Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Identification and characterization of myeloid cells localized in the tadpole liver cortex in Xenopus laevis
Dev Comp Immunol. 2024 Apr 8:105178. doi: 10.1016/j.dci.2024.105178. Online ahead of print.ABSTRACTIn the present study, using transgenic frogs that express GFP specifically in myeloid cells under the myeloperoxidase enhancer sequence, we found that myeloperoxidase-positive cells are localized in the liver cortex at the late tadpole stages. Immunohistochemical analysis revealed that myelopoiesis in the liver cortex became evident after st. 50 and reached its peak by st. 56. Transplantation experiments indicated that cells with a high density at the liver cortex were derived from the dorso-lateral plate tissue in the neurul...
Source: Developmental and Comparative Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Mitsugu Ma éno Miki Tanabe Ayame Ogawa Haruka Kobayashi Yumi Izutsu Takashi Kato Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Optimizing nutrition in hepatic cirrhosis: A comprehensive assessment and care approach
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.ABSTRACTCirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites...
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Osvely Mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez Source Type: research
Identification and characterization of myeloid cells localized in the tadpole liver cortex in Xenopus laevis
Dev Comp Immunol. 2024 Apr 8:105178. doi: 10.1016/j.dci.2024.105178. Online ahead of print.ABSTRACTIn the present study, using transgenic frogs that express GFP specifically in myeloid cells under the myeloperoxidase enhancer sequence, we found that myeloperoxidase-positive cells are localized in the liver cortex at the late tadpole stages. Immunohistochemical analysis revealed that myelopoiesis in the liver cortex became evident after st. 50 and reached its peak by st. 56. Transplantation experiments indicated that cells with a high density at the liver cortex were derived from the dorso-lateral plate tissue in the neurul...
Source: Developmental and Comparative Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Mitsugu Ma éno Miki Tanabe Ayame Ogawa Haruka Kobayashi Yumi Izutsu Takashi Kato Source Type: research
GSE200550 Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Contributors : Hexin Yan ; Xu ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusCell therapy shows great promise as an alternative therapy for the cirrhotic liver. We have previously developed an approach for efficient expansion of both murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro without genetic modification. The current study aimed to apply HepLPCs to treatment of liver cirrhosis. The effects of allogeneic HepLPCs transplantation were studied in rat models of liver cirrhosis induced by carbon tetrachloride (CCl4) . Liver tissues were co...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Outcomes of 6000 living donor liver transplantation procedures: a pioneering experience at ASAN Medical Center
This study demonstrated outstanding long-term outcomes, with patient survival rat es at 1, 5, 10, and 20 years of 92.7%, 85.9%, 82.1%, and 70.9%, respectively, in LDLT group for adults aged 50 and under at the time of LDLT, and 92.9%, 89.0%, 88.1%, and 81.9%, respectively, in the pediatric group. The in-hospital mortality rate of adult recipients was 3.8% (n = 214/5688). This study demonstrates the importance of refined surgical techniques, selection of grafts tailored to the recipient, and comprehensive multidisciplinary perioperative patient care in expanding the scope of LDLT and improving recipient outcomes. (Sour...
Source: Updates in Surgery - April 10, 2024 Category: Surgery Source Type: research
Coronary artery calcium assessment on non-gated chest CT to optimize pre-operative cardiac screening in liver transplantation
This study evaluated the ability of coronary artery calcification (CAC) assessment on consecutively available scans, to identify a selection of low-risk patients, in whom further cardiac imaging can be safely withheld. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 10, 2024 Category: Cardiology Authors: Roos A. Groen, Fei Lynn Barbero, Susan E. Fischer, Paul R.M. van Dijkman, Jeroen J. Bax, Maarten E. Tushuizen, J. Wouter Jukema, Minneke J. Coenraad, Michiel A. de Graaf Source Type: research
Application of a laparoscopic device for cell-derived sheet transplantation on the liver in a porcine model
CONCLUSION: We confirmed the feasibility of a simple universal device to transplant cell-derived sheets via laparoscopic surgery. This device could support a minimally invasive procedure for sheet transplantation.PMID:38592474 | DOI:10.1080/13645706.2024.2328610 (Source: Minimally Invasive Therapy and Allied Technologies)
Source: Minimally Invasive Therapy and Allied Technologies - April 9, 2024 Category: Surgery Authors: Keisuke Toya Yoshito Tomimaru Shogo Kobayashi Kiyokazu Nakajima Akima Harada Kazuki Sasaki Yoshifumi Iwagami Daisaku Yamada Takehiro Noda Hidenori Takahashi Koichi Hayakawa Isamu Matsuda Takahiro Naka Shigeru Miyagawa Yuichiro Doki Hidetoshi Eguchi Source Type: research
Indications to LDLT: a changing pathway?
AbstractLiver transplantation (LT) revolutionized the outlook for cirrhotic patients, offering a potential cure with over 80% life expectancy after 5 years. Cirrhosis, with or without hepatocellular carcinoma (HCC), is the primary LT indication. Living donor LT (LDLT) initially explored as an alternative, declined due to poorer outcomes. Studies on LDLT improved outcomes through precise recipient selection, emphasizing the importance of careful donor/recipient matching. Emerging concepts like left lobe preference and minimally invasive donor approaches enhance LDLT outcomes. The RAPID technique shows promise in both cirr...
Source: Updates in Surgery - April 9, 2024 Category: Surgery Source Type: research
A complement C4-derived glycopeptide is a biomarker for PMM2-CDG
CONCLUSIONComplement C4-derived Man5GlcNAc2 glycopeptide could be a biomarker for accurate diagnosis and therapeutic monitoring of patients with PMM2-CDG and other CDGs.FUNDINGU54NS115198 (Frontiers in Congenital Disorders of Glycosylation: NINDS; NCATS; Eunice Kennedy Shriver NICHD; Rare Disorders Consortium Disease Network); K08NS118119 (NINDS); Minnesota Partnership for Biotechnology and Medical Genomics; Rocket Fund; R01DK099551 (NIDDK); Mayo Clinic DERIVE Office; Mayo Clinic Center for Biomedical Discovery; IA/CRC/20/1/600002 (Center for Rare Disease Diagnosis, Research and Training; DBT/Wellcome Trust India Alliance)...
Source: Genomics Proteomics ... - April 8, 2024 Category: Genetics & Stem Cells Authors: Kishore Garapati Rohit Budhraja Mayank Saraswat Jinyong Kim Neha Joshi Gunveen S Sachdeva Anu Jain Anna N Ligezka Silvia Radenkovic Madan Gopal Ramarajan Savita Udainiya Kimiyo Raymond Miao He Christina Lam Austin Larson Andrew C Edmondson Kyriakie Sarafo Source Type: research
