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Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Anna Tervasm äki, Tuomo Mantere, Jaana M. Hartikainen, Saila Kauppila, Hang‐Mao Lee, Susanna Koivuluoma, Mervi Grip, Peeter Karihtala, Arja Jukkola‐Vuorinen, Arto Mannermaa, Robert Winqvist, Katri Pylkäs Tags: Research Article Source Type: research

HOXD ‐AS1/miR‐130a sponge regulates glioma development by targeting E2F8
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Yinan Chen, Fengbo Zhao, Daming Cui, Rui Jiang, Jian Chen, Qingfeng Huang, Jinlong Shi Tags: Research Article Source Type: research

Conditionally reprogrammed cells (CRC) methodology does not allow the in vitro expansion of patient ‐derived primary and metastatic lung cancer cells
In conclusion, patient‐derived primary and metastatic lung cancer cells were negatively selected under CRC conditions, limiting the expansion to non‐malignant lung epithelial stem cells either from tumor and non‐tumor tissue sources. Thus, CRC approach cannot be applied for direct therapeutic testing of patient lung tumor cells, as the tumor‐derived CRC cultures are composed of (non tumoral) airway basal cells. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 17, 2018 Category: Cancer & Oncology Authors: Giovanni Sette, Valentina Salvati, Ilenia Giordani, Emanuela Pillozzi, Denise Quacquarini, Enrico Duranti, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Mario Falchi, Roberto Pallini, Ruggero De Maria, Adriana Eramo Tags: Research Article Source Type: research

Eurogin Roadmap 2017: Triage strategies for the management of HPV ‐positive women in cervical screening programmes
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 17, 2018 Category: Cancer & Oncology Authors: K Cuschieri, G Ronco, A Lorincz, L Smith, G Ogilvie, L Mirabello, F Carozzi, H Cubie, N Wentzensen, P Snijders, M Arbyn, J Monsonego J, S Franceschi Tags: Mini Review Source Type: research

The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 13, 2018 Category: Cancer & Oncology Authors: Kwang ‐Pil Ko, Shana J. Kim, Tomasz Huzarski, Jacek Gronwald, Jan Lubinski, Henry T. Lynch, Susan Armel, Sue K Park, Beth Karlan, Christian F. Singer, Susan L. Neuhausen, Steven A. Narod, Joanne Kotsopoulos, Tags: Research Article Source Type: research

Inhibition of novel GCN5 –ATM axis restricts the onset of acquired drug resistance in leukemia
Leukemia is majorly treated by topoisomerase inhibitors that induce DNA double strand breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders leukemic cells resistant to therapy. As we do not fully understand the regulation of DSB repair acquired by resistant cells, targeting these cells has been a challenge. Here we investigated the regulation of DSB repair pathway in early drug resistant population (EDRP) and late drug resistant population (LDRP). We found that doxorubicin induced equal DSBs in parent and EDRP cells; however, cell death is induced only in the parent cells. Further ana...
Source: International Journal of Cancer - January 13, 2018 Category: Cancer & Oncology Authors: Sameer Salunkhe, Saket V. Mishra, Jyothi Nair, Samadri Ghosh, Neha Choudhary, Ekjot Kaur, Sanket Shah, Ketaki Patkar, Dev Anand, Navin Khattry, Syed K. Hasan, Shilpee Dutt Tags: Cancer Therapy and Prevention Source Type: research

Reproductive history, breast ‐feeding and risk of triple negative breast cancer: The Breast Cancer Etiology in Minorities (BEM) Study
Abstract Few risk factors have been identified for triple negative breast cancer (TNBC) which lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). This more aggressive subtype disproportionately affects some racial/ethnic minorities and is associated with lower survival. We pooled data from three population‐based studies (558 TNBC and 5,111 controls) and examined associations of TNBC risk with reproductive history and breast‐feeding. We estimated odds ratios (OR) and 95% confidence intervals (CI) using multivariable logistic regression. For younger women, aged
Source: International Journal of Cancer - January 13, 2018 Category: Cancer & Oncology Authors: Esther M. John, Lisa M. Hines, Amanda I. Phipps, Jocelyn Koo, Teri A. Longacre, Sue A. Ingles, Kathy B. Baumgartner, Martha L. Slattery, Anna H. Wu Tags: Research Article Source Type: research

