Relative carcinogenicity of tacrolimus < em > vs < /em > mycophenolate after solid organ transplantation and its implications for liver transplant care
CONCLUSION: The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.PMID:38689747 | PMC:PMC11056899 | DOI:10.4254/wjh.v16.i4.650 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Dorothy Liu Mark M Youssef Josephine A Grace Marie Sinclair Source Type: research
Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen: Novel viral biomarkers for chronic hepatitis B management
World J Hepatol. 2024 Apr 27;16(4):550-565. doi: 10.4254/wjh.v16.i4.550.ABSTRACTThe management of hepatitis B virus (HBV) infection now involves regular and appropriate monitoring of viral activity, disease progression, and treatment response. Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness. Quantitation of HBV core antibodies (qAnti-HBc) is a novel non-invasive biomarker that may help with a variety of diagnostic issues. It was shown to correlate strongly with infection stages, hepatic inflammation and fibrosis, chronic infection exacerbations, an...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
< em > Klebsiella pneumoniae < /em > infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
CONCLUSION: KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.PMID:38689752 | PMC:PMC11056902 | DOI:10.4254/wjh.v16.i4.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Long Guo Peng Peng Wei-Ting Peng Jie Zhao Qi-Quan Wan Source Type: research
Prospective study of hepatitis B and D epidemiology and risk factors in Romania: A 10-year update
CONCLUSION: This study shows that HDV infection among those with HBV remains endemic in Romania and updates our understanding of HDV epidemiology and associated risk factors. It emphasizes the need for systematic screening for HDV infection and collaborative initiatives for controlling and preventing HBV and HDV infection.PMID:38689751 | PMC:PMC11056896 | DOI:10.4254/wjh.v16.i4.640 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Speranta Iacob Liana Gheorghe Mirela Onica Laura Huiban Corina Silvia Pop Ciprian Brisc Roxana Sirli Carmen Ester Cristina Mihaela Brisc Sorina Diaconu Ion Rogoveanu Larisa Sandulescu Deiana Vuletici Anca Trifan Source Type: research
Relative carcinogenicity of tacrolimus < em > vs < /em > mycophenolate after solid organ transplantation and its implications for liver transplant care
CONCLUSION: The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.PMID:38689747 | PMC:PMC11056899 | DOI:10.4254/wjh.v16.i4.650 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Dorothy Liu Mark M Youssef Josephine A Grace Marie Sinclair Source Type: research
Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen: Novel viral biomarkers for chronic hepatitis B management
World J Hepatol. 2024 Apr 27;16(4):550-565. doi: 10.4254/wjh.v16.i4.550.ABSTRACTThe management of hepatitis B virus (HBV) infection now involves regular and appropriate monitoring of viral activity, disease progression, and treatment response. Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness. Quantitation of HBV core antibodies (qAnti-HBc) is a novel non-invasive biomarker that may help with a variety of diagnostic issues. It was shown to correlate strongly with infection stages, hepatic inflammation and fibrosis, chronic infection exacerbations, an...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop
This study offers new understanding of stress’s role in cancer progression and potential targets for HCC treatment. The scientists concluded that more research is required to fully comprehend these results for future cancer therapies.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Chen Wang Jiaping Ni Dongqing Zhai Yanchao Xu Zijie Wu Yuyuan Chen Ning Liu Juan Du Yumeng Shen Guilai Liu Yong Yang Linjun You Weiwei Hu Source Type: research
Clinical value of [18F]AlF-NOTA-FAPI-04 PET/CT for assessing early-stage liver fibrosis in adult liver transplantation recipients compared with chronic HBV patients
Conclusion[18F]AlF-NOTA-FAPI-04 PET/CT could be applied to evaluate early-stage liver fibrosis in LT recipients and CHB patients properly, with the potential additional advantages in monitoring and predicting complications after LT. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - May 1, 2024 Category: Radiology Source Type: research
Optimal Management of Obesity in Transplant Candidates and Recipients
AbstractPurpose of ReviewObesity constitutes a global crisis with profound implications on the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). This paper aims to comprehensively explore the escalating obesity epidemic ’s implications on liver transplantation, focusing on trends, clinical consequences, and therapeutic interventions to optimize outcomes for transplant candidates and recipients.Recent FindingsLifestyle modifications, including dietary and exercise programs, are crucial for pre- and post-transplant obesity managements....
