Hepatic and Extrahepatic Characteristics of Autoimmune Hepatitis: A 23-year Hospital-Based Cohort Study
ConclusionIn an Asian country endemic for viral hepatitis, the female-to-male and baseline cirrhosis rates of AIH patients were lower than expected, while over 60% of the patients eventually developed cirrhosis. The high posttherapy relapse rate warrants cautious monitoring, particularly for patients with high baseline Alk-p levels. Baseline age, cirrhosis status and ANA titers are crucial for outcomes. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Single is not combined: the role of Co and Ni bioavailability on toxicity mechanisms in liver and brain cells
In this study, we focused on the treatment of liver carcinoma (HepG2) and astrocytoma (CCF-STTG1) cells as a model for the target sites of these two metals. We investigated their effects in single and combined exposure on cell survival, cell death mechanisms, bioavailability, and the induction of oxidative stress. The combination of CoCl2 and NiCl2 resulted in higher Co levels with subsequent decreased amount of Ni compared to the individual treatment. Only CoCl2 and the combination of both metals led to RONS induction and increased GSSG formation, while apoptosis and necrosis seem to be involved in the cell death mechanis...
Source: Chemosphere - April 22, 2024 Category: Chemistry Authors: Alicia Thiel Vivien Michaelis Marco Restle Sabrina Figge Martin Simon Tanja Schwerdtle Julia Bornhorst Source Type: research
Gelatin nanocarriers assembled by a self-immolative cross-linker for targeted cancer therapy
Int J Biol Macromol. 2024 Apr 20;268(Pt 1):131722. doi: 10.1016/j.ijbiomac.2024.131722. Online ahead of print.ABSTRACTWith a number of outstanding properties, gelatin is an ideal candidate for assembling nanoplatforms in biomedical applications. Generally, gelatin nanocarriers are cross-linked by aldehydes to improve their stability in water solution. However, aldehydes could cause multiple toxicities and their cross-linking products are uncontrollable. Here, we first used a self-immolative cross-linker to assemble gelatin nanocarriers for the controlled release of drugs and targeted cancer therapy. The cross-linker contai...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Jingtong Wang Zhao Li Yajing Chen Ningbin Luo Shengbin He Source Type: research
Single is not combined: the role of Co and Ni bioavailability on toxicity mechanisms in liver and brain cells
In this study, we focused on the treatment of liver carcinoma (HepG2) and astrocytoma (CCF-STTG1) cells as a model for the target sites of these two metals. We investigated their effects in single and combined exposure on cell survival, cell death mechanisms, bioavailability, and the induction of oxidative stress. The combination of CoCl2 and NiCl2 resulted in higher Co levels with subsequent decreased amount of Ni compared to the individual treatment. Only CoCl2 and the combination of both metals led to RONS induction and increased GSSG formation, while apoptosis and necrosis seem to be involved in the cell death mechanis...
Source: Chemosphere - April 22, 2024 Category: Chemistry Authors: Alicia Thiel Vivien Michaelis Marco Restle Sabrina Figge Martin Simon Tanja Schwerdtle Julia Bornhorst Source Type: research
Long-term outcomes of fully covered self-expandable metal stents for refractory biliary strictures after living donor liver transplantation: a retrospective study at a tertiary center
ConclusionsFCSEMS placement appears to be an effective and advisable intervention for refractory ABS as it can provide persistent stricture improvement over the long-term. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 22, 2024 Category: Surgery Source Type: research
Artificial intelligence-assisted colonoscopy to identify histologic remission and predict the outcomes of patients with ulcerative colitis: A systematic review
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Yasuharu Maeda, Shin-ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci Tags: Alimentary Tract Source Type: research
Automated liver volumetry and hepatic steatosis quantification with magnetic resonance imaging proton density fat fraction
CONCLUSION: Automated ME-Dixon MRI liver volumetry and MRI-PDFF were strongly correlated with CT liver volumetry and MRS hepatic steatosis measurements, especially in donors with hepatic steatosis.PMID:38643056 | DOI:10.1016/j.jfma.2024.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 20, 2024 Category: General Medicine Authors: Yuan-Chen Chang Kuang-Chen Yen Po-Chin Liang Ming-Chih Ho Cheng-Maw Ho Chih-Yang Hsiao Chiu-Han Hsiao Chia-Hsun Lu Chih-Horng Wu Source Type: research
New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study