Serum inflammatory markers in relation to prostate cancer severity and death in the Swedish AMORIS study
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 11, 2018 Category: Cancer & Oncology Authors: R. Arthur, R. Williams, H. Garmo, L. Holmberg, P. Stattin, H. Malmstrom, M. Lambe, N. Hammar, G. Walldius, D. Robinsson, I. Jungner, M. Van Hemelrijck Tags: Research Article Source Type: research

Periodontitis and Cancer Mortality: Register ‐based Cohort Study of 68 273 Adults in 10‐year Follow‐up
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 11, 2018 Category: Cancer & Oncology Authors: Pia Heikkil ä, Anna But, Timo Sorsa, Jari Haukka Tags: Research Article Source Type: research

The Yin and Yang of YY1 in Tumor Growth and Suppression
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 11, 2018 Category: Cancer & Oncology Authors: Levon M. Khachigian Tags: Mini Review Source Type: research

WT1 peptide ‐based immunotherapy for advanced thymic epithelial malignancies
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 11, 2018 Category: Cancer & Oncology Authors: Yusuke Oji, Masayoshi Inoue, Yoshito Takeda, Naoki Hosen, Yasushi Shintani, Manabu Kawakami, Takuya Harada, Yui Murakami, Miki Iwai, Mari Fukuda, Sumiyuki Nishida, Jun Nakata, Yoshiki Nakae, Satoshi Takashima, Toshiaki Shirakata, Hiroko Nakajima, Kana Has Tags: Research Article Source Type: research

Breast cancer extent and survival among diabetic women in a Finnish nationwide cohort study
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 10, 2018 Category: Cancer & Oncology Authors: MO Murto, M Artama, E Pukkala, K Visvanathan, TJ Murtola Tags: Research Article Source Type: research

The efficacy and safety of anti ‐PD‐1/PD‐L1 antibodies combined with chemotherapy or CTLA4 antibody as a first‐line treatment for advanced lung cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Xiaoling Xu, Zhiyu Huang, Lei Zheng, Yun Fan Tags: Research Article Source Type: research

Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study
Abstract Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. Critically short telomeres can trigger programmed cell death while cells with longer telomeres may have increased likelihood of replicative errors, resulting in genetic mutations and chromosomal alterations, and ultimately promoting oncogenesis. Data on telomere length and lung cancer risk from large prospective cohort studies are spare. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiplex quantitative polymerase chain reaction (qPCR) method in 26,540 participants of the ...
Source: International Journal of Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Jian ‐Min Yuan, Kenneth B. Beckman, Renwei Wang, Caroline Bull, Jennifer Adams‐Haduch, Joyce Y. Huang, Aizhen Jin, Patricia Opresko, Anne B. Newman, Yun‐Ling Zheng, Michael Fenech, Woon‐Puay Koh Tags: Research Article Source Type: research

A 24 ‐year prospective study of dietary α‐linolenic acid and lethal prostate cancer
In conclusion, higher intake of ALA was associated with an increased risk of lethal prostate cancer in the pre‐PSA era, but not in the PSA era. Potential reasons for the differential associations warrant further investigation. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Juan Wu, Kathryn M. Wilson, Meir J. Stampfer, Walter C. Willett, Edward L. Giovannucci Tags: Research Article Source Type: research

KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK ‐ERK pathway in pancreatic cancer
In conclusion, our studies demonstrate how KRAS inhibits the tumor suppressor RKIP, thus offering novel justification for targeting RKIP as a strategy to overcome KRAS‐induced tumor metastasis and chemoresistance in PDAC. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Kege Yang, Yaqing Li, Guoda Lian, Haoming Lin, Changzhen Shang, Linjuan Zeng, Shaojie Chen, Jiajia Li, Chumei Huang, Kaihong Huang, Yinting Chen Tags: Research Article Source Type: research

Circulating Anti ‐Müllerian Hormone and Breast Cancer Risk: A Study in Ten Prospective Cohorts
Abstract A strong positive association has been observed between circulating anti‐Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important because of the paucity of biomarkers of breast cancer risk in premenopausal women. We conducted a consortium study including ten prospective cohorts that had collected blood from premenopausal women. A nested case‐control design was implemented within each cohort. A total of 2,835 invasive (80%) and in situ (20%) breast cancer cases were individually matched to controls (n = 3,122) on ...
Source: International Journal of Cancer - January 8, 2018 Category: Cancer & Oncology Authors: Wenzhen Ge, Tess V. Clendenen, Yelena Afanasyeva, Karen L. Koenig, Claudia Agnoli, Louise A. Brinton, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, G öran Hallmans, Susan E. Hankinson, Judith Hoffman‐Bolton, Timothy J. Key, Vittorio Krogh, Hazel Tags: Research Article Source Type: research