Source: Current Transplantation Reports - May 1, 2024 Category: Transplant Surgery Source Type: research
Plasma exchange improves survival in acute liver failure - An updated systematic review and meta-analysis focussed on comparing within single etiology
ConclusionPLEX is safe and improves survival, independent of the volumes utilized, in patients with ALF as compared to standard medical treatment. The survival benefit is especially pronounced in studies restricted to single etiology.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Source Type: research
Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Conclusion: Hypoxic/ischemic injury and infection are the predominant etiologies of NALF in China. The overall prognosis of NALF is poor, but its short-term prognosis is determined by the etiology. What is Known: • Neonatal acute liver failure (NALF) is a rare disorder with limited cohort studies, especially in China. • Gestational alloimmune liver disease, viral infections (especially herpes simplex virus), metabolic diseases and ischemic insults are common etiologies of NALF, which are significantly different from other populations. • There are no reliable biochemical markers to predict the outcome of NALF. What is...
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Suhua Xu Peng Zhang Mengmeng Ge Yuanyuan Shan Guoqiang Cheng Source Type: research
A consortium of < em > Hordeum vulgare < /em > and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):250-260. doi: 10.1080/21691401.2024.2347380. Epub 2024 Apr 30.ABSTRACTDespite many recent studies on non-alcoholic fatty liver disease (NAFLD) therapeutics, the optimal treatment has yet to be determined. In this unfinished project, we combined secondary metabolites (SMs) from the gut microbiota (GM) and Hordeum vulgare (HV) to investigate their combinatorial effects via network pharmacology (NP). Additionally, we analyzed GM or barley - signalling pathways - targets - metabolites (GBSTMs) in combinatorial perspectives (HV, and GM). A total of 31 key targets were analysed via ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been Lee Haripriya Gupta Byeong-Hyun Min Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Sang Youn Lee Mi-Ran Choi Dong Joon Kim Ki-Kwang Oh Ki-Tae Suk Source Type: research
Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Conclusion: Hypoxic/ischemic injury and infection are the predominant etiologies of NALF in China. The overall prognosis of NALF is poor, but its short-term prognosis is determined by the etiology. What is Known: • Neonatal acute liver failure (NALF) is a rare disorder with limited cohort studies, especially in China. • Gestational alloimmune liver disease, viral infections (especially herpes simplex virus), metabolic diseases and ischemic insults are common etiologies of NALF, which are significantly different from other populations. • There are no reliable biochemical markers to predict the outcome of NALF. What is...
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Suhua Xu Peng Zhang Mengmeng Ge Yuanyuan Shan Guoqiang Cheng Source Type: research
A consortium of < em > Hordeum vulgare < /em > and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):250-260. doi: 10.1080/21691401.2024.2347380. Epub 2024 Apr 30.ABSTRACTDespite many recent studies on non-alcoholic fatty liver disease (NAFLD) therapeutics, the optimal treatment has yet to be determined. In this unfinished project, we combined secondary metabolites (SMs) from the gut microbiota (GM) and Hordeum vulgare (HV) to investigate their combinatorial effects via network pharmacology (NP). Additionally, we analyzed GM or barley - signalling pathways - targets - metabolites (GBSTMs) in combinatorial perspectives (HV, and GM). A total of 31 key targets were analysed via ...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been Lee Haripriya Gupta Byeong-Hyun Min Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Sang Youn Lee Mi-Ran Choi Dong Joon Kim Ki-Kwang Oh Ki-Tae Suk Source Type: research
A consortium of Hordeum vulgare and gut microbiota against non-alcoholic fatty liver disease via data-driven analysis
Volume 52, Issue 1, December 2024, Page 250-260 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - April 30, 2024 Category: Biotechnology Authors: Su-Been LeeHaripriya GuptaByeong-Hyun MinRaja GanesanSatya Priya SharmaSung-Min WonJin-Ju JeongMin-Gi ChaGoo-Hyun KwonMin-Kyo JeongJi-Ye HyunJung-A EomHee-Jin ParkSang-Jun YoonSang Youn LeeMi-Ran ChoiDong Joon KimKi-Kwang OhKi-Tae SukInstitute for Liver a Source Type: research