CONCLUSIONS: In human liver regeneration FGF19 upregulation may constitute a protective response from BAs excess during liver regeneration. Our findings suggest the existence of post-translational mechanisms regulating CYP7A1 activity, and therefore BAs synthesis, independent from CYP7A1/Cyp7a1 gene transcription.PMID:38642480 | DOI:10.1016/j.bbadis.2024.167166 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Iker Uriarte Eva Santamaria Amaya L ópez-Pascual Mar ía J Monte Josepmaria Argem í M Ujue Latasa Elena Ad án-Villaescusa Ainara Irigaray Jose M Herranz Mar ía Arechederra Jorge Basualdo Felipe Lucena Fernando J Corrales Fernando Rotellar Fernando Par Source Type: research
Risk factors and prediction score for new ‐onset diabetes mellitus after liver transplantation
ConclusionsAge at the time of transplantation, preoperative IFG, postoperative FPG, and length of hospital stay were independent predictive factors of NODALT. The use of a simple risk prediction score can identify the patients who have the highest risk of NODALT and interventions may start early. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 20, 2024 Category: Endocrinology Authors: Ruiping Bai,
Rui An,
Siyu Chen,
Wenkang Ding,
Mengwen Xue,
Ge Zhao,
Qingyong Ma,
Xin Shen Tags: Original Article Source Type: research
Cancers, Vol. 16, Pages 1582: Hepatocellular Carcinoma: Current Drug Therapeutic Status, Advances and Challenges
Wanjin Hong
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for ~90% of liver neoplasms. It is the second leading cause of cancer-related deaths and the seventh most common cancer worldwide. Although there have been rapid developments in the treatment of HCC over the past decade, the incidence and mortality rates of HCC remain a challenge. With the widespread use of the hepatitis B vaccine and antiviral therapy, the etiology of HCC is shifting more toward metabolic-associated steatohepatitis (MASH). Early-stage HCC can be treated with potentially curative strategies such as surgical...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Shunzhen Zheng Siew Wee Chan Fei Liu Jun Liu Pierce Kah Hoe Chow Han Chong Toh Wanjin Hong Tags: Review Source Type: research
Antiplatelet agent for the prevention of late hepatic vascular complications in living donor liver transplant dominant population
CONCLUSION: We recommend against antiplatelet therapy for more than 1 year in clinically stable LT recipients.PMID:38641537 | DOI:10.1016/j.asjsur.2024.04.002 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 19, 2024 Category: Surgery Authors: Deok-Gie Kim Sung Hwa Kim Jun Young Lee Jae Geun Lee Source Type: research
Early utilization of Ruxolitinib in acute graft-versus-Host Disease after liver transplant
Asian J Surg. 2024 Apr 18:S1015-9584(24)00655-9. doi: 10.1016/j.asjsur.2024.04.023. Online ahead of print.NO ABSTRACTPMID:38641533 | DOI:10.1016/j.asjsur.2024.04.023 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 19, 2024 Category: Surgery Authors: Siqi Qiu Xingjie Li Yongbing Qian Kang He Source Type: research
Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy
CONCLUSION: Metformin for DM and statins for HLP have chemopreventive effects on HCC risk in CHC patients who failed antiviral therapy. These findings emphasize the importance of personalized preventive strategies for managing patients with these clinical profiles.PMID:38637957 | DOI:10.3350/cmh.2024.0038 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Pei-Chien Tsai Chung-Feng Huang Ming-Lun Yeh Meng-Hsuan Hsieh Hsing-Tao Kuo Chao-Hung Hung Kuo-Chih Tseng Hsueh-Chou Lai Cheng-Yuan Peng Jing-Houng Wang Jyh-Jou Chen Pei-Lun Lee Rong-Nan Chien Chi-Chieh Yang Gin-Ho Lo Jia-Horng Kao Chun-Jen Liu Chen-Hua L Source Type: research
Modulation of lipid profile by secretory phospholipase A2 group IIA: Verification with a transgenic mouse model
Biochem Biophys Res Commun. 2024 Apr 16;712-713:149955. doi: 10.1016/j.bbrc.2024.149955. Online ahead of print.ABSTRACTWe previously demonstrated a positive relation of secretory phospholipase A2 group IIA (sPLA2-IIA) with circulating high-density lipoprotein cholesterol (HDL-C) in patients with coronary artery disease, and sPLA2-IIA increased cholesterol efflux in THP-1 cells through peroxisome proliferator-activated receptor-γ (PPAR-γ)/liver X receptor α/ATP-binding cassette transporter A1 (ABCA1) signaling pathway. The aim of the present study was to examine the role of sPLA2-IIA over-expression on lipid profile in a...
Source: Biochemical and Biophysical Research communications - April 19, 2024 Category: Biochemistry Authors: Ling Liang Jing Song Shisheng Miao Qiang Xie Weihua Li Honglang Huang Dongyan Shen Wei Zhang Source Type: research
Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy
CONCLUSION: Metformin for DM and statins for HLP have chemopreventive effects on HCC risk in CHC patients who failed antiviral therapy. These findings emphasize the importance of personalized preventive strategies for managing patients with these clinical profiles.PMID:38637957 | DOI:10.3350/cmh.2024.0038 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Pei-Chien Tsai Chung-Feng Huang Ming-Lun Yeh Meng-Hsuan Hsieh Hsing-Tao Kuo Chao-Hung Hung Kuo-Chih Tseng Hsueh-Chou Lai Cheng-Yuan Peng Jing-Houng Wang Jyh-Jou Chen Pei-Lun Lee Rong-Nan Chien Chi-Chieh Yang Gin-Ho Lo Jia-Horng Kao Chun-Jen Liu Chen-Hua L Source Type: research