Near ‐Infrared Photoimmunotherapy Targeting EGFR ‐ Shedding New Light on Glioblastoma Treatment
In conclusion, the ZEGFR:03115‐IR700DX showed specific uptake in vitro and enabled imaging of EGFR expression in the orthotopic brain tumor model. Moreover, the proof‐of‐concept in vivo PIT study demonstrated therapeutic efficacy of the conjugate in subcutaneous glioma xenografts. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 5, 2018 Category: Cancer & Oncology Authors: Thomas A. Burley, Justyna M ączyńska, Anant Shah, Wojciech Szopa, Kevin J. Harrington, Jessica K.R. Boult, Anna Mrozek‐Wilczkiewicz, Maria Vinci, Jeffrey C. Bamber, Wojciech Kaspera, Gabriela Kramer‐Marek Tags: Research Article Source Type: research

Whole Blood FPR1 mRNA Expression Predicts Both Non ‐Small Cell and Small Cell Lung Cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 5, 2018 Category: Cancer & Oncology Authors: Scott Morris, Anil Vachani, Harvey I. Pass, William N. Rom, Kirk Ryden, Glen J. Weiss, D. K. Hogarth, George Runger, Donald Richards, Troy Shelton, David W. Mallery Tags: Research Article Source Type: research

Issue Information
(Source: International Journal of Cancer)
Source: International Journal of Cancer - January 5, 2018 Category: Cancer & Oncology Tags: Issue Information Source Type: research

Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival
Abstract Cutaneous melanoma (CM) is considered as a steroid hormone‐related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR‐related genes) in CM‐specific survival (CMSS). Here, we performed a pathway‐based analysis to evaluate genetic variants of 191 SHR‐related genes in 858 CMSS patients using a dataset from a genome‐wide association study (GWAS) from The University of Texas MD Anderson Cancer Center (MDACC), and then validated the results in an additional dataset of 409 patients from the Harvard GWAS. Using...
Source: International Journal of Cancer - January 4, 2018 Category: Cancer & Oncology Authors: Bo Li, Yanru Wang, Yinghui Xu, Hongliang Liu, Wendy Bloomer, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Xin Li, Jiali Han, Qingyi Wei Tags: Research Article Source Type: research

Mouse model of post ‐surgical primary tumor recurrence and regional lymph node metastasis progression in HPV‐related head and neck cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 4, 2018 Category: Cancer & Oncology Authors: Maxime Mermod, Agn ès Hiou‐Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W. Vermeer, John H. Lee, Tatiana V. Petrova, Jean‐Paul Rivals, Yan Monnier, Genrich V. Tolstonog, Christian Simon Tags: Research Article Source Type: research

In vivo antitumor function of tumor antigen ‐specific CTLs generated in the presence of OX40 co‐stimulation in vitro
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 4, 2018 Category: Cancer & Oncology Authors: Ngoc Pham Minh, Satoshi Murata, Naomi Kitamura, Tomoyuki Ueki, Masatsugu Kojima, Toru Miyake, Katsushi Takebayashi, Hirokazu Kodama, Eiji Mekata, Masaji Tani Tags: Research Article Source Type: research

Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 4, 2018 Category: Cancer & Oncology Authors: Brian Z. Huang, Loic Le Marchand, Christopher A. Haiman, Kristine R. Monroe, Lynne R. Wilkens, Zuo ‐Feng Zhang, Veronica Wendy Setiawan Tags: Research Article Source Type: research

Inhibition of novel GCN5 ‐ATM axis restricts the onset of acquired drug resistance in leukemia
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 3, 2018 Category: Cancer & Oncology Authors: Sameer Salunkhe, Saket V Mishra, Jyothi Nair, Samadri Ghosh, Neha Choudhary, Ekjot Kaur, Sanket Shah, Ketaki Patkar, Dev Anand, Navin Khattry, Syed K Hasan, Shilpee Dutt Tags: Research Article Source Type: research

Think before you leap
(Source: International Journal of Cancer)
Source: International Journal of Cancer - December 28, 2017 Category: Cancer & Oncology Authors: Frank C. Detterbeck Tags: Letter to the Editor Source Type: research

Vaccination protects against invasive HPV ‐associated cancers
(Source: International Journal of Cancer)
Source: International Journal of Cancer - December 27, 2017 Category: Cancer & Oncology Authors: Tapio Luostarinen, Dan Apter, Joakim Dillner, Tiina Eriksson, Katja Harjula, Kari Natunen, Jorma Paavonen, Eero Pukkala, Matti Lehtinen Tags: Letter to the Editor Source Type: research

