport, Ursula Hille ‐Betz, Lena Wendeburg, Janin Bublitz, Marcel Tauscher, Karl Hackmann, Evelin Schroeck, Caroline Scholz Tags: Research Article Source Type: research

Brd4 inhibition suppresses HPV16 E6 expression and enhances chemoresponse: A potential new target in cervical cancer therapy
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Olga Rataj, Juliane Haedicke ‐Jarboui, Frank Stubenrauch, Thomas Iftner Tags: Research Article Source Type: research

Altered function of the glutamate ‐aspartate transporter GLAST, a potential therapeutic target in glioblastoma
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 12, 2018 Category: Cancer & Oncology Authors: Cristina Corbetta, Natalia Di Ianni, Maria Grazia Bruzzone, Monica Patan è, Bianca Pollo, Gabriele Cantini, Manuela Cominelli, Ileana Zucca, Federica Pisati, Pietro Luigi Poliani, Gaetano Finocchiaro, Serena Pellegatta Tags: Research Article Source Type: research

Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti ‐PD‐1 inhibitor
Although programmed death (PD) ‐1 immune checkpoint therapies target the immune system, the relationship between inflammatory factors and the clinical outcome of anti‐PD‐1 therapy for nonsmall cell lung cancer (NSCLC) is not fully understood. Here we examined the association between soluble immune mediators and the outcome of treatment with PD‐1 inhibitors in patients with advanced/recurrent NSCLC. In two independent cohorts, we assessed the levels of 88 different soluble immune mediators in peripheral blood before and after anti‐PD‐1 treatment, and evaluated their associations with clinical outcomes. In the tr...
Source: International Journal of Cancer - November 12, 2018 Category: Cancer & Oncology Authors: Norikazu Matsuo, Koichi Azuma, Satoshi Hattori, Junya Ohtake, Akihiko Kawahara, Hidenobu Ishii, Takaaki Tokito, Kazuhiko Yamada, Yuji Shibata, Tadasuke Shimokawaji, Tetsuro Kondo, Terufumi Kato, Haruhiro Saito, Kouzo Yamada, Tetsuro Sasada, Tags: Cancer Therapy and Prevention Source Type: research

Upregulation of mtSSB by interleukin ‐6 promotes cell growth through mitochondrial biogenesis‐mediated telomerase activation in colorectal cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 10, 2018 Category: Cancer & Oncology Authors: Gang Wang, Qian Wang, Qichao Huang, Yibing Chen, Xiacheng Sun, Linjie He, Lei Zhan, Xu Guo, Chun Yin, Yujiang Fang, Xianli He, Jinliang Xing Tags: Research Article Source Type: research

Demographic Trends and KRAS/BRAFV600E Mutations in Colorectal Cancer Patients of South China: a Single ‐site Report
In conclusion, in recent eight years, there is a shift to the colon, especially right colon in the incidence of Chinese CRC. Moreover tubular adenocarcinoma is becoming the primary histology type.This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 10, 2018 Category: Cancer & Oncology Authors: Xinhui Fu, Yan Huang, Xinjuan Fan, Yanhong Deng, Huanliang Liu, Hongzhi Zou, Peihuang Wu, Zhiting Chen, Jinglin Huang, Jingxuan Wang, Hanjie Lin, Shuhui Huang, Xiaoli Tan, Ping Lan, Lei Wang, Jian ‐ping Wang Tags: Research Article Source Type: research

Newly developed anti ‐S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 10, 2018 Category: Cancer & Oncology Authors: Rie Kinoshita, Hiroki Sato, Akira Yamauchi, Yuta Takahashi, Yusuke Inoue, I Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Kota Araki, Kazuhiko Shien, Shuta Tomida, Hidejiro Torigoe, Kei Namba, Eisuke Kurihara, Yusuke Ogoshi, Hitoshi Murata, Tags: Short Report Source Type: research

Glioblastoma endothelium drives bevacizumab ‐induced infiltrative growth via modulation of PLXDC1
Bevacizumab, a VEGF ‐targeting monoclonal antibody, may trigger an infiltrative growth pattern in glioblastoma. We investigated this pattern using both a human specimen and rat models. In the human specimen, a substantial fraction of infiltrating tumor cells were located along perivascular spaces in close relationshi p with endothelial cells. Brain xenografts of U87MG cells treated with bevacizumab were smaller than controls (p=0.0055; Student‐t test), however, bands of tumor cells spread through the brain farther than controls (p
Source: International Journal of Cancer - November 10, 2018 Category: Cancer & Oncology Authors: Maria Laura Falchetti, Quintino Giorgio D'Alessandris, Simone Pacioni, Mariachiara Buccarelli, Liliana Morgante, Stefano Giannetti, Valentina Lulli, Maurizio Martini, Luigi Maria Larocca, Eliza Vakana, Louis Stancato, Lucia Ricci ‐Vitiani, R Tags: Research Article Source Type: research

Multi ‐gene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non‐CDKN2A/CDK4 melanoma families
In this study we comprehensively characterized 488 melanoma cases from 451 non‐CDKN2A/CDK4 families for mutations in 30 established and candidate melanoma susceptibility genes using a custom ‐designed targeted gene panel approach. We identified (likely) pathogenic variants in established melanoma susceptibility genes in 18 families (n=3BAP1, n=15MITF p.E318K; diagnostic yield 4.0%). Among the three identifiedBAP1‐families, there were no reported diagnoses of uveal melanoma or malignant mesothelioma. We additionally identified two potentially deleterious missense variants in the telomere maintenance genesACD andTERF2I...
Source: International Journal of Cancer - November 10, 2018 Category: Cancer & Oncology Authors: Thomas P. Potjer, Sander Bollen, Anneliese J.E.M. Grimbergen, Remco Doorn, Nelleke A. Gruis, Christi J. Asperen, Frederik J. Hes, Nienke Stoep, on behalf of the Dutch Working Group for Clinical Oncogenetics, A. Wagner, L.E. van der Kolk, M.G. A Tags: Research Article Source Type: research

Vesicle ‐bound EBV‐BART13‐3p miRNA in circulation distinguishes nasopharyngeal‐ from head & neck cancer and asymptomatic EBV ‐infections
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 9, 2018 Category: Cancer & Oncology Authors: Octavia Ramayanti, Sandra A.W.M Verkuijlen, Putri Novianti, Chantal Scheepbouwer, Branislav Misovic, Danijela Koppers ‐Lalic, Jan Weering, Lisa Beckers, Marlinda Adham, Debora Martorelli, Jaap M. Middeldorp, D. Michiel Pegtel Tags: Research Article Source Type: research

Genetic variants in CCL5 and CCR5 genes and serum VEGF ‐A levels predict efficacy of bevacizumab in metastatic colorectal cancer patients
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - November 9, 2018 Category: Cancer & Oncology Authors: Mitsukuni Suenaga, Shu Cao, Wu Zhang, Dongyun Yang, Yan Ning, Satoshi Okazaki, Martin D. Berger, Yuji Miyamoto, Marta Schirripa, Shivani Soni, Afsaneh Barzi, Toshiharu Yamaguchi, Heinz ‐Josef Lenz Tags: Research Article Source Type: research