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis
Eukaryotic elongation factor 2 kinase (eEF2K) negatively regulates the elongation phase of mRNA translation and hence protein synthesis. Increasing evidence indicates that eEF2K plays an important role in the survival and migration of cancer cells and in tumor progression. As demonstrated by two‐dimensional wound‐healing and three‐dimensional transwell invasion assays, knocking down or inhibiting eEF2K in cancer cells impairs migration and invasion of cancer cells. Conversely, exogenous expression of eEF2K or knocking down eEF2 (the substrate of eEF2K) accelerates wound healing and invasion. Importantly, using LC‐H...
Source: International Journal of Cancer - December 27, 2017 Category: Cancer & Oncology Authors: Jianling Xie, Kaikai Shen, Roman V. Lenchine, Lee A. Gethings, Paul J. Trim, Marten F. Snel, Ying Zhou, Justin W. Kenney, Makoto Kamei, Marina Kochetkova, Xuemin Wang, Christopher G. Proud Tags: Molecular Cancer Biology Source Type: research

COPS5 and LASP1 synergistically interact to downregulate 14 ‐3‐3σ expression and promote colorectal cancer progression via activating PI3K/AKT pathway
Overexpression of LIM and SH3 protein 1 (LASP1) is required for colorectal cancer (CRC) development and progression. Here, C‐Jun activation domain‐binding protein‐1 (Jab1), also known as COP9 signalosome subunit 5 (COPS5), was verified as a new LASP1‐interacting protein through yeast two‐hybrid assay. The role of COPS5 in LASP1‐mediated CRC progression remains unknown. GST pull‐down assay indicated that the SH3 domain of LASP1 could directly bind to MPN domain of COPS5. In vitro gain‐ and loss‐of‐function analyses revealed the stimulatory role of COPS5 on CRC cell proliferation, migration and invasion. ...
Source: International Journal of Cancer - December 27, 2017 Category: Cancer & Oncology Authors: Rui Zhou, Ziyun Shao, Jian Liu, Wanqi Zhan, Qingzu Gao, Zhihua Pan, Ling Wu, Lijun Xu, Yanqing Ding, Liang Zhao Tags: Molecular Cancer Biology Source Type: research

Enzalutamide and CXCR7 inhibitor Combination Treatment Suppresses Cell Growth and Angiogenic Signaling in Castration ‐Resistant Prostate Cancer Models
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Yong Luo, Abul Kalam Azad, Styliani Karanika, Spyridon P. Basourakos, Xuemei Zuo, Jianxiang Wang, Yang Luan, Guang Yang, Dimitrios Korentzelos, Jianhua Yin, Sanghee Park, Penglie Zhang, James J. Campbell, Thomas J. Schall, Guangwen Cao, Likun Li, Timothy Tags: Research Article Source Type: research

PD ‐1 blockade enhances the antitumor efficacy of GM‐CSF surface‐modified bladder cancer stem cells vaccine
Eliminating cancer stem cells (CSCs) is a key issue in eradicating tumor. The streptavidin–granulocyte‐macrophage‐colony stimulating factor (SA–GM‐CSF) surface‐modified bladder CSCs vaccine previously developed using our protein–anchor technology could effectively induce specific immune response for eliminating CSCs. However, program death receptor‐1 (PD‐1)/program death ligand 1 (PD‐L1) signaling in tumor microenvironment results in tumor‐adaptive immune resistance. Although the CSCs vaccine could increase the number of CD8+T cells, a part of these CD8+T cells expressed PD‐1. Moreover, ...
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Xiaojun Shi, Xinji Zhang, Jinlong Li, Lijun Mo, Hongfan Zhao, Yongtong Zhu, Zhiming Hu, Jimin Gao, Wanlong Tan Tags: Tumor Immunology and Microenvironment Source Type: research

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated ‐recombinant arginase I BCT‐100
Arginine is a semi‐essential amino acid that plays a key role in cell survival and proliferation in normal and malignant cells. BCT‐100, a pegylated (PEG) recombinant human arginase, can deplete arginine and starve malignant cells of the amino acid. Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood, yet for patients with high risk or relapsed disease prognosis remains poor. We show that BCT‐100 is cytotoxic to ALL blasts from patients in vitro by necrosis, and is synergistic in combination with dexamethasone. Against ALL xenografts, BCT‐100 leads to a reduction in ALL engraftment and a prolo...
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Carmela De Santo, Sarah Booth, Ashley Vardon, Antony Cousins, Vanessa Tubb, Tracey Perry, Boris Noyvert, Andrew Beggs, Margaret Ng, Christina Halsey, Pamela Kearns, Paul Cheng, Francis Mussai Tags: Cancer Therapy and Prevention Source Type: research

DCLK1 Promotes Epithelial ‐Mesenchymal Transition via the PI3K/Akt/NF‐κB Pathway in Colorectal Cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Weiying Liu, Shixing Wang, Qi Sun, Zhen Yang, Min Liu, Hua Tang Tags: Research Article Source Type: research

Quantitative Fecal Immunochemical Tests for Colorectal Cancer Screening
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Anton Gies, Megha Bhardwaj, Christian Stock, Petra Schrotz ‐King, Hermann Brenner Tags: Mini Review Source Type: research

Fluorescence ‐ and multispectral optoacoustic imaging for an optimised detection of deeply located tumours in an orthotopic mouse model of pancreatic carcinoma
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Joanna Napp, Marieke A. Stammes, Jing Claussen, Hendrica A.J.M. Prevoo, Cornelis F. M. Sier, Freek J. M. Hoeben, Marc S. Robillard, Alexander L. Vahrmeijer, Tim Devling, Alan B. Chan, Lioe ‐Fee de Geus‐Oei, Frauke Alves Tags: Research Article Source Type: research

RhoA ‐stimulated Intra‐capillary Morphology Switch Facilitates the Arrest of Individual Circulating Tumor Cells
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Xi Huang, Yu Yang, Yuwei Zhao, Cao Dan, Xiaolin Ai, Anqi Zeng, Maling Gou, Lulu Cai, Hanshuo Yang, Chengjian Zhao Tags: Research Article Source Type: research

Survivin Is a Novel Transcription Regulator of KIT and Is Downregulated by miRNA ‐494 in Gastrointestinal Stromal Tumors
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: SeongJu Yun, Won Kyu Kim, Yujin Kwon, Mi Jang, Sebastian Bauer, Hoguen Kim Tags: Research Article Source Type: research

The sphingosine kinase 2 inhibitor ABC294640 displays anti ‐non‐small cell lung cancer activities in vitro and in vivo
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 26, 2017 Category: Cancer & Oncology Authors: Lu Dai, Charles D. Smith, Maryam Foroozesh, Lucio Miele, Zhiqiang Qin Tags: Research Article Source Type: research

Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer – disparities in outcomes (ABC‐DO) study
Breast cancer (BC) survival rates in sub‐Saharan Africa (SSA) are low in part due to advanced stage at diagnosis. As one component of a study of the entire journey of SSA women with BC, we aimed to identify shared and setting‐specific drivers of advanced stage BC. Women newly diagnosed in the multicountry African Breast Cancer–Disparities in Outcomes (ABC‐DO) study completed a baseline interview and their stage information was extracted from medical records. Ordinal logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for advanced stage (I, II, III, IV) in relation to indi...
Source: International Journal of Cancer - December 23, 2017 Category: Cancer & Oncology Authors: Fiona McKenzie, Annelle Zietsman, Moses Galukande, Angelica Anele, Charles Adisa, Groesbeck Parham, Leeya Pinder, Herbert Cubasch, Maureen Joffe, Frederick Kidaaga, Robert Lukande, Awa U. Offiah, Ralph O. Egejuru, Aaron Shibemba, Joachim Schuz, Benjamin O Tags: Cancer Epidemiology Source Type: research

p53 and miR ‐210 regulated NeuroD2, a neuronal basic helix–loop–helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment
The factors involved in cell differentiation have recently garnered interest for their role in inhibition of pathogenesis in various tumors. However, their role in glioblastoma (GBM) remains poorly understood. We analyzed The Cancer Genome Atlas (TCGA) GBM data and found significant downregulation of neurogenic differentiation factor NeuroD2 in GBM patients. Low levels of NeuroD2 were found to be correlated with poor overall survival of GBM patients in TCGA dataset as well as in our cohort. Interestingly, NeuroD2 was shown to be transcriptionally induced by p53 and post‐transcriptionally targeted by hypoxia‐ inducible ...
Source: International Journal of Cancer - December 23, 2017 Category: Cancer & Oncology Authors: Rahul Agrawal, Ankita Garg, Prit Benny Malgulwar, Vikas Sharma, Chitra Sarkar, Ritu Kulshreshtha Tags: Cancer Genetics and Epigenetics Source Type: research

Use of hormone replacement therapy improves the prognosis in patients with colorectal cancer: A population ‐based study in Sweden
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Authors: Jianguang Ji, Jan Sundquist, Kristina Sundquist Tags: Research Article Source Type: research

Issue Information
(Source: International Journal of Cancer)
Source: International Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Tags: Issue Information Source Type: research

The association of weight change in young adulthood and smoking status with risk of prostate cancer recurrence
Abstract The decades before prostate cancer diagnosis represent an etiologically relevant time period for prostate cancer carcinogenesis. However, the association of weight gain in young adulthood with subsequent biochemical recurrence among men with prostate cancer is not well studied, particularly among smokers. We conducted a prospective cohort study of 1082 men with prostate cancer and treated with either radical prostatectomy or radiation between 2003‐2010. The association of weight at age 20, weight at age 50, and weight change from age 20 to 50 with biochemical recurrence was assessed using Cox Proportional Hazard...
Source: International Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Authors: Saira Khan, Veronica Hicks, Graham A. Colditz, Adam S. Kibel, Bettina F. Drake Tags: Research Article Source Type: research

Live birth outcomes after adolescent and young adult breast cancer
We examined the incidence of live birth and the prevalence of adverse birth outcomes according to tumor and treatment characteristics among AYAs with breast cancer. Women diagnosed with breast cancer at ages 15‐39 during 2000‐2013 were identified using the North Carolina Central Cancer Registry (n=4978). Cancer registry records were linked to state birth certificate files from 2000‐2014 to identify births to women with and without a breast cancer history. The breast cancer cohort was followed until live birth, death, age 46, or December 31, 2014, whichever occurred first. For each birth to breast cancer survivors (n=...
Source: International Journal of Cancer - December 21, 2017 Category: Cancer & Oncology Authors: Chelsea Anderson, Stephanie M. Engel, Carey K. Anders, Hazel B. Nichols Tags: Research Article Source Type: research

Targeting Tumor ‐Infiltrating Ly6G+ Myeloid Cells Improves Sorafenib Efficacy in Mouse Orthotopic Hepatocellular Carcinoma
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 20, 2017 Category: Cancer & Oncology Authors: Chun ‐Jung Chang, Yao‐Hsu Yang, Chiao‐Juno Chiu, Li‐Chun Lu, Chien‐Chia Liao, Cher‐wei Liang, Chih‐Hung Hsu, Ann‐Lii Cheng Tags: Research Article Source Type: research

Secreted Factors from Metastatic Prostate Cancer Cells Stimulate Mesenchymal Stem Cell Transition to a Pro ‐tumourigenic ‘Activated' State that Enhances Prostate Cancer Cell Migration
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 20, 2017 Category: Cancer & Oncology Authors: Sarah M Ridge, Dibyangana Bhattacharyya, Eoin Dervan, Serika D Naicker, Amy J Burke, JM Murphy, Karen O'Leary, John Greene, Aideen E Ryan, Francis J Sullivan, Sharon A Glynn Tags: Research Article Source Type: research

Telomerase reverse transcriptase mutations are independent predictor of disease ‐free survival in middle eastern papillary thyroid cancer
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 20, 2017 Category: Cancer & Oncology Authors: Rong Bu, Abdul K. Siraj, Sasidharan Padmaja Divya, Yan Kong, Sandeep Kumar Parvathareddy, Maha Al ‐Rasheed, Khadija A. S. Al Obaisi, Ingrid G. Victoria, Saif Al‐, Deen Alsobhi, Mohammed Al‐Dawish, Fouad Al‐Dayel, Khawla S. Al‐Kuraya Tags: Research Article Source Type: research

Risk of suicide within 1 year of cancer diagnosis
This study explored the suicide hazard at different time points after a first cancer diagnosis during the 1‐year period before suicide. This case–crossover study included 2,907 suicide cases from 2002 to 2012 in Taiwan and compared the odds of suicide risk at different time points during one year after any cancer diagnosis with self‐matched periods. The 13th month preceding the suicide date was used as the control period, and the hazard period was the duration from the 1st to 12th month in the conditional logistic regression for case–crossover comparisons. Among major groups of cancers, group of lip, oral c...
Source: International Journal of Cancer - December 18, 2017 Category: Cancer & Oncology Authors: Shun ‐Mu Wang, Jung‐Chen Chang, Shu‐Chuan Weng, Ming‐Kung Yeh, Chau‐Shoun Lee Tags: Research Article Source Type: